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1. 发明申请

US20080274984A1 METHOD, COMPOSITION AND KIT FOR ANTIGENIC BINDING OF NORWALK-LIKE VIRUSES 有权
标题翻译：方法，组合物和用于抗病毒结合的病毒样病毒
公开(公告)号：US20080274984A1
公开(公告)日：2008-11-06
申请号：US12040530
申请日：2008-02-29
申请人： Xi Jiang , Jacques Le Pendu
发明人： Xi Jiang , Jacques Le Pendu
IPC分类号： A61K31/70 , C07H3/00
CPC分类号： G01N33/56983 , A61K31/70 , G01N33/80 , G01N2333/08 , G01N2469/10 , G01N2500/02
摘要： A method for detecting a Norwalk-Like Virus (NLV) in a biological sample, comprising the steps of: obtaining a biological sample suspected of containing a NLV; contacting the biological sample with at least one human histo-blood group antigen to allow formation of a complex of the NLV with the antigen; and detecting the antigen-NLV complex. The antigen-NLV complex can be detected by contacting the NLV-antigen complex with a NLV antibody that binds at an epitope of the NLV, and detecting the NLV antibody. The invention also includes a method for identifying compounds, and the compounds, that can inhibit the binding between a Norwalk-Like Virus (NLV) and a histo-blood group antigen. The method includes the steps of contacting the NLV target with a compound; subsequently contacting the NLV with a standard compound that is known to be bound at a determinant binding site of the NLV; and determining whether the binding of the standard compound is decreased in the presence of the test compound, the decrease in binding being an indication that the test compound inhibits the binding activity of the NLV with the standard compound. In preferred embodiments, the standard compound is a histo-blood group antigen.
摘要翻译：一种用于在生物样品中检测诺瓦克样病毒（NLV）的方法，包括以下步骤：获得怀疑含有NLV的生物样品; 使所述生物样品与至少一种人组织血型抗原接触以允许形成所述NLV与所述抗原的复合物; 并检测抗原-NAV复合物。可以通过使NLV-抗原复合物与在NLV的表位结合的NLV抗体接触并检测NLV抗体来检测抗原-NOV复合物。本发明还包括鉴定可以抑制诺沃克样病毒（NLV）和组织血型抗原之间的结合的化合物和化合物的方法。该方法包括使NLV靶与化合物接触的步骤; 随后使NLV与已知结合在NLV的决定簇结合位点的标准化合物接触; 并测定在测试化合物存在下标准化合物的结合是否降低，结合的降低表明测试化合物抑制NLV与标准化合物的结合活性。在优选的实施方案中，标准化合物是组织 - 血型抗原。

2. 发明授权

US07977098B2 Antigenic binding patterns of norovirus to human histo-blood group antigens 有权
标题翻译：诺维病毒与人组织血型抗原的抗原结合模式
公开(公告)号：US07977098B2
公开(公告)日：2011-07-12
申请号：US11264992
申请日：2005-11-02
申请人： Xi Jiang , Jacques Le Pendu
发明人： Xi Jiang , Jacques Le Pendu
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/56983 , A61K31/70 , G01N33/80 , G01N2333/08 , G01N2469/10 , G01N2500/02 , Y10S435/975
摘要： The invention provides a compound which competitively inhibits the binding of a norovirus with a native blood antigen of a human host, as well as a kit for determining whether an individual has been infected by a norovirus. Also provided is a method for determining the susceptibility of an individual to infection by a particular, known strain of norovirus. The invention is based on the determination that noroviruses recognize human blood antigens such as human histo-blood group antigens (HBGAs) as a receptor in seven specific binding patterns. The invention allows one to predict that a particular strain of norovirus can infect humans who have a particular human histo-blood type, as well as blood antigens that can bind the particular strain of infecting norovirus. The invention also allows one to predict that a particular strain of norovirus will bind with one or more particular histo-blood group antigens, but will not bind with other blood group antigens.
摘要翻译：本发明提供了竞争性抑制诺如病毒与人宿主的天然血液抗原结合的化合物，以及用于确定个体是否已经被诺如病毒感染的试剂盒。还提供了一种用于确定个体对特定的已知病毒型诺如病毒感染的敏感性的方法。本发明基于诺华病毒在七种特异性结合模式中识别人类血液抗原如人组织血型抗原（HBGAs）作为受体的确定。本发明允许预测特定的诺如病毒株可以感染具有特定人组织血型的人，以及能够结合感染性诺如病毒的特定菌株的血液抗原。本发明还允许预测特定的诺如病毒株与一种或多种特定组织血型抗原结合，但不会与其他血型抗原结合。

3. 发明授权

US08026221B2 Method, composition and kit for antigenic binding of norwalk-like viruses 有权
标题翻译：诺沃克样病毒的抗原结合方法，组合物和试剂盒
公开(公告)号：US08026221B2
公开(公告)日：2011-09-27
申请号：US12040530
申请日：2008-02-29
申请人： Xi Jiang , Jacques Le Pendu
发明人： Xi Jiang , Jacques Le Pendu
IPC分类号： A61K31/702 , C07H15/04 , C07H15/06 , C07H5/04
CPC分类号： G01N33/56983 , A61K31/70 , G01N33/80 , G01N2333/08 , G01N2469/10 , G01N2500/02
摘要： A method for detecting a Norwalk-Like Virus (NLV) in a biological sample, comprising the steps of: obtaining a biological sample suspected of containing a NLV; contacting the biological sample with at least one human histo-blood group antigen to allow formation of a complex of the NLV with the antigen; and detecting the antigen-NLV complex. The antigen-NLV complex can be detected by contacting the NLV-antigen complex with a NLV antibody that binds at an epitope of the NLV, and detecting the NLV antibody. The invention also includes a method for identifying compounds, and the compounds, that can inhibit the binding between a Norwalk-Like Virus (NLV) and a histo-blood group antigen. The method includes the steps of contacting the NLV target with a compound; subsequently contacting the NLV with a standard compound that is known to be bound at a determinant binding site of the NLV; and determining whether the binding of the standard compound is decreased in the presence of the test compound, the decrease in binding being an indication that the test compound inhibits the binding activity of the NLV with the standard compound. In preferred embodiments, the standard compound is a histo-blood group antigen.
摘要翻译：一种用于在生物样品中检测诺瓦克样病毒（NLV）的方法，包括以下步骤：获得怀疑含有NLV的生物样品; 使所述生物样品与至少一种人组织血型抗原接触以允许形成所述NLV与所述抗原的复合物; 并检测抗原-NAV复合物。可以通过使NLV-抗原复合物与在NLV的表位结合的NLV抗体接触并检测NLV抗体来检测抗原-NOV复合物。本发明还包括鉴定可以抑制诺沃克样病毒（NLV）和组织血型抗原之间的结合的化合物和化合物的方法。该方法包括使NLV靶与化合物接触的步骤; 随后使NLV与已知结合在NLV的决定簇结合位点的标准化合物接触; 并测定在测试化合物存在下标准化合物的结合是否降低，结合的降低表明测试化合物抑制NLV与标准化合物的结合活性。在优选的实施方案中，标准化合物是组织 - 血型抗原。

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