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1. 发明授权

US5976066A Neutron capture therapies 失效
标题翻译：中子捕获治疗
公开(公告)号：US5976066A
公开(公告)日：1999-11-02
申请号：US919870
申请日：1997-08-28
申请人： Jacquelyn C. Yanch , Ruth E. Shefer , Robert E. Klinkowstein
发明人： Jacquelyn C. Yanch , Ruth E. Shefer , Robert E. Klinkowstein
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/10 , A61N2005/109 , Y10S376/904
摘要： In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.
摘要翻译：在一个实施方案中，提供了用于治疗类风湿性关节炎的10B（n，α）7Li核反应或其他中子捕获反应的应用。这种称为硼中子捕获滑膜切除术（BNCS）的应用对于中子束设计要求比对深部肿瘤治疗的要求大大改变。提供了通过BNCS治疗关节炎关节的中子束设计的考虑因素，并与肿瘤的硼中子俘获治疗（BNCT）的设计要求进行了比较。另外，提供了基于（p，n）基于加速剂的反应产生强烈，高质量的中子束的示例性的慢化剂/反射器组件。在另一个实施方案中，提供了使用基于氘核的带电粒子反应作为中子俘获疗法的超热或热中子束的来源。许多d，n反应（例如使用氘，氚或铍靶）在相对较低的氘核能量下是非常多产的。

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