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1. 发明申请

US20110059100A1 C/CLP Antagonists And Methods Of Use Thereof 审中-公开
标题翻译： C / CLP拮抗剂及其使用方法
公开(公告)号：US20110059100A1
公开(公告)日：2011-03-10
申请号：US12351145
申请日：2009-01-09
申请人： Jennifer L. Reed , Wendy I. White , Anthony Coyle , Alexander Kozhich , Jack Elias , Nanci Donacki , Changshou Gao , Herren Wu
发明人： Jennifer L. Reed , Wendy I. White , Anthony Coyle , Alexander Kozhich , Jack Elias , Nanci Donacki , Changshou Gao , Herren Wu
IPC分类号： A61K39/395 , C07K16/00 , A61P11/00
CPC分类号： C07K16/40 , A61K48/00 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C12N9/2442 , C12N15/86 , C12N2710/10343 , C12Y302/01014
摘要： The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL-13 mediated inflammatory diseases. Accordingly the present invention provides C/CLP antagonists and also provides compositions and methods for the prevention, management, treatment or amelioration of an inflammatory condition associated with the upregulation of a C/CLP or one or more symptoms thereof and/or the inhibition of IL-13 mediated inflammation.
摘要翻译：本发明涉及拮抗C / CLP的新发现，可用于治疗与上调一种或多种C / CLP如Th2驱动和/或IL-13介导的炎性疾病相关的疾病。因此，本发明提供了C / CLP拮抗剂，并且还提供了用于预防，治疗，改善与C / CLP或其一种或多种症状的上调相关的炎性病症和/或抑制IL的组合物和方法 -13介导的炎症。

2. 发明申请

US20060030562A1 Use of an inhibitor of cathepsin-S-or-B to treat or prevent chronic obstructive pulmonary disease 审中-公开
标题翻译：使用组织蛋白酶S-or-B的抑制剂治疗或预防慢性阻塞性肺疾病
公开(公告)号：US20060030562A1
公开(公告)日：2006-02-09
申请号：US11242411
申请日：2005-10-03
申请人： Tao Zheng , Jack Elias , Stephen Underwood
发明人： Tao Zheng , Jack Elias , Stephen Underwood
IPC分类号： A61K31/5377
CPC分类号： A61K31/545 , A61K31/00 , A61K31/5377 , A61K38/005
摘要： This invention is directed to the use of an inhibitor of cathepsin-S or -B, or composition thereof to treat or prevent chronic obstruction pulmonary disease, or physiological condition associated therewith. Such a therapy would occur using at least one of such inhibitors alone or in combination with the other, or further in combination with an anti-inflammatory agent.
摘要翻译：本发明涉及组织蛋白酶-S或-B抑制剂或其组合物用于治疗或预防慢性阻塞性肺疾病或与之相关的生理状况的用途。这种治疗将使用至少一种这样的抑制剂单独或与另一种组合发生，或进一步与抗炎剂组合发生。

3. 发明授权

US4195769A Method and apparatus for fault-testing of electrical system monitor communication circuits 失效
标题翻译：电气系统监控通信电路故障检测方法及装置
公开(公告)号：US4195769A
公开(公告)日：1980-04-01
申请号：US914786
申请日：1978-06-12
申请人： Jack Elias , Arthur M. Olen
发明人： Jack Elias , Arthur M. Olen
IPC分类号： G05B23/02 , G01R31/00 , G01R31/02 , G06F11/00
CPC分类号： G01R31/026 , G01R31/00
摘要： A method for fault-testing of electrical apparatus includes the steps of interrupting the application of control signals normally producing changes in the electrical apparatus, disconnecting electrical apparatus monitoring circuits from energizing signal means used to produce output signals from the electrical apparatus monitoring circuits dependent on the state of electrical apparatus, and checking the subsequent output of monitoring circuits to detect the output signal to detect output signals during the deenergized state indicative of a fault in the monitoring circuits. An apparatus for performing the aforesaid testing method includes a digital computer having a stored test control program therein for selectively addressing the power supply connection means of the monitoring equipment to produce a deenergization of the monitoring equipment and means for checking the output of the monitoring equipment after the deenergization thereof.
摘要翻译：一种用于电气设备故障检测的方法包括：中断正常产生电气设备变化的控制信号的应用，将电气设备监控电路与用于根据电气设备监控电路产生输出信号的激励信号装置断开连接并且检查监视电路的后续输出以检测输出信号以在表示监视电路中的故障的断电状态期间检测输出信号。用于执行上述测试方法的装置包括：数字计算机，其具有存储的测试控制程序，用于选择性地寻址监视设备的电源连接装置，以产生监控设备的断电和检测监视设备的输出的装置，其断电。

4. 发明授权

US4065676A Battery backup for AC powered DC supply 失效
标题翻译：交流电源直流电源的电池备份
公开(公告)号：US4065676A
公开(公告)日：1977-12-27
申请号：US692127
申请日：1976-06-02
申请人： Jack Elias
发明人： Jack Elias
IPC分类号： H02H3/46 , H02J9/06 , H02J9/00
CPC分类号： H02H3/46 , H02J9/061 , Y10T307/625 , Y10T307/735
摘要： A battery backup system for an AC energized DC supply has an AC line monitor for producing a pulse signal having a pulse width dependent on rise time of the AC signal and a frequency dependent on zero line crossings of the AC signal. The pulse signals are checked for frequency and pulse width by being used to control the charging time of a timing capacitor for a timer and to be compared with the pulse width of a predetermined reference pulse, respectively. The occurrence of a defect in the pulse signals stemming from either pulse testing criteria is effective to trigger an SCR circuit into conduction to connect a backup battery to the load devices to replace the DC power formerly being supplied by the AC line. After restoration of the AC power, the backup battery is removed following a fixed time delay to allow the AC powered DC supply to stabilize. A battery charging power supply is connected to the backup battery and is automatically switched between a battery "float-rate" and a "high-rate" charging operation following an AC outage and returned when the charging current indicates that the backup battery is fully charged.
摘要翻译：用于AC通电DC电源的电池备用系统具有AC线路监视器，用于产生具有取决于AC信号的上升时间的脉冲宽度的脉冲信号和取决于AC信号的零线路交叉的频率。通过用于控制定时器的定时电容器的充电时间并分别与预定参考脉冲的脉冲宽度进行比较来检查脉冲信号的频率和脉冲宽度。由脉冲测试标准产生的脉冲信号的缺陷的发生是有效的，以触发SCR电路导通以将备用电池连接到负载装置以替代以前由AC线提供的DC电力。在交流电源恢复之后，在固定的时间延迟之后，备用电池被移除，以允许交流供电的直流电源稳定。电池充电电源连接到备用电池，并且在交流电中断之后自动切换电池“浮充电”和“高速”充电操作之间，并且当充电电流指示备用电池充满电时返回。

5. 发明申请

US20060063728A1 Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease 审中-公开
公开(公告)号：US20060063728A1
公开(公告)日：2006-03-23
申请号：US10980354
申请日：2004-11-03
申请人： Jack Elias , Zhou Zhu
发明人： Jack Elias , Zhou Zhu
IPC分类号： A61K48/00 , A61K38/16 , A61K38/12 , A61K39/395 , A61K31/525 , A61K31/195
CPC分类号： A61K39/395 , A61K31/00 , A61K31/70 , A61K38/12 , C07K16/18 , C07K16/40 , C07K2317/77 , C12N9/2442 , C12Y302/01014 , Y10S424/81 , Y10S530/868
摘要： The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.

6. 发明授权

US836333A Chimney closure and ventilator. 失效
标题翻译： CHIMNEY关闭和通风器。
公开(公告)号：US836333A
公开(公告)日：1906-11-20
申请号：US1905267620
申请日：1905-06-29
申请人： NELSON JACK ELIAS
发明人： NELSON JACK ELIAS
CPC分类号： E04H15/14

7. 发明申请

US20070071746A1 C/CLP antagonists and methods of use thereof 审中-公开
标题翻译： C / CLP拮抗剂及其使用方法
公开(公告)号：US20070071746A1
公开(公告)日：2007-03-29
申请号：US11512267
申请日：2006-08-30
申请人： Jennifer Reed , Wendy White , Anthony Coyle , Alexander Kozhich , Jack Elias
发明人： Jennifer Reed , Wendy White , Anthony Coyle , Alexander Kozhich , Jack Elias
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/40 , A61K48/00 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C12N9/2442 , C12N15/86 , C12N2710/10343 , C12Y302/01014
摘要： The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL-13 mediated inflammatory diseases. Accordingly the present invention provides C/CLP antagonists and also provides compositions and methods for the prevention, management, treatment or amelioration of an inflammatory condition associated with the upregulation of a C/CLP or one or more symptoms thereof and/or the inhibition of IL-13 mediated inflammation.
摘要翻译：本发明涉及拮抗C / CLP的新发现，可用于治疗与上调一种或多种C / CLP如Th2驱动和/或IL-13介导的炎性疾病相关的疾病。因此，本发明提供了C / CLP拮抗剂，并且还提供了用于预防，治疗，改善与C / CLP或其一种或多种症状的上调相关的炎性病症和/或抑制IL的组合物和方法 -13介导的炎症。

8. 发明授权

US06973188B1 Analog scrambler 有权
标题翻译：模拟扰频器
公开(公告)号：US06973188B1
公开(公告)日：2005-12-06
申请号：US10080560
申请日：2002-02-25
申请人： Jack Elias Seitner
发明人： Jack Elias Seitner
IPC分类号： H04K1/04 , H04B1/68 , H04L9/00
CPC分类号： H04K1/04
摘要： A method for scrambling/descrambling an analog signal includes receiving an analog signal and converting the signal into an intermediate frequency signal. A Gaussian pseudo-random noise signal is generated and then multiplied with the intermediate frequency signal to scramble/descramble the received analog signal.
摘要翻译：用于对模拟信号进行加扰/解扰的方法包括接收模拟信号并将该信号转换成中频信号。产生高斯伪随机噪声信号，然后与中频信号相乘以加扰/解扰所接收的模拟信号。

9. 发明授权

US4584651A Process controller with power outage analysis capability 失效
标题翻译：具有停电分析能力的过程控制器
公开(公告)号：US4584651A
公开(公告)日：1986-04-22
申请号：US528311
申请日：1983-08-31
申请人： John L. Carey, Jr. , Jack Elias
发明人： John L. Carey, Jr. , Jack Elias
IPC分类号： G04F10/00 , G05B19/042 , G06F1/14 , G07C3/04
CPC分类号： G05B19/0428 , G04F10/00 , G06F1/14 , G07C3/04 , G05B2219/25375
摘要： A process controller with power outage analysis capability uses a real time clock generator powered by an uninterruptible power source for providing a real time reference which is used to measure the actual duration of a process controller disabling power outage. A non-volatile memory is also powered by the uninterruptible power source and is used to store the maximum allowable outage time limit for a particular process being controlled. The clock generator is initialized at the start of the power outage by a power outage detector which provides an early warning of an imminent power outage. After the power is restored to the controller, a digital computer used in the process controller compares the actual power outage time as represented by the accumulated clock time with allowable power outage time limit stored in the memory and is arranged to provide a first process control sequence if the actual power outage time is less than the maximum allowable time and a second process control sequence if the actual power outage time is greater than the maximum allowable time.
摘要翻译：具有停电分析功能的过程控制器使用由不间断电源供电的实时时钟发生器，用于提供实时参考，用于测量过程控制器禁用停电的实际持续时间。非易失性存储器还由不间断电源供电，并用于存储被控制的特定过程的最大允许停电时间限制。时钟发生器在断电开始时被停电检测器初始化，该断电检测器提供即将发生的断电的早期警告。在电源恢复到控制器之后，在过程控制器中使用的数字计算机将由累积时钟时间表示的实际停电时间与存储在存储器中的允许停电时间限制进行比较，并且被布置成提供第一过程控制序列如果实际断电时间小于最大允许时间，则实际断电时间大于最大允许时间时的第二过程控制序列。

10. 发明授权

US4181842A D.C. monitoring circuit 失效
标题翻译：直流监控电路
公开(公告)号：US4181842A
公开(公告)日：1980-01-01
申请号：US722785
申请日：1976-09-13
申请人： Jack Elias , Theodore B. Bozarth
发明人： Jack Elias , Theodore B. Bozarth
IPC分类号： G01R19/165 , H02J9/06 , H02J9/00
CPC分类号： G01R19/16538 , H02J9/061 , Y10T307/615 , Y10T307/625
摘要： A power supply structure for an electronic system includes a primary power source and a stand-by or secondary power source. The secondary power source is ground circuit isolated from the primary source. A monitoring circuit, which is energized from the secondary source is connected to monitor the primary source for incipient failure, then to produce an output signal which may be used to trigger an alarm and/or switch the secondary power source into energizing connection with respect to the electronic system.
摘要翻译：电子系统的电源结构包括主电源和待机或二次电源。二次电源是与主电源隔离的接地电路。从二次电源通电的监控电路被连接以监测初始故障的初始源，然后产生可用于触发报警和/或将次级电源切换到相对于电子系统。

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