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1. 发明授权

US08932498B2 Device for preparation of liposomes and method thereof 有权
标题翻译：脂质体制备装置及其制备方法
公开(公告)号：US08932498B2
公开(公告)日：2015-01-13
申请号：US12870693
申请日：2010-08-27
申请人： JA-An Ho , Yeh-Chun Lin
发明人： JA-An Ho , Yeh-Chun Lin
IPC分类号： A61K9/127 , B01J8/00 , B01J13/04 , B01J13/12
CPC分类号： A61K9/127 , A61K9/1277 , B01J13/04 , B01J13/125
摘要： Disclosed is a device for preparation of liposomes, comprises a reaction tank and an infusion unit. The reaction tank comprises a collector mounted in a predetermined position of the reaction tank; Two inlet ports are included: the first inlet port for infusing an aqueous solution; and the second inlet port for infusing an organic solution. The infusion unit can introduce a bioactive agent containing-aqueous solution into the reaction tank. The infusion unit comprises a filter connected to one end of the infusion unit and being adjacent to the collector. The method using the device comprises the steps of infusing an aqueous solution and an organic solution into the reaction tank of the device and thus forming an interface between the filter and the collector; infusing a bioactive agent containing-aqueous solution and being filtered by the filter, the bioactive agent is encapsulated to form a water-in-oil emulsion; the water-in-oil emulsion is passing through the aqueous solution and thus to form a water-in-oil-in-water double emulsion. Finally the removal of the organic phase of water-in-oil-in-water double emulsion enables the harvest a plurality of liposomes. It has advantages such that simple-used and automation production. Thus nano size or sub-micro size liposomes can be prepared with high encapsulation efficiency without sonicators or delicate microfluidic systems.
摘要翻译：公开了用于制备脂质体的装置，包括反应罐和输注单元。反应槽包括安装在反应罐的预定位置的集流器; 包括两个入口：用于注入水溶液的第一入口; 以及用于注入有机溶液的第二入口。输液单元可以将含有水溶液的生物活性剂引入反应罐。输注单元包括连接到输注单元的一端并且与收集器相邻的过滤器。使用该装置的方法包括将水溶液和有机溶液注入装置的反应槽中并由此形成过滤器和收集器之间的界面的步骤; 注入含有水溶液的生物活性剂并通过过滤器过滤，将生物活性剂包封以形成油包水乳液; 油包水乳液通过水溶液，从而形成水包油包水双乳液。最后，去除水包油包水双乳液中的有机相使得能够收获多个脂质体。它具有简单易用和自动化生产的优点。因此，在没有超声波清洗机或精细微流体系统的情况下，可以以高的包封效率制备纳米尺寸或亚微米尺寸的脂质体。

2. 发明申请

US20110089379A1 Development Of Phopholipid-Capped Gold Nanoparticles (PLGNPs) As Surface Enhanced Raman Scattering Probes 有权
标题翻译：作为表面增强拉曼散射探针的磷脂包覆的金纳米颗粒（PLGNP）的开发
公开(公告)号：US20110089379A1
公开(公告)日：2011-04-21
申请号：US12857327
申请日：2010-08-16
申请人： Ja-An Ho , Si-Han Chen
发明人： Ja-An Ho , Si-Han Chen
IPC分类号： B32B15/02 , C23F1/00 , B82Y15/00 , B82Y40/00
CPC分类号： B82Y15/00 , B82Y5/00 , C40B70/00
摘要： The molecule is prepared by capping phospholipid on a single gold nanoparticle (GNP). Since the thiol-related molecule bounded on GNP shows the characteristic of surface-enhanced Raman scattering (SERS), the phospholipid-capped gold nanoparticle (PLGNP) can be formed as a nanoprobe applied on the detection device integrating optics and chemistry and used in the fields of biomedicine, medical diagnosis and environment for detecting, such as solutions containing salts or proteins.
摘要翻译：该分子通过在单一金纳米颗粒（GNP）上封端磷脂来制备。由于与GNP结合的硫醇相关分子显示了表面增强拉曼散射（SERS）的特征，磷脂封端的金纳米颗粒（PLGNP）可以形成为纳米探针，其应用于集成光学和化学的检测装置，并用于生物医学领域，医学诊断和检测环境，如含有盐或蛋白质的溶液。

3. 发明授权

US08753541B2 Development of phopholipid-capped gold nanoparticles (PLGNPs) as surface enhanced Raman scattering probes 有权
标题翻译：作为表面增强拉曼散射探针的磷脂脂封端金纳米粒子（PLGNP）的开发
公开(公告)号：US08753541B2
公开(公告)日：2014-06-17
申请号：US12857327
申请日：2010-08-16
申请人： Ja-An Ho , Si-Han Chen
发明人： Ja-An Ho , Si-Han Chen
IPC分类号： G01N21/01 , B82Y15/00 , B82Y40/00
CPC分类号： B82Y15/00 , B82Y5/00 , C40B70/00
摘要： The molecule is prepared by capping phospholipid on a single gold nanoparticle (GNP). Since the thiol-related molecule bounded on GNP shows the characteristic of surface-enhanced Raman scattering (SERS), the phospholipid-capped gold nanoparticle (PLGNP) can be formed as a nanoprobe applied on the detection device integrating optics and chemistry and used in the fields of biomedicine, medical diagnosis and environment for detecting, such as solutions containing salts or proteins.
摘要翻译：该分子通过在单一金纳米颗粒（GNP）上封端磷脂来制备。由于与GNP结合的硫醇相关分子显示了表面增强拉曼散射（SERS）的特征，磷脂封端的金纳米颗粒（PLGNP）可以形成为纳米探针，其应用于集成光学和化学的检测装置，并用于生物医学领域，医学诊断和检测环境，如含有盐或蛋白质的溶液。

4. 发明申请

US20110163468A1 Device For Preparation of Liposomes and Method Thereof 有权
标题翻译：脂质体制备装置及方法
公开(公告)号：US20110163468A1
公开(公告)日：2011-07-07
申请号：US12870693
申请日：2010-08-27
申请人： Ja-an Ho , Yeh-Chun Lin
发明人： Ja-an Ho , Yeh-Chun Lin
IPC分类号： A61K9/127 , B01J8/00
CPC分类号： A61K9/127 , A61K9/1277 , B01J13/04 , B01J13/125
摘要： Disclosed is a device for preparation of liposomes, comprises a reaction tank and an infusion unit. The reaction tank comprises a collector mounted in a predetermined position of the reaction tank; Two inlet ports are included: the first inlet port for infusing an aqueous solution; and the second inlet port for infusing an organic solution. The infusion unit can introduce a bioactive agent containing-aqueous solution into the reaction tank. The infusion unit comprises a filter connected to one end of the infusion unit and being adjacent to the collector. The method using the device comprises the steps of infusing an aqueous solution and an organic solution into the reaction tank of the device and thus forming an interface between the filter and the collector; infusing a bioactive agent containing-aqueous solution and being filtered by the filter, the bioactive agent is encapsulated to form a water-in-oil emulsion; the water-in-oil emulsion is passing through the aqueous solution and thus to form a water-in-oil-in-water double emulsion. Finally the removal of the organic phase of water-in-oil-in-water double emulsion enables the harvest a plurality of liposomes. It has advantages such that simple-used and automation production. Thus nano size or sub-micro size liposomes can be prepared with high encapsulation efficiency without sonicators or delicate microfluidic systems.
摘要翻译：公开了用于制备脂质体的装置，包括反应罐和输注单元。反应槽包括安装在反应罐的预定位置的集流器; 包括两个入口：用于注入水溶液的第一入口; 以及用于注入有机溶液的第二入口。输液单元可以将含有水溶液的生物活性剂引入反应罐。输注单元包括连接到输注单元的一端并且与收集器相邻的过滤器。使用该装置的方法包括将水溶液和有机溶液注入装置的反应槽中并由此形成过滤器和收集器之间的界面的步骤; 注入含有水溶液的生物活性剂并通过过滤器过滤，将生物活性剂包封以形成油包水乳液; 油包水乳液通过水溶液，从而形成水包油包水双乳液。最后，去除水包油包水双乳液中的有机相使得能够收获多个脂质体。它具有简单易用和自动化生产的优点。因此，在没有超声波清洗机或精细微流体系统的情况下，可以以高的包封效率制备纳米尺寸或亚微米尺寸的脂质体。

5. 发明授权

US08758811B2 Biofunctionalized phospholipid-capped mesoporous silica nanoshuttles for targeted drug delivery 有权
标题翻译：用于靶向药物递送的生物功能化的磷脂封端的介孔二氧化硅纳米片
公开(公告)号：US08758811B2
公开(公告)日：2014-06-24
申请号：US12952094
申请日：2010-11-22
申请人： Ja-An Ho , Li-Sheng Wang , Chia-Min Yang , Li-Chen Wu
发明人： Ja-An Ho , Li-Sheng Wang , Chia-Min Yang , Li-Chen Wu
IPC分类号： A61K9/127 , A61K51/12 , A61K38/16 , A61K39/395 , A61K38/18 , A61K31/7088 , A61K31/519 , A61P43/00 , A61P37/00 , A61K47/06 , B82Y5/00
CPC分类号： B82Y5/00 , A61K31/519 , A61K47/6923
摘要： The present invention provides a multilayer vehicle, including a mesoporous silica core and a lipid bilayer coating thereon. Hydrophobic molecules are formed between the silica core and lipid layer. Additionally, methods and uses of the multilayer vehicle are also provided.
摘要翻译：本发明提供了一种多层载体，其中包括介孔二氧化硅芯和脂质双层涂层。在二氧化硅芯和脂质层之间形成疏水分子。此外，还提供了多层车辆的方法和用途。

6. 发明申请

US20110120889A1 Detection Device of Screen-Printed Electrode With High Sensitivity 审中-公开
标题翻译：具有高灵敏度的丝网印刷电极检测装置
公开(公告)号：US20110120889A1
公开(公告)日：2011-05-26
申请号：US12708869
申请日：2010-02-19
申请人： Ja-An HO , Wei-Ching LIAO
发明人： Ja-An HO , Wei-Ching LIAO
IPC分类号： G01N27/26
CPC分类号： G01N33/5438 , G01N27/3277 , G01N2333/245
摘要： A detection device for detecting Escherichia coli in a sample includes: an electrode coated with a metal layer, which is further bound with a first nucleic acid sequence; and a second nucleic acid sequence bound with a liposome having an electrochemical material. The second nucleic acid sequence competes with the first nucleic acid sequence for a complementary binding ability, and the liposome is broken to release the electrochemical material. Then, the release electrochemical material is determined so as to estimate whether a third nucleic acid sequence specific for E. coli exists in the sample, where the third nucleic acid sequence is complementary with the first nucleic acid sequence. A trace amount (10−15 mole) of first nucleic acid sequence can be detected using the detection device, which is has advantages of low price, speedy reaction, portability and minimization etc. and can be used for detecting other molecules.
摘要翻译：用于检测样品中的大肠杆菌的检测装置包括：涂覆有金属层的电极，其进一步与第一核酸序列结合; 和与具有电化学材料的脂质体结合的第二核酸序列。第二核酸序列与第一核酸序列竞争互补结合能力，并且破坏脂质体以释放电化学材料。然后，确定释放电化学材料，以便估计样品中是否存在对大肠杆菌特异性的第三核酸序列，其中第三核酸序列与第一核酸序列互补。可以使用检测装置检测微量（10-15摩尔）的第一核酸序列，其具有价格低廉，反应速度快，携带性和最小化等优点，并且可用于检测其他分子。

7. 发明申请

US20110123601A1 BIOFUNCTIONALIZED PHOSPHOLIPID-CAPPED MESOPOROUS SILICA NANOSHUTTLES FOR TARGETED DRUG DELIVERY 有权
标题翻译：用于定向药物递送的生物功能化的磷脂酰胺多糖二氧化硅纳米颗粒
公开(公告)号：US20110123601A1
公开(公告)日：2011-05-26
申请号：US12952094
申请日：2010-11-22
申请人： Ja-An HO , Li-Sheng Wang , Chia-Min Yang , Li-Chen Wu
发明人： Ja-An HO , Li-Sheng Wang , Chia-Min Yang , Li-Chen Wu
IPC分类号： A61K9/127 , A61K51/12 , A61K38/16 , A61K39/395 , A61K38/18 , A61K31/7088 , A61K31/519 , A61P43/00 , A61P37/00 , A61K47/06 , B82Y5/00
CPC分类号： B82Y5/00 , A61K31/519 , A61K47/6923
摘要： The present invention provides a multilayer vehicle, including a mesoporous silica core and a lipid bilayer coating thereon. Hydrophobic molecules are formed between the silica core and lipid layer. Additionally, methods and uses of the multilayer vehicle are also provided.
摘要翻译：本发明提供了一种多层载体，其中包括介孔二氧化硅芯和脂质双层涂层。在二氧化硅芯和脂质层之间形成疏水分子。此外，还提供了多层车辆的方法和用途。

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