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1. 发明申请

US20060292184A1 Bioadhesive liquid composition which is substantially free of water 审中-公开
标题翻译：基本上不含水的生物粘合剂液体组合物
公开(公告)号：US20060292184A1
公开(公告)日：2006-12-28
申请号：US10545974
申请日：2004-02-13
申请人： Johnathan Richardson , Colin Melia , Peter Dettmar , Frank Hampson , Ian Jolliffe
发明人： Johnathan Richardson , Colin Melia , Peter Dettmar , Frank Hampson , Ian Jolliffe
IPC分类号： A61K9/00
CPC分类号： A61K9/0095 , A61K9/006 , A61K31/00 , A61K31/734 , A61K47/10 , A61K47/34
摘要： A liquid composition for adherence to a bodily surface, notably to a bodily surface, especially a mucosal surface, comprises water-swellable polymer particles suspended in a water-miscible liquid diluent, wherein the liquid diluent is substantially free of water or includes an amount of water insufficient to fully swell the polymer particles. On admixture with water the composition thickens and becomes more adherent to surfaces. Thus the composition may be easy to administer but may become thick and adherent at the treatment site.
摘要翻译：用于粘附到身体表面，特别是身体表面，特别是粘膜表面的液体组合物包括悬浮在与水混溶的液体稀释剂中的水溶胀性聚合物颗粒，其中液体稀释剂基本上不含水或包括一定量的水不足以使聚合物颗粒完全溶胀。在与水混合时，组合物变稠并变得更粘附于表面。因此，组合物可能易于施用，但可能在治疗部位变稠和粘附。

2. 发明申请

US20070087038A1 GELLING COMPOSITIONS AND METHODS 审中-公开
标题翻译：凝胶组合物和方法
公开(公告)号：US20070087038A1
公开(公告)日：2007-04-19
申请号：US11538678
申请日：2006-10-04
申请人： JOHNATHAN RICHARDSON , PETER DETTMAR , OLAV GASEROD , TROND HELGERUD
发明人： JOHNATHAN RICHARDSON , PETER DETTMAR , OLAV GASEROD , TROND HELGERUD
IPC分类号： A61K47/00
CPC分类号： A61K31/715 , A23L33/30 , A61K9/0065 , A61K9/0095 , A61K9/20 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K47/02 , A61K47/36
摘要： A method for the administration of a composition that augments the acidity of gastric fluid such that intra-gastric gelation of the polysaccharide:acid soluble multivalent cation formulation is initiated independent of endogenous acid secretion. The composition includes:(a) at least one of a polysaccharide, modified polysaccharide, or polysaccharide salt, each capable of ionotropic gelation, (b) at least one source of multivalent cations capable of solubilization at an acidic pH, and (c) at least one acid component capable of providing a controlled release of protons sufficient to solubilize the multivalent cations. The composition is capable of hydrating in aqueous media and subsequently forming a gel in a stomach when ingested, which gel resists peristaltic forces and remains in the stomach for an extended time. Also disclosed are edible compositions including this composition, as well as methods of inducing a satiety effect and providing controlled release of various components employing the composition of the invention.
摘要翻译：用于施用增加胃液酸度的组合物的方法，使得多糖：酸溶性多价阳离子制剂的胃内凝胶化独立于内源性酸分泌而开始。组合物包括：（a）多糖，改性多糖或多糖盐中的至少一种，各自能够具有离子型凝胶化，（b）至少一种能够在酸性pH下溶解的多价阳离子源，和（c）能够提供足以溶解多价阳离子的质子的受控释放的至少一种酸组分。该组合物能够在水性介质中水合，随后在摄入时在胃中形成凝胶，该凝胶抵抗蠕动力并在胃中长时间保留。还公开了包括该组合物的可食用组合物，以及诱导饱腹效果并使用本发明组合物提供控制释放各种组分的方法。

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