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    • 3. 发明申请
    • Antiviral Activity of Novel Bicyclic Heterocycles
    • 新型双环杂环的抗病毒活性
    • US20160030447A1
    • 2016-02-04
    • US14884997
    • 2015-10-16
    • Steven De JongheLing-Jie GaoPiet HerdewijnJean HermanMiyeon JangPieter LeyssenThierry LouatJohan NeytsChristophe PannecouqueBart Vanderhoydonck
    • Steven De JongheLing-Jie GaoPiet HerdewijnJean HermanMiyeon JangPieter LeyssenThierry LouatJohan NeytsChristophe PannecouqueBart Vanderhoydonck
    • A61K31/551A61K31/5377A61K31/519
    • A61K31/551A61K31/519A61K31/52A61K31/5377C07D473/00C07D513/04Y02A50/385Y02A50/465
    • The present invention relates to compound of Formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with RNA-viruses belonging to the family of the Retroviridae, the family of the Flaviviridae and the family of the Picornaviridae and more preferably infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HN2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovirus. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of viral disorders and pathologic conditions such as, but not limited to, viral infections with Human Immunodeficiency Virus 1 (HIV1), Human Immunodeficiency Virus 2 (HN2), Hepatitis C virus (HCV), Dengue virus, and enteroviruses like Coxsackievirus, Rhinovirus and Poliovints.
    • 本发明涉及式I,II,III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物,其中R1,R2,R3,R4,R5, R6,R7,R8,R9,R11和R12如权利要求1中所定义或如在本发明的描述中详细描述的,以及所述化合物用于治疗或预防病毒感染及其用于制造 治疗或预防病毒感染的药物,特别是属于逆转录病毒科的家族,微病毒科的家族和小核糖核酸病毒科家族的RNA病毒的感染,更优选人免疫缺陷病毒1(HIV1),人类免疫缺陷病毒2 (HN2),丙型肝炎病毒(HCV),登革热病毒和诸如柯萨奇病毒,鼻病毒和脊髓灰质炎病毒的肠道病毒。 本发明还涉及所述化合物的药物组合物和所述药物组合物用于治疗或预防病毒感染的用途。 本发明还涉及所述化合物作为生物活性成分的用途,更具体地说,作为治疗病毒性病症和病理状况的药物,例如但不限于人免疫缺陷病毒1(HIV1),人类免疫缺陷病毒 病毒2(HN2),丙型肝炎病毒(HCV),登革热病毒和诸如柯萨奇病毒,鼻病毒和Poliovints的肠道病毒。
    • 8. 发明授权
    • Communications techniques for bursty noise environments
    • 突发噪声环境的通信技术
    • US08824288B2
    • 2014-09-02
    • US12960614
    • 2010-12-06
    • Jie GaoXintian LinQinghua LiHsin-Yuo Liu
    • Jie GaoXintian LinQinghua LiHsin-Yuo Liu
    • H04L12/26
    • H04L43/0811H04L43/10H04L47/14H04L47/22H04L47/263
    • Techniques are disclosed that involve communicating in bursty noise environments. For instance, a source device may send a probing packet to a destination device. This probing packet is for determining whether the communications medium (e.g., one or more frequency channels) is currently exhibiting a busy or jammed (e.g., due to bursty noise) condition. More particularly, based on whether an acknowledgment of the probing packet is received, the source device determines whether the channel is jammed (or busy) or clear. For example, an unacknowledged probing packet indicates that the channel is jammed or busy, while an acknowledged probing packet indicates that the channel is clear. If the channel is determined to be clear, then the source device may transmit one or more data packets to the destination device. Such data packet transmissions may be in accordance with a non rate-adaptive technique.
    • 公开了涉及在突发噪声环境中进行通信的技术。 例如,源设备可以向目的地设备发送探测分组。 该探测分组用于确定通信介质(例如,一个或多个频率信道)当前是否正在呈现忙或卡住(例如,由于突发噪声)条件。 更具体地,基于是否接收到探测分组的确认,源设备确定信道是否被卡住(或忙)或清除。 例如,未确认的探测分组指示信道被卡住或占线,而确认的探测分组指示信道是清除的。 如果信道被确定为清除,则源设备可以向目的设备发送一个或多个数据分组。 这样的数据分组传输可以是根据非速率自适应技术。