专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070117170A1 Method for cleaving and deglycosylating antibodies to promote ligand binding 审中-公开
标题翻译：用于切割和去糖基化抗体以促进配体结合的方法
公开(公告)号：US20070117170A1
公开(公告)日：2007-05-24
申请号：US11649947
申请日：2007-01-05
申请人： Lisa Kelly , J. Puett , J. Pierce
发明人： Lisa Kelly , J. Puett , J. Pierce
IPC分类号： G01N33/00
CPC分类号： G01N33/54306 , G01N33/76
摘要： The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to remove the carbohydrate moiety, and orienting the cleaved fragment on a matrix to enhance recognition of a ligand are also described. Methods of differentiating pregnancy-derived and disease derived samples are also described.
摘要翻译：本发明详述了检测样品中糖蛋白以识别疾病状态的方法。特别地，使用抗体和凝集素阵列描述了改进的夹心测定法。还描述了通过切割抗体以除去碳水化合物部分并且将切割的片段取向于基质以增强配体的识别来提高抗体与配体的相互作用效率的方法。还描述了区分妊娠衍生和疾病衍生样品的方法。

2. 发明申请

US20060073534A1 Method for cleaving and deglycosylating antibodies to promote ligand binding 审中-公开
标题翻译：用于切割和去糖基化抗体以促进配体结合的方法
公开(公告)号：US20060073534A1
公开(公告)日：2006-04-06
申请号：US10958566
申请日：2004-10-05
申请人： Lisa Kelly , J. Puett , J. Pierce
发明人： Lisa Kelly , J. Puett , J. Pierce
IPC分类号： G01N33/537
CPC分类号： G01N33/54306 , G01N33/76
摘要： The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to remove the carbohydrate moiety, and orienting the cleaved fragment on a matrix to enhance recognition of a ligand are also described. Methods of differentiating pregnancy-derived and disease derived samples are also described.
摘要翻译：本发明详述了检测样品中糖蛋白以识别疾病状态的方法。特别地，使用抗体和凝集素阵列描述了改进的夹心测定法。还描述了通过切割抗体以除去碳水化合物部分并且将切割的片段取向于基质以增强配体的识别来提高抗体与配体的相互作用效率的方法。还描述了区分妊娠衍生和疾病衍生样品的方法。

3. 发明授权

US06569938B1 Protective coating for painted surfaces 失效
标题翻译：涂漆表面的保护涂层
公开(公告)号：US06569938B1
公开(公告)日：2003-05-27
申请号：US09520527
申请日：2000-03-08
申请人： Shawn J. Puett
发明人： Shawn J. Puett
IPC分类号： C08L3300
CPC分类号： C09D5/008
摘要： A composition for protecting a target surface and a method of applying the composition is provided. The composition includes a PVP compound (i.e., polyvinylpyrrolidone and moieties thereof) or an anionic polymer dispersed in a solvent such as water or a C1-C4 alcohol. The compositions can further include optional ingredients such as surfactants, fragrances, waterproofing agents, and coloring agents. The compositions are applied to the target surface in a thin layer and allowed to dry. Preferably, at least one additional coat is subsequently applied to the first layer. The dried coating layers are essentially invisible to observers and have an ASTM D2240-97 hardness of at least about 70, making them useful for protecting the target surface from potentially damaging foreign elements (e.g., such as protecting the front end of an automobile from paint chips caused by flying rocks). The layers remain substantially in place upon exposure to rain. Additional layers can be applied periodically as desired.
摘要翻译：提供了用于保护靶表面的组合物和施用组合物的方法。组合物包括PVP化合物（即聚乙烯吡咯烷酮及其部分）或分散在溶剂如水或C1-C4醇中的阴离子聚合物。组合物还可以包括任选的成分，例如表面活性剂，香料，防水剂和着色剂。将组合物以薄层施加到目标表面并使其干燥。优选地，随后将至少一个另外的涂层施加到第一层。干燥的涂层对于观察者基本上是不可见的，并且具有至少约70的ASTM D2240-97硬度，使得它们可用于保护目标表面免受潜在的有害的异物（例如，例如保护汽车的前端免受涂料由飞行岩石引起的筹码）。暴露于雨水时，这些层基本保持在适当的位置。可以根据需要周期性地施加附加层。

4. 外观设计

USD389705S Ground engaging fertilizer delivery tube 失效
公开(公告)号：USD389705S
公开(公告)日：1998-01-27
申请号：US60064
申请日：1996-09-20
申请人： Shawn J. Puett
设计人： Shawn J. Puett

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式