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    • 2. 发明授权
    • Dual-range photon detector
    • 双光子探测器
    • US08212221B2
    • 2012-07-03
    • US12674932
    • 2009-02-16
    • Jürgen SteinGuntram PauschCristina Plettner
    • Jürgen SteinGuntram PauschCristina Plettner
    • G01T1/20
    • G01T1/2018
    • The invention relates to a detector for measuring nuclear radiation, especially gamma-radiation, comprising a scintillator crystal with a light decay time of less than 100 ns, a silicon drift detector (SDD) for the measurement of both direct hits of low energy radiation and the light, being emitted from the scintillator crystal, the silicon drift detector being mounted between the scintillation crystal and the radiation entry window, a preamplifier, connected to the SDD, electronic devices, being capable of determining the signal rise time of the measured signals and of separating the signals on the basis of said rise time, electronic devices, being capable of separately collecting the energy spectra of SDD and scintillator detection events on the basis of the different rise times.
    • 本发明涉及一种用于测量核辐射,特别是伽马辐射的检测器,其包括具有小于100ns的光衰减时间的闪烁体晶体,用于测量低能量辐射的直接命中的硅漂移检测器(SDD)和 从闪烁体晶体发射的光,硅漂移检测器安装在闪烁晶体和辐射入口窗口之间,连接到SDD的电子设备的前置放大器能够确定测量信号的信号上升时间, 基于所述上升时间分离信号的电子设备,能够基于不同的上升时间单独收集SDD的能量谱和闪烁体检测事件。
    • 3. 发明申请
    • APPARATUS AND METHOD FOR NEUTRON DETECTION BY CAPTURE-GAMMA CALORIMETRY
    • 装置和方法通过捕获 - 伽马气压检测中子检测
    • US20120080599A1
    • 2012-04-05
    • US13376613
    • 2009-07-27
    • Guntram PauschClaus Michael HerbachJürgen Stein
    • Guntram PauschClaus Michael HerbachJürgen Stein
    • G01T3/06
    • G01T3/06
    • An apparatus for detecting neutron radiation includes a first section with a high neutron absorption capability and a second section with a low neutron absorption capability. The second section includes a gamma ray scintillator having an inorganic material with an attenuation length of less than 10 cm for gamma rays of 5 MeV energy. The material of the first section releases the energy deployed in the first section by neutron capture mainly via gamma radiation. A substantial portion of the first section is covered by the second section. An evaluation device determines the amount of light detected by a light detector for one scintillation event, and the amount is in a known relation to the energy deployed by gamma radiation in the second section. The evaluation device classifies detected radiation as neutrons when the measured total gamma energy Esum is above 2,614 MeV.
    • 用于检测中子辐射的装置包括具有高中子吸收能力的第一部分和具有低中子吸收能力的第二部分。 第二部分包括对于5MeV能量的γ射线,具有衰减长度小于10cm的无机材料的伽马射线闪烁体。 第一部分的材料通过主要通过γ辐射的中子捕获来释放在第一部分中部署的能量。 第一部分的主要部分由第二部分覆盖。 评估装置确定由一个闪烁事件的光检测器检测到的光量,并且该量与第二部分中由伽马辐射部署的能量已知关系。 当测量的总伽马能量Esum高于2614MeV时,评估装置将检测到的辐射分类为中子。
    • 4. 发明授权
    • Stabilization of a scintillation detector
    • 闪烁检测器的稳定化
    • US07642518B1
    • 2010-01-05
    • US12259111
    • 2008-10-27
    • Jürgen SteinGuntram Pausch
    • Jürgen SteinGuntram Pausch
    • G01T1/164
    • G01T1/40G01T1/208
    • A detector for the measurement of radiation, preferably ionizing radiation, includes a medium, means for the conversion of the radiation energy absorbed by the medium into electrical charge, means for digital sampling of the charge signals, means for the determination of a calibration factor K, and means for the stabilization of the output signals of the detector. The medium at least partly absorbs the radiation to be measured. The electric charge is at least partially proportional to the energy of the radiation. The sampling is done preferably with a sampling rate between 1 and 1000 MHz. Further signal processing is digital. The calibration factor K has a fixed relation with respect to the decay time τ of the medium. The output signals of the detector are mainly proportional to the radiation energy, and are stabilized with the help of the calibration factor K.
    • 用于测量辐射,优选电离辐射的检测器包括介质,用于将由介质吸收的辐射能转换成电荷的装置,用于对电荷信号进行数字采样的装置,用于确定校准因子K 以及用于稳定检测器的输出信号的装置。 该介质至少部分地吸收要测量的辐射。 电荷至少部分地与辐射的能量成比例。 采样速率优选在1到1000 MHz之间。 进一步的信号处理是数字的。 校准因子K相对于介质的衰减时间τ具有固定的关系。 检测器的输出信号主要与辐射能成比例,并借助于校准因子K得到稳定。
    • 6. 发明授权
    • Method for linearizing an energy spectrum of radiation detectors
    • 线性化辐射探测器能谱的方法
    • US08008623B2
    • 2011-08-30
    • US12821449
    • 2010-06-23
    • Jürgen SteinGuntram PauschYong Kong
    • Jürgen SteinGuntram PauschYong Kong
    • G01T1/00
    • G01T1/17
    • A method for linearizing a radiation detector is provided, the method including measuring a pulse height spectrum of a predetermined radiation source, identifying at least one spectrum template for the predetermined radiation source, and determining a linearization function by comparing the measured pulse height spectrum with the at least one identified spectrum template. The at least one spectrum template is a predefined synthesized energy spectrum for the predetermined radiation source and for the corresponding radiation detector. Further, a detector for measuring one or more types of radiation is provided, the detector being adapted for transforming the measured pulse height spectrum in an energy-calibrated spectrum, the transformation including a linearization step, where a linearization function used with the linearization step is determined according to the inventive method.
    • 提供了一种用于线性化放射线检测器的方法,该方法包括测量预定辐射源的脉冲高度谱,识别用于预定辐射源的至少一个光谱模板,以及通过将所测量的脉冲高度谱与 至少一个识别的光谱模板。 至少一个光谱模板是用于预定辐射源和对应的辐射探测器的预定的合成能谱。 此外,提供了一种用于测量一种或多种类型的辐射的检测器,所述检测器适于在能量校准的光谱中变换测量的脉冲高度谱,该变换包括线性化步骤,其中线性化步骤使用的线性化函数是 根据本发明的方法测定。
    • 7. 发明申请
    • DUAL-RANGE PHOTON DETECTOR
    • 双色光电探测器
    • US20100200762A1
    • 2010-08-12
    • US12674932
    • 2009-02-16
    • Jürgen SteinGuntram PauschCristina Plettner
    • Jürgen SteinGuntram PauschCristina Plettner
    • G01T1/20
    • G01T1/2018
    • The invention relates to a detector for measuring nuclear radiation, especially gamma-radiation, comprising a scintillator crystal with a light decay time of less than 100 ns, a silicon drift detector (SDD) for the measurement of both direct hits of low energy radiation and the light, being emitted from the scintillator crystal, the silicon drift detector being mounted between the scintillation crystal and the radiation entry window, a preamplifier, connected to the SDD, electronic devices, being capable of determining the signal rise time of the measured signals and of separating the signals on the basis of said rise time, electronic devices, being capable of separately collecting the energy spectra of SDD and scintillator detection events on the basis of the different rise times.
    • 本发明涉及一种用于测量核辐射,特别是伽马辐射的检测器,其包括具有小于100ns的光衰减时间的闪烁体晶体,用于测量低能量辐射的直接命中的硅漂移检测器(SDD)和 从闪烁体晶体发射的光,硅漂移检测器安装在闪烁晶体和辐射入口窗口之间,连接到SDD的电子设备的前置放大器能够确定测量信号的信号上升时间, 基于所述上升时间分离信号的电子设备,能够基于不同的上升时间单独收集SDD的能量谱和闪烁体检测事件。
    • 9. 发明申请
    • APPARATUS AND METHOD FOR NEUTRON DETECTION WITH NEUTRON-ABSORBING CALORIMETRIC GAMMA DETECTORS
    • 用中性吸收型卡路里检测器进行中子检测的装置和方法
    • US20120074326A1
    • 2012-03-29
    • US13376609
    • 2009-07-27
    • Guntram PauschClaus Michael HerbachJürgen Stein
    • Guntram PauschClaus Michael HerbachJürgen Stein
    • G01T1/20
    • G01T3/06G01T3/00
    • An apparatus for detecting neutron radiation includes a gamma ray scintillator having an inorganic material with an attenuation length Lg of less than 10 cm for gamma rays of 5 MeV energy to provide for high gamma ray stopping power for energetic gamma rays within the -gamma ray scintillator. The gamma ray scintillator includes components with a product of neutron capture cross section and concentration leading to an absorption length Ln for thermal neutrons which is larger than 0.5 cm but smaller than five times the attenuation length Lg for 5 MeV gammas, the gamma ray scintillator having a diameter or edge length of at least 50% of Lg. The apparatus includes an evaluation device to determine the amount of light, detected by a light detector for one scintillation event The evaluation device classifies detected radiation as neutrons when the measured total gamma energy Esum is above 2,614 MeV.
    • 用于检测中子辐射的装置包括伽马射线闪烁体,其具有对于5MeV能量的伽马射线具有小于10cm的衰减长度Lg的无机材料,以为γ射线闪烁体内的能量伽马射线提供高伽马射线停止功率 。 伽马射线闪烁体包括具有中子俘获截面积和浓度的乘积的组分,导致热中子的吸收长度Ln大于0.5MeV,但小于5MeV伽马的衰减长度Lg的五倍,伽马射线闪烁体具有 直径或边缘长度至少为Lg的50%。 该装置包括用于确定由一个闪烁事件的光检测器检测到的光量的评估装置。当测量的总伽马能量Esum高于2,614MeV时,评估装置将检测到的辐射分类为中子。
    • 10. 发明申请
    • Dosage Form Containing The Active Ingredient Cholylsarcosine
    • 含有活性成分Cholyls肌氨酸的剂型
    • US20070243247A1
    • 2007-10-18
    • US11569581
    • 2005-05-12
    • Jennifer DressmanHans-Jürgen SteinThomas FurstChristiane Bott
    • Jennifer DressmanHans-Jürgen SteinThomas FurstChristiane Bott
    • A61K9/16A61K9/20
    • A61K9/5026A61K31/575
    • The invention relates to a dosage form, containing the active ingredient cholylsarcosine, in the form of pellets, which are provided with a polymer coating that is resistant to gastric juices. The invention is characterised in that it discloses pellets comprising an active ingredient, which contain between 50 and 80 wt. % of the active ingredient cholylsarcosine and between 50 and 20 wt. % of one or more conventional pharmaceutical adjuvants as binding agents, whereby at least 90 wt. % of said adjuvants are water-soluble and the size of at least 80 % of the pellets comprising an active ingredient is between 800 and 2,500 $g(m)m. The granulates containing an active ingredient are coated with an anonic, film-forming polymer coating agent, which dissolves in a 0.07M sodium phosphate buffer with a pH value of 5.5 at a dissolution rate of at least 10 mg/min*g and whose dissolution rate in a 0.07M sodium phosphate buffer with a pH value of 6.0 is at least 200 mg/min*g. The polymer coating amounts to between 5 and 15 wt. % of the pellet weight. The invention also relates to a method for producing said dosage form.
    • 本发明涉及一种剂型,其含有丸粒形式的活性成分胆甾肌苷,其具有耐胃液的聚合物涂层。 本发明的特征在于它公开了包含活性成分的丸剂,其含有50至80wt。 %的活性成分胆固醇和50至20wt。 %的一种或多种常规药物佐剂作为粘合剂,其中至少90wt。 所述佐剂的百分比是水溶性的,并且至少80%的包含活性成分的丸粒的尺寸为800-2,500元(m)m。 含有活性成分的颗粒用无声成膜聚合物涂层剂涂覆,其溶解速率至少为10mg / min * g,溶解于pH值为5.5的0.07M磷酸钠缓冲液中,其溶解度 pH值为6.0的0.07M磷酸钠缓冲液中的速率为至少200mg / min * g。 聚合物涂层为5至15wt。 颗粒重量的百分比。 本发明还涉及生产所述剂型的方法。