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1. 发明公开

US20230147467A1 Novel Contrast Agents and Imaging Methods for Early Detection of Diseases 审中-公开
公开(公告)号：US20230147467A1
公开(公告)日：2023-05-11
申请号：US17523911
申请日：2021-11-11
申请人： Ishtar Faisal Algburi
发明人： Ishtar Faisal Algburi
IPC分类号： A61K49/04
CPC分类号： A61K49/0438
摘要： This invention relates to novel contrast agents for detection of diseases by using any or both or all of CT, SPECT and PET scans. Previously, there was no way to use these novel contrast agents for imaging and early detection of neurodegenerative diseases, multiple sclerosis disease, concussion, and traumatic brain injury. Also, previously, there was no way to use Computed Tomography (CT) imaging to early detect and map the neurodegenerative diseases. Embodiments of the present invention use a novel contrast agent is disclosed for early detection of diseases by using any or both or all of CT, SPECT and PET. Also, these novel contrast agents can be used for detection of amyloid beta, tau protein, alpha-synuclein protein, and aggregation proteins in neurodegenerative diseases and inflammation in many diseases such as neurodegenerative diseases, cancer and other inflammatory diseases, blood brain barrier leakage or break down, aggressive cancer tissue, brain activation in neurodegenerative diseases and other diseases, and hypoxia in tissue. Also, these novel contrast agents increase there binding in diseases compared to healthy subjects, therefore induce higher contrast in diseases such as in neurodegenerative diseases, cancer and other inflammatory diseases, blood brain barrier leakage or break down, aggressive cancer tissue, brain activation in neurodegenerative diseases and other diseases, and hypoxic tissue.

2. 发明公开

US20230337918A1 Novel Treatment and Imaging Methods for Early Detection of Diseases 审中-公开
公开(公告)号：US20230337918A1
公开(公告)日：2023-10-26
申请号：US17098380
申请日：2020-11-14
申请人： Ishtar Faisal Algburi
发明人： Ishtar Faisal Algburi
IPC分类号： A61B5/00 , A61B5/055 , A61K31/07 , A61K31/375 , A61K31/355 , A61K31/05 , A61K31/343 , A61K31/352 , A61K31/12 , A61K31/155 , A61K31/138 , A61K31/5377
CPC分类号： A61B5/0036 , A61B5/055 , A61B5/0042 , A61B5/4842 , A61K31/07 , A61K31/375 , A61K31/355 , A61K31/05 , A61K31/343 , A61K31/352 , A61K31/12 , A61K31/155 , A61K31/138 , A61K31/5377
摘要： This invention relates to treatment and detection of the diseases by Magnetic Resonance Imaging. Previously, there was no way to use MRI imaging to early detect and map the agent bind to hypoxia in tissue, blood brain barrier leakage or break down, tissue under glycolysis, brain activation in neurodegenerative diseases, aggressive cancer, senescent tissues, and T-cells senescent. Also, novel methods to treat neurodegenerative diseases, aging, senescent tissues and T-cells senescent. Embodiments of the present invention use novel treatment and imaging methods are disclosed for early detection and mapping of diseases by using MRI. The endogenous of the biological tissue and exogenous agents can be used to produce MRI contrast which rely on the endogenous proteins and exogenous protons, as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging and mapping for the early detection of hypoxia in tissue, blood brain barrier leakage or break down, tissue under glycolysis, brain activation in neurodegenerative diseases, aggressive cancer, senescent tissues, T-cells senescent, and other diseases by using endogenous and exogenous protons contrast by using MRI. Also, this invention relates to novel methods to treatment neurodegenerative disease, senescent cells and T-cells senescent.

3. 发明申请

US20220313171A1 Imaging and Treatment Methods for Early Detection of Diseases 有权
公开(公告)号：US20220313171A1
公开(公告)日：2022-10-06
申请号：US17221742
申请日：2021-04-02
申请人： Ishtar Faisal Algburi
发明人： Ishtar Faisal Algburi
IPC分类号： A61B5/00 , A61B5/055 , G01R33/48 , A61K49/10 , A61K45/06 , A61K33/00 , A61K31/517 , A61K31/353 , A61K49/04 , G01R33/485 , G01R33/28
摘要： This invention relates to disease detection by imaging and treatment of virus infection. Previously, there was no way to use CEST MRI imaging to early detect and map the neurodegenerative diseases, multiple sclerosis disease, concussion, and traumatic brain injury. Also, previously, there was no way to use Computed Tomography (CT) imaging to early detect and map the neurodegenerative diseases. Embodiments of the present invention use a non-invasive CEST MRI imaging method is disclosed for early detection of diseases by using MRI or by using CT. The endogenous (MRI) contrast of the biological tissue can rely on the endogenous protons of the proteins and peptides as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging and mapping for the early detection of the neurodegenerative diseases, multiple sclerosis disease, concussion, traumatic brain injury, and other diseases by using endogenous protons contrast via CEST MRI. Also, the exogenous agents can be used to produce MRI contrast, such as agents contain exchangeable protons and thereby provide imaging and mapping the inflammation in cancer and the expressed proteins in cancer cells for cancer detection. Also, using exogenous CT contrast agents for detection of amyloid beta, tau protein, alpha-synuclein protein, and aggregation proteins in neurodegenerative diseases and inflammation in many diseases such as neurodegenerative diseases, cancer and other inflammatory diseases Also, this invention relates to novel methods of treatment virus infection and enhance the immune system to produce antibodies against the viruses.

4. 发明申请

US20190128981A1 NON-INVASIVE IMAGING METHOD FOR EARLY DETECTION AND MAPPING THE SEVERITY OF DISEASES BY USING CEST MRI 审中-公开
公开(公告)号：US20190128981A1
公开(公告)日：2019-05-02
申请号：US16172502
申请日：2018-10-26
申请人： Ishtar Faisal Algburi
发明人： Ishtar Faisal Algburi
IPC分类号： G01R33/48 , G01R33/56 , A61K38/17
摘要： A non-invasive CEST MRI imaging method is disclosed for early detection and mapping the severity of diseases by using MRI. The endogenous magnetic resonance image (MRI) contrast of the biological tissue can rely on the endogenous protons of the proteins and peptides as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging of the accumulation of amyloid beta, accumulation of neurofibrillary tangles, aggregation proteins and peptides, the hypoxia in cancer and non-cancer tissue, the tissues atrophy, distinguish the edema from the tumor, determine tumor boundary, monitor response of tumor to treatment and detect lower grade tumor by using endogenous protons contrast via CEST MRI. The difference in CEST images signals is used to detect and map severity of the diseases and predict response to treatment. The method works without contrast agents or tracers.

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