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    • 3. 发明授权
    • Pseudoceramides, and dermatologic external preparations containing the same
    • 假甲酰胺和含有它们的皮肤外用制剂
    • US06221371B1
    • 2001-04-24
    • US09308031
    • 1999-05-10
    • In-sub BaikJong-gi LeeByeong-deog ParkYoon KimMyung-jin Lee
    • In-sub BaikJong-gi LeeByeong-deog ParkYoon KimMyung-jin Lee
    • A61K600
    • A61Q19/00A61K8/68A61Q5/00A61Q5/02A61Q17/00A61Q19/08C07C235/08C07C235/74C07H15/12
    • The present invention relates to pseudoceramide derivatives represented by formula(I) or (II): R1—COCHR2CONR3R4  (I) R1—CH(OH)CHR2CONR3R4  (II) wherein, each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6˜22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2˜C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in an dermatologic external preparations the moisture-retaining property and resilience of skin and hair is enhanced such so that the derivatives are useful in protection of skin-aging. In addition, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.
    • 本发明涉及由式(I)或(II)表示的假花生酰胺衍生物:其中,R1和R2各自表示具有6〜22个碳原子的直链或支链烷基或烯基; R 3和R 4各自表示氢,甲基,乙基,丙基或具有一个或多个羟基或单糖的直链或支链C 2 -C 6烷基,其制备方法和含有该羟基的皮肤外用制剂 。 当根据本发明的假心外酰胺衍生物应用于皮肤外用制剂时,皮肤和毛发的保湿性和弹性得到增强,使得衍生物可用于保护皮肤老化。 此外,该衍生物可用于诱导损伤皮肤上形成脂质层并防止脂质合成的抑制。
    • 4. 发明授权
    • Herb medicine extract-containing non-bleeding striped dentifrice
composition
    • 含草药提取物含有非渗色条纹牙膏组合物
    • US5980870A
    • 1999-11-09
    • US934544
    • 1997-09-19
    • In Sub BaikJong Gi LeeIn Sik ChoYoun Woo Park
    • In Sub BaikJong Gi LeeIn Sik ChoYoun Woo Park
    • A61K8/19A61K8/26A61K8/73A61K8/97A61Q11/00A61K9/16
    • A61K8/0237A61K8/19A61K8/26A61K8/73A61K8/97A61Q11/00
    • A herb medicine extract-containing non-bleeding striped dentifrice composition, consisting essentially of a striped dentifrice component and a base dentifrice component, each component comprising the following ingredients at the substantially same amount: a. an abrasive that has a BET surface area of 10 m.sup.2 /g or less and an average particle diameter of 1 to 30 .mu.m upon measurement by Coulter Counter method, and shows oil absorption (linseed oil, ml/100 g) of 50 or less; b. a binder selected from the group consisting of xanthan gum, carrageenan, sodium carboxymethylcellulose, and the mixtures thereof; c. an alkyl sulfonate of anionic surfactants; and d. a humectant, and said striped dentifrice component containing herb medicine extracts at an amount of 0.001 to 10% by weight, on the basis of dry solid substance. It is non-bleeding by virtue of the substantially same formulation in the two components and the herb medicine extracts allow the dentifrice composition to suppress the formation of plaque.
    • 一种草本药物提取物含有非出血性条状洁齿剂组合物,其基本上由条状洁牙剂组分和基础洁齿剂组分组成,每种组分包含基本相同量的以下成分:a。 通过Coulter Counter法测定的BET表面积为10m 2 / g以下,平均粒径为1〜30μm的研磨剂,油吸收(亚麻子油,ml / 100g)为50以下 ; b。 选自黄原胶,角叉菜胶,羧甲基纤维素钠及其混合物的粘合剂; C。 阴离子表面活性剂的烷基磺酸盐; 和d。 湿润剂,所述条状洁齿剂组分含有基于干固体物质的0.001至10重量%的草药提取物。 由于在两个成分中基本相同的制剂是不渗血的,草药提取物允许洁牙剂组合物抑制斑块的形成。