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    • 1. 发明授权
    • Gastroprotective pharmaceutical preparations containing
N-benzyl-N-((1S,5S)-6,6-dimethylbicyclo(3,1,1)-hept-2-ylethoxy-ethyl)-mo
rpholinium salts
    • 含有N - 苄基-N - ((1S,5S)-6,6-二甲基苯甲酰基(3,1,1) - 庚-2-炔基 - 乙基) - 吗啉盐的保护性药物制剂
    • US5232686A
    • 1993-08-03
    • US548718
    • 1990-07-06
    • Marie-Odile ChristenBrigitte NoelIlse Philippi
    • Marie-Odile ChristenBrigitte NoelIlse Philippi
    • A61K31/535A61K31/5375A61P1/00A61P1/04
    • A61K31/535Y10S514/922
    • A method of inhibiting peripheral blood circulation disorders or damage such as hemorrhagic lesions induced by gastrotoxic doses of substances such as alcohol or non-steroid, antiinflammatory medicaments in the gastrointestinal tract of a mammal comprising administering to said mammal an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6-dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-ethyl}-morpholinium salt, and pharmaceutical compositions comprising a substance having a tendency to induce a peripheral blood circulation disorder or damage such as a hemorrhagic lesion in the stomach and/or intestinal wall of a mammal and an effective peripheral circulation disorder or gastrointestinal damage inhibiting amount of a quaternary N-benzyl-N-{2-[2-((1S,5S)-6,6-dimethylbicyclo[3,1,1]hept-2-yl)-ethoxy]-ethyl}-morpholinium salt.
    • 一种抑制外周血液循环障碍或损伤的方法,所述方法包括向所述哺乳动物施用有效的外周循环障碍或胃肠损伤,所述外周血液循环障碍或损伤例如由胃肠毒性剂量的物质例如醇或非类固醇,抗炎药物在哺乳动物的胃肠道中引起的出血性损伤 抑制量N-苄基-N- {2- [2 - ((1S,5S)-6,6-二甲基双环[3,1,1]庚-2-基) - 乙氧基] - 乙基} - 吗啉 盐和药物组合物,其包含具有诱发哺乳动物的胃和/或肠壁中的外周血液循环障碍或出血性损伤的损伤的倾向的物质和有效的外周循环障碍或胃肠损伤抑制量的四级 N-苄基-N- {2- [2 - ((1S,5S)-6,6-二甲基双环[3,1,1]庚-2-基) - 乙氧基] - 乙基} - 吗啉鎓盐。