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1. 发明申请

US20110294754A1 NOVEL PHARMACEUTICAL COMPOUNDS 有权
标题翻译：新型药物化合物
公开(公告)号：US20110294754A1
公开(公告)日：2011-12-01
申请号：US12791364
申请日：2010-06-01
申请人： Ilan ZIV , Hagit Grimberg
发明人： Ilan ZIV , Hagit Grimberg
IPC分类号： A61K31/4375 , A61K31/513 , A61K31/7068 , A61P35/00 , C07H19/06 , C07D491/22 , C07D239/10
CPC分类号： C07D491/22 , C07D239/10 , C07D403/04 , C07H19/06
摘要： Novel compounds and pharmaceutical compositions are provided. In one aspect of the invention the compounds may be utilized in medical practice, for example, in treatment of cancer and immune disorders.
摘要翻译：提供新的化合物和药物组合物。在本发明的一个方面，化合物可用于医学实践中，例如用于治疗癌症和免疫疾病。

2. 发明授权

US07947253B2 Perturbed membrane-binding compounds and methods of using the same 有权
标题翻译：干扰的膜结合化合物及其使用方法
公开(公告)号：US07947253B2
公开(公告)日：2011-05-24
申请号：US10585928
申请日：2005-01-16
申请人： Ilan Ziv , Anat Shirvan
发明人： Ilan Ziv , Anat Shirvan
IPC分类号： A61K51/00 , A61K49/04
CPC分类号： A61K49/0002 , A61K47/542 , A61K49/0021 , A61K49/0052 , A61K51/0402 , A61K51/0497 , C07F13/005
摘要： The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for utilizing said compounds in medical practice, for diagnostic and therapeutic purposes.
摘要翻译：本发明涉及选择性结合经历其正常质膜组织的干扰和改变的细胞的细胞，例如经历凋亡或活化血小板的细胞。本发明进一步提供了在医学实践中利用所述化合物用于诊断和治疗目的的方法。

3. 发明授权

US07196063B1 Peptides and pharmaceutical compositions comprising same 失效
公开(公告)号：US07196063B1
公开(公告)日：2007-03-27
申请号：US10048955
申请日：2000-08-01
申请人： Anat Shirvan , Ilan Ziv
发明人： Anat Shirvan , Ilan Ziv
IPC分类号： A61K38/00 , A61K49/00 , A61K51/00
CPC分类号： C07K14/4721
摘要： The present invention relates to an NST500 compound of general formula (I): comprising the following components: X1—X2—{(X3)a/X4/X5}—X6, wherein: X1 stands for a saturated or unsaturated fatty acid residue comprising 6–20 carbon atoms; or a cysteine residue bound through a thioether bond to a prenyl group comprising 5–20 carbon atoms; said residue being linked to the adjacent component of the compound through an amide bond; X2 is 0; X3 comprises 1–6 amino acids, of which 1–6 are positively charged and 0–2 are negatively charged, the other amino acid residues being polar uncharged amino acids; X4 comprises 1–6 amino acids, of which 1–2 are aromatic amino acids, the other amino acids being selected among polar uncharged amino acids and hydrophobic aliphatic amino acids; X5 comprises 6–8 amino acids, of which 4–6 are positively charged and 0–2 are negatively charged, the other amino acid residues being polar uncharged amino acids, wherein the amino acids form a cyclic structure; X6 is a compound of general formula II, wherein Z stands for a spacer group selected among alkane and alkene containing 1–5 carbon atoms, J stands for a functional group selected among amines, thiols, alcohols, carboxylic acids and esters, aldehydes and alkyl halides; U is 0 or is selected among a labeling group; wherein a stands for an integer of 1–3; and the groups X3, X4 and X5 being located at various places in the compound; as well as functional equivalents thereof and/or compounds having the same biological activity thereto. The present also relates to pharmaceutical compositions and methods of using the same.

4. 发明授权

US06602852B1 Basic peptides and pharmaceutical compositions containing same 有权
标题翻译：碱性肽和含有它们的药物组合物
公开(公告)号：US06602852B1
公开(公告)日：2003-08-05
申请号：US09763548
申请日：2001-02-23
申请人： Ilan Ziv , Anat Shirvan
发明人： Ilan Ziv , Anat Shirvan
IPC分类号： A61K3817
CPC分类号： C07K14/4721
摘要： The present invention relates to an NST300 compound of general formula (I): comprising the following components: X1—[(X3)a/(X4)b] in which X1 represents a fatty acid or prenyl group; and X3 represents a domain of positively charged amino acids; and X4 represents a domain containing aromatic amino acids; and a stands for an integer of 1-8; and b stands for an integer of 1-8. The invention relates also to pharmaceutical compositions comprising a compound of general formula (I), the use of the compound and of the pharmaceutical composition in the preparation of a medicament and in methods for the treatment or prevention of prothrombic states in disorders which are associated with excessive procoagulant activity, initiated or propagated by CMLA loss. The invention relates also to the use of the compound and of the pharmaceutical composition for the diagnosis of CMLA loss; as a targeting agent; as targeting drugs to tissues inflicted by CMLA loss; and for basic research in fields of research in which CMLA loss takes place both in vitro and in vivo.
摘要翻译：本发明涉及通式（I）的NST300化合物：其中X1表示脂肪酸或异戊烯基，X 1 - [（X 3）a /（X 4）b] X3表示带正电氨基酸的结构域。 X4表示含有芳香族氨基酸的结构域。 a代表1-8的整数; b代表1-8的整数。本发明还涉及包含通式（I）的化合物的药物组合物，该化合物和药物组合物在制备药物中的用途以及用于治疗或预防与疾病相关的疾病中的血栓前状态的方法过度促凝活性，由CMLA损失引发或传播。本发明还涉及化合物和药物组合物用于诊断CMLA损失的用途; 作为靶向剂; 作为CMLA损伤造成的组织靶向药物; 以及在体外和体内发生CMLA损失的研究领域的基础研究。

5. 发明授权

US08101666B2 Methods and compounds for detection of medical disorders 失效
标题翻译：用于检测医学疾病的方法和化合物
公开(公告)号：US08101666B2
公开(公告)日：2012-01-24
申请号：US11631490
申请日：2005-07-07
申请人： Ilan Ziv , Anat Shirvan
发明人： Ilan Ziv , Anat Shirvan
IPC分类号： A01N33/02 , A61K31/135 , C07C211/00
CPC分类号： C07C323/49 , A61K51/0406 , C07B2200/05 , C07C323/03 , G01N33/5005 , G01N33/5091 , G01N33/6896 , G01N2800/2821
摘要： The invention provides methods for detection of medical disorders, associated with cellular oxidative stress, cell degeneration and/or cell death. The invention further relates to compounds comprising a thiol (—SH) group, for detecting cells undergoing oxidative stress, degeneration and/or a death process. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.
摘要翻译：本发明提供了用于检测与细胞氧化应激，细胞变性和/或细胞死亡有关的医学病症的方法。本发明还涉及包含硫醇（-SH）基团的化合物，用于检测经历氧化应激，变性和/或死亡过程的细胞。本发明还提供了在医学实践中用于诊断和治疗目的的化合物的使用方法。

6. 发明授权

US07670590B2 Perturbed membrane-binding compounds and methods of using the same 有权
标题翻译：干扰的膜结合化合物及其使用方法
公开(公告)号：US07670590B2
公开(公告)日：2010-03-02
申请号：US11882490
申请日：2007-08-02
申请人： Ilan Ziv , Anat Shirvan
发明人： Ilan Ziv , Anat Shirvan
IPC分类号： A61K51/00 , A61K49/04
CPC分类号： C07F13/005 , A61K49/0002 , A61K51/04
摘要： The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for utilizing said compounds in medical practice, for diagnostic and therapeutic purposes.
摘要翻译：本发明涉及选择性结合经历其正常质膜组织的干扰和改变的细胞的细胞，例如经历凋亡或活化血小板的细胞。本发明进一步提供了在医学实践中利用所述化合物用于诊断和治疗目的的方法。

7. 发明授权

US07396859B2 Perturbed membrane-binding compounds 有权
标题翻译：干扰的膜结合化合物
公开(公告)号：US07396859B2
公开(公告)日：2008-07-08
申请号：US10433668
申请日：2001-12-03
申请人： Ilan Ziv , Anat Shievan , Sharon Ebner
发明人： Ilan Ziv , Anat Shievan , Sharon Ebner
IPC分类号： A01N37/12 , A01N37/44
CPC分类号： A61K31/18 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/198 , C07C311/39
摘要： The present invention provides uses of compounds that bind selectively to cells undergoing perturbations and alterations of their normal membrane organization, while binding to a lesser degree to cell having membranes of normal organization. These compounds are termed perturbed-membrane-binding compounds (PMBC). The PMBC group of compounds includes new compounds and also known compounds.
摘要翻译：本发明提供了与经历微扰和改变其正常膜组织的细胞选择性结合的化合物的用途，同时与具有正常组织膜的细胞结合程度较小。这些化合物被称为扰动膜结合化合物（PMBC）。 PMBC组的化合物包括新化合物和已知化合物。

8. 发明申请

US20070232702A1 Methods and Compounds for Detection of Medical Disorders 失效
标题翻译：用于检测医疗障碍的方法和化合物
公开(公告)号：US20070232702A1
公开(公告)日：2007-10-04
申请号：US11631490
申请日：2005-07-07
申请人： Ilan Ziv , Anat Shirvan
发明人： Ilan Ziv , Anat Shirvan
IPC分类号： A61K31/095 , C07C381/00 , C12Q1/00
CPC分类号： C07C323/49 , A61K51/0406 , C07B2200/05 , C07C323/03 , G01N33/5005 , G01N33/5091 , G01N33/6896 , G01N2800/2821
摘要： The invention provides methods for detection of medical disorders, associated with cellular oxidative stress, cell degeneration and/or cell death. The invention further relates to compounds comprising a thiol (—SH) group, for detecting cells undergoing oxidative stress, degeneration and/or a death process. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.
摘要翻译：本发明提供了用于检测与细胞氧化应激，细胞变性和/或细胞死亡有关的医学病症的方法。本发明还涉及包含硫醇（-SH）基团的化合物，用于检测经历氧化应激，变性和/或死亡过程的细胞。本发明还提供了在医学实践中用于诊断和治疗目的的化合物的使用方法。

9. 发明申请

US20110257434A1 PERTURBED MEMBRANE-BINDING COMPOUNDS AND METHODS OF USING THE SAME 审中-公开
标题翻译： PERTURBED膜结合化合物及其使用方法
公开(公告)号：US20110257434A1
公开(公告)日：2011-10-20
申请号：US13086477
申请日：2011-04-14
申请人： Ilan ZIV , Anat Shirvan
发明人： Ilan ZIV , Anat Shirvan
IPC分类号： C07C55/02
CPC分类号： A61K49/0002 , A61K47/542 , A61K49/0021 , A61K49/0052 , A61K51/0402 , A61K51/0497 , C07F13/005
摘要： The invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, i.e., cells undergoing cell death, apoptotic cells or activated platelets. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.
摘要翻译：本发明涉及选择性结合经历其正常质膜组织的扰动和改变的细胞，即经历细胞死亡的细胞，凋亡细胞或活化的血小板的化合物。本发明还提供了在医学实践中用于诊断和治疗目的的化合物的使用方法。

10. 发明申请

US20080014148A1 Perturbed membrane-binding compounds and methods of using the same 有权
标题翻译：干扰的膜结合化合物及其使用方法
公开(公告)号：US20080014148A1
公开(公告)日：2008-01-17
申请号：US11882490
申请日：2007-08-02
申请人： Ilan ZIV , Anat SHIRVAN
发明人： Ilan ZIV , Anat SHIRVAN
IPC分类号： A61K49/00 , A61P43/00 , C12Q1/02
CPC分类号： C07F13/005 , A61K49/0002 , A61K51/04
摘要： The present invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, such as cells undergoing apoptosis or activated platelets. The invention further provides methods for utilizing said compounds in medical practice, for diagnostic and therapeutic purposes.
摘要翻译：本发明涉及选择性结合经历其正常质膜组织的干扰和改变的细胞的细胞，例如经历凋亡或活化的血小板的细胞。本发明进一步提供了在医学实践中利用所述化合物用于诊断和治疗目的的方法。

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