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1. 发明授权

US08535229B2 Ultrasonographic device 有权
标题翻译：超声波装置
公开(公告)号：US08535229B2
公开(公告)日：2013-09-17
申请号：US11719770
申请日：2005-07-15
申请人： Shin-ichiro Umemura , Takashi Azuma , Yuichi Miwa
发明人： Shin-ichiro Umemura , Takashi Azuma , Yuichi Miwa
IPC分类号： A61B8/00
CPC分类号： G01S15/8993 , A61B8/483 , G01S7/5202 , G01S7/52046 , G01S7/5209 , G01S7/52095
摘要： An ultrasonographic technique capable of forming a transmission beam enabling multi-beam transmission/reception of identical transmission sensitivity. An ultrasonographic device for imaging inside of an examinee includes a transmitter for transmitting an ultrasonic pulse signal from an ultrasonic element array to the examinee, and a receiver for receiving the ultrasonic pulse reflected from the examinee. The transmitter transmits an ultrasonic pulse signal having a plurality of peaks of substantially equal transmission intensity in the azimuth direction and a trace in the depth direction of each peak as a substantially straight line, from a transmission opening of the ultrasonic element array to the examinee.
摘要翻译：一种能够形成能够实现相同传输灵敏度的多波束发射/接收的传输波束的超声波技术。用于在受检者内部成像的超声波诊断装置包括用于从超声波元件阵列向受检者发送超声波脉冲信号的发射器，以及用于接收从受检者反射的超声波脉冲的接收器。发射机从超声波元件阵列的传输开口向受检者发送具有在方位方向上具有基本相等的传输强度的多个峰值和超过每个峰值深度方向的迹线作为基本上直线的超声波脉冲信号。

2. 发明授权

US08323620B2 Ultrasound contrast agent 有权
标题翻译：超声造影剂
公开(公告)号：US08323620B2
公开(公告)日：2012-12-04
申请号：US11658591
申请日：2005-08-04
申请人： Kenichi Kawabata , Nami Sugita , Shin-ichiro Umemura
发明人： Kenichi Kawabata , Nami Sugita , Shin-ichiro Umemura
IPC分类号： A61B8/00
CPC分类号： A61K49/223
摘要： An ultrasound contrast agent composed of at least one kind of low-boiling water-insoluble substance (with a boiling point lower than 37° C.) and at least one kind of high-boiling water-insoluble substance (with a boiling point higher than 37° C.). The former vaporizes to absorb ultrasonic energy upon application of ultrasound, thereby causing the latter to vaporize secondarily, with the resulting bubbles producing an echo image. It is less liable to bumping and hence safe.
摘要翻译：由至少一种低沸点水不溶性物质（沸点低于37℃）和至少一种高沸点水不溶性物质（沸点高于 37℃）。前者在施加超声波时蒸发以吸收超声能量，从而使后者二次蒸发，产生的回波图像产生气泡。它不太容易碰撞，因此安全。

3. 发明授权

US08079956B2 Ultrasonographic device and ultrasonographic method 失效
标题翻译：超声检查仪和超声检查仪
公开(公告)号：US08079956B2
公开(公告)日：2011-12-20
申请号：US12348135
申请日：2009-01-02
申请人： Takashi Azuma , Shin-ichiro Umemura , Hirotaka Baba
发明人： Takashi Azuma , Shin-ichiro Umemura , Hirotaka Baba
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , G01S7/52077 , G01S15/8995
摘要： In an ultrasonic imaging device having an image synthesizing unit, correlation between images to be synthesized is computed for balancing between an improvement in contrast resolution and an improvement in spatial resolution, and an amount of displacement between the images is computed. When the amount of displacement is large, the signals after envelop detection are synthesized. When the amount of displacement is small, RF signals are synthesized. Alternatively, the mixing frequency may be variable according to the amount of displacement, and the balance between an improvement in spatial resolution and that in contract resolution is achieved according to a degree of the positional displacement.
摘要翻译：在具有图像合成单元的超声波成像装置中，计算要合成的图像之间的相关性，以在对比度分辨率的提高和空间分辨率的改善之间进行平衡，并且计算图像之间的位移量。当位移量大时，合成包络检测后的信号。当位移量小时，合成RF信号。或者，混合频率可以根据位移量而变化，并且根据位置偏移的程度来实现空间分辨率和合同分辨率的改善之间的平衡。

4. 发明授权

US08002703B2 Ultrasonic imaging device 有权
标题翻译：超声波成像装置
公开(公告)号：US08002703B2
公开(公告)日：2011-08-23
申请号：US10586665
申请日：2005-01-06
申请人： Takashi Azuma , Shin-ichiro Umemura , Hiroshi Kuribara , Tatsuya Hayashi
发明人： Takashi Azuma , Shin-ichiro Umemura , Hiroshi Kuribara , Tatsuya Hayashi
IPC分类号： A61B8/00
CPC分类号： G01S15/102 , A61B8/481 , G01S7/5202 , G01S7/52038 , G01S7/52039 , G01S15/8959 , G01S15/8963
摘要： This invention provides an ultrasonic imaging system that implements imaging by distinguishing sharply and definitely the echo components generated by scattering in a microbubble contrast medium, from the tissue harmonic components generated by nonlinear propagation of a transmitted pulse. This ultrasonic imaging system, constructed to transmit/receive ultrasonic pulses to/from a living body and form a contrast image of the inside of the living body by using the contrast-imaging microbubbles, repeats the transmitting/receiving operations four times in all, under the same transmitting/receiving focus conditions at different phase angles [(a)=0°, (b)=120°, (c)=−120°, (d)=180°] of the carrier of a transmitted pulse wave including a common envelope signal, sums up three time-series receive echo signals associated with (a), (b), (c), forms the contrast image, sums up two time-series receive echo signals associated with (a), (d), forms an image of the living body having a nonlinear pulse propagation property, and makes a superimposed display of the two kinds of images.
摘要翻译：本发明提供了一种超声成像系统，其通过从由发射脉冲的非线性传播产生的组织谐波分量中清楚地和明确地区分由微泡造影剂中的散射产生的回波分量来实现成像。该超声波成像系统被构造成通过使用对比度成像微泡将生物体的超声波脉冲发送/接收生物体内部的对比图像，全部重复发送/接收操作四次发射脉冲波的载波的不同相位角[（a）= 0°，（b）= 120°，（c）= - 120°，（d）= 180°）的相同发射/接收对焦条件包括共同的包络信号，与（a），（b），（c）相关联的三个时间序列接收回波信号相加形成对比度图像，将与（a），（d）相关联的两个时间序列接收回波信号相加），形成具有非线性脉冲传播特性的活体的图像，并且叠加显示两种图像。

5. 发明申请

US20110201606A1 PYRIMIDINE DERIVATIVES 失效
标题翻译：吡嗪衍生物
公开(公告)号：US20110201606A1
公开(公告)日：2011-08-18
申请号：US13095760
申请日：2011-04-27
申请人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
发明人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
IPC分类号： A61K31/5383 , C07D239/48 , C07D401/12 , C07D413/12 , C07D403/14 , C07D265/36 , A61K31/506 , A61K31/505 , A61K31/5377 , A61K31/497 , A61P35/00
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14
摘要： Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them
摘要翻译：式I的新型嘧啶衍生物用于其制备方法，它们作为药物的用途以及包含它们的药物组合物

6. 发明申请

US20110172231A1 2,4- DIAMINOPYRIMIDINE DERIVATIVES 有权
标题翻译： 2,4-二氨基嘧啶衍生物
公开(公告)号：US20110172231A1
公开(公告)日：2011-07-14
申请号：US13069816
申请日：2011-03-23
申请人： Rolf BAENTELI , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人： Rolf BAENTELI , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/506 , A61P29/00 , A61P35/00 , A61P35/02 , C07D239/48 , C07D413/12 , A61K31/496
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要： There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译：提供式I化合物，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如权利要求1所述，其可用于ZAP-70和/或Syk抑制起作用或由与FAK连接的信号级联故障引起的。

7. 发明授权

US07964592B2 2,4-di (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders 有权
标题翻译： 2,4-二（苯基氨基）嘧啶可用于治疗肿瘤性疾病，炎症和免疫系统疾病
公开(公告)号：US07964592B2
公开(公告)日：2011-06-21
申请号：US10549250
申请日：2004-03-12
申请人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
发明人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14
摘要： Novel pyrimidine derivatives of formula I to process for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译：用于制备式I的新型嘧啶衍生物，其用作药物和包含它们的药物组合物。

8. 发明授权

US07893074B2 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders 有权
标题翻译： 2，4-嘧啶二胺可用于治疗肿瘤性疾病，炎症和免疫系统疾病
公开(公告)号：US07893074B2
公开(公告)日：2011-02-22
申请号：US10568367
申请日：2004-08-13
申请人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
发明人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要： Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译：式I的新型嘧啶衍生物用于其制备方法，它们作为药物的用途以及包含它们的药物组合物。

9. 发明授权

US07864306B2 Personal identification system 有权
标题翻译：个人识别系统
公开(公告)号：US07864306B2
公开(公告)日：2011-01-04
申请号：US12654888
申请日：2010-01-07
申请人： Miyuki Kono , Shin-ichiro Umemura , Takafumi Miyatake , Kunio Harada , Yoshitoshi Ito , Hironori Ueki
发明人： Miyuki Kono , Shin-ichiro Umemura , Takafumi Miyatake , Kunio Harada , Yoshitoshi Ito , Hironori Ueki
IPC分类号： G06K9/74
CPC分类号： G06K9/00013 , G06K9/00 , G06K9/20 , G06K2009/00932
摘要： A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.
摘要翻译：使用手指的静脉图案的个人识别系统基于捕获的手指图像优化光源的光量，并且在用于识别的图像处理期间强调静脉图案。

10. 发明授权

US07785260B2 Ultrasonograph 有权
标题翻译：超声波检查
公开(公告)号：US07785260B2
公开(公告)日：2010-08-31
申请号：US10482789
申请日：2002-06-05
申请人： Shin-ichiro Umemura , Yuichi Miwa , Takashi Azuma , Takashi Sugiyama , Hiroshi Kuribara
发明人： Shin-ichiro Umemura , Yuichi Miwa , Takashi Azuma , Takashi Sugiyama , Hiroshi Kuribara
IPC分类号： A61B8/00
CPC分类号： G01S7/52047 , A61B8/481 , G01S7/5202 , G01S7/52026 , G01S7/52038 , G01S15/8963 , G10K11/346
摘要： An ultrasonograph capable of generating a transmission beam comprising a main beam having a uniform width over a wide range in an ultrasonic wave propagation direction by one-time transmission of an ultrasonic pulse. A weighted mean value of a plurality of transmission delay time values corresponding to focal lengths of transmission pulse waves having a plurality of focal points which are set in the ultrasonic wave propagation direction is calculated for each of elements constituting a transmission aperture and used as the delay time. The curvature of a transmitted wave front is close to a short focal length in the center portion of the transmit aperture and is close to a long focal length in the peripheral portion. Thus, a transmission beam including a relatively narrow main beam with a uniform width over a wide range in the ultrasonic wave propagation direction can be generated.
摘要翻译：一种能够通过超声波脉冲的一次发送，能够在超声波传播方向上产生宽波长宽泛的主波束的发射束的超声波检查仪。针对构成传输孔径的每个元素计算与设置在超声波传播方向上的多个焦点的传输脉冲波的焦距相对应的多个传输延迟时间值的加权平均值，并将其用作延迟时间。透射波前的曲率在发射孔的中心部分接近短焦距，并且在周边部分中接近长焦距。因此，可以产生包括在超声波传播方向上在宽范围内具有均匀宽度的相对窄的主波束的发射波束。

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