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1. 发明授权

US09249253B2 Polylactide-urethane copolymers 有权
标题翻译：聚丙交酯 - 聚氨酯共聚物
公开(公告)号：US09249253B2
公开(公告)日：2016-02-02
申请号：US12442481
申请日：2007-09-27
申请人： Philippe Dubois , Philippe Coszach , Gloria Vendrell , Philippe Degee , Michael Alexandre , Ibrahim Barakat , Jean Marie Raquez
发明人： Philippe Dubois , Philippe Coszach , Gloria Vendrell , Philippe Degee , Michael Alexandre , Ibrahim Barakat , Jean Marie Raquez
IPC分类号： C08G18/42 , C08G18/32 , C08G18/08 , C08G18/10
CPC分类号： C08G18/4283 , C08G18/0895 , C08G18/10 , C08G18/3206 , C08G18/3228 , C08G18/3231 , C08G18/428 , C08G2230/00 , C08G18/3225
摘要： The process of obtaining a polylactide-urethane copolymer is described which includes contacting an α, ω dihydroxyl polylactide prepolymer of general formula I wherein X is NH or O, R is an alkyl or an aryl group, n and n′ are integer numbers which are substantially the same and are in the range from 20 to 140, with a diisocyanate compound of general formula II O═C═N—R′—N═C═O wherein R′ is an alkyl or an aryl group and with an amine or an alcohol of general formula III R″X′]2 wherein R″ is an alkyl or an aryl group and X′ is NH2 or OH, and with the proviso that at least one of R or R″ is an aryl group.
摘要翻译：描述了获得聚丙交酯 - 氨基甲酸酯共聚物的方法，该方法包括使通式I的α，ω二羟基聚丙交酯预聚物，其中X是NH或O，R是烷基或芳基，n和n'是整数，基本相同并且在20至140的范围内，与通式II的二异氰酸酯化合物O = C = N-R'-N = C = O，其中R'为烷基或芳基，并与胺或通式III R“X”] 2的醇，其中R“是烷基或芳基，X'是NH 2或OH，条件是R”或R“中的至少一个是芳基。

2. 发明申请

US20100016538A1 POLYLACTIDE-URETHANE COPOLYMERS 有权
标题翻译：聚氨酯 - 尿素共聚物
公开(公告)号：US20100016538A1
公开(公告)日：2010-01-21
申请号：US12442481
申请日：2007-09-27
申请人： Philippe Dubois , Philippe Coszach , gloria Vendrell , Philippe Degee , Michael Alexandre , Ibrahim Barakat , Jean Marie Raquez
发明人： Philippe Dubois , Philippe Coszach , gloria Vendrell , Philippe Degee , Michael Alexandre , Ibrahim Barakat , Jean Marie Raquez
IPC分类号： C08G18/34
CPC分类号： C08G18/4283 , C08G18/0895 , C08G18/10 , C08G18/3206 , C08G18/3228 , C08G18/3231 , C08G18/428 , C08G2230/00 , C08G18/3225
摘要： A polylactide-urethane copolymer obtainable by a process, which comprises the step of contacting: an α, ω dihydroxyl polylactide prepolymer of general formula I wherein: X is NH or O, R is an alkyl or an aryl group, n and n′ are integer numbers which are substantially the same and which are comprised in the range from 20 to 140, a diisocyanate compound of general formula II O═C═N—R′—N═C═O wherein: R′ is an alkyl or an aryl group and an amine or an alcohol of general formula III R″[X′]2 wherein: R″ is an alkyl or an aryl group and X′ is NH2 or OH with the proviso that at least one of R or R″ is an aryl group
摘要翻译：可通过以下方法获得的聚丙交酯 - 氨基甲酸酯共聚物，该方法包括使通式I的α，ω-二羟基聚丙交酯预聚物与下列步骤接触：其中：X为NH或O，R为烷基或芳基，n和n'为基本相同且为20〜140的整数，通式II的二异氰酸酯化合物OCN-R'-NCO其中：R'为烷基或芳基，以及胺或醇通式III R''[X'] 2其中：R“是烷基或芳基，X'是NH 2或OH，条件是R或R”中的至少一个是芳基

3. 发明申请

US20070196927A1 Method For Qualitative And/Or Quantitative Detection Of Polyethylene Glycols In Biological Fluids 审中-公开
标题翻译：用于定性和/或定量检测聚乙二醇在生物流体中的方法
公开(公告)号：US20070196927A1
公开(公告)日：2007-08-23
申请号：US10570784
申请日：2004-08-31
申请人： Christian Grandfils , Guy Dandrifosse , Rene Remacle , Ibrahim Barakat , Patricia Deloyer
发明人： Christian Grandfils , Guy Dandrifosse , Rene Remacle , Ibrahim Barakat , Patricia Deloyer
IPC分类号： G01N33/44
CPC分类号： G01N33/52 , G01N31/22
摘要： The subject matter of the present invention relates a method for detection of polyethylene glycols (PEG) in an aqueous solution or in a sample of a biological fluid in a qualitative and/or semi-quantitative and/or quantitative manner, the method comprising the addition of a reagent containing iodine, alkali metal iodide and an acid; and a method for assessing the permeability of the intestine wherein two PEGs of different molecular weight, low molecular weight PEG (l.m.w. PEG) and high molecular weight PEG (h.m.w. PEG) are used as markers, wherein the l.m.w. PEG is able to cross the intestinal mucosa under physiological conditions and the h.m.w. PEG is essentially not able to cross the intestinal mucosa under physiological conditions, but is able to cross the intestinal mucosa under non-physiological, irregular conditions; and wherein h.m.w. and l.m.w. PEG concentrations are measured in a sample of urine from an individual after oral administration of h.m.w. PEG and l.m.w. PEG, wherein the differential index of h.m.w. PEG and l.m.w. PEG in the urine is calculated after determining the concentrations of h.m.w. PEG and l.m.w. PEG by using a reagent for quantitative detection of polyethylene glycol (PEG) in biological fluids, the reagent containing iodine, alkali metal iodide and an acid; and a kit for qualitative and/or semi-quantitative and/or quantitative detection of polyethylene glycol in biological fluids, e.g. in urine.
摘要翻译：本发明的主题涉及以定性和/或半定量和/或定量方式在水溶液或生物流体样品中检测聚乙二醇（PEG）的方法，该方法包括加入含有碘，碱金属碘化物和酸的试剂; 和用于评估肠的渗透性的方法，其中使用不同分子量的低分子量PEG（1m.w.PEG）和高分子量PEG（h.m.w.PEG）的两种PEG作为标记物，其中l.m.w. PEG在生理条件下能够穿过肠粘膜，而h.m.w. PEG在生理条件下基本上不能穿过肠粘膜，但能够在非生理，不规则的条件下穿过肠粘膜; 并且其中h.m.w 和l.m.w. 在口服h.m.w后，来自个体的尿液样品中测量PEG浓度。 PEG和l.m.w. PEG，其中h.m.w的微分指数 PEG和l.m.w. 在确定h.m.w的浓度后计算尿中的PEG。 PEG和l.m.w. PEG通过使用用于在生物体液中定量检测聚乙二醇（PEG）的试剂，含有碘，碱金属碘化物和酸的试剂; 以及用于生物流体中聚乙二醇的定性和/或半定量和/或定量检测的试剂盒，例如。在尿液

4. 发明申请

US20100113734A1 PROCESS FOR PRODUCING POLYLACTIDE-URETHANE COPOLYMERS 审中-公开
标题翻译：生产聚酯 - 尿素共聚物的方法
公开(公告)号：US20100113734A1
公开(公告)日：2010-05-06
申请号：US12442478
申请日：2007-09-27
申请人： Philippe Dubois , Philippe Coszach , Gloria Vendrell , Fabrice Stassin , Caroline Jourdanne , Luc Lienard , Philippe Degee , Ibrahim Barakat , Michael Alexandre , Jean Marie Raquez
发明人： Philippe Dubois , Philippe Coszach , Gloria Vendrell , Fabrice Stassin , Caroline Jourdanne , Luc Lienard , Philippe Degee , Ibrahim Barakat , Michael Alexandre , Jean Marie Raquez
IPC分类号： C08G18/00
CPC分类号： C08G18/0895 , C08G18/244 , C08G18/428 , C08G18/73 , C08G63/08 , C08G63/6852 , C08G63/912 , C08G2230/00
摘要： A process for producing polylactide-urethane copolymers, which comprises the step of contacting a polylactide having terminal hydroxyl groups, produced by contacting at least one lactide monomer with a diol or diamine, with a diisocyanate compound optionally in the presence of a second diol or diamine in the presence of a catalytic system under polymerisation conditions characterised in that the polylactide and the polylactide-urethane copolymers are produced by reactive extrusion.
摘要翻译：一种生产聚丙交酯 - 氨基甲酸酯共聚物的方法，其包括使具有末端羟基的聚交酯与通过使二醇或二胺与至少一种丙交酯单体接触的方法与二异氰酸酯化合物任选地在第二种二醇或二胺在聚合条件下的催化体系存在下，其特征在于聚丙交酯和聚丙交酯 - 聚氨酯共聚物通过反应性挤出制备。

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