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1. 发明申请

US20070043026A1 Dopamine receptor modulators as antipsychotic agents 审中-公开
公开(公告)号：US20070043026A1
公开(公告)日：2007-02-22
申请号：US10513919
申请日：2003-05-09
申请人： David Cooper , Ian Forbes , Andrew Gribble , Andrew Lightfoot , Andrew Payne
发明人： David Cooper , Ian Forbes , Andrew Gribble , Andrew Lightfoot , Andrew Payne
IPC分类号： A61K31/55 , A61K31/47 , C07D223/16
CPC分类号： C07D223/16 , C07D217/04
摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m—and —(CH2)n-respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8—(CH2)pNR7COR8, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R3 represents hydrogen or C1-6alkyl; R4 represents optionally substituted aryl or optionally substituted heteroaryl; R5 and R6each independently represent hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8, —(CH2)pNR7COR8, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R7 and R8 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; and either: Z represents —CR9R10X— or —XCR9R10— and X represents oxygen, sulfur, —SO— or —SO2, or Z represents —CONR11— or —NR9CO— and X represents —CH2—, oxygen, sulfur, —SO— or —SO2; R9 and R10 each independently represent hydrogen, C1-6alkyl or fluoro; R11 represents hydrogen or C1-6alkyl; or a pharmaceutically acceptable salt or solvate thereof. The compounds of the invention are useful in therapy, in particular as antipsychotic agents.

2. 发明申请

US20050261279A1 Compounds 失效
公开(公告)号：US20050261279A1
公开(公告)日：2005-11-24
申请号：US10515998
申请日：2003-05-28
申请人： Ian Forbes , Vincenzo Garzya , Andrew Gribble , Andrew Lightfoot , Andrew Payne , Graham Walker
发明人： Ian Forbes , Vincenzo Garzya , Andrew Gribble , Andrew Lightfoot , Andrew Payne , Graham Walker
IPC分类号： C07D217/22 , A61K20060101 , A61K31/4035 , A61K31/47 , A61K31/4704 , A61K31/472 , A61K31/55 , A61P20060101 , A61P1/00 , A61P1/08 , A61P3/04 , A61P15/00 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/36 , A61P43/00 , C07D20060101 , C07D209/44 , C07D217/02 , C07D223/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D223/16 , C07D209/44 , C07D217/02
摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxy C1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR5R6, —SO2NR5R6, —(CH2)pNR5R6, —(CF)pNR5COR6, optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring; R3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring; R4 represents hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, trifluoromethyl, trifluoromethoxy, halogen, —OSO2CF3, —(CH2)pC3-6cycloalkyl, —(CH2)qOC1-6alkyl or —(CH2)pOC3-6cycloalkyl; R5 and R6 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; Z represents —(CH2)rX— wherein the —(CH2)r— group is attached to R3, or —X(CH2)r— wherein X is attached to R3, and wherein any of the —CH2— groups may be optionally substituted by one or more C1-6alkyl groups; X represents oxygen, —NR7 or —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups; R7 represents hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 1, 2 and 3; r independently represents an integer selected from 0, 1, and 2; or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful in therapy, in particular as antipsychotic agents.

3. 发明授权

US07584161B2 Software system for managing information in context 失效
标题翻译：用于在上下文中管理信息的软件系统
公开(公告)号：US07584161B2
公开(公告)日：2009-09-01
申请号：US11225138
申请日：2005-09-13
申请人： David Ian Forbes , Sharon Flank , David Austin
发明人： David Ian Forbes , Sharon Flank , David Austin
IPC分类号： G06N5/02 , G06F17/00
CPC分类号： G06Q10/10 , G06Q10/0637 , G06Q10/067
摘要： A software system that uses the rigor and rules of business process automation to capture and structure organizational expertise, processes, and procedures—the non-automatable activities and actions of an organization—into a single, common, enterprise-wide, information framework. The capture function is engineered for usability and structured to reflect the patterns and semantics of business users rather than imposing software or process terminology. The produced framework generates a process-driven, centralized taxonomy of information and resources as business requirements are captured. The framework delivers users an organization-specific context to activities and information to be used for learning, training, reference, improvisation, collaboration, and operations. Said system has application in disseminating policies, procedures and compliance; business continuity; improved productivity and culture; training and learning; increasing the return on existing and requirements gathering for future IT investments; employee attrition, retention, and onboarding; capturing and managing knowledge and intellectual capital; and continuous improvement and process reengineering.
摘要翻译：一个使用业务流程自动化的严格性和规则的软件系统可以将组织的专业知识，流程和程序（组织的非自动化活动和行为）捕获并组织成一个单一的，通用的企业级信息框架。捕获功能旨在实现可用性和结构化，以反映业务用户的模式和语义，而不是强加软件或流程术语。所产生的框架在捕获业务需求时，会生成过程驱动的集中分类信息和资源。该框架为用户提供了组织特定的环境，用于学习，培训，参考，即兴创作，协作和操作的活动和信息。所述制度适用于传播政策，程序和合规性; 业务连续性; 提高生产力和文化; 培训和学习; 提高未来IT投资的现有收益和需求收益; 员工流失，保留和入职; 掌握和管理知识和智力资本; 持续改进和流程再造。

4. 发明申请

US20070225276A1 7-Phenylsulfonyl-Tetrahydro-3-Benzazepine Dervatives as Antipsychotic Agents 审中-公开
标题翻译： 7-苯基磺酰基 - 四氢-3-苯并氮杂作为抗精神病药
公开(公告)号：US20070225276A1
公开(公告)日：2007-09-27
申请号：US10580641
申请日：2004-11-25
申请人： Ian Forbes , Gabriella Gentile , Andrew Gribble , Andrew Lightfoot , Andrew Payne , Alexander Smith
发明人： Ian Forbes , Gabriella Gentile , Andrew Gribble , Andrew Lightfoot , Andrew Payne , Alexander Smith
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D413/12
摘要： The invention provides one or more chemical entities selected from a compound of formula (I): wherein R1 represents C1-6alkyl, C1-6alkoxy, trifluoromethyl, trifluoromethoxy, halo, cyano, 5-methyl-1,2,4-oxadiazol-3-yl or a group —SO2X; R2 represents hydrogen, C1-6alkyl, C1-6alkoxy, halo or cyano; X is C1-6alkyl, —NR3R4 or morpholino; R3 and R4 independently represent hydrogen or C1-6alkyl; and a pharmaceutically acceptable salt and solvate thereof; with the proviso that the compound {8-[4-(4-fluoro-benzyl)-benzenesulfonyl]-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-dimethyl-amine is excluded. The compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof are useful in therapy, in particular as antipsychotic agents.
摘要翻译：本发明提供一种或多种选自式（I）化合物的化学实体：其中R 1表示C 1-6烷基，C 1-6烷基，三氟甲基，三氟甲氧基，卤素，氰基，5-甲基-1,2,4-恶二唑-3-基或基团-SO 2 X; R 2表示氢，C 1-6烷基，C 1-6烷氧基，卤素或氰基; X是C 1-6烷基，-NR 3 R 4或吗啉代; R 3和R 4独立地表示氢或C 1-6烷基; 及其药学上可接受的盐和溶剂合物; 条件是化合物{8- [4-（4-氟 - 苄基） - 苯磺酰基] -3-甲基-2,3,4,5-四氢-1H-3-苯并吖庚因-7-基} - 二甲基 - 胺被排除。式（I）化合物及其药学上可接受的盐和溶剂合物可用于治疗，特别是抗精神病药。

5. 发明申请

US20060063757A1 Sulfonamide derivatives as antipsychotic agents 失效
标题翻译：磺酰胺衍生物作为抗精神病药
公开(公告)号：US20060063757A1
公开(公告)日：2006-03-23
申请号：US10530538
申请日：2003-10-06
申请人： Ian Forbes , Andrew Gribble , Andrew Lightfoot , Andrew Payne
发明人： Ian Forbes , Andrew Gribble , Andrew Lightfoot , Andrew Payne
IPC分类号： A61K31/55 , C07D409/02
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR5R6, —SO2NR5R6, —(CH2)NR5R6, —(CH2)pNR5COR6, optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring; R3 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, —(CH2)pNR7R8 or —(CH2)pNR7COR8; R4represents hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, trifluoromethyl, trifluoromethoxy, halogen, —OSO2CF3, —(CH2)pC3-6cycloalkyl, —(CH2)qOC1-6alkyl or —(CH2)pOC3-6cycloalkyl; R5 and R6 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R7 and R8 each independently represent hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that the compounds 8-hydroxy-3-methyl-7-phenylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 8-hydroxy-7-4-(hydroxyphenyl)sulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 7-phenylsulfonyl- 1,2,3,4-tetrahydroisoquinoline and 7-phenylsulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride are excluded. The compounds are useful in therapy, in particular as antipsychotic agents
摘要翻译：本发明提供式（I）化合物：

6. 发明申请

US20050222124A1 Benzenesulfonamide derivatives as antipsychotic agents 审中-公开
公开(公告)号：US20050222124A1
公开(公告)日：2005-10-06
申请号：US10504111
申请日：2003-02-13
申请人： Steven Bromidge , David Cooper , Ian Forbes , Andrew Gribble , Christopher Johnson , Andrew Plightfoot , Stephen Moss , Andrew Payne , Shahzad Rahman , David Witty
发明人： Steven Bromidge , David Cooper , Ian Forbes , Andrew Gribble , Christopher Johnson , Andrew Plightfoot , Stephen Moss , Andrew Payne , Shahzad Rahman , David Witty
IPC分类号： A61K31/40 , A61K31/4035 , A61K31/47 , A61K31/472 , A61K31/55 , A61P1/08 , A61P3/04 , A61P15/10 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D209/44 , C07D217/02 , C07D217/04 , C07D223/16 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/12 , C07D407/10 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12
CPC分类号： C07D223/16 , A61K31/40 , A61K31/47 , A61K31/55 , C07D209/44 , C07D217/02 , C07D217/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The invention provides compounds of formula (I) wherein A and B represent the groups —(CH2)m- and —(CH2)n-respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C3-7cycloalkylC1-6alkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pC3-6cycloalkyloxy, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, —CO2C1-6alkyl, —CO2NR7R8, —SO2NR7R8, C1-6alkylsulfonamido, C1-6alkylsulfonamidoC1-6alkyl, —(CH2)pNR7R8, C1-6alkylamidoC1-6alkyl, —(CH2)pNR7COR8, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, aroylC1-6alkyl, arylC1-6alkanoyl, —SO2NR7R8, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl, or a group CONR7R8 or SO2NR7R8 wherein R7 and R8 together may be fused to form a 5- 7-membered aromatic or non-aromatic heterocyclic ring optionally interrupted by an O or S atom; R3 represents hydrogen or C1-6alkyl; Ar represents optionally substituted phenyl or optionally substituted monocyclic heteroaryl group; R4 represents optionally substituted aryl or optionally substituted heteroaryl; R7 and R8 each independently represent hydrogen, C1-6alkyl or together form a 5- to 7-membered heterocyclic ring; Z represents a bond, an oxygen atom or C1-6alkyl; Y represents hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q represents an integer from 1 to 3; r represents an integer from 1 to 4; or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful in therapy, in particular as antipsychotic agents.

7. 发明申请

US20070093473A1 7-Heteroarylsulfonyl-tetrahydro-3-benzazepine derivatives as antipsychotic agents 审中-公开
公开(公告)号：US20070093473A1
公开(公告)日：2007-04-26
申请号：US10571220
申请日：2004-09-09
申请人： David Cooper , Ian Forbes , Vincenzo Garzya , Andrew Gribble , Andrew Lightfoot , Andrew Payne , Alexander Smith
发明人： David Cooper , Ian Forbes , Vincenzo Garzya , Andrew Gribble , Andrew Lightfoot , Andrew Payne , Alexander Smith
IPC分类号： A61K31/55 , C07D403/02 , C07D409/02
CPC分类号： C04B35/632 , C07D401/12 , C07D409/12
摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR3R4, —SO2NR3R4, —(CH2)pNR3R4, —(CH2)pNR3COR4, optionally substituted aryl ring, optionally substituted heteroaryl ring, a fused bicyclic heteroaromatic ring system or optionally substituted heterocyclyl ring; Ar1 represents optionally substituted heteroaryl ring; Ar2 represents optionally substituted aryl ring or optionally substituted heteroaryl ring; Z represents —(CH2)qX— wherein the —(CH2)q— group is attached to Ar2, or —X(CH2)q— wherein X is attached to Ar2, and wherein any of the —CH2— groups may be optionally substituted by one or more C1-6alkyl groups; X represents oxygen, —CH(OR5)—, —NR5— or —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups; R3 and R4 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R5 represents hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 0, 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when Ar1 is a pyridyl group, and Z is —CH2X— where X is attached to the Ar1 group, X is selected from —CH(OR5)—, —NR5— and —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups. The compounds of formula (I) are useful in therapy, in particular as antipsychotic agents.

8. 发明申请

US20050176759A1 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment cns disorders 审中-公开
标题翻译： 7-磺酰基-3-苯并吖庚因衍生物作为多巴胺受体的调节剂及其用于治疗cns病症的用途
公开(公告)号：US20050176759A1
公开(公告)日：2005-08-11
申请号：US10499776
申请日：2002-12-20
申请人： Mahmood Ahmed , Steven Bromidge , Ian Forbes , Andrew Gribble , Christopher Johnson , Francis King , Andrew Lightfoot , Gregor Macdonald , Stephen Moss , Mervyn Thompson , David Witty
发明人： Mahmood Ahmed , Steven Bromidge , Ian Forbes , Andrew Gribble , Christopher Johnson , Francis King , Andrew Lightfoot , Gregor Macdonald , Stephen Moss , Mervyn Thompson , David Witty
IPC分类号： C07D223/14 , A61K31/55 , A61P1/08 , A61P3/04 , A61P15/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D223/16 , C07D401/12 , C07D403/12 , A61K31/47 , A61K31/4035
CPC分类号： C07D223/16 , C07D401/12 , C07D403/12
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译：发明的是非肽TPO模拟物。还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的羟基-1-偶氮苯衍生物。

9. 发明申请

US20080058378A1 Compounds which have activity at M1 receptor and their uses in medicine. 失效
标题翻译：具有M1受体活性的化合物及其在药物中的用途。
公开(公告)号：US20080058378A1
公开(公告)日：2008-03-06
申请号：US11852455
申请日：2007-09-10
申请人： Brian Budzik , David Cooper , Ian Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Graham Walker
发明人： Brian Budzik , David Cooper , Ian Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Graham Walker
IPC分类号： A61K31/445 , A61P43/00
CPC分类号： C07D405/12 , C07D235/26
摘要： Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
摘要翻译：提供式（I）化合物和盐和溶剂化物：其中R 4是氟，R 5选自氢，卤素，氰基，C 1〜 C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基，C 1-6烷氧基和C 1-6 - 被一个或多个氟原子取代的烷氧基; 和R 6选自卤素，氰基，C 1-6烷基，被一个或多个氟原子取代的C 1-6烷基， C 3-6环烷基，被一个或多个氟原子取代的C 3-6环烷基，C 1-6烷氧基和C 1-6烷基， 1-6个被一个或多个氟原子取代的烷氧基，Q是氢或C 1-6烷基。预期化合物可用于治疗，例如治疗精神病和认知障碍。

10. 发明申请

US20100169233A1 SOFTWARE SYSTEM FOR MANAGING INFORMATION IN CONTEXT 审中-公开
标题翻译：用于管理信息的软件系统
公开(公告)号：US20100169233A1
公开(公告)日：2010-07-01
申请号：US12551120
申请日：2009-08-31
申请人： David Ian Forbes , Sharon Flank , David Austin
发明人： David Ian Forbes , Sharon Flank , David Austin
IPC分类号： G06Q10/00 , G06F3/048
CPC分类号： G06Q10/10 , G06Q10/0637 , G06Q10/067
摘要： A software system that uses the rigor and rules of business process automation to capture and structure organizational expertise, processes, and procedures—the non-automatable activities and actions of an organization—into a single, common, enterprise-wide, information framework. The capture function is engineered for usability and structured to reflect the patterns and semantics of business users rather than imposing software or process terminology. The produced framework generates a process-driven, centralized taxonomy of information and resources as business requirements are captured. The framework delivers users an organization-specific context to activities and information to be used for learning, training, reference, improvisation, collaboration, and operations. Said system has application in disseminating policies, procedures and compliance; business continuity; improved productivity and culture; training and learning; increasing the return on existing and requirements gathering for future IT investments; employee attrition, retention, and on boarding; capturing and managing knowledge and intellectual capital; and continuous improvement and process reengineering.
摘要翻译：一个使用业务流程自动化的严格性和规则的软件系统可以将组织的专业知识，流程和程序（组织的非自动化活动和行为）捕获并组织成一个单一的，通用的企业级信息框架。捕获功能旨在实现可用性和结构化，以反映业务用户的模式和语义，而不是强加软件或流程术语。所产生的框架在捕获业务需求时，会生成过程驱动的集中分类信息和资源。该框架为用户提供了组织特定的环境，用于学习，培训，参考，即兴创作，协作和操作的活动和信息。所述制度适用于传播政策，程序和合规性; 业务连续性; 提高生产力和文化; 培训和学习; 提高未来IT投资的现有收益和需求收益; 员工流失，保留和上船; 掌握和管理知识和智力资本; 持续改进和流程再造。

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