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1. 发明申请

US20100183676A1 COMPOSITIONS COMPRISING OPA PROTEIN EPITOPES 审中-公开
标题翻译：包含OPA蛋白抗原决定簇的组合物
公开(公告)号：US20100183676A1
公开(公告)日：2010-07-22
申请号：US11722330
申请日：2005-12-22
申请人： Martin Maiden , Ian Feavers , Andrew Pollard
发明人： Martin Maiden , Ian Feavers , Andrew Pollard
IPC分类号： A61K39/04 , C07H21/00 , A61P31/04 , A61P37/04
CPC分类号： A61K39/095 , A61K2039/55555
摘要： The present invention relates to a composition comprising at least one purified Opa HV 1 protein epitope and at least one purified Opa HV2 protein epitope. The epitopes are preferably purified protein epitopes, preferably recombinant epitopes. The composition is preferably a pharmaceutical composition, more preferably a vaccine composition. The invention also relates to methods of immunisation and to specific formulations presented in the tables, and to novel nucleic acids encoding Opa alleles.
摘要翻译：本发明涉及包含至少一种纯化的Opa HV1蛋白表位和至少一种纯化的Opa HV2蛋白表位的组合物。表位优选是纯化的蛋白质表位，优选重组表位。组合物优选为药物组合物，更优选为疫苗组合物。本发明还涉及表中给出的免疫方法和特定制剂，以及编码Opa等位基因的新型核酸。

2. 发明授权

US08318179B2 Neisserial vaccines 失效
标题翻译：奈瑟氏体疫苗
公开(公告)号：US08318179B2
公开(公告)日：2012-11-27
申请号：US11628106
申请日：2005-06-03
申请人： Martin Maiden , Ian Feavers , Andrew Pollard
发明人： Martin Maiden , Ian Feavers , Andrew Pollard
IPC分类号： A61K39/116 , A61K39/00 , A61K39/095 , A61K45/00
CPC分类号： A61K39/095
摘要： The present invention relates to compositions comprising at least one purified PorA protein antigen and at least one purified FetA protein antigen. In particular, said PorA/FetA antigens are antigenically variable antigens comprising the variable regions of PorA/FetA. Specific combinations of PorA/FetA epitopes are presented for example in Table 3. The invention also relates to methods of immunization comprising administering said compositions, and to methods for producing compositions. Preferably the compositions are purified protein compositions. Preferably the compositions are vaccine compositions.
摘要翻译：本发明涉及包含至少一种纯化的PorA蛋白抗原和至少一种纯化的FetA蛋白抗原的组合物。特别地，所述PorA / FetA抗原是包含PorA / FetA的可变区的抗原可变抗原。 PorA / FetA表位的具体组合例如列于表3中。本发明还涉及免疫的方法，包括施用所述组合物，以及制备组合物的方法。优选地，组合物是纯化的蛋白质组合物。优选地，组合物是疫苗组合物。

3. 发明申请

US20110262484A1 OUTER MEMBRANE VESICLE PRIME-PROTEIN BOOST VACCINE 审中-公开
标题翻译：外膜VESICLE PRIME-PROTEIN BOOST VACCINE
公开(公告)号：US20110262484A1
公开(公告)日：2011-10-27
申请号：US13062168
申请日：2009-09-04
申请人： Ian Feavers
发明人： Ian Feavers
IPC分类号： A61K39/095 , A61P37/04 , A61P31/04 , A61P19/02
CPC分类号： A61K39/095 , A61K2039/545 , A61K2039/57
摘要： The present invention provides a method of immunizing a subject against a disease caused by Neisseria meningitidis, comprising administering to the subject a primer composition comprising a meningococcal outer membrane vesicle preparation, and a booster composition comprising a meningococcal protein antigen preparation. Vaccine combinations comprising primer and booster compositions and associated uses are also provided.
摘要翻译：本发明提供一种针对脑膜炎奈瑟球菌引起的疾病免疫受试者的方法，其包括对受试者施用包含脑膜炎球菌外膜囊泡制剂的引物组合物和包含脑膜炎球菌蛋白质抗原制备物的增效组合物。还提供了包含引物和增强组合物和相关用途的疫苗组合。

4. 发明申请

US20070224222A1 Neisserial Vaccines 失效
标题翻译：奈瑟氏体疫苗
公开(公告)号：US20070224222A1
公开(公告)日：2007-09-27
申请号：US11628106
申请日：2005-06-03
申请人： Martin Maiden , Ian Feavers , Andrew Pollard
发明人： Martin Maiden , Ian Feavers , Andrew Pollard
IPC分类号： A61K39/095 , A61K39/02 , C07K14/00
CPC分类号： A61K39/095
摘要： The present invention relates to compositions comprising at least one purified PorA protein antigen and at least one purified FetA protein antigen. In particular, said PorA/FetA antigens are antigenically variable antigens comprising the variable regions of PorA/FetA. Specific combinations of PorA/FetA epitopes are presented for example in Table 3. The invention also relates to methods of immunisation comprising administering said compositions, and to methods for producing compositions. Preferably the compositions are purified protein compositions. Preferably the compositions are vaccine compositions.
摘要翻译：本发明涉及包含至少一种纯化的PorA蛋白抗原和至少一种纯化的FetA蛋白抗原的组合物。特别地，所述PorA / FetA抗原是包含PorA / FetA的可变区的抗原可变抗原。 PorA / FetA表位的具体组合例如列于表3中。本发明还涉及免疫的方法，包括施用所述组合物，以及制备组合物的方法。优选地，组合物是纯化的蛋白质组合物。优选地，组合物是疫苗组合物。

5. 发明申请

US20130089571A1 Vaccine 审中-公开
标题翻译：疫苗
公开(公告)号：US20130089571A1
公开(公告)日：2013-04-11
申请号：US13659139
申请日：2012-10-24
申请人： Martin Maiden , Ian Feavers , Andrew Pollard
发明人： Martin Maiden , Ian Feavers , Andrew Pollard
IPC分类号： A61K39/095
CPC分类号： A61K39/095
摘要： The present invention relates to compositions comprising at least one purified PorA protein antigen and at least one purified FetA protein antigen. In particular, said PorA/FetA antigens are antigenically variable antigens comprising the variable regions of PorA/FetA. Specific combinations of PorA/FetA epitopes are presented for example in Table 3. The invention also relates to methods of immunisation comprising administering said compositions, and to methods for producing compositions. Preferably the compositions are purified protein compositions. Preferably the compositions are vaccine compositions.
摘要翻译：本发明涉及包含至少一种纯化的PorA蛋白抗原和至少一种纯化的FetA蛋白抗原的组合物。特别地，所述PorA / FetA抗原是包含PorA / FetA的可变区的抗原可变抗原。 PorA / FetA表位的具体组合例如列于表3中。本发明还涉及免疫的方法，包括施用所述组合物，以及制备组合物的方法。优选地，组合物是纯化的蛋白质组合物。优选地，组合物是疫苗组合物。

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