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1. 发明申请

US20120114746A1 Immunostimulatory Compositions Comprising Liposome-Encapsulated Oligonucleotides and Epitopes 有权
标题翻译：包含脂质体包封的寡核苷酸和表位的免疫刺激组合物
公开(公告)号：US20120114746A1
公开(公告)日：2012-05-10
申请号：US13383898
申请日：2010-06-16
申请人： Hyung-Joo Kwon
发明人： Hyung-Joo Kwon
IPC分类号： A61K9/127 , A61P37/04 , G01N33/566 , A61P31/12 , A61K39/00 , A61K39/12
CPC分类号： A61K47/48815 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/29 , A61K39/39 , A61K45/06 , A61K47/6911 , A61K2039/55555 , A61K2039/55561 , C12N7/00 , C12N2760/16134 , C12N2760/16161 , C12N2760/16171 , C12N2760/18534 , C12N2770/24234 , G01N33/5023 , G01N33/6878 , A61K2300/00
摘要： The present invention relates to a composition for enhancing an immune response, an epitope having immunogenicity, screening and preparing method thereof, a antibody to peptide antigen and screening and preparing method thereof. The composition of the present invention may be effectively used for preventing or treating diverse immune-deficiency diseases such as cancer, influenza virus, hepatitis C virus and RSV (respiratory syncytial virus) by enhancing immune responses.
摘要翻译：本发明涉及用于增强免疫应答的组合物，具有免疫原性的表位，其筛选及其制备方法，抗体抗体及其筛选及制备方法。通过增强免疫应答，本发明的组合物可有效地用于预防或治疗各种免疫缺陷疾病如癌症，流感病毒，丙型肝炎病毒和RSV（呼吸道合胞病毒）。

2. 发明授权

US07934289B2 Foldable cross-patterned pull-handle and bag having the same 失效
标题翻译：可折叠的交叉图案拉手和具有相同的袋子
公开(公告)号：US07934289B2
公开(公告)日：2011-05-03
申请号：US12142513
申请日：2008-06-19
申请人： Hyung Joo Kwon
发明人： Hyung Joo Kwon
IPC分类号： B25G1/04
CPC分类号： A45C13/262 , A45C5/14 , A45C2013/265 , Y10T16/451 , Y10T16/4554 , Y10T16/473
摘要： Disclosed is a foldable cross-patterned pull-handle and a bag having the same. The pull-handle includes a folding means having a first link assembly and a second link assembly connected to an end of the first link assembly so that the folding means can be folded and retracted or unfolded and extended, the first link assembly having two links connected to each other so that the links cross each other at a center portion, a first end of the second link assembly being supported on a bag; and a handle means mounted on a second end of the folding means and grabbed by a user with hand. Due to the structural characteristics of the link assemblies constituting the folding means, the length of the bag handle can be adjusted variously by folding or unfolding it, and the bag handle can be installed in a reduced space.
摘要翻译：公开了一种可折叠的交叉图案拉手和具有该拉手的袋。所述拉手包括折叠装置，所述折叠装置具有第一连杆组件和连接到所述第一连杆组件的端部的第二连杆组件，使得所述折叠装置可以被折叠和缩回或展开和延伸，所述第一连杆组件具有连接的两个连杆使得所述连杆在中心部分处彼此交叉，所述第二连杆组件的第一端支撑在袋上; 以及安装在折叠装置的第二端并由用户用手抓住的手柄装置。由于构成折叠装置的连杆组件的结构特征，可以通过折叠或展开来不同地调节袋手柄的长度，并且袋手柄可以安装在减小的空间中。

3. 发明申请

US20090062224A1 Therapeutic use of cpg oligodeoxynucleotide for skin disease 有权
标题翻译： cpg寡脱氧核苷酸治疗皮肤病
公开(公告)号：US20090062224A1
公开(公告)日：2009-03-05
申请号：US10589102
申请日：2005-11-04
申请人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
发明人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
IPC分类号： A61K31/7125 , A61P37/00 , A61P17/00
CPC分类号： A61K31/7088 , A61K31/7125
摘要： Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.
摘要翻译：公开了CpG寡脱氧核苷酸对皮肤疾病的治疗用途。本发明的CpG寡脱氧核苷酸（CpG ODNs）在具有硫代磷酸酯骨架的CpG ODNs和具有磷酸二酯骨架的CpG ODNs的情况下都显示出对皮肤疾病的优异的免疫活性。

4. 发明申请

US20080249291A1 Oligonucleotides Derived From Mycobacterium for Stimulating Immune Function, Treating Immune-Related Diseases, Atopic Dermatitis and/or Protecting Normal Immune Cell 有权
标题翻译：衍生自分枝杆菌的寡核苷酸用于刺激免疫功能，治疗免疫相关疾病，特应性皮炎和/或保护正常免疫细胞
公开(公告)号：US20080249291A1
公开(公告)日：2008-10-09
申请号：US10581656
申请日：2005-01-28
申请人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
发明人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
IPC分类号： C07H21/04
CPC分类号： C07H21/00 , A61K2039/55561 , A61K2039/57
摘要： Disclosed are oligonucleotides for manipulating an immune reaction. The oligonucleotides of the present invention may be useful to stimulate the immune function, to treat the immune-related diseases and the atopic dermatitis, or to protect the normal immune cells.
摘要翻译：公开了用于操纵免疫反应的寡核苷酸。本发明的寡核苷酸可用于刺激免疫功能，治疗免疫相关疾病和特应性皮炎，或保护正常免疫细胞。

5. 发明授权

US06881561B1 Endonuclease of immune cell, process for producing the same and immune adjuvant using the same 失效
标题翻译：免疫细胞的内切核酸酶，其制备方法和使用其的免疫佐剂
公开(公告)号：US06881561B1
公开(公告)日：2005-04-19
申请号：US09722776
申请日：2000-11-27
申请人： Doo Sik Kim , Hyung Joo Kwon
发明人： Doo Sik Kim , Hyung Joo Kwon
IPC分类号： C12N9/22 , C12N9/00 , C07K1/00 , C12N9/14
CPC分类号： C12N9/22
摘要： The present invention relates to a novel endonuclease enzyme which is secreted from immune cell and recognizes bacterial DNA as foreign agent and processes it to produce about 10 bp single-stranded oligonucleotide including CpG motif which is involved in immune response. Also, the present invention relates to a process for producing the endonuclease which comprises culturing human B-lymphoblastic IM9 cell line or TPA-treated myelogenous U937 cell line on an appropriate medium to produce the said endonuclease and isolating the said endonuclease from the cell lysate or the culture medium. In addition, the present invention relates to an immune adjuvant comprising about 10 bp single-stranded oligonucleotide having CpG motif produced by treatment of bacterial DNA by endonuclease.
摘要翻译：本发明涉及从免疫细胞分泌并识别细菌DNA作为外来试剂的新型内切核酸酶，并将其处理以产生约10bp的单链寡核苷酸，包括参与免疫应答的CpG基序。此外，本发明涉及生产内切核酸酶的方法，其包括在合适的培养基上培养人B淋巴细胞IM9细胞系或TPA处理的骨髓瘤U937细胞系以产生所述内切核酸酶并从细胞裂解物中分离所述内切核酸酶或培养基。此外，本发明涉及包含通过内切核酸酶处理细菌DNA产生的具有CpG基序的约10bp单链寡核苷酸的免疫佐剂。

6. 发明申请

US20110226575A1 BAG HAVING A HANDLE UNIT WITH IMPROVED PRECISION OF AN EXTENDABLE LENGTH 审中-公开
标题翻译：具有改善长度精度的手柄单元的袋子
公开(公告)号：US20110226575A1
公开(公告)日：2011-09-22
申请号：US13048145
申请日：2011-03-15
申请人： Hyung Joo KWON
发明人： Hyung Joo KWON
IPC分类号： A45C13/26 , F16H1/02
CPC分类号： A45C13/262 , A45C2013/267 , Y10T74/19642
摘要： Disclosed is a bag having a handle unit with improved precision of an extendable length. The bag includes a body and a handle unit mounted on one side of the body. The handle unit includes a housing coupled with one side of the body and having an installation space therein, a foldable section arranged in the installation space and having a configuration in which a plurality of links cross each other such that the plurality of links are extended and contracted in folded or unfolded states, a lock gear section that fixes an extendable length of the foldable section and is coupled to an upper end of the foldable section to reduce tolerance occurring when the foldable section is extended and contracted, and a lock gear adjustment section that adjusts driving of the lock gear section such that the foldable section.
摘要翻译：公开了具有手柄单元的袋，其具有可延长长度的精度。该袋包括主体和安装在身体一侧的手柄单元。所述把手单元包括与所述主体的一侧耦合并且在其中具有安装空间的壳体，布置在所述安装空间中的折叠部分，并且具有多个连杆彼此交叉以使得所述多个连杆延伸的构造，以及以折叠或展开状态收缩的锁定齿轮部分，其固定可折叠部分的可延伸长度并且联接到可折叠部分的上端，以减小当可折叠部分伸缩时发生的公差;以及锁定齿轮调节部分其调节锁定齿轮部分的驱动，使得可折叠部分。

7. 发明申请

US20080280830A1 FUSION PROTEIN COMPRISING FK506 BINDING PROTEIN AND METHOD OF MAKING AND USING THE SAME 有权
标题翻译：包含FK506结合蛋白的融合蛋白及其制备和使用方法
公开(公告)号：US20080280830A1
公开(公告)日：2008-11-13
申请号：US12144890
申请日：2008-06-24
申请人： Soo Young Choi , Jinseu Park , Won Sik Eum , Dae-Won Kim , Jin-Hee Choi , Tae-Yoon Kim , Hyung-Joo Kwon
发明人： Soo Young Choi , Jinseu Park , Won Sik Eum , Dae-Won Kim , Jin-Hee Choi , Tae-Yoon Kim , Hyung-Joo Kwon
IPC分类号： A61K8/64 , C07K14/00 , C07H21/00 , C12N15/63 , A61Q19/00
CPC分类号： C12N9/90 , C07K2319/01
摘要： Disclosed is a fusion protein containing a FK506 binding protein and a cell-transducing domain. Also, disclosed is a method of making the fusion protein and use of the fusion protein in a pharmaceutical or cosmetic composition. The cell-transducing domain is, for example, a PEP-1.
摘要翻译：披露了含有FK506结合蛋白和细胞转导结构域的融合蛋白。此外，还公开了在药物或化妆品组合物中制备融合蛋白并使用融合蛋白的方法。细胞转导结构域是例如PEP-1。

8. 发明授权

US08889181B2 Immunostimulatory compositions comprising liposome-encapsulated oligonucleotides and epitopes 有权
标题翻译：包含脂质体包封的寡核苷酸和表位的免疫刺激组合物
公开(公告)号：US08889181B2
公开(公告)日：2014-11-18
申请号：US13383898
申请日：2010-06-16
申请人： Hyung-Joo Kwon
发明人： Hyung-Joo Kwon
IPC分类号： A61K9/127 , A61K39/00 , A61P37/04 , A61P31/12 , A61K39/29 , A61K39/155 , A61K31/7088 , A61K45/06 , C12N7/00 , A61K47/48 , A61K39/145
CPC分类号： A61K47/48815 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/29 , A61K39/39 , A61K45/06 , A61K47/6911 , A61K2039/55555 , A61K2039/55561 , C12N7/00 , C12N2760/16134 , C12N2760/16161 , C12N2760/16171 , C12N2760/18534 , C12N2770/24234 , G01N33/5023 , G01N33/6878 , A61K2300/00
摘要： The present invention relates to a composition for enhancing an immune response, an epitope having immunogenicity, screening and preparing method thereof, a antibody to peptide antigen and screening and preparing method thereof. The composition of the present invention may be effectively used for preventing or treating diverse immune-deficiency diseases such as cancer, influenza virus, hepatitis C virus and RSV (respiratory syncytial virus) by enhancing immune responses.
摘要翻译：本发明涉及用于增强免疫应答的组合物，具有免疫原性的表位，其筛选及其制备方法，抗体抗体及其筛选及制备方法。通过增强免疫应答，本发明的组合物可有效地用于预防或治疗各种免疫缺陷疾病如癌症，流感病毒，丙型肝炎病毒和RSV（呼吸道合胞病毒）。

9. 发明授权

US07935678B2 Therapeutic use of CPG oligodeoxynucleotide for skin disease 有权
标题翻译： CPG寡脱氧核苷酸治疗皮肤病的疗效
公开(公告)号：US07935678B2
公开(公告)日：2011-05-03
申请号：US10589102
申请日：2005-11-04
申请人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
发明人： Tae-Yoon Kim , Doo-Sik Kim , Hyung-Joo Kwon , Yang-Soon Kim
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： A61K31/7088 , A61K31/7125
摘要： Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.
摘要翻译：公开了CpG寡脱氧核苷酸对皮肤疾病的治疗用途。本发明的CpG寡脱氧核苷酸（CpG ODNs）在具有硫代磷酸酯骨架的CpG ODNs和具有磷酸二酯骨架的CpG ODNs的情况下都显示出对皮肤疾病的优异的免疫活性。

10. 发明授权

US07902161B2 Oligonucleotides derived from mycobacterium for stimulating immune function, treating immune-related diseases, atopic dermatitis and/or protecting normal immune cell 有权
标题翻译：衍生自分枝杆菌的寡核苷酸用于刺激免疫功能，治疗免疫相关疾病，特应性皮炎和/或保护正常免疫细胞
公开(公告)号：US07902161B2
公开(公告)日：2011-03-08
申请号：US10581656
申请日：2005-01-28
申请人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
发明人： Hyung-Joo Kwon , Tae-Yoon Kim , Doo-Sik Kim
IPC分类号： A01N43/04 , A61K31/70 , A61K45/00 , A61K47/00 , C07H21/02 , C07H21/04
CPC分类号： C07H21/00 , A61K2039/55561 , A61K2039/57
摘要： Disclosed are oligonucleotides for manipulating an immune reaction. The oligonucleotides of the present invention may be useful to stimulate the immune function, to treat the immune-related diseases and the atopic dermatitis, or to protect the normal immune cells.
摘要翻译：公开了用于操纵免疫反应的寡核苷酸。本发明的寡核苷酸可用于刺激免疫功能，治疗免疫相关疾病和特应性皮炎，或保护正常免疫细胞。

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