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1. 发明申请

US20150240416A1 METHOD OF DYEING ARTIFICIAL HAIRS 审中-公开
标题翻译：染色人造毛发的方法
公开(公告)号：US20150240416A1
公开(公告)日：2015-08-27
申请号：US14210779
申请日：2014-03-14
申请人： Hyun Joo SHIM
发明人： Hyun Joo SHIM
IPC分类号： D06P1/00
CPC分类号： D06P1/002 , D06P1/0032 , D06P1/0096 , D06P1/92 , D06P3/002 , D06P3/004
摘要： Disclosed is a method of dyeing artificial hairs. The method includes increasing a temperature of a first dye mixture solution, primarily dyeing a bundle of artificial hairs after introducing the artificial hairs into a body, cleaning the body after drying the primarily-dyed artificial hairs, and moving up the artificial hairs while draining the first dye mixture solution, increasing a temperature of a second dye mixture solution composed by water and a dye representing another color by a hot water supply, and dyeing secondarily the artificial hairs by reversing the primarily-dyed artificial hairs, and slowly supplying a dye to the body to gradually increase the concentration of the second dye mixture solution. The artificial hairs are gradient-dyed in two colors or three colors to be dyed in various colors required by consumers. The time spent for a dyeing work is short, so the artificial hairs are dyed for a short time.
摘要翻译：公开了一种染色人造毛发的方法。该方法包括增加第一染料混合物溶液的温度，主要在将人造毛发引入人体中之后染色一束人造毛发，在干燥主染色的人造毛发之后清洁身体，并且在排出人造毛发的同时向上移动人造毛发第一染料混合溶液，通过热水供应使由水和代表另一种颜色的染料的第二染料混合物溶液的温度升高，并且通过逆转主染色的人造毛发来次要染色人造毛发，并缓慢地将染料供给身体逐渐增加第二染料混合溶液的浓度。人造毛发以两种颜色或三种颜色进行渐变染色，以消费者所需的各种颜色染色。染色工作花费的时间很短，所以人造毛发染色时间很短。

2. 发明授权

US08242159B2 1,3-dihydro-5-isobenzofurancarbonitrile derivatives and pharmaceutical composition thereof for the treatment of premature ejaculation 失效
标题翻译： 1,3-二氢-5-异苯并呋喃腈衍生物及其药物组合物，用于治疗早泄
公开(公告)号：US08242159B2
公开(公告)日：2012-08-14
申请号：US12739870
申请日：2008-10-31
申请人： Yeong Geon Lee , Soo-Jung Choi , Tae-Kyung Kang , Mi-Jeong Seo , Chang-Yong Shin , Kyung-Seok Lee , Gook-Jun Ahn , Seul-Min Choi , Yong-Duck Kim , Dong-Hwan Kim , Kyung-Koo Kang , Hyun-Joo Shim , Dong-Sung Kim , Byoung-Ok Ahn , Moo-Hi Yoo
发明人： Yeong Geon Lee , Soo-Jung Choi , Tae-Kyung Kang , Mi-Jeong Seo , Chang-Yong Shin , Kyung-Seok Lee , Gook-Jun Ahn , Seul-Min Choi , Yong-Duck Kim , Dong-Hwan Kim , Kyung-Koo Kang , Hyun-Joo Shim , Dong-Sung Kim , Byoung-Ok Ahn , Moo-Hi Yoo
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/38 , A61K31/34 , C07D233/00 , C07D231/00 , C07D409/00 , C07D307/02
CPC分类号： C07D307/87 , C07D405/06 , C07D409/04 , C07D409/06
摘要： Disclosed herein are novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives represented by Formula 1, or pharmaceutically acceptable salts thereof. Also disclosed is a pharmaceutical composition for treating or preventing premature ejaculation including the compound. The 1,3-dihydro-5-isobenzofurancarbonitrile derivatives have a short half-life and inhibit the ejaculation process by selectively inhibiting serotonin reuptake via a serotonin reuptake transporter present in a presynaptic neuron. Thus, the compounds are useful in the treatment and prevention of premature ejaculation.
摘要翻译：本文公开了由式1表示的新的1,3-二氢-5-异苯并呋喃腈衍生物或其药学上可接受的盐。还公开了用于治疗或预防早泄的药物组合物，包括该化合物。 1,3-二氢-5-异苯并呋喃腈衍生物具有短的半衰期，并通过选择性地通过存在于突触前神经元中的5-羟色胺再摄取转运蛋白选择性抑制5-羟色胺再摄取来抑制射精过程。因此，这些化合物可用于治疗和预防早泄。

3. 发明申请

US20100240725A1 NOVEL 1,3-DIHYDRO-5-ISOBENZOFURANCARBONITRILE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF PREMATURE EJACULATION 失效
标题翻译：新型1,3-二氢-5-ISOBENZFURBANITRILE衍生物及其药物组合物，用于治疗预防性呕吐
公开(公告)号：US20100240725A1
公开(公告)日：2010-09-23
申请号：US12739870
申请日：2008-10-31
申请人： Yeong Geon Lee , Soo-Jung Choi , Tae-Kyung Kang , Mi-Jeong Seo , Chang-Yong Shin , Kyung-Seok Lee , Gook-Jun Ahn , Seul-Min Choi , Yong-Duck Kim , Dong-Hwan Kim , Kyung-Koo Kang , Hyun-Joo Shim , Dong-Sung Kim , Byoung-Ok Ahn , Moo-Hi Yoo
发明人： Yeong Geon Lee , Soo-Jung Choi , Tae-Kyung Kang , Mi-Jeong Seo , Chang-Yong Shin , Kyung-Seok Lee , Gook-Jun Ahn , Seul-Min Choi , Yong-Duck Kim , Dong-Hwan Kim , Kyung-Koo Kang , Hyun-Joo Shim , Dong-Sung Kim , Byoung-Ok Ahn , Moo-Hi Yoo
IPC分类号： A61K31/4178 , C07D307/87 , A61K31/343 , A61P15/00 , C07D405/06 , A61K31/4155 , C07D409/04 , A61K31/381
CPC分类号： C07D307/87 , C07D405/06 , C07D409/04 , C07D409/06
摘要： Disclosed herein are novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives represented by Formula 1, or pharmaceutically acceptable salts thereof. Also disclosed is a pharmaceutical composition for treating or preventing premature ejaculation including the compound. The 1,3-dihydro-5-isobenzofurancarbonitrile derivatives have a short half-life and inhibit the ejaculation process by selectively inhibiting serotonin reuptake via a serotonin reuptake transporter present in a presynaptic neuron. Thus, the compounds are useful in the treatment and prevention of premature ejaculation.
摘要翻译：本文公开了由式1表示的新的1,3-二氢-5-异苯并呋喃腈衍生物或其药学上可接受的盐。还公开了用于治疗或预防早泄的药物组合物，包括该化合物。 1,3-二氢-5-异苯并呋喃腈衍生物具有短的半衰期，并通过选择性地通过存在于突触前神经元中的5-羟色胺再摄取转运蛋白选择性抑制5-羟色胺再摄取来抑制射精过程。因此，这些化合物可用于治疗和预防早泄。

4. 发明授权

US08598347B2 Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate 有权
标题翻译：二肽基肽酶-IV抑制剂和中间体的制备方法
公开(公告)号：US08598347B2
公开(公告)日：2013-12-03
申请号：US13260179
申请日：2010-03-30
申请人： Woo Young Kwak , Heung Jae Kim , Jong Pil Min , Tae Hyun Yoon , Hyun Joo Shim , Moohi Yoo
发明人： Woo Young Kwak , Heung Jae Kim , Jong Pil Min , Tae Hyun Yoon , Hyun Joo Shim , Moohi Yoo
IPC分类号： C07D241/08 , C07C323/58 , C07C227/10
CPC分类号： C07D203/18 , C07C269/06 , C07D265/32 , Y02P20/55 , C07C271/22
摘要： The present invention relates to an improved method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention allows reduction of production costs by reacting low cost reagents, improves yield and is adaptable for mass production.
摘要翻译：本发明涉及二肽基肽酶-IV抑制剂和中间体的改进方法。本发明通过使低成本试剂反应，可以提高生产成本，提高产量，适用于批量生产。

5. 发明申请

US20120016126A1 METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE 有权
标题翻译：制备DIPEPTIDYP肽酶IV抑制剂和中间体的方法
公开(公告)号：US20120016126A1
公开(公告)日：2012-01-19
申请号：US13260179
申请日：2010-03-30
申请人： Woo Young Kwak , Heung Jae Kim , Jong Pil Min , Tae Hyun Yoon , Hyun Joo Shim , Moohi Yoo
发明人： Woo Young Kwak , Heung Jae Kim , Jong Pil Min , Tae Hyun Yoon , Hyun Joo Shim , Moohi Yoo
IPC分类号： C07D241/08 , C07C323/58 , C07C227/10
CPC分类号： C07D203/18 , C07C269/06 , C07D265/32 , Y02P20/55 , C07C271/22
摘要： The present invention relates to an improved method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention allows reduction of production costs by reacting low cost reagents, improves yield and is adaptable for mass production.
摘要翻译：本发明涉及二肽基肽酶-IV抑制剂和中间体的改进方法。本发明通过使低成本试剂反应，可以提高生产成本，提高产量，适用于批量生产。

6. 发明授权

US11944145B1 Wig capable of forming volume with wig yarn and method for manufacturing same 有权
公开(公告)号：US11944145B1
公开(公告)日：2024-04-02
申请号：US18467142
申请日：2023-09-14
申请人： Hyun Joo Shim
发明人： Hyun Joo Shim
IPC分类号： A41G3/00
CPC分类号： A41G3/0066 , A41G3/005 , A41G3/0075
摘要： The present technology relates to a wig capable of naturally implementing a wave with wig yarns without using an additional beauty tool by regularly knotting long hairs and short hairs in an arbitrarily set region of a hair net, and more specifically, to a wig shaped by knotting natural or artificial hairs, which are wig yarns, on a hair net formed in a head shape, in which the wig includes a non-wave area where long hairs are knotted and a wave area where the long hairs and short hairs are knotted to have an area of a regular pattern, thereby allowing the long hairs resting on the short hairs to have a volume, in which the wave area includes a long hair section where long hairs are knotted and a short hair section where short hairs are knotted.

7. 发明申请

US20100063041A1 NOVEL PHENYLPROPIONIC ACID DERIVATIVES AS PEROXISOME PROLIFERATOR-ACTIVATED GAMMA RECEPTOR MODULATORS, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新戊二酸衍生物作为过氧化物促进剂活化的游离体受体调节剂，其方法和包含其的药物组合物
公开(公告)号：US20100063041A1
公开(公告)日：2010-03-11
申请号：US12449979
申请日：2008-03-07
申请人： Ho-Sang Moon , Moo-Hi Yoo , Soon-Hoe Kim , Joong-In Lim , Moon-Ho Son , Mi-Kyung Kim , Chang-Yell Shin , Jin-Kwan Kim , Sang-Kuk Park , Yu-Na Chae , Hyun-Joo Shim , Sun-Ho Jeon , Hae-Sun Kim , Gil-Tae Wie , Dong-Hwan Kim , Byung-Kyu Lee , Chan-Sun Park , Byung-Nak Ahn , Eunkyung Kim , Myung-Ho Bae , Young-Ah Shin , Youn Hur , Chun-Ho Lee , Hyun-Ho Choi , Bongtae Kim , Wonee Chong
发明人： Ho-Sang Moon , Moo-Hi Yoo , Soon-Hoe Kim , Joong-In Lim , Moon-Ho Son , Mi-Kyung Kim , Chang-Yell Shin , Jin-Kwan Kim , Sang-Kuk Park , Yu-Na Chae , Hyun-Joo Shim , Sun-Ho Jeon , Hae-Sun Kim , Gil-Tae Wie , Dong-Hwan Kim , Byung-Kyu Lee , Chan-Sun Park , Byung-Nak Ahn , Eunkyung Kim , Myung-Ho Bae , Young-Ah Shin , Youn Hur , Chun-Ho Lee , Hyun-Ho Choi , Bongtae Kim , Wonee Chong
IPC分类号： A61K31/538 , C07D333/16 , A61K31/381 , C07D413/02 , A61K31/5377 , A61K31/5355 , C07D277/20 , A61K31/426 , C07D409/02 , A61K31/501 , C07D498/02 , A61P3/10 , A61P3/06
CPC分类号： C07D333/16 , C07D277/24 , C07D307/42 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel phenylpropionic acid derivative and a PPAR-γ modulator comprising the same as an active ingredient. The phenylpropionic acid derivative of the present invention has modulatory action on function of PPAR-γ and then exhibits hypoglycemic, hypolipidemic and insulin resistance-reducing effects on PPAR-mediated diseases or disorders. Therefore, the present invention is prophylactically or therapeutically effective for diabetes and metabolic diseases.
摘要翻译：本发明提供了一种新的苯丙酸衍生物和包含其作为活性成分的PPAR-γ调节剂。本发明的苯基丙酸衍生物对PPAR-γ的功能具有调节作用，然后对PPAR介导的疾病或病症表现出降血糖，降血脂和胰岛素抵抗降低作用。因此，本发明对于糖尿病和代谢疾病具有预防性或治疗上的有效性。

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