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1. 发明授权

US07820692B2 Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof 有权
标题翻译：四氢异喹啉衍生物，其制备方法及其医药用途
公开(公告)号：US07820692B2
公开(公告)日：2010-10-26
申请号：US12309299
申请日：2007-07-10
申请人： Yungen Xu , Jinggen Liu , Ting Guo , Dechuan Wang , Tianjiang Sun , Hongguo Lu
发明人： Yungen Xu , Jinggen Liu , Ting Guo , Dechuan Wang , Tianjiang Sun , Hongguo Lu
IPC分类号： A61K31/4725 , C07D217/00
CPC分类号： C07D401/06 , C07D217/14
摘要： A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.
摘要翻译：一种四氢异喹啉衍生物（I），其制备方法，药物组合物及其药用，特别是其作为治疗疼痛缓解的焦虑受体兴奋剂的用途，属于药物化学。通式（I）的取代基R 1，R 2，R 3，R 4定义为描述。

2. 发明申请

US20090275607A1 Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof 有权
标题翻译：四氢异喹啉衍生物，其制备方法及其医药用途
公开(公告)号：US20090275607A1
公开(公告)日：2009-11-05
申请号：US12309299
申请日：2007-07-10
申请人： Yungen Xu , Jinggen Liu , Ting Guo , Dechuan Wang , Tianjiang Sun , Hongguo Lu
发明人： Yungen Xu , Jinggen Liu , Ting Guo , Dechuan Wang , Tianjiang Sun , Hongguo Lu
IPC分类号： A61K31/4725 , C07D403/04
CPC分类号： C07D401/06 , C07D217/14
摘要： A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.
摘要翻译：一种四氢异喹啉衍生物（I），其制备方法，药物组合物及其药用，特别是其作为止痛药中的卡帕阿片受体兴奋剂的用途，属于药物化学。通式（I）的取代基R 1，R 2，R 3，R 4定义为描述。

3. 发明申请

US20100317604A1 FORSYTHIASIDE INJECTION PREPARATION AND PREPARATIVE METHOD THEREOF 审中-公开
标题翻译：甲基硫脲注射剂的制备及其制备方法
公开(公告)号：US20100317604A1
公开(公告)日：2010-12-16
申请号：US12521494
申请日：2007-12-24
申请人： Zhenyu Xuan , Yong Wang , Xiaochun Huang , Hongguo Lu , Tianjiang Sun , Guojun Chen , Qiuling Tang
发明人： Zhenyu Xuan , Yong Wang , Xiaochun Huang , Hongguo Lu , Tianjiang Sun , Guojun Chen , Qiuling Tang
IPC分类号： A61K31/7034 , A61P31/00
CPC分类号： A61K47/12 , A61K9/0019 , A61K31/702 , A61K47/183 , A61K47/20 , A61K47/26
摘要： The present invention discloses a Forsythiaside injection preparation and preparative method thereof. This injection preparation is prepared by Forsythiaside and pharmaceutical adjuvant.
摘要翻译：本发明公开了连翘酯注射剂及其制备方法。这种注射制剂由连翘酯和药物佐剂制备。

4. 发明授权

US07696228B2 Oral preparation of dyclonine hydrochloride 有权
标题翻译：口服盐酸德乐宁制剂
公开(公告)号：US07696228B2
公开(公告)日：2010-04-13
申请号：US11914681
申请日：2006-01-13
申请人： Tianjiang Sun , Xiaohong Gu , Hongguo Lu , Min Chen
发明人： Tianjiang Sun , Xiaohong Gu , Hongguo Lu , Min Chen
IPC分类号： A61K31/4453
CPC分类号： A61K9/08 , A61K9/0056 , A61K9/0095 , A61K31/4453 , A61K47/10 , A61K47/32
摘要： The present invention discloses an oral preparation of dyclonine hydrochloride for the endoscopic examination in upper gastrointestinal tract, which has the effects of anesthetization and lubrication, and an oral preparation comprising dyclonine hydrochloride that has the advantages of avoiding foam in the body cavity, preventing vomiting, and offering a clear view. The preparation of the present invention comprises, as main ingredients, 0.2%-3% weight percent of dyclonine hydrochloride, 1%-12% weight percent of polyvinyl alcohol, 1%-10% volume percent of glycerin, 1%-10% volume percent of a defoaming agent, and a balance of a pharmaceutically acceptable adjuvant. The viscosity of the preparation is in a range of 30 to 300 mpa·s and the pH value is in a range of 2.0 to 8.0.
摘要翻译：本发明公开了一种口服上海胃肠道内镜检查口服制剂，具有麻醉和润滑作用，含有盐酸德格林的口服制剂，其具有避免体腔泡沫，防止呕吐，并提供清晰的看法。本发明的制剂作为主要成分包含0.2％-3％重量的盐酸德克罗宁，1％-12％重量的聚乙烯醇，1％-10％的甘油体积％，1％-10％的体积百分比的消泡剂，以及药学上可接受的佐剂的余量。制剂的粘度为30〜300mpa·s，pH值为2.0〜8.0。

5. 发明申请

US20080200506A1 Oral Preparation of Dyclonine Hydrochloride 有权
标题翻译：口服盐酸达克罗宁制剂
公开(公告)号：US20080200506A1
公开(公告)日：2008-08-21
申请号：US11914681
申请日：2004-01-13
申请人： Tianjiang Sun , Xiaohong Gu , Hongguo Lu , Min Chen
发明人： Tianjiang Sun , Xiaohong Gu , Hongguo Lu , Min Chen
IPC分类号： A61K31/4453
CPC分类号： A61K9/08 , A61K9/0056 , A61K9/0095 , A61K31/4453 , A61K47/10 , A61K47/32
摘要： The present invention discloses an oral preparation of dyclonine hydrochloride for the endoscope examination in upper gastrointestinal tract, which has the effects of anaesthetization and lubrication, and especially an oral preparation comprising dyclonine hydrochloride that has the advantages of avoiding the foam in the body cavity, preventing vomit, and offering a clear view. The preparation of the present invention comprises, as main ingredients, 0.2%-3% weight percent of dyclonine hydrochloride, 1%-12% weight percent of polyvinyl alcohol, 1%-10% volume percent of glycerin, 1%-10% volume percent of a defoaming agent, and a balance of a pharmaceutically acceptable adjuvant. The viscosity of the preparation is in a range of 30 to 300 mpa·s and the pH value is in a range of 2.0 to 8.0.
摘要翻译：本发明公开了一种用于上消化道内窥镜检查的口服制剂，其具有麻醉和润滑作用，特别是包含盐酸德克伦宁的口服制剂，其具有避免体腔泡沫的优点，预防呕吐，并提供清晰的看法。本发明的制剂作为主要成分包含0.2％-3％重量的盐酸德克罗宁，1％-12％重量的聚乙烯醇，1％-10％的甘油体积％，1％-10％的体积百分比的消泡剂，以及药学上可接受的佐剂的余量。制剂的粘度为30〜300mpa.s，pH值为2.0〜8.0。

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