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1. 发明授权

US08524876B2 RNAi molecule targeting thymidylate synthase and application thereof 有权
标题翻译：靶向胸苷酸合酶的RNAi分子及其应用
公开(公告)号：US08524876B2
公开(公告)日：2013-09-03
申请号：US13258591
申请日：2010-03-29
申请人： Hiromi Wada , Cheng Long Huang
发明人： Hiromi Wada , Cheng Long Huang
IPC分类号： C07H21/04
CPC分类号： A61K31/7088 , A61K31/4412 , A61K31/513 , A61K31/53 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12N2320/31 , C12Y201/01045 , A61K2300/00
摘要： This invention provides a novel RNAi molecule that can significantly potentiate antitumor effects of a 5-FU antitumor agent. The RNAi molecule comprises the nucleotide sequence shown in SEQ ID NO: 2. The invention also provides an antitumor agent comprising such RNAi molecule and a 5-FU antitumor agent.
摘要翻译：本发明提供了可显着增强5-FU抗肿瘤剂抗肿瘤作用的新型RNAi分子。 RNAi分子包含SEQ ID NO：2所示的核苷酸序列。本发明还提供包含这种RNAi分子和5-FU抗肿瘤剂的抗肿瘤剂。

2. 发明授权

US08288085B2 Method of separating pancreatic islet 有权
标题翻译：分离胰岛的方法
公开(公告)号：US08288085B2
公开(公告)日：2012-10-16
申请号：US11793679
申请日：2005-12-22
申请人： Shinichi Matsumoto , Hiromi Wada , Hirofumi Noguchi
发明人： Shinichi Matsumoto , Hiromi Wada , Hirofumi Noguchi
IPC分类号： A01N1/00 , A01N1/02 , A01N63/02
CPC分类号： C12N5/0677 , A01N1/0205 , A01N1/0226 , A61K35/12 , C12N2509/00
摘要： The present invention provides a pancreatic islet isolation method comprising the steps of (1) injecting a protection solution containing a protease inhibitor into the pancreatic duct of an procured pancreas; (3) digesting the pancreas into which the protection solution has been injected; and (4) purifying the digested pancreatic tissue using a purification solution containing a density gradient reagent. The present invention also provides a protection solution for injection into the pancreatic duct, a pancreas preservation solution for the two-layer method, and an islet purification solution.
摘要翻译：本发明提供一种胰岛分离方法，其包括以下步骤：（1）将含有蛋白酶抑制剂的保护溶液注入胰腺胰管; （3）消化注入保护液的胰腺; 和（4）使用含有密度梯度试剂的纯化溶液纯化消化的胰腺组织。本发明还提供了用于注射胰管的保护溶液，用于双层方法的胰脏保存溶液和胰岛净化溶液。

3. 发明申请

US20060227755A1 Partner node migration control unit and method 失效
公开(公告)号：US20060227755A1
公开(公告)日：2006-10-12
申请号：US11451181
申请日：2006-06-12
申请人： Hiromi Wada , Takashi Yozawa , Tatsuya Ohnishi
发明人： Hiromi Wada , Takashi Yozawa , Tatsuya Ohnishi
IPC分类号： H04Q7/24 , H04L12/56
CPC分类号： H04W36/0011 , H04L29/12009 , H04L29/12216 , H04L29/12311 , H04L29/1233 , H04L29/12339 , H04L29/12349 , H04L29/12462 , H04L61/2007 , H04L61/2084 , H04L61/2507 , H04L61/255 , H04W4/18 , H04W8/04 , H04W8/26 , H04W60/00 , H04W80/04 , H04W88/06 , H04W88/16
摘要： Disclosed is a migration communication control device constructed to control a continuous communication between a mobile node and a node unaffected the mobile node's migration. The migration communication control device comprises a first migration control unit, a second migration control unit on the mobile node, and a third migration control unit on the partner node. The first migration control unit comprises a packet transfer unit and an address post unit. The packet transfer unit receives a packet which was destined for an outdated address of the mobile node, generates a conversion packet which holds an updated address instead of the outdated address, and then transmits the conversion packet, while an address post unit transmits an address post message which indicates the updated address to the third migration control unit. The second migration control unit comprises a migration post unit and a packet resumption unit. The migration post unit transmits to the first migration control unit a migration post message which indicates the updated address when the mobile node migrates to another network while a packet resumption unit receives the conversion packet from both the first migration control unit and the third migration control unit and resumes an original packet from the conversion packet. The third migration control unit comprises a packet conversion unit which converts a destination address of a packet into the updated address, then transmits it to the mobile node.

4. 发明申请

US20050245478A1 Postoperative adjuvant chemotherapy with UFT 有权
标题翻译：术后辅助化疗与UFT
公开(公告)号：US20050245478A1
公开(公告)日：2005-11-03
申请号：US11115394
申请日：2005-04-27
申请人： Mitsuo Ohta , Hiromi Wada , Harubumi Kato , Yukito Ichinose , Masahiro Tsuboi
发明人： Mitsuo Ohta , Hiromi Wada , Harubumi Kato , Yukito Ichinose , Masahiro Tsuboi
IPC分类号： A61K31/513 , A61K31/7072
CPC分类号： A61K31/513 , A61K31/7072
摘要： The present invention provides an improved method for treating lung cancer, preferably non-small cell lung cancer, by orally administering UFT to postoperative lung cancer patients.
摘要翻译：本发明提供了通过口服给予术后肺癌患者的UFT来治疗肺癌，优选非小细胞肺癌的改进方法。

5. 发明授权

US06674439B1 Information terminal device 有权
标题翻译：信息终端设备
公开(公告)号：US06674439B1
公开(公告)日：2004-01-06
申请号：US09566810
申请日：2000-05-08
申请人： Hidehiko Shin , Hiromi Wada , Naoya Yoshida , Atsunobu Kato
发明人： Hidehiko Shin , Hiromi Wada , Naoya Yoshida , Atsunobu Kato
IPC分类号： G06T100
CPC分类号： G06T3/4092 , G06F17/30905 , H04M1/72522 , H04M1/72544 , H04M1/72561
摘要： A mobile terminal is provided which can obtain an image from a server and change the size of the image so as to use the image as a background image. An image obtaining unit obtains an image from a server. An over-size decision unit decides whether the entirety of the image obtained by the image obtaining unit can be displayed within the display area in a screen. When the over-size decision unit provides a negative decision, an image resizing unit changes the size of the image obtained by the image obtaining unit so that it can be displayed within the display area in the screen.
摘要翻译：提供一种移动终端，其可以从服务器获得图像并改变图像的大小以便将该图像用作背景图像。图像获取单元从服务器获取图像。超大尺寸决定单元决定图像获取单元获得的图像的整体是否可以在屏幕的显示区域内显示。当超尺寸决定单元提供否定决定时，图像调整单元改变由图像获取单元获得的图像的尺寸，使得其可以在屏幕的显示区域内显示。

6. 发明授权

US5845079A Mobile migration communication control device 失效
标题翻译：移动通信控制设备
公开(公告)号：US5845079A
公开(公告)日：1998-12-01
申请号：US635027
申请日：1996-04-19
申请人： Hiromi Wada , Takashi Yozawa , Tatsuya Ohnishi
发明人： Hiromi Wada , Takashi Yozawa , Tatsuya Ohnishi
IPC分类号： H04L12/56 , H04L29/06 , H04L29/12 , H04W4/18 , H04W8/04 , H04W8/26 , H04W36/00 , H04W36/14 , H04W60/00 , H04W80/04 , H04W88/06 , H04W88/16 , G06F13/00
CPC分类号： H04W36/0011 , H04L29/12009 , H04L29/12216 , H04L29/12311 , H04L29/1233 , H04L29/12349 , H04L29/12462 , H04L61/2007 , H04L61/2084 , H04L61/2507 , H04L61/255 , H04W8/04 , H04W8/26 , H04L29/12339 , H04W4/18 , H04W60/00 , H04W80/04 , H04W88/06 , H04W88/16
摘要： Disclosed is a migration communication control device constructed to control a continuous communication between a mobile node and a node unaffected the mobile node's migration. The migration communication control device comprises a first migration control unit, a second migration control unit on the mobile node, and a third migration control unit on the partner node. The first migration control unit comprises a packet transfer unit and an address post unit. The packet transfer unit receives a packet which was destined for an outdated address of the mobile node, generates a conversion packet which holds an updated address instead of the outdated address, and then transmits the conversion packet, while an address post unit transmits an address post message which indicates the updated address to the third migration control unit. The second migration control unit comprises a migration post unit and a packet resumption unit. The migration post unit transmits to the first migration control unit a migration post message which indicates the updated address when the mobile node migrates to another network while a packet resumption unit receives the conversion packet from both the first migration control unit and the third migration control unit and resumes an original packet from the conversion packet. The third migration control unit comprises a packet conversion unit which converts a destination address of a packet into the updated address, then transmits it to the mobile node.
摘要翻译：公开了一种迁移通信控制设备，其被构造为控制移动节点和节点之间的连续通信，而不影响移动节点的迁移。迁移通信控制装置包括移动节点上的第一迁移控制单元，第二迁移控制单元和伙伴节点上的第三迁移控制单元。第一迁移控制单元包括分组传送单元和地址后置单元。分组传送单元接收目的地是移动节点的过期地址的分组，生成保存更新地址而不是过期地址的转换分组，然后发送转换分组，而地址后单元发送地址信息消息，其指示到第三迁移控制单元的更新地址。第二迁移控制单元包括迁移站单元和分组恢复单元。迁移站单元在第一迁移控制单元向移动站信息发送移动后消息时，当移动节点迁移到另一网络时，指示更新的地址，而分组恢复单元从第一迁移控制单元和第三迁移控制单元接收到转换分组并从转换数据包恢复原始数据包。第三迁移控制单元包括将分组的目的地地址转换为更新的地址的分组转换单元，然后将其发送到移动节点。

7. 外观设计

USD282515S Thermoelectric cooling pillow 失效
公开(公告)号：USD282515S
公开(公告)日：1986-02-11
申请号：US493218
申请日：1983-05-10
申请人： Hiromi Wada , Shuhei Tsuchihashi , Yoshimi Miyamoto
设计人： Hiromi Wada , Shuhei Tsuchihashi , Yoshimi Miyamoto

8. 发明授权

US08512940B2 Method for preserving liver in a solution comprising dibutyryl cAMP 有权
标题翻译：在包含二丁酰cAMP的溶液中保存肝脏的方法
公开(公告)号：US08512940B2
公开(公告)日：2013-08-20
申请号：US13222407
申请日：2011-08-31
申请人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Koichi Tanaka , Masami Nakamura
发明人： Takaaki Koshiba , Xiangdong Zhao , Hiromi Wada , Takayuki Nakamura , Koichi Tanaka
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxicity due to nitroglycerin, which is observed during liver preservation, has been improved, liver transplantation can be performed with a high engrafted rate.
摘要翻译：本发明提供含有海藻糖和二丁酰基cAMP的肝保存液。保存溶液中硝酸甘油的含量优选低于0.44mM。在本发明的肝保存液中，由于在肝脏保存期间观察到的硝酸甘油的毒性已经得到改善，因此可以以高的移植率进行肝移植。

9. 发明授权

US07016681B2 Mobile communication device and data communication method using the same 有权
标题翻译：移动通信设备和数据通信方法使用相同
公开(公告)号：US07016681B2
公开(公告)日：2006-03-21
申请号：US10040786
申请日：2002-01-09
申请人： Koichi Hata , Munehito Matsuda , Kiyoshi Ogishi , Hiromi Wada , Atsunobu Kato
发明人： Koichi Hata , Munehito Matsuda , Kiyoshi Ogishi , Hiromi Wada , Atsunobu Kato
IPC分类号： H04Q7/20 , G06F3/00 , G06F17/60
CPC分类号： H04W88/06 , G06Q30/0217 , G06Q30/0236 , G06Q30/0238 , G06Q30/0239
摘要： A mobile communication device that flexibly supports various services which utilize both Internet communications and short-distance wireless communications. An instruction data receiving section receives instruction data indicating a protocol in which a set of data exchanges are to be performed. An instruction data analysis section analyzes the received instruction data, and controls a reception switching section and a transmission switching section based on a result of the analysis. The reception switching section receives data from either an Internet reception section or a short-distance wireless reception section under the control of the instruction data analysis section. The transmission switching section outputs data to either an Internet transmission section or a short-distance wireless transmission section under the control of the instruction data analysis section.
摘要翻译：一种移动通信设备，其灵活地支持利用互联网通信和短距离无线通信的各种服务。指令数据接收部分接收指示要执行一组数据交换的协议的指令数据。指令数据分析部分分析所接收的指令数据，并根据分析结果控制接收切换部分和传输切换部分。接收切换部分在指令数据分析部分的控制下从互联网接收部分或短距离无线接收部分接收数据。传输切换部分在指令数据分析部分的控制下将数据输出到因特网传输部分或短距离无线传输部分。

10. 发明授权

US06980213B1 Terminal device for mobile communication 有权
标题翻译：移动通信终端设备
公开(公告)号：US06980213B1
公开(公告)日：2005-12-27
申请号：US09567112
申请日：2000-05-08
申请人： Takako Hirose , Hiromi Wada , Hidehiko Shin , Atsunobu Kato
发明人： Takako Hirose , Hiromi Wada , Hidehiko Shin , Atsunobu Kato
IPC分类号： G09G5/00 , H04M1/247 , H04M1/725 , G06T11/00 , G08B5/22 , H04B1/38 , H04M1/00
CPC分类号： H04M1/72519 , G09G5/00 , G09G2370/027 , H04M1/72561
摘要： In a mobile communication terminal device that obtains data including text or an image from an external server through a digital network, a display displays display data DD generated based on data in a first storage unit. A plurality of display modes are predetermined in a display mode switching unit. When instructed by a user while the display data is displayed on the display, the display mode switching unit switches the display mode according to a predetermined order. A display data generator generates the display data DD according to the next display mode. The display displays the display data DD generated by the display data generator. It is thus possible to provide a mobile communication terminal device capable of displaying data while switching among a plurality of display modes (character sets or image display forms) through simpler operation.
摘要翻译：在通过数字网络从外部服务器获取包括文本或图像的数据的移动通信终端设备中，显示器显示基于第一存储单元中的数据生成的显示数据DD。多个显示模式在显示模式切换单元中被预先确定。当在显示器上显示显示数据时由用户指示时，显示模式切换单元根据预定顺序切换显示模式。显示数据发生器根据下一显示模式生成显示数据DD。显示器显示由显示数据发生器产生的显示数据DD。因此，可以提供能够通过更简单的操作在多个显示模式（字符集或图像显示形式）之间切换的同时显示数据的移动通信终端装置。

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