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1. 发明申请

US20050245478A1 Postoperative adjuvant chemotherapy with UFT 有权
标题翻译：术后辅助化疗与UFT
公开(公告)号：US20050245478A1
公开(公告)日：2005-11-03
申请号：US11115394
申请日：2005-04-27
申请人： Mitsuo Ohta , Hiromi Wada , Harubumi Kato , Yukito Ichinose , Masahiro Tsuboi
发明人： Mitsuo Ohta , Hiromi Wada , Harubumi Kato , Yukito Ichinose , Masahiro Tsuboi
IPC分类号： A61K31/513 , A61K31/7072
CPC分类号： A61K31/513 , A61K31/7072
摘要： The present invention provides an improved method for treating lung cancer, preferably non-small cell lung cancer, by orally administering UFT to postoperative lung cancer patients.
摘要翻译：本发明提供了通过口服给予术后肺癌患者的UFT来治疗肺癌，优选非小细胞肺癌的改进方法。

2. 发明授权

US07157459B2 Postoperative adjuvant chemotherapy with UFT 有权
标题翻译：术后辅助化疗与UFT
公开(公告)号：US07157459B2
公开(公告)日：2007-01-02
申请号：US11115394
申请日：2005-04-27
申请人： Mitsuo Ohta , Hiromi Wada , Harubumi Kato , Yukito Ichinose , Masahiro Tsuboi
发明人： Mitsuo Ohta , Hiromi Wada , Harubumi Kato , Yukito Ichinose , Masahiro Tsuboi
IPC分类号： A01N43/58
CPC分类号： A61K31/513 , A61K31/7072
摘要： The present invention provides an improved method for treating lung cancer, preferably non-small cell lung cancer, by orally administering UFT to postoperative lung cancer patients.
摘要翻译：本发明提供了通过口服给予术后肺癌患者的UFT来治疗肺癌，优选非小细胞肺癌的改进方法。

3. 发明授权

US06383175B1 Medical laser apparatus and diagnostic/treatment apparatus using the medical laser apparatus 有权
标题翻译：医用激光装置及使用医疗用激光装置的诊断·治疗装置
公开(公告)号：US06383175B1
公开(公告)日：2002-05-07
申请号：US09406734
申请日：1999-09-28
申请人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
发明人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
IPC分类号： A61B1822
CPC分类号： A61N5/062 , A61N2005/0644 , A61N2005/067
摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.
摘要翻译：在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。此外，使用单个光源实现诊断和治疗。治疗期间同时诊断也得到实现。半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。光传输线引导照射的激光附近的焦点，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光，图像提取/分析装置拾取并分析所提取的荧光的图像，并且图像显示装置显示分析结果。

4. 发明授权

US08148090B2 Method for prediction of postoperative prognosis and diagnosis kit 失效
标题翻译：方法预测术后预后及诊断试剂盒
公开(公告)号：US08148090B2
公开(公告)日：2012-04-03
申请号：US12738522
申请日：2008-10-17
申请人： Yousuke Fukui , Atsushi Ogiwara , Shingo Akimoto , Takao Kawakami , Takashi Hirano , Junichi Maeda , Harubumi Kato
发明人： Yousuke Fukui , Atsushi Ogiwara , Shingo Akimoto , Takao Kawakami , Takashi Hirano , Junichi Maeda , Harubumi Kato
IPC分类号： G01N33/53
CPC分类号： G01N33/57423 , G01N2333/4712 , G01N2800/54
摘要： The present invention relates to a method for predicting the postoperative prognosis of a lung adenocarcinoma patient with high sensitivity and/or specificity by identifying a protein with an expression level that specifically varies in a lung adenocarcinoma patient, comprising: step (a) of determining expression levels of myosin IIA and/or vimentin in a biological sample collected from a lung adenocarcinoma patient; and step (b) of predicting or determining a prognosis based on the expression levels of myosin IIA and/or vimentin obtained as a result of determination.
摘要翻译：本发明涉及通过鉴定具有在肺腺癌患者中具体变化的表达水平的蛋白质来预测具有高灵敏度和/或特异性的肺腺癌患者的术后预后的方法，其包括：步骤（a）从肺腺癌患者收集的生物样品中肌球蛋白IIA和/或波形蛋白的水平; 和步骤（b），其基于作为测定结果获得的肌球蛋白IIA和/或波形蛋白的表达水平来预测或确定预后。

5. 发明申请

US20100221744A1 METHOD FOR PREDICTION OF POSTOPERATIVE PROGNOSIS AND DIAGNOSIS KIT 失效
标题翻译：术后预防和诊断试剂盒预测方法
公开(公告)号：US20100221744A1
公开(公告)日：2010-09-02
申请号：US12738522
申请日：2008-10-17
申请人： Yousuke Fukui , Atsushi Ogiwara , Shingo Akimoto , Takao Kawakami , Takashi Hirano , Junichi Maeda , Harubumi Kato
发明人： Yousuke Fukui , Atsushi Ogiwara , Shingo Akimoto , Takao Kawakami , Takashi Hirano , Junichi Maeda , Harubumi Kato
IPC分类号： G01N33/53
CPC分类号： G01N33/57423 , G01N2333/4712 , G01N2800/54
摘要： The present invention relates to a method for predicting the postoperative prognosis of a lung adenocarcinoma patient with high sensitivity and/or specificity by identifying a protein with an expression level that specifically varies in a lung adenocarcinoma patient, comprising: step (a) of determining expression levels of myosin IIA and/or vimentin in a biological sample collected from a lung adenocarcinoma patient; and step (b) of predicting or determining a prognosis based on the expression levels of myosin IIA and/or vimentin obtained as a result of determination.
摘要翻译：本发明涉及通过鉴定具有在肺腺癌患者中具体变化的表达水平的蛋白质来预测具有高灵敏度和/或特异性的肺腺癌患者的术后预后的方法，其包括：步骤（a）从肺腺癌患者收集的生物样品中肌球蛋白IIA和/或波形蛋白的水平; 和步骤（b），其基于作为测定结果获得的肌球蛋白IIA和/或波形蛋白的表达水平来预测或确定预后。

6. 发明授权

US07016718B2 Medical laser apparatus and diagnostic/treatment apparatus using the medical laser apparatus 失效
公开(公告)号：US07016718B2
公开(公告)日：2006-03-21
申请号：US10097259
申请日：2002-03-15
申请人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
发明人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
IPC分类号： A61F9/008
CPC分类号： A61N5/062 , A61N2005/0644 , A61N2005/067
摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.

7. 发明授权

US06214033B1 Medical laser apparatus and diagnostic/treatment apparatus using the medical laser apparatus 失效
标题翻译：医用激光装置及使用医疗用激光装置的诊断·治疗装置
公开(公告)号：US06214033B1
公开(公告)日：2001-04-10
申请号：US08545101
申请日：1995-10-19
申请人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
发明人： Yoshiteru Ii , Akira Kaneda , Takayoshi Yuzu , Toshiyoshi Yamamoto , Harubumi Kato , Katsuo Aizawa
IPC分类号： A61N506
CPC分类号： A61N5/062 , A61N2005/0644 , A61N2005/067
摘要： In photodynamic diagnosis and photodynamic therapy, the oscillating wavelength of laser light from a light source is fitted to a plurality of different kinds of photosensitizers and exciting conditions thereof. Moreover, diagnosis and treatment are achieved using a single light source. Concurrent diagnosis during treatment is realized as well. A semiconductor laser generates laser light having an oscillating wavelength which is variable and a full width at half maximum which is narrow. A light transmission line guides an irradiated laser light to the vicinity of a focus, an image transmission line observes the focus and the periphery thereof, a fluorescence light extracting device extracts only the fluorescence light emitted from a photosensitizer excited by the irradiated laser light, an image-pick-up/analyzing device picks up and analyzes an image of the extracted fluorescence light and an image display device displays the analyzing result.
摘要翻译：在光动力学诊断和光动力学治疗中，来自光源的激光的振荡波长适合于多种不同种类的光敏剂和激发条件。此外，使用单个光源实现诊断和治疗。治疗期间同时诊断也得到实现。半导体激光器产生具有可变的振荡波长的激光，半波长的半峰全宽。光传输线将照射的激光引导到焦点附近，图像传输线观察其焦点和周围，荧光提取装置仅提取由照射的激光激发的光敏剂发射的荧光，图像拾取/分析装置拾取并分析提取的荧光的图像，并且图像显示装置显示分析结果。

8. 发明授权

US5243612A Cancer therapy system 失效
标题翻译：癌症治疗系统
公开(公告)号：US5243612A
公开(公告)日：1993-09-07
申请号：US924479
申请日：1992-08-04
申请人： Takeshi Udagawa , Takeyasu Amano , Hiroyuki Shiozaki , Mikio Mori , Sadao Degawa , Harubumi Kato
发明人： Takeshi Udagawa , Takeyasu Amano , Hiroyuki Shiozaki , Mikio Mori , Sadao Degawa , Harubumi Kato
IPC分类号： A61B18/20 , A61N5/06 , A61N5/067 , H01S3/00 , H01S3/109
CPC分类号： A61N5/0601 , A61N2005/067
摘要： In a solid-state laser, a YAG laser generates laser beam with a predetermined wavelength in response to which a titanium-sapphire laser is pumped to generate laser beam with a predetermined wavelength which is administered through a fiberscope to irradiate focuses, treating or destroying the same.

9. 发明授权

US4556057A Cancer diagnosis device utilizing laser beam pulses 失效
标题翻译：癌症诊断装置利用激光束脉冲
公开(公告)号：US4556057A
公开(公告)日：1985-12-03
申请号：US474302
申请日：1983-03-11
申请人： Teruo Hiruma , Atsushi Honma , Tooru Hirano , Yutaka Tsuchiya , Yoshihiro Hayata , Katsuo Aizawa , Harubumi Kato , Keiji Kainuma
发明人： Teruo Hiruma , Atsushi Honma , Tooru Hirano , Yutaka Tsuchiya , Yoshihiro Hayata , Katsuo Aizawa , Harubumi Kato , Keiji Kainuma
IPC分类号： A61B1/04 , A61B5/00 , A61B18/20 , A61N5/06 , G01J3/12 , G01N21/64 , A61B6/08
CPC分类号： A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61N5/0601 , A61N5/062 , G01N21/6456 , G01N2021/6417
摘要： Cancer diagnosis device contains an endoscope comprising a light pipe used to transmit light beams from respective light sources and an image guide used to observe the flesh of the organism during both diagnosis and treatment. The tip of the endoscope faces toward the focuses where a photosensitive material having an affinity to the focuses of cancer has been absorbed so that a treatment for cancer can be performed by exposing the organism affected by cancer to the laser beam. The attainable the laser beam within a focus is thus increased by the use of the laser beam pulse from a first laser beam pulse source. In addition to the above, the cancer diagnosis device contains a second laser beam pulse source used to transmit a light beam to the focuses through the light pipe for making a diagnosis, a selector used to selectively pick up the light beam from the first laser beam pulse source or the second laser beam pulse source, a spectroscope used to obtain the spectral response from emission of light led through the image guide used for observation from the flesh of the organism where fluorescence occurs, an imaging device used to pick up the spectral response, a graphic display used to graphically display the processed spectra picked up by the imaging device, and a controller used to control emission of light from the second laser beam pulse source and also to make the operation of the imaging device synchronize with the second laser beam pulse source.
摘要翻译：癌症诊断装置包括内窥镜，其包括用于透射来自各个光源的光束的光管和用于在诊断和治疗期间观察生物体的肉体的图像引导件。内窥镜的尖端朝向焦点，其中已经吸收了对癌症焦点具有亲和力的感光材料，从而可以通过将受癌症影响的生物体暴露于激光束来进行癌症治疗。因此，可以通过使用来自第一激光束脉冲源的激光束脉冲来增加聚焦内的可达到的激光束。除了上述之外，癌症诊断装置包含第二激光束脉冲源，用于通过光管将光束传输到焦点进行诊断，选择器用于选择性地拾取来自第一激光束的光束脉冲源或第二激光束脉冲源，用于获得从发射的光的光谱响应的光谱仪，其通过用于从发生荧光的生物体的肉体观察的图像引导件，用于拾取光谱响应的成像装置，用于图形显示由成像装置拾取的处理光谱的图形显示器，以及用于控制来自第二激光束脉冲源的光的发射的控制器，并且还使成像装置的操作与第二激光束同步脉冲源。

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