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1. 发明授权

US08815211B2 Radioactive metal-labeled anti-cadherin antibody 有权
标题翻译：放射性金属标记的抗钙粘蛋白抗体
公开(公告)号：US08815211B2
公开(公告)日：2014-08-26
申请号：US13578462
申请日：2011-02-09
申请人： Akihiro Hino , Akio Nagano , Masahiko Watanabe , Tadasi Matsuura , Hirokazu Satoh , Fumiko Nomura , Katsuyuki Mitomo
发明人： Akihiro Hino , Akio Nagano , Masahiko Watanabe , Tadasi Matsuura , Hirokazu Satoh , Fumiko Nomura , Katsuyuki Mitomo
IPC分类号： A61K49/00 , A61K39/395 , C07K16/00 , C07K16/28
CPC分类号： A61K51/1027 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/46 , C07K2317/24 , C12N15/02 , C12N15/85
摘要： An object of the present invention is to provide a radioactive metal anti-cadherin antibody which is highly accumulated specifically in cancer tissue. Another object is to provide a cancer therapeutic agent having high anti-cancer effect and safety and a cancer diagnostic agent. The radioactive metal-labeled anti-cadherin antibody is obtained by binding a radioactive metallic element to an anti-cadherin antibody via a metal-chelating reagent.
摘要翻译：本发明的目的是提供一种在癌组织中高度积累的放射性金属抗钙粘蛋白抗体。另一个目的是提供具有高抗癌作用和安全性的癌症治疗剂和癌症诊断剂。放射性金属标记的抗钙粘蛋白抗体是通过金属螯合剂将放射性金属元素与抗钙粘蛋白抗体结合而获得的。

2. 发明授权

US08403669B2 Artificial tooth 有权
标题翻译：人造牙
公开(公告)号：US08403669B2
公开(公告)日：2013-03-26
申请号：US12596437
申请日：2007-04-18
申请人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
发明人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
IPC分类号： A61C13/00
CPC分类号： A61C13/097 , A61C5/70
摘要： Artificial teeth of upper and lower jaws, allowing easy operation by clarifying the three-dimensional positional relation of cusp tips and pits to contact with each other in occlusion. Each pair of artificial teeth may include cusp tips and pits, and the positional relation of the cusp tips and pits are set appropriately.
摘要翻译：上下爪的人造牙，通过澄清尖端尖端和凹坑的三维位置关系在闭塞中彼此接触而容易操作。每对人造牙齿可以包括尖头和凹坑，适当地设定尖尖和凹坑的位置关系。

3. 发明申请

US20100266988A1 ARTIFICIAL TEETH EASILY ENABLING BILATERAL BALANCED OCCLUSION 有权
标题翻译：人工智能轻松实现双边平衡化
公开(公告)号：US20100266988A1
公开(公告)日：2010-10-21
申请号：US12680892
申请日：2007-10-01
申请人： Hirokazu Satoh , Kunihiro Fujii , Noriyuki Negoro
发明人： Hirokazu Satoh , Kunihiro Fujii , Noriyuki Negoro
IPC分类号： A61C13/08
CPC分类号： A61C13/097 , A61C5/70 , A61C13/10
摘要： It is intended to provide artificial teeth designed to easily enable bilateral balanced occlusion with less grinding adjustment. According to the present invention, angles formed by occlusal facets of the artificial teeth with an occlusal plane are suitably set. An artificial tooth for maxillary central incisor, for example, has a protrusive facet and a retrusive facet on an incisal edge thereof. Of angles formed by the protrusive facet with the occlusal plane, the angle in cross section along a sagittal plane is 22.0° to 25.5°, and the angle in cross section along a coronal plane is 1.5° to 6.5°. Of angles formed by the retrusive facet with the occlusal plane, the angle in cross section along the sagittal plane is 20.5° to 23.0°, and the angle in cross section along the coronal plane is 1.5° to 6.5°.
摘要翻译：旨在提供设计成容易实现双边平衡闭塞和较少研磨调节的人造牙齿。根据本发明，适当地设定由人造牙的咬合面与咬合面形成的角度。例如，用于上颌中切牙的人造牙在其切缘上具有突出小面和侵蚀性小面。由凸起小面与咬合面形成的角度，沿矢状面的横截面角度为22.0°〜25.5°，沿冠状平面的截面角为1.5°〜6.5°。由侵蚀面与咬合面形成的角度，沿矢状面的横截面角度为20.5°〜23.0°，沿冠状平面的截面角为1.5°〜6.5°。

4. 发明申请

US20080003623A1 Monitoring Agent for Seriousness of Hepatitis 审中-公开
标题翻译：监测肝炎严重程度
公开(公告)号：US20080003623A1
公开(公告)日：2008-01-03
申请号：US11575109
申请日：2005-10-03
申请人： Atsushi Nakajima , Hiroyuki Aburatani , Hiroko Iwanari , Masao Ohkuchi , Hirokazu Satoh
发明人： Atsushi Nakajima , Hiroyuki Aburatani , Hiroko Iwanari , Masao Ohkuchi , Hirokazu Satoh
IPC分类号： G01N33/53 , C07K16/18 , G01N33/563
CPC分类号： G01N33/57438 , G01N33/576 , G01N2800/085
摘要： The present invention relates to a method of monitoring seriousness of hepatitis, comprising measuring GPC3 using an antibody which recognizes an N-terminal region of GPC3. According to the present invention, seriousness of hepatitis, specifically, progression of hepatitis or cirrhosis toward hepatoma can be presumed.
摘要翻译：本发明涉及一种监测肝炎严重性的方法，包括使用识别GPC3的N末端区域的抗体测量GPC3。根据本发明，可以推测肝炎的严重性，特别是肝硬化对肝癌的发展。

5. 发明申请

US20070069848A1 PTC element and production process thereof 失效
标题翻译： PTC元件及其制造方法
公开(公告)号：US20070069848A1
公开(公告)日：2007-03-29
申请号：US11521543
申请日：2006-09-15
申请人： Hisanao Tosaka , Tokuhiko Handa , Hirokazu Satoh , Tsutomu Hatakeyama
发明人： Hisanao Tosaka , Tokuhiko Handa , Hirokazu Satoh , Tsutomu Hatakeyama
IPC分类号： H01C7/13
CPC分类号： H01C7/027 , H01C1/1406
摘要： A method of manufacturing a PTC element comprising a pair of lead terminals bonded together by thermocompression with a matrix held therebetween comprises a matrix preparing step of preparing a matrix constructed by dispersing a conductive filler into a crystalline polymer; a terminal preparing step of preparing a pair of lead terminals holding the matrix therebetween, a surface of each lead terminal facing the matrix being formed with a plurality of anchor protrusions separated from each other; a flattening step of flattening the anchor protrusions formed in respective nonoverlapping areas in the pair of lead terminals kept from overlapping the matrix; and a thermocompression bonding step of holding the matrix between respective overlapping areas in the pair of lead terminals overlapping the matrix, and securing the pair of lead terminals and the matrix together by thermocompression bonding.
摘要翻译：一种PTC元件的制造方法，其特征在于，包括通过热压接合在一起的一对引线端子与保持在基体之间的基体的方法，所述方法包括：制备通过将导电填料分散在结晶聚合物中而构成的基体的基质制备步骤一个端子准备步骤，准备一对保持基体的引线端子，每个引线端子面向基体的表面形成有彼此分开的多个锚定突起; 使形成在所述一对引线端子中的相邻的非重叠区域中形成的所述锚固突起变平的平坦化步骤保持与所述矩阵重叠; 以及热压接合步骤，其将矩阵保持在与矩阵重叠的一对引线端子中的各个重叠区域之间，并且通过热压接将所述一对引线端子和所述基体固定在一起。

6. 发明申请

US20100133124A1 BLISTER TYPE ARTIFICIAL TEETH PACKAGING CONTAINER 审中-公开
标题翻译：吸塑型人造纤维包装容器
公开(公告)号：US20100133124A1
公开(公告)日：2010-06-03
申请号：US12733042
申请日：2007-08-08
申请人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
发明人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
IPC分类号： A61C19/10
CPC分类号： A61C19/02 , A61C13/08 , A61C2202/00
摘要： An artificial teeth packaging container 1 including an accommodating member 7 having a plurality of accommodating pockets 10 to 13 in which artificial teeth 2 are inserted from opening portions 14 to 17 and accommodated therein, and a seal member 8 fixed to the accommodating member 7, for sealing the opening portions 14 to 17 of the plurality of pockets 10 to 13 accommodating the artificial teeth 2.
摘要翻译：一种包括容纳构件7的人造牙齿包装容器1，其具有多个容纳凹部10〜13，容纳口部10〜13，其中从开口部分14至17插入人造牙齿2并容纳在其中;密封构件8，固定到容纳构件7，用于密封容纳人造牙齿2的多个口袋10至13的开口部分14至17。

7. 外观设计

USD616988S1 Artificial tooth 有权
标题翻译：人造牙
公开(公告)号：USD616988S1
公开(公告)日：2010-06-01
申请号：US29303255
申请日：2008-02-04
申请人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
设计人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii

8. 外观设计

USD616547S1 Artificial tooth 有权
公开(公告)号：USD616547S1
公开(公告)日：2010-05-25
申请号：US29303258
申请日：2008-02-04
申请人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
设计人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii

9. 发明申请

US20100119992A1 ARTIFICIAL TOOTH 有权
标题翻译：人造牙科
公开(公告)号：US20100119992A1
公开(公告)日：2010-05-13
申请号：US12596437
申请日：2007-04-18
申请人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
发明人： Hirokazu Satoh , Noriyuki Negoro , Kunihiro Fujii
IPC分类号： A61C13/08
CPC分类号： A61C13/097 , A61C5/70
摘要： The present invention provides artificial teeth of upper and lower jaws pairing between the cusp tips and pits, allowing to operate the arrangement easily by clarifying the three-dimensional positional relation of cusp tips and pits to contact with each other in occlusion and the contact region. In an artificial tooth of a mandibular first premolar tooth having a buccal cusp tip, a lingual cusp tip, a mesial pit, and a distal pit, the azimuth originating from the distal pit, the ratio of distance to the mesial surface, distal surface, buccal surface, and the lingual surface, and the positional relation of the cusp tips and pits are set appropriately. Further, in an artificial tooth of a maxillary first premolar tooth having a buccal cusp tip, a lingual cuts point, a mesial pit, and a distal pit, the azimuth originating from the lingual cusp tip, the ratio of distance to the mesial surface, distal surface, buccal surface, and the lingual surface, and the positional relation of the cusp tips and pits are set appropriately. The distal pit of the artificial tooth of the mandibular first premolar tooth is made to contact with the lingual cusp tip of the artificial tooth of the maxillary first premolar tooth, and the buccal cusp tip of the artificial tooth of the mandibular first premolar tooth is made to contact with the mesial pit of the artificial tooth of the maxillary first premolar tooth.
摘要翻译：本发明提供了在尖头尖端和凹坑之间配对的上下爪的人造牙，允许通过澄清尖端尖端和凹坑在闭塞和接触区域中彼此接触的三维位置关系而容易地操作该布置。在具有颊尖尖，舌尖，中间凹坑和远端凹陷的下颌第一前磨牙的人造牙中，源自远端凹坑的方位角，距离到中间表面的距离，远侧表面，颊面和舌面，适当地设定尖尖和凹坑的位置关系。此外，在具有颊尖尖，舌侧切口，中间凹坑和远侧凹坑的上颌第一前磨牙的人造牙中，来自舌侧尖端的方位角，距离与中间面的距离，远端表面，口腔表面和舌侧表面，适当地设定尖尖和凹坑的位置关系。将下颌第一前磨牙齿的人造牙的远端凹坑与上颌第一前磨牙的人造牙的舌尖尖接触，并且制造下颌第一前磨牙的人造牙的颊尖尖与上颌第一前磨牙的人造牙的中间孔接触。

10. 发明授权

US07326889B2 PTC element and production process thereof 失效
标题翻译： PTC元件及其制造方法
公开(公告)号：US07326889B2
公开(公告)日：2008-02-05
申请号：US11521543
申请日：2006-09-15
申请人： Hisanao Tosaka , Tokuhiko Handa , Hirokazu Satoh , Tsutomu Hatakeyama
发明人： Hisanao Tosaka , Tokuhiko Handa , Hirokazu Satoh , Tsutomu Hatakeyama
IPC分类号： H05B3/10 , H01C7/13
CPC分类号： H01C7/027 , H01C1/1406
摘要： A method of manufacturing a PTC element comprising a pair of lead terminals bonded together by thermocompression with a matrix held therebetween comprises a matrix preparing step of preparing a matrix constructed by dispersing a conductive filler into a crystalline polymer; a terminal preparing step of preparing a pair of lead terminals holding the matrix therebetween, a surface of each lead terminal facing the matrix being formed with a plurality of anchor protrusions separated from each other; a flattening step of flattening the anchor protrusions formed in respective nonoverlapping areas in the pair of lead terminals kept from overlapping the matrix; and a thermocompression bonding step of holding the matrix between respective overlapping areas in the pair of lead terminals overlapping the matrix, and securing the pair of lead terminals and the matrix together by thermocompression bonding.
摘要翻译：一种PTC元件的制造方法，其特征在于，包括通过热压接合在一起的一对引线端子与保持在基体之间的基体的方法，所述方法包括：制备通过将导电填料分散在结晶聚合物中而构成的基体的基质制备步骤一个端子准备步骤，准备一对保持基体的引线端子，每个引线端子面向基体的表面形成有彼此分开的多个锚定突起; 使形成在所述一对引线端子中的相邻的非重叠区域中形成的所述锚固突起变平的平坦化步骤保持与所述矩阵重叠; 以及热压接合步骤，其将矩阵保持在与矩阵重叠的一对引线端子中的各个重叠区域之间，并且通过热压接将所述一对引线端子和所述基体固定在一起。

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