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1. 发明申请

US20100184774A1 METHODS OF TREATMENT 审中-公开
标题翻译：治疗方法
公开(公告)号：US20100184774A1
公开(公告)日：2010-07-22
申请号：US12602623
申请日：2008-05-29
申请人： Kevin J. Duffy , Connie Lynn Erickson-Miller , Hideo Kikkawa , Anna Coco Maroney
发明人： Kevin J. Duffy , Connie Lynn Erickson-Miller , Hideo Kikkawa , Anna Coco Maroney
IPC分类号： A61K31/498 , A61P25/28 , A61P25/00 , A61P35/00 , A61P19/08 , A61P19/10 , A61P13/12 , A61P3/10 , A61P25/24 , A61P25/30 , A61P3/04 , A61P15/00
CPC分类号： A61K31/497
摘要： This invention relates to a method of treating a disease state selected from: Alzheimer's disease, Down's syndrome, mental retardation, memory defects, memory loss, pancreatic cancer, bone resorption disease, osteoporosis, sickle cell anemia, chronic kidney disease, diabetes, depression, and subsets of depression including: alcoholism, anxiety, obsessive compulsive disorder, panic disorder, chronic pain, obesity, senile dementia, migraine, bulimia, anorexia, social phobia, pre-menstrual syndrome (PMS), adolescent depression, trichotillomania, dysthymia and substance abuse, in a mammal in need thereof, including a human, which comprises administering to such mammal a therapeutically effective amount of a selected substituted thiazol compound. The invention also relates to a method of enhancing cognition in a mammal in need thereof which comprises administering to such mammal a therapeutically effective amount of a selected substituted thiazol compound.
摘要翻译：本发明涉及治疗选自以下的疾病状态的方法：阿尔茨海默氏病，唐氏综合征，智力迟钝，记忆缺陷，记忆丧失，胰腺癌，骨吸收疾病，骨质疏松症，镰状细胞性贫血，慢性肾脏病，糖尿病，抑郁症，抑郁症，包括酗酒，焦虑，强迫症，恐慌症，慢性疼痛，肥胖症，老年痴呆，偏头痛，贪食症，厌食症，社交恐惧症，月经前期综合征（PMS），青春期抑郁症，头发性躁狂症，精神郁闷和物质在有需要的哺乳动物中包括人，其包括向所述哺乳动物施用治疗有效量的选择的取代的噻唑化合物。本发明还涉及增强需要的哺乳动物的认知的方法，该方法包括向所述哺乳动物施用治疗有效量的选择的取代的噻唑化合物。

2. 发明授权

US5965730A Pyridine derivatives 失效
标题翻译：吡啶衍生物
公开(公告)号：US5965730A
公开(公告)日：1999-10-12
申请号：US985042
申请日：1997-12-04
申请人： Tatsuzo Ukita , Masakatsu Sugahara , Katsuo Ikezawa , Hideo Kikkawa , Kazuaki Naito
发明人： Tatsuzo Ukita , Masakatsu Sugahara , Katsuo Ikezawa , Hideo Kikkawa , Kazuaki Naito
IPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04 , A61K31/47 , A61K31/535 , C07D413/14
CPC分类号： C07D401/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04
摘要： A pyridine derivative of the formula (I): ##STR1## wherein A is group of the following formulae: ##STR2## (R.sup.1 and R.sup.2 are each H, or protected or unprotected OH, R.sup.31, R.sup.41 and R.sup.42 are protected or unprotected hydroxymethyl, R.sup.32 is H, lower alkyl, or protected or unprotected hydroxymethyl, R.sup.33 is substituted or unsubstituted lower alkyl, and the dotted line means the presence or absence of a double bond), R.sup.5 and R.sup.6 are H, or protected or unprotected amino, or both combine together with the adjacent nitrogen to form substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof, these compounds showing excellent bronchoconstriction inhibitory activity and/or anti-inflammatory activity of airway, and being useful in the prophylaxis or treatment of asthma.
摘要翻译：式（I）的吡啶衍生物：其中A是下式的基团：（R 1和R 2各自为H或受保护或未被保护的OH，R 31，R 41和R 42为保护或未被保护的羟甲基，R 32为H，低级烷基，或保护的或未被保护的羟甲基，R 33是取代或未取代的低级烷基，虚线表示双键的存在或不存在），R 5和R 6是H或被保护或未被保护的氨基，或两者与相邻氮形成取代或未取代的杂环或其药学上可接受的盐，这些化合物显示优异的气道收缩抑制活性和/或气道抗炎活性，并且可用于预防或治疗哮喘。

3. 发明申请

US20060205819A1 Methods of treatment inflammatory bowel with lxr agonists 审中-公开
标题翻译：用lxr激动剂治疗炎症性肠道的方法
公开(公告)号：US20060205819A1
公开(公告)日：2006-09-14
申请号：US10566637
申请日：2004-07-27
申请人： Yukio Goto , Hideo Kikkawa , Mine Kinoshita
发明人： Yukio Goto , Hideo Kikkawa , Mine Kinoshita
IPC分类号： A61K31/195 , A61K31/18
CPC分类号： A61K31/195 , A61K31/00 , A61K31/18 , A61K31/196
摘要： The present invention relates generally to the use of LXR agonists in the prevention and/or treatment of inflammatory bowel diseases.
摘要翻译：本发明一般涉及LXR激动剂在预防和/或治疗炎性肠病中的应用。

4. 发明申请

US20050153880A1 Methods of treating or preventing ibd with il-18 审中-公开
标题翻译：用il-18治疗或预防ibd的方法
公开(公告)号：US20050153880A1
公开(公告)日：2005-07-14
申请号：US10518333
申请日：2003-06-05
申请人： Yukio Goto , Hideo Kikkawa , Mine Kinoshita
发明人： Yukio Goto , Hideo Kikkawa , Mine Kinoshita
IPC分类号： A61K38/17 , A61K38/20
CPC分类号： A61K38/20
摘要： The present invention relates generally to the use of IL-18, also known as interferon-γ-inducing factor (IGIF), in the prevention and/or treatment of inflammatory bowel diseases.
摘要翻译：本发明一般涉及IL-18（也称为干扰素-γ诱导因子（IGIF））在预防和/或治疗炎症性肠病中的用途。

5. 发明授权

US5342941A Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor 失效
标题翻译：萘衍生物，其制备方法及其合成中间体
公开(公告)号：US5342941A
公开(公告)日：1994-08-30
申请号：US19885
申请日：1993-02-19
申请人： Tameo Iwasaki , Kazuhiko Kondo , Katsuo Ikezawa , Hideo Kikkawa , Shinsuke Yamagata
发明人： Tameo Iwasaki , Kazuhiko Kondo , Katsuo Ikezawa , Hideo Kikkawa , Shinsuke Yamagata
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4418 , A61K31/4425 , A61K31/443 , A61P11/00 , A61P11/08 , C07C45/63 , C07C59/13 , C07C59/84 , C07C69/00 , C07C69/738 , C07D20060101 , C07D213/30 , C07D213/55 , C07D213/61 , C07D213/63 , C07D213/64 , C07D213/89 , C07D237/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D413/06
CPC分类号： C07D213/30 , C07C45/63 , C07C69/738 , C07D213/61 , C07D213/64 , C07D213/89 , C07D237/14 , C07D405/04 , C07D405/06 , C07D413/06
摘要： Naphthalene derivative of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted lower alkoxy group, or both combine each other to form lower alkylenedioxy group, R.sup.3 is substituted or unsubstituted nitrogen-containing 6-membered heterocyclic group, and groups of the formulae: --OR.sup.4 and --OR.sup.5 are the same or different and are protected or unprotected hydroxy group, processes for preparing thereof, and synthetic intermediates therefor, these compounds have excellent bronchodilating activity, and are useful in the prophylaxis and treatment of asthma.
摘要翻译：式[I]的萘衍生物：其中R 1和R 2相同或不同，为氢原子，羟基，环低级烷氧基，取代或未取代的低级烷氧基或两者相互结合形成低级亚烷基二氧基，R 3为取代或未取代的含氮6元杂环基，式-OR4和-OR5基团相同或不同，为保护或未保护的羟基，其制备方法和合成中间体，这些化合物具有优异的支气管扩张活性，可用于预防和治疗哮喘。

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