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1. 发明授权

US4619925A 3-Propenyl cephalosporin derivatives 失效
标题翻译： 3-丙烯基头孢菌素衍生物
公开(公告)号：US4619925A
公开(公告)日：1986-10-28
申请号：US796146
申请日：1985-11-08
申请人： Hideaki Hoshi , Takayuki Naito
发明人： Hideaki Hoshi , Takayuki Naito
IPC分类号： A61K31/545 , C07D501/22
CPC分类号： C07D501/22
摘要： The present invention relates to 7-[(D)-2-amino-2-(3-hydroxyphenyl)acetamido]-3-[(Z)-1-propenyl]-3-cephem-4-carboxylic acid, which is an orally active antibiotic against Gram-positive and Gram-negative bacteria.
摘要翻译：本发明涉及7 - [（D）-2-氨基-2-（3-羟基苯基）乙酰氨基] -3 - [（Z）-1-丙烯基] -3-头孢烯-4-羧酸，它是针对革兰氏阳性和革兰氏阴性菌的口服活性抗生素。

2. 发明授权

US4520022A Substituted vinyl cephalosporins 失效
公开(公告)号：US4520022A
公开(公告)日：1985-05-28
申请号：US564604
申请日：1983-12-28
申请人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
发明人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
IPC分类号： A61K20060101 , A61K31/245 , A61K31/545 , C07C20060101 , C07D20060101 , C07D501/00 , C07D501/06 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/36 , C07F9/54 , C07F9/6561
CPC分类号： C07D501/20 , C07D501/22 , Y02P20/55
摘要： 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.

3. 发明授权

US4299610A Method and apparatus for manufacturing crystalline blast furnace slag 失效
标题翻译：结晶高炉矿渣的制造方法和装置
公开(公告)号：US4299610A
公开(公告)日：1981-11-10
申请号：US133931
申请日：1980-03-25
申请人： Ryo Ando , Shigeru Araki , Hideaki Hoshi , Kazuyoshi Sato
发明人： Ryo Ando , Shigeru Araki , Hideaki Hoshi , Kazuyoshi Sato
IPC分类号： C21B3/08 , C04B5/00
CPC分类号： C21B3/08 , Y10S425/815
摘要： A method and an apparatus for manufacturing a crystalline blast furnace slag, which comprises: endlessly connecting at prescribed intervals a plurality of rectangular metal cooling bodies each with a hollow for cooling water, to form a plurality of cooling grooves with a width at the top end thereof of from 40 to 80 mm corresponding to said prescribed intervals and a depth of from 100 to 300 mm and becoming narrower toward the depth thereof, each between two adjacent ones of said cooling bodies; continuously pouring a molten blast furnace slag sequentially into said plurality of cooling grooves in an atmosphere of an inert gas and/or a reducing gas, while moving said plurality of cooling bodies endlessly connected in circulation in the connecting direction thereof; and, circulating a cooling water through said hollows for cooling water of said plurality of cooling bodies during the pouring of said molten blast furnace slag into said plurality of cooling grooves, to cool said plurality of cooling bodies, thereby cooling and solidifying said molten blast furnace slag poured into said plurality of cooling grooves by the contact with mutually facing outer surfaces of two adjacent ones of said cooling bodies thus cooled, to manufacture a crystalline blast furnace slag.
摘要翻译：一种用于制造结晶高炉矿渣的方法和装置，包括：以规定的间隔连续地连接多个矩形金属冷却体，每个具有用于冷却水的中空的矩形金属冷却体，以形成多个在顶端具有宽度的冷却槽对应于所述规定间隔为40至80mm，深度为100至300mm，并且朝向其深度变窄，每个位于两个相邻的所述冷却体之间; 在惰性气体和/或还原气体的气氛中，连续地将熔融的高炉渣顺序地倾倒到所述多个冷却槽中，同时使所述多个冷却体在其连接方向上循环连续地连续移动; 并且在将所述熔融高炉矿渣倒入所述多个冷却槽期间使冷却水循环通过所述中空部分，以冷却所述多个冷却体的水，以冷却所述多个冷却体，从而冷却和固化所述熔融高炉通过与被冷却的两个相邻的冷却体的相互相对的外表面接触而将渣倒入所述多个冷却槽中，以制造结晶高炉炉渣。

4. 发明授权

US4198506A 2-Carboxyalkyl-2,3-dihydro-6-mercapto-s-triazolo[4,3-b]-pyridazin-3-ones 失效
标题翻译： 2-羧基烷基-2,3-二氢-6-巯基 - 三唑并[4,3-b] - 哒嗪-3-酮
公开(公告)号：US4198506A
公开(公告)日：1980-04-15
申请号：US22408
申请日：1979-03-21
申请人： Takayuki Naito , Jun Okumura , Hajime Kamachi , Seiji Iimura , Hideaki Hoshi , Masahisa Oka
发明人： Takayuki Naito , Jun Okumura , Hajime Kamachi , Seiji Iimura , Hideaki Hoshi , Masahisa Oka
IPC分类号： C07D217/24 , C07D333/24 , C07D487/04 , C07D495/04
CPC分类号： C07D487/04 , C07D217/24 , C07D333/24 , C07D495/04
摘要： Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. A preferred embodiment was 7-[o-(methylaminomethyl)phenylacetamido]-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.
摘要翻译：某些7-酰基酰氨基-3-（2-羧基烷基-2,3-二氢 - 三唑并[4,3-b]哒嗪-3-酮-6-基硫甲基）-3-头孢烯-4-羧酸及其盐合成了4-羧基的易水解酯，发现其具有良好的水溶性。优选的实施方案是7- [O-（甲基氨基甲基）苯基乙酰氨基] -3-（2-羧基烷基-2,3-二氢 - 三唑并[4,3-b]哒嗪-3-酮基）硫基甲基）-3 - 头孢-4-羧酸。

5. 发明授权

US4151352A 7-Amino-3- (2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethy l)-3-cephem-4-carboxylic acids 失效
标题翻译： 7-氨基-3-（2-羧基烷基-2,3-二氢-s-三唑并[8,3,3-b {9哒嗪-3-酮硫基甲基）-3-头孢烯-4-羧酸
公开(公告)号：US4151352A
公开(公告)日：1979-04-24
申请号：US877132
申请日：1978-02-13
申请人： Takayuki Naito , Jun Okumura , Hajime Kamachi , Seiji Iimura , Hideaki Hoshi , Masahisa Oka
发明人： Takayuki Naito , Jun Okumura , Hajime Kamachi , Seiji Iimura , Hideaki Hoshi , Masahisa Oka
IPC分类号： C07D217/24 , C07D333/24 , C07D487/04 , C07D495/04 , C07D501/18 , C07D501/36
CPC分类号： C07D487/04 , C07D217/24 , C07D333/24 , C07D495/04
摘要： Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. A preferred embodiment was 7-[o-(methylaminomethyl)phenylacetamido]-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.

6. 发明授权

US5066645A Epipodophyllotoxin altroside derivatives 失效
标题翻译：环丙氯地洛毒素衍生物
公开(公告)号：US5066645A
公开(公告)日：1991-11-19
申请号：US401712
申请日：1989-09-01
申请人： Takeshi Ohnuma , Hideaki Hoshi , Hideo Kamei , Takayuki Naito
发明人： Takeshi Ohnuma , Hideaki Hoshi , Hideo Kamei , Takayuki Naito
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07H17/04
CPC分类号： C07H17/04
摘要： The present invention provides antitumor 4'-Demethylepipodophyllotoxin glycosides characterized by the fact that the glycoside moiety is altrose.

7. 发明授权

US4997931A Epipodophyllotoxin glycosides 失效
标题翻译：表鬼臼毒苷
公开(公告)号：US4997931A
公开(公告)日：1991-03-05
申请号：US536925
申请日：1990-06-11
申请人： Takeshi Ohnuma , Hideaki Hoshi
发明人： Takeshi Ohnuma , Hideaki Hoshi
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07H17/04
CPC分类号： C07H17/04
摘要： The present invention relates to novel antitumor compounds which are 4'-demethylepipodophylloxtoxin derivatives. More particularly, the novel compounds are 4'-demethylepipodophyllotoxin allopyranosides, allofuranosides, and mannopyranosides.

8. 发明授权

US4699979A 7-amino-3-propenylcephalosporanic acid and esters thereof 失效
标题翻译： 7-氨基-3-丙烯基头孢烷酸及其酯
公开(公告)号：US4699979A
公开(公告)日：1987-10-13
申请号：US843537
申请日：1986-03-25
申请人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
发明人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
IPC分类号： A61K31/545 , C07D501/18 , C07D501/22
CPC分类号： C07D501/18
摘要： This invention provides novel cephalosporin intermediates, 7.beta.-amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and esters thereof having the general formula ##STR1## wherein the configuration of the 3-propenyl group is Z sometimes referred to as cis- and R is hydrogen or a conventional carboxy-protected group, or a physiologically hydrolyzable esterifying group, and acid addition salts thereof and the metal salts of the foregoing substance wherein R is hydrogen. These compounds are useful as intermediates for preparation of orally active cephalosporins.
摘要翻译：本发明提供了具有通式“IMAGE”的新型头孢菌素中间体7β-氨基-3 - [（Z）-1-丙烯-1-基] -3-头孢烯-4-羧酸及其酯，其中 3-丙烯基有时称为顺式 - ，R是氢或常规的羧基保护基团，或生理上可水解的酯化基团，及其酸加成盐和前述物质的金属盐，其中R是氢。这些化合物可用作制备口服活性头孢菌素的中间体。

9. 发明授权

US4591641A Substituted vinyl cephalosporins 失效
公开(公告)号：US4591641A
公开(公告)日：1986-05-27
申请号：US713207
申请日：1985-03-18
申请人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
发明人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
IPC分类号： C07D501/22 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/18 , C07D501/24 , C07F9/6561
CPC分类号： C07D501/22 , C07D501/20 , Y02P20/55
摘要： 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.

10. 发明授权

US4661590A Substituted vinyl cephalosporins 失效
标题翻译：取代乙烯基头孢菌素
公开(公告)号：US4661590A
公开(公告)日：1987-04-28
申请号：US761115
申请日：1985-07-31
申请人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
发明人： Hideaki Hoshi , Jun Okumura , Takayuki Naito , Yoshio Abe , Shimpei Aburaki
IPC分类号： C07D501/22 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/18 , C07D501/24 , C07F9/6561
CPC分类号： C07D501/22 , C07D501/20 , Y02P20/55
摘要： 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.
摘要翻译：其中7-酰基是苯基甘氨酰基或取代的苯基甘氨酰基的3- [（Z）-1-丙烯-1-基] -7-酰基氨基头孢菌素是针对革兰氏阴性菌和革兰氏阴性菌的口服活性抗生素。

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