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1. 发明授权

US09097674B2 Method for detecting a resonant nonlinear optical signal and device for implementing said method 有权
标题翻译：用于检测谐振非线性光信号的方法和用于实现所述方法的装置
公开(公告)号：US09097674B2
公开(公告)日：2015-08-04
申请号：US13574508
申请日：2011-01-18
申请人： Hervé Rigneault , David Gachet , Sophie Brustlein , Franck Billard
发明人： Hervé Rigneault , David Gachet , Sophie Brustlein , Franck Billard
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/44 , G01J3/4412 , G01N21/658 , G01N2021/653 , G01N2021/655
摘要： A method and a device for detecting a resonant non-linear optical signal induced in a sample including a resonant medium and a non-resonant medium forming an interface is disclosed. The device includes an excitation light beam that intercepts the sample along an optical axis. The device further includes a first optical detection module for detecting a nonlinear optical signal resulting from the interaction of the beam with the sample, and a mirror that reflects the excitation beam. The device further includes a second optical detection module for detecting a nonlinear optical signal resulting from the interaction of the reflected excitation beam with the sample, and a processing module for processing the optical signals, detected by the first and second detection modules. Processing the optical signals includes calculating a difference in the detected signals, the difference being characteristic of a vibrational or electronic resonance of the resonant medium.
摘要翻译：公开了一种用于检测在包括共振介质和形成界面的非共振介质的样品中感应的共振非线性光信号的方法和装置。该装置包括沿着光轴截取样品的激发光束。该装置还包括第一光学检测模块，用于检测由光束与样品的相互作用产生的非线性光学信号，以及反射激发光束的反射镜。该装置还包括第二光学检测模块，用于检测由反射的激发光束与样本的相互作用产生的非线性光信号，以及用于处理由第一和第二检测模块检测的光信号的处理模块。处理光信号包括计算检测信号的差异，该差是谐振介质的振动或电子共振的特征。

2. 发明授权

US08804117B2 Method for detecting a resonant nonlinear optical signal and device for implementing said method 有权
标题翻译：用于检测谐振非线性光信号的方法和用于实现所述方法的装置
公开(公告)号：US08804117B2
公开(公告)日：2014-08-12
申请号：US13574482
申请日：2011-01-18
申请人： Hervé Rigneault , David Gachet , Sophie Brustlein
发明人： Hervé Rigneault , David Gachet , Sophie Brustlein
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N2021/653
摘要： A method and device for detecting a resonant non-linear optical signal induced in a sample, the sample including a resonant medium and a non-resonant medium forming an interface. The device includes an emission source of at least one first excitation light beam, called a pump beam, at a given angular frequency ωp for the excitation of the resonant medium of said sample, an optical detection module for detecting a non-linear optical signal resulting from the interaction of said pump beam with an axial interface between the resonant and non-resonant media of the sample, in at least two symmetrical directions ({right arrow over (k)}, {right arrow over (k)}′) relative to the optical axis of said excitation beam incident in the sample, and a processing unit for processing signals (IFwd({right arrow over (k)}), IFwd({right arrow over (k)}′)) thus detected, allowing the difference between said signals to be obtained.
摘要翻译：一种用于检测在样本中感应的共振非线性光信号的方法和装置，所述样本包括形成界面的共振介质和非共振介质。该装置包括用于激发所述样品的谐振介质的给定角频率ωp的至少一个称为泵浦光束的第一激发光束的发射源，用于检测所产生的非线性光信号的光学检测模块从所述泵浦光束与样品的共振介质和非共振介质之间的轴向界面的相互作用，在至少两个对称方向（{右箭头（k）}，{右箭头（k）}'）相对（IFwd（{right arrow over（k）}），IFwd（{right arrow over（k）}'））的处理单元），从而允许要获得的所述信号之间的差异。

3. 发明申请

US20110158853A1 PIXEL-TYPE BIOLOGICAL ANALYSIS DEVICE, BIOSENSOR, AND FABRICATION PROCESSES THEREOF 有权
标题翻译：像素类生物分析装置，生物传感器及其制造方法
公开(公告)号：US20110158853A1
公开(公告)日：2011-06-30
申请号：US12970615
申请日：2010-12-16
申请人： Jeffrey M. Raynor , Michael Maurin , Mitchell O'Neal Perley , Pierre-Francois Lenne , Hervé Rigneault , Renaud Vincentelli
发明人： Jeffrey M. Raynor , Michael Maurin , Mitchell O'Neal Perley , Pierre-Francois Lenne , Hervé Rigneault , Renaud Vincentelli
IPC分类号： G01N27/00 , B05D5/12 , B05D3/12 , B05D5/00
CPC分类号： G01N21/6454 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00713 , B01J2219/00725 , C40B50/14 , Y10T156/10
摘要： The disclosure relates to a pixel-type biological analysis device comprising a photosensitive layer, a capture mixture for the capture of targeted proteins, the capture mixture being placed on an external surface of the photosensitive layer and comprising a protein probe grafted to a hydrogel, collection means for collecting photoelectrons in the photosensitive layer, and reading and treatment means of an electrical quantity supplied by the collection means, for the supply of a characteristic value of a luminous intensity detected by the photosensitive layer.
摘要翻译：本公开涉及一种像素型生物分析装置，其包括感光层，用于捕获目标蛋白质的捕获混合物，捕获混合物置于感光层的外表面上并且包括接枝到水凝胶上的蛋白质探针用于在感光层中收集光电子的装置以及由收集装置提供的电量的读取和处理装置，以提供由感光层检测的发光强度的特征值。

4. 发明申请

US20130038871A1 METHOD FOR DETECTING A RESONANT NONLINEAR OPTICAL SIGNAL AND DEVICE FOR IMPLEMENTING SAID METHOD 有权
标题翻译：用于检测共振非线性光信号的方法和用于实现所述方法的装置
公开(公告)号：US20130038871A1
公开(公告)日：2013-02-14
申请号：US13574508
申请日：2011-01-18
申请人： Hervé Rigneault , David Gachet , Sophie Brustlein , Franck Billard
发明人： Hervé Rigneault , David Gachet , Sophie Brustlein , Franck Billard
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/44 , G01J3/4412 , G01N21/658 , G01N2021/653 , G01N2021/655
摘要： The invention relates to a method and a device for detecting a resonant non-linear optical signal induced in a sample (805) comprising a resonant medium (61) and a non-resonant medium forming an interface, the device comprising: an emission source (801) of at least one first excitation light beam of a resonant medium, called a pump beam, at a first given angular frequency ωp, said pump beam being incident on a sample along an optical axis, and intercepting the sample at a given position of a transverse interface between the resonant and non-resonant medium, a first optical detection module (803) for detection of the nonlinear optical signal resulting from the interaction of said beam or beams with the sample, means of reflection (813) of said excitation beam or beams, the excitation beam or beams thus reflected intercepting said transverse interface substantially at the same position as the incident excitation beam or beams, a second optical detection module (806) for detection of the nonlinear optical signal resulting from the interaction of said reflected excitation beam or beams with the sample, a processing module (830) for processing the optical signals detected by said first and second detection modules, comprising the calculation of a difference in the detected signals, the difference being characteristic of a vibrational or electronic resonance of the resonant medium.
摘要翻译：本发明涉及一种用于检测在包括共振介质（61）和形成界面的非共振介质（61）的样品（805）中感应的共振非线性光信号的方法和装置，该装置包括：发射源 801）至少一个谐振介质的第一激发光束（称为泵浦光束），以第一给定角频率ωp，所述泵浦光束沿着光轴入射在样本上，并且在给定位置处拦截样品所述谐振和非谐振介质之间的横向接口，用于检测由所述光束或光束与样本的相互作用产生的非线性光学信号的第一光学检测模块（803），所述激发光束的反射（813）或光束，所述反射的激励光束或光束基本上在与入射激发光束或光束相同的位置处拦截所述横向界面;第二光学检测模块（806），用于检测由所述反射的激发光束或光束与样本的相互作用产生的非线性光信号，用于处理由所述第一和第二检测模块检测的光信号的处理模块（830），包括计算检测信号的差异，差异是共振介质的振动或电子共振的特征。

5. 发明申请

US20130021606A1 METHOD FOR DETECTING A RESONANT NONLINEAR OPTICAL SIGNAL AND DEVICE FOR IMPLEMENTING SAID METHOD 有权
标题翻译：用于检测共振非线性光信号的方法和用于实现所述方法的装置
公开(公告)号：US20130021606A1
公开(公告)日：2013-01-24
申请号：US13574482
申请日：2011-01-18
申请人： Hervé Rigneault , David Gachet , Sophie Brustlein
发明人： Hervé Rigneault , David Gachet , Sophie Brustlein
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N2021/653
摘要： The invention relates to a method and a device (100) for detecting a resonant non-linear optical signal induced in a sample (105), the sample comprising a resonant medium (41) and a non-resonant medium (42) forming an interface (43), the device comprising: an emission source (101) of at least one first excitation light beam, called a pump beam, at a first given angular frequency ωp for the excitation of the resonant medium of said sample, an optical detection module (106) for detecting a non-linear optical signal resulting from the interaction of said pump beam with an axial interface between the resonant and the non-resonant media of the sample, in at least two symmetrical directions (, ′) relative to the optical axis of said excitation beam incident in the sample, and a processing unit (125) for processing signals (IFwd(), IFwd(′)) thus detected, allowing the difference between said signals to be obtained, the resulting difference signal being characteristic of a vibrational or electronic resonance of the resonant medium of the sample.
摘要翻译：本发明涉及一种用于检测在样品（105）中感应的共振非线性光学信号的方法和装置（100），该样品包括共振介质（41）和形成界面的非共振介质（42）（43），所述装置包括：以用于激发所述样品的共振介质的第一给定角频率ωp的至少一个第一激发光束（称为泵浦光束）的发射源（101），光学检测模块（106），用于检测由所述泵浦光束与样品的谐振和非共振介质之间的轴向界面的相互作用产生的非线性光学信号，所述非线性光学信号相对于光学器件至少在两个对称方向（，'）入射到样本中的所述激发光束的轴;以及处理单元（125），用于处理如此检测的信号（IFwd（），IFwd（'）），从而允许获得所述信号之间的差异，所得到的差分信号是振动或样品的共振介质的电子共振。

6. 发明授权

US08858885B2 Pixel-type biological analysis device, biosensor, and fabrication processes thereof 有权
标题翻译：像素型生物分析装置，生物传感器及其制造方法
公开(公告)号：US08858885B2
公开(公告)日：2014-10-14
申请号：US12970615
申请日：2010-12-16
申请人： Jeffrey M. Raynor , Michael Maurin , Mitchell O'Neal Perley , Pierre-Francois Lenne , Hervé Rigneault , Renaud Vincentelli
发明人： Jeffrey M. Raynor , Michael Maurin , Mitchell O'Neal Perley , Pierre-Francois Lenne , Hervé Rigneault , Renaud Vincentelli
IPC分类号： G01N21/01 , C40B50/14 , G01N21/64 , B01J19/00
CPC分类号： G01N21/6454 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00713 , B01J2219/00725 , C40B50/14 , Y10T156/10
摘要： The disclosure relates to a pixel-type biological analysis device comprising a photosensitive layer, a capture mixture for the capture of targeted proteins, the capture mixture being placed on an external surface of the photosensitive layer and comprising a protein probe grafted to a hydrogel, collection means for collecting photoelectrons in the photosensitive layer, and reading and treatment means of an electrical quantity supplied by the collection means, for the supply of a characteristic value of a luminous intensity detected by the photosensitive layer.
摘要翻译：本公开涉及一种像素型生物分析装置，其包括感光层，用于捕获目标蛋白质的捕获混合物，捕获混合物置于感光层的外表面上并且包括接枝到水凝胶上的蛋白质探针用于在感光层中收集光电子的装置以及由收集装置提供的电量的读取和处理装置，以提供由感光层检测的发光强度的特征值。

7. 发明授权

US08502169B2 Device for the exalted detection of the emission of a target particle 有权
标题翻译：用于高级检测目标粒子发射的装置
公开(公告)号：US08502169B2
公开(公告)日：2013-08-06
申请号：US12515664
申请日：2007-11-21
申请人： Hervé Rigneault , Pierre-François Lenne , Jérôme Wenger , Evgueni Popov , Thomas Ebbesen
发明人： Hervé Rigneault , Pierre-François Lenne , Jérôme Wenger , Evgueni Popov , Thomas Ebbesen
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/6452
摘要： The invention relates to a device (1) for detecting the emission of a target particle (6) at an emission wavelength, said device comprising: a photo-detector (2, 2A, 2B) comprising a sensitive detection surface having a high optical index; wherein said target particle (6) can be positioned in the vicinity of said sensitive surface in an analysis medium (13) having a low optical index; said device being characterized in that it further comprises: a mask (3) covering said sensitive surface, said mask including at least one area (4) opaque at said emission wavelength and at least one hole (5), said hole being capable of receiving the target particle; and in that the mask includes at least one interface; 7 said device further comprising at least one groove (10, 10A, 10B) provided at said interface, each of said at least one groove surrounding each of said at least one hole.
摘要翻译：本发明涉及一种用于检测发射波长的目标颗粒（6）的发射的装置（1），所述装置包括：光检测器（2,2A，2B），包括具有高光学指数的敏感检测表面 ; 其中所述目标颗粒（6）可以位于具有低光学指数的分析介质（13）中的所述敏感表面附近; 所述装置的特征在于，其还包括：覆盖所述敏感表面的掩模（3），所述掩模包括至少一个在所述发射波长处不透明的区域（4）和至少一个孔（5），所述孔能够接收目标粒子; 并且所述掩模包括至少一个界面; 7，所述装置还包括设置在所述界面处的至少一个凹槽（10,10A，10B），每个所述至少一个凹槽围绕所述至少一个孔的每一个。

8. 发明授权

US08223343B2 Interferometric confocal microscope 有权
标题翻译：干涉共焦显微镜
公开(公告)号：US08223343B2
公开(公告)日：2012-07-17
申请号：US12304238
申请日：2007-05-30
申请人： Hervé Rigneault , Nicolas Sandeau , Hugues Giovannini
发明人： Hervé Rigneault , Nicolas Sandeau , Hugues Giovannini
IPC分类号： G01B11/02
CPC分类号： G02B27/58 , G02B21/0056 , G02B21/0072 , G02B21/0076
摘要： The invention concerns a confocal microscope for imaging a sample comprising at least a light source, said microscope comprising at least an objective and a tube lens with an image focus, said microscope comprising interference means constructed to generate interference figures from said light source, characterized in that said interference means comprising first image generation means constructed to generate a first image of said light source, second image generation means constructed to generate a second image of said light source symmetrical to the first image relative to the image focus, image interference means constructed to make said first image and said second image interfere.
摘要翻译：本发明涉及一种共焦显微镜，其用于对包含至少一个光源的样品进行成像，所述显微镜至少包括物镜和具有图像焦点的管透镜，所述显微镜包括构造成从所述光源产生干涉图的干涉装置，其特征在于所述干涉装置包括构成为产生所述光源的第一图像的第一图像产生装置，被构造成产生相对于图像焦点对称于第一图像的所述光源的第二图像的第二图像产生装置，被构造成使第一个图像表示第二个图像干扰。

9. 发明申请

US20110147613A1 DEVICE AND METHOD FOR ENHANCED ANALYSIS OF PARTICLE SAMPLE 审中-公开
标题翻译：用于粒子样品增强分析的装置和方法
公开(公告)号：US20110147613A1
公开(公告)日：2011-06-23
申请号：US12937937
申请日：2009-04-14
申请人： Hervé Rigneault , Jérôme Wenger , Gerard Davy
发明人： Hervé Rigneault , Jérôme Wenger , Gerard Davy
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N2021/6417 , G01N2021/6421
摘要： The present disclosure relates to a device for analyzing a dissolved particle sample, said device comprising a microscope system, said microscope system comprising support supporting said sample, an illumination source operably emitting a luminous energizing beam, an optic member focusing said luminous energizing beam into a focal point on said sample, and a spatial filter operably defining an analyzed space around the focal point, and said microscope system comprising an interface operably enhancing said luminous energizing beam, said enhancement interface including a strictly positive focal length and a refractive index greater than the refractive index of said sample, at least a portion of said enhancement interface being disposed on the path of said luminous energizing beam downstream from said support and upstream from said focal point, and at least a portion of said enhancement interface not being rigidly connected to said support. The present disclosure also relates to a method for analyzing a dissolved particle sample by such an analyzing device.
摘要翻译：本公开涉及一种用于分析溶解的颗粒样品的装置，所述装置包括显微镜系统，所述显微镜系统包括支撑所述样品的支撑件，可操作地发射发光束的照明源，将所述发光束聚焦成所述样品上的焦点和可操作地限定围绕焦点的分析空间的空间滤光器，并且所述显微镜系统包括可操作地增强所述发光束的界面，所述增强界面包括严格正的焦距和大于所述样品的折射率，所述增强界面的至少一部分设置在所述发光束的路径上，所述光通量在所述支撑件的下游和所述焦点的上游，并且所述增强界面的至少一部分不是刚性地连接到所述支持。本公开还涉及通过这种分析装置分析溶解颗粒样品的方法。

10. 发明申请

US20100140460A1 DEVICE FOR THE EXALTED DETECTION OF THE EMISSION OF A TARGET PARTICLE 有权
标题翻译：用于显着检测目标颗粒的排放的装置
公开(公告)号：US20100140460A1
公开(公告)日：2010-06-10
申请号：US12515664
申请日：2007-11-21
申请人： Hervé Rigneault , Pierre-Francois Lenne , Jerome Wenger , Evgueni Popov , Thomas Ebbesen
发明人： Hervé Rigneault , Pierre-Francois Lenne , Jerome Wenger , Evgueni Popov , Thomas Ebbesen
IPC分类号： G01J3/50 , G01J1/58
CPC分类号： G01N21/6428 , G01N21/6452
摘要： The invention relates to a device (1) for detecting the emission of a target particle (6) at an emission wavelength, said device comprising: a photo-detector (2, 2A, 2B) comprising a sensitive detection surface having a high optical index; wherein said target particle (6) can be positioned in the vicinity of said sensitive surface in an analysis medium (13) having a low optical index; said device being characterised in that it further comprises: a mask (3) covering said sensitive surface, said mask including at least one area (4) opaque at said emission wavelength and at least one hole (5), said hole being capable of receiving the target particle; and in that the mask includes at least one interface; 7 said device further comprising at least one groove (10, 10A, 10B) provided at said interface, each of said at least one groove surrounding each of said at least one hole.
摘要翻译：本发明涉及一种用于检测发射波长的目标颗粒（6）的发射的装置（1），所述装置包括：光检测器（2,2A，2B），包括具有高光学指数的敏感检测表面 ; 其中所述目标颗粒（6）可以位于具有低光学指数的分析介质（13）中的所述敏感表面附近; 所述装置的特征在于，其还包括：覆盖所述敏感表面的掩模（3），所述掩模包括至少一个在所述发射波长处不透明的区域（4）和至少一个孔（5），所述孔能够接收目标粒子; 并且所述掩模包括至少一个界面; 7，所述装置还包括设置在所述界面处的至少一个凹槽（10,10A，10B），每个所述至少一个凹槽围绕所述至少一个孔的每一个。

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