专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120190569A1 ENDOGENETIC RETROVIRAL SEQUENCES, ASSOCIATED WITH AUTOIMMUNE DISEASES OR WITH PREGNANCY DISORDERS 审中-公开
标题翻译：与自发性疾病相关的内分泌病变序列或与PREGNANCY病症相关
公开(公告)号：US20120190569A1
公开(公告)日：2012-07-26
申请号：US13336712
申请日：2011-12-23
申请人： Frédéric BESEME , Jean-Luc BLOND , Olivier BOUTON , Bernard MANDRAND , Francois MALLET , Hervé PERRON
发明人： Frédéric BESEME , Jean-Luc BLOND , Olivier BOUTON , Bernard MANDRAND , Francois MALLET , Hervé PERRON
IPC分类号： C40B30/04
CPC分类号： C12Q1/6883 , A61K38/00 , A61K39/00 , C07K14/005 , C12N2740/10022 , C12Q2600/156 , C12Q2600/158 , G01N33/564 , G01N2800/24
摘要： A genomic retroviral nucleic material, in an isolated or purified state, at least partially functional or non-functional, wherein the genome comprises a reference nucleotide sequence selected from the group including sequences of SEQ ID NOs: 1-15, their complementary sequences, and their equivalent sequences, in particular, nucleotide sequences having, for every series of 100 contiguous monomers, at least 70% and preferably at least 90% homology with the sequences of SEQ ID NOs: 1-15.
摘要翻译：一种分离或纯化的基因组逆转录病毒核酸，至少部分是功能性或非功能性的，其中所述基因组包含参考核苷酸序列，其选自SEQ ID NO：1-15的序列，其互补序列和它们的等同序列，特别是对于每个100个连续单体的系列，具有与SEQ ID NO：1-15的序列至少70％，优选至少90％的同源性的核苷酸序列。

2. 发明授权

US08158441B2 Method for detecting aggregate-forming circulating protein forms using an agent for aggregating said forms and an agent for capturing formed aggregates 有权
标题翻译：用于聚集所述形式的试剂和用于捕获形成的聚集体的试剂检测聚集体形成循环蛋白形式的方法
公开(公告)号：US08158441B2
公开(公告)日：2012-04-17
申请号：US11988402
申请日：2006-07-07
申请人： Sébastien Cecillon , Anthony William Coleman , Anne Eveno-Nobile , Hervé Perron , Marc Rodrigue
发明人： Sébastien Cecillon , Anthony William Coleman , Anne Eveno-Nobile , Hervé Perron , Marc Rodrigue
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/2835
摘要： The present invention concerns a method for detecting aggregate-forming circulating protein forms in a biological sample of human origin that may contain said aggregate-forming circulating protein forms, characterized in that it uses a non-protein agent I producing aggregation of the circulating forms of the noninfectious proteins involved in pathological aggregation processes of the central nervous system and/or a non-protein agent II for capturing the natural aggregrates of aggregate-forming circulating protein forms or the aggregates induced by said agents I.
摘要翻译：本发明涉及一种用于检测可能含有所述聚集形成循环蛋白形式的人源生物样品中的聚集体形成循环蛋白形式的方法，其特征在于其使用非蛋白质试剂I产生循环形式的聚集体参与中枢神经系统的病理学聚集过程的非感染性蛋白质和/或用于捕获聚集形成循环蛋白质形式的天然聚集物或由所述试剂诱导的聚集体的非蛋白质试剂II。

3. 发明授权

US07695918B2 Process for detecting PrPSC using an antibiotic from the family of aminoglycosides 失效
标题翻译：使用来自氨基糖苷类家族的抗生素检测PrPSC的方法
公开(公告)号：US07695918B2
公开(公告)日：2010-04-13
申请号：US11151066
申请日：2005-06-13
申请人： Aly Moussa , Anthony William Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Hervé Perron , Ambroise Martin
发明人： Aly Moussa , Anthony William Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Hervé Perron , Ambroise Martin
IPC分类号： G01N33/48 , C07H15/22 , A01N43/04
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10T436/104998
摘要： A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.
摘要翻译：通过沉淀PrPsc来检测或诊断PrPsc的浓缩过程，其中从动物或人类生物体产生或获自动物或人类生物体的组织或生物流体与来自氨基糖苷类，优选链霉素或其衍生物之一的抗生素结合在一起。还公开了使用这种抗生素从组织或生物流体中消除PrPsc和用于诊断与PrPsc存在相关的病理学的试剂盒。

4. 发明授权

US06555091B1 Polypeptide capable of reacting with antibodies of patients suffering from multiple sclerosis and uses 失效
标题翻译：能够与患有多发性硬化症和使用的患者的抗体反应的多肽
公开(公告)号：US06555091B1
公开(公告)日：2003-04-29
申请号：US09403343
申请日：1999-10-18
申请人： Colette Jolivet-Reynaud , Hervé Perron , Bernard Mandrand
发明人： Colette Jolivet-Reynaud , Hervé Perron , Bernard Mandrand
IPC分类号： A61B5055
CPC分类号： C07K7/06 , A61K39/00 , C07K5/1013 , C07K5/1021 , C07K7/08 , C07K14/005 , C07K14/4713 , C12N2740/10022 , Y10S435/81 , Y10S435/975
摘要： The invention concerns a polypeptide specifically reacting with the antibodies of patients suffering from multiple sclerosis (SEP) and whereof the peptide sequence comprises at least one sequence selected among SEQ ID No. 1 to SEQ ID NO: 19, and their equivalent sequences, and the use of this polypeptide in a reagent and a kit for detecting multiple sclerosis, an immunoreactive composition and in a method for fixing, in a biological sample, antibodies characteristic and/or specific of multiple sclerosis.
摘要翻译：本发明涉及与患有多发性硬化症（SEP）的患者的抗体特异性反应的多肽，其肽序列包含选自SEQ ID No.1至SEQ ID NO：19中的至少一个序列及其等同序列，在试剂和用于检测多发性硬化的试剂盒中使用该多肽，免疫反应性组合物和在生物样品中固定多发性硬化症特征和/或特异性的抗体的方法。

5. 发明授权

US07700294B2 Method of isolating cytotoxic heterocomplex associated with multiple sclerosis 失效
标题翻译：分离与多发性硬化相关的细胞毒异型复合物的方法
公开(公告)号：US07700294B2
公开(公告)日：2010-04-20
申请号：US10582674
申请日：2004-12-22
申请人： Hervé Perron , Anne Eveno-Nobile , Jacques Portoukalian , Nicole Battail-Poirot
发明人： Hervé Perron , Anne Eveno-Nobile , Jacques Portoukalian , Nicole Battail-Poirot
IPC分类号： G01N33/536 , C07K16/18
CPC分类号： G01N33/564 , C07K14/47 , C07K14/52 , C07K16/18 , C07K16/24 , C07K16/3084 , C07K2317/32 , G01N2800/285
摘要： The invention relates to an isolated cytotoxic factor which is associated with multiple sclerosis and which is selected from the heterocomplex GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14, and to the method of detecting said factor in a biological sample to be tested. The inventive method comprises the following steps consisting in: (i) bringing the biological sample into contact with at least one capture antibody selected from antibodies that bind specifically to the GM2AP protein, to the mutated GM2AP protein, to the MRP14 protein, to the complex GM2AP/GM2, to the complex mutated GM2AP/GM2 and to the complex MRP14/GM2, and with at least one labeled detection antibody selected from antibodies that bind specifically to the GM2AP protein, to the mutated GM2AP protein, to the MRP14 protein, to the complex GM2AP/GM2, to the complex mutated GM2AP/GM2 and to the complex MRP14/GM2, and (ii) detecting and/or quantifying the cytotoxic factor by detecting and/or quantifying the labeled detection antibody.
摘要翻译：本发明涉及与多发性硬化相关并且选自异型复合体GM2AP / GM2 / MRP14和突变的GM2AP / GM2 / MRP14的分离的细胞毒性因子，以及检测待测生物样品中所述因子的方法。本发明的方法包括以下步骤：（i）将生物样品与至少一种选自与GM2AP蛋白特异性结合的抗体，至突变型GM2AP蛋白，至MRP14蛋白的捕获抗体接触至复合物 GM2AP / GM2，复合突变的GM2AP / GM2和复合物MRP14 / GM2，以及至少一种选自与GM2AP蛋白特异性结合的抗体的标记检测抗体与突变的GM2AP蛋白相关的MRP14蛋白，至复合体GM2AP / GM2，复合突变的GM2AP / GM2和复合物MRP14 / GM2，以及（ii）通过检测和/或定量标记的检测抗体来检测和/或定量细胞毒性因子。

6. 发明申请

US20100062540A1 Method for Detecting Aggregate-Forming Circulating Protein Forms Using an Agent for Aggregating Said Forms and an Agent for Capturing Formed Aggregates 有权
标题翻译：使用聚集所述形式的试剂和捕集形成的聚集体的试剂检测聚集体形成的循环蛋白质形式的方法
公开(公告)号：US20100062540A1
公开(公告)日：2010-03-11
申请号：US11988402
申请日：2006-07-07
申请人： Sébastien Cecillon , Anthony William Coleman , Anne Eveno-Nobile , Hervé Perron , Marc Rodrigue
发明人： Sébastien Cecillon , Anthony William Coleman , Anne Eveno-Nobile , Hervé Perron , Marc Rodrigue
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/2835
摘要： The present invention concerns a method for detecting aggregate-forming circulating protein forms in a biological sample of human origin that may contain said aggregate-forming circulating protein forms, characterized in that it uses a non-protein agent I producing aggregation of the circulating forms of the noninfectious proteins involved in pathological aggregation processes of the central nervous system and/or a non-protein agent II for capturing the natural aggregrates of aggregate-forming circulating protein forms or the aggregates induced by said agents I.
摘要翻译：本发明涉及一种用于检测可能含有所述聚集形成循环蛋白形式的人源生物样品中的聚集体形成循环蛋白形式的方法，其特征在于其使用非蛋白质试剂I产生循环形式的聚集体参与中枢神经系统的病理学聚集过程的非感染性蛋白质和/或用于捕获聚集形成循环蛋白质形式的天然聚集物或由所述试剂诱导的聚集体的非蛋白质试剂II。

7. 发明授权

US07081345B1 Use of a polypeptide for detecting, preventing or treating a pathological condition associated with a degenerative, neurological or autoimmune disease 失效
公开(公告)号：US07081345B1
公开(公告)日：2006-07-25
申请号：US10030937
申请日：2000-07-17
申请人： Dominique Roecklin , Hanno Kolbe , Marie-Hélène Charles , Carine Malcus , Lyse Santoro , Hervé Perron
发明人： Dominique Roecklin , Hanno Kolbe , Marie-Hélène Charles , Carine Malcus , Lyse Santoro , Hervé Perron
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , A61K38/1709 , C07K14/47 , G01N33/6896 , G01N2800/52
摘要： The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide sequence in native state corresponds to SEQ ID No 1, SEQ ID No 2, SEQ ID No 3, SEQ ID No 4, SEQ ID No 5, SEQ ID No 6, SEQ ID No 7, SEQ ID No 8, SEQ ID No 9, SEQ ID No 10, SEQ ID No 11, SEQ ID No 12, SEQ ID No 13, SEQ ID No 14, SEQ ID No 15, SEQ ID No 16, SEQ ID No 17, SEQ ID No 18, SEQ ID No 19, SEQ ID No 20, SEQ ID No 21, SEQ ID No 22, SEQ ID No 23, SEQ ID No 24, SEQ ID No 25, SEQ ID No 26, SEQ ID No 27, SEQ ID No 28, and SEQ ID No 29, and the peptide sequences having at least 70% identity, preferably at least 80% identity and advantageously at least 98% identity with any one of the peptide sequences SEQ ID No 1 to SEQ ID No 8 and SEQ ID No 10 to SEQ ID No 29, and the peptide sequences or fragments of said sequences belonging to a common family of proteins selected among perlecan, the precursor of the retinol-binding plasmatic protein, of the GM2 activator protein, of calgranulin B and of saponin B.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式