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1. 发明授权

US5759147A Blood separation chamber 失效
标题翻译：血液分离室
公开(公告)号：US5759147A
公开(公告)日：1998-06-02
申请号：US472671
申请日：1995-06-07
申请人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
发明人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
IPC分类号： B04B1/00 , B04B5/04 , C07K16/30 , F04B9/02 , F04B43/10 , B04B7/08
CPC分类号： F04B43/10 , B04B1/00 , B04B5/0428 , B04B5/0442 , C07K16/30 , F04B9/02 , B04B2005/045 , B04B2005/0464
摘要： A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer circumferential wall plus an inner circumferential wall, spaced from the outer wall, to define a circumferential slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
摘要翻译：血液成分分离装置包括适于在离心机中围绕其轴旋转的离心机碗。碗限定外周壁加上与外壁间隔开的内周壁，以限定适于接收血液成分的圆周槽。接入管适用于与槽连通。优选地，在狭槽中设置细长的，柔性的可折叠内衬。单独的进入管也可以与细长的可收缩容器的端部之间的细长的容器内部连通。此外，槽的一部分可以限定向外延伸的螺旋的形状，以在流体沿着狭槽移动时为其中的流体提供增加的重力场。

2. 发明授权

US4937194A Method for metering nutrient media to cell culture containers 失效
标题翻译：计量营养培养基至细胞培养容器的方法
公开(公告)号：US4937194A
公开(公告)日：1990-06-26
申请号：US303188
申请日：1989-01-30
申请人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
发明人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
IPC分类号： C12M1/00 , C12M1/26 , C12N5/02
CPC分类号： C12M23/14 , C12M33/07 , Y10S435/80
摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.
摘要翻译：用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。在优选的实施方案中，无菌连接器可用于基本上无菌的条件。分支导管在与端部间隔开的位置处从流动管道延伸。分支管道与用于从所述一端通过介质流动管道接收预定体积等分的介质的装置连通。流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚

3. 发明授权

US4151844A Method and apparatus for separating whole blood into its components and for automatically collecting one component 失效
标题翻译：用于将全血分离成其组分并自动收集一种组分的方法和装置
公开(公告)号：US4151844A
公开(公告)日：1979-05-01
申请号：US850624
申请日：1977-11-11
申请人： Herbert M. Cullis , Almond, Anthony L. , Michael B. Uffer , Mirza A. Kohja , Rodolfo R. Rodgriguez
发明人： Herbert M. Cullis , Almond, Anthony L. , Michael B. Uffer , Mirza A. Kohja , Rodolfo R. Rodgriguez
IPC分类号： G01N33/48 , A61K35/14 , A61M1/02 , A61M1/36 , B04B5/04 , A61M5/00
CPC分类号： B04B5/0442 , A61M1/3693 , A61M1/3696
摘要： The method, and the apparatus for carrying out the steps of the method, are utilized in the centrifugal liquid processing of whole blood wherein whole blood is withdrawn from a donor, passed through a fluid system and the blood is centrifuged to separate the same into at least three components. One component which is to be collected is withdrawn at a fixed rate of volumetric displacement while the other two components are withdrawn at variable rates of volumetric displacement. The other two components are recombined and returned to the donor. The withdrawal of the one component is optically monitored to determine whether or not either one of the other components is being mixed with the one component. When such a mixing is sensed, the rate of withdrawal of one of the other two components is increased while the rate of withdrawal of the other components is decreased thereby to ensure withdrawal of the desired one component, e.g., white blood cells with minimal contamination thereof with the other two components, e.g., red blood cells and plasma containing platelets. A given amount of the one component withdrawn is collected in a receptacle.
摘要翻译：该方法和用于实施该方法的装置用于全血的离心液体处理，其中全血从供体排出，通过流体系统，并将血液离心以将其分离成至少三个组成部分。要收集的一个组分以固定的体积位移速率取出，而另外两个组分以可变的体积位移速率取出。另外两个组分被重组并返回给供体。光学地监测一个组分的抽出，以确定其它组分中的任一个是否与一个组分混合。当感测到这种混合时，其他两种组分之一的提取速率增加，而其它组分的抽出速率降低，从而确保所需的一种组分例如白细胞的最小污染与其他两个组分，例如红细胞和血浆含血小板。将给定量的一个组分撤回收集在容器中。

4. 发明授权

US4095923A Peristaltic pump with accommodating rollers 失效
标题翻译：蠕动泵带容纳辊
公开(公告)号：US4095923A
公开(公告)日：1978-06-20
申请号：US714459
申请日：1976-08-16
申请人： Herbert M. Cullis
发明人： Herbert M. Cullis
IPC分类号： F04C5/00 , F04B43/12 , F04B43/08 , F04B45/06
CPC分类号： F04B43/1253
摘要： The rollers of a peristaltic pump are provided with an unyielding surface, so as to insure uniform compression of the pumped tube. The rollers are mounted on their driving axles by means including yielding rubber bushings, whereby the rollers accommodate to varying diameters of pump tubing and do so without generating objectionable noise. Because the rollers yieldingly ride over the irregularities, two adjacent tubes of slightly differing diameters can simultaneously be contacted and stripped by one set of rollers.
摘要翻译：蠕动泵的辊子设置有不屈曲的表面，以确保泵送管的均匀压缩。辊子通过包括产生橡胶衬套的装置安装在它们的驱动轴上，由此辊容纳泵管的不同直径，并且不产生令人不快的噪音。由于辊子顺利地越过不规则部分，所以直径稍微不同的两个相邻的管子可以同时被一组辊子接触和剥离。

5. 发明授权

US4093545A Method and apparatus for determining the amount of ultrafiltration during dialysis 失效
标题翻译：用于确定透析期间超滤量的方法和装置
公开(公告)号：US4093545A
公开(公告)日：1978-06-06
申请号：US550051
申请日：1975-02-14
申请人： Herbert M. Cullis
发明人： Herbert M. Cullis
IPC分类号： G01N33/52 , A61M1/14 , A61M1/16 , B01D61/20 , B01D61/22 , B01D61/30 , B01D61/32 , B01D61/34 , B01D65/10 , B01D31/00
CPC分类号： A61M1/1694 , B01D61/28 , B01D61/32 , A61M2205/3382 , Y10S210/929
摘要： A dialysis device is disclosed which includes dialysis solution conduit means for passing dialysis solution through a membrane dialyzer. In accordance with this invention, controlled volumes of dialysis solution are supplied and withdrawn to and from at least a portion of the dialysis solution conduit means, plus the dialyzer connected to the conduit means. By this, the input and output of the dialysis solution to and from the conduit portion and connected dialyzer is positively controlled. The total liquid volume of the conduit portion and connected dialyzer is measured. Accordingly, changes in the total liquid volume which are not attributable to the dialysis solution input and output indicate the amount of ultrafiltration during dialysis.
摘要翻译：公开了一种透析装置，其包括用于使透析溶液通过膜透析器的透析溶液管道装置。根据本发明，提供控制体积的透析溶液并将其从透析溶液导管装置的至少一部分加上连接到导管装置的透析器抽出。通过这种方式，可以积极地控制渗透溶液与导管部分和连接的透析器的输入和输出。测量导管部分和连接的透析器的总液体体积。因此，不能归因于透析溶液输入和输出的总液体体积的变化表示透析期间的超滤量。

6. 发明授权

US4934995A Blood component centrifuge having collapsible inner liner 失效
标题翻译：具有可折叠内衬的血液成分离心机
公开(公告)号：US4934995A
公开(公告)日：1990-06-19
申请号：US824182
申请日：1977-08-12
申请人： Herbert M. Cullis
发明人： Herbert M. Cullis
IPC分类号： B04B1/00 , B04B5/04 , C07K16/06 , C07K16/30 , F04B9/02 , F04B43/10
CPC分类号： C07K16/06 , B04B1/00 , B04B5/0428 , B04B5/0442 , C07K16/30 , F04B43/10 , F04B9/02 , B04B2005/045 , B04B2005/0464
摘要： A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
摘要翻译：血液成分分离装置包括适于在离心机中围绕其轴旋转的离心机碗。碗定义了外弧形壁加上与外壁间隔开的内周壁，以限定适于接收血液成分的弧形槽。接入管适用于与槽连通。优选地，在狭槽中设置细长的，柔性的可折叠内衬。单独的进入管也可以与细长的可收缩容器的端部之间的细长的容器内部连通。此外，槽的一部分可以限定向外延伸的螺旋的形状，以在流体沿着狭槽移动时为其中的流体提供增加的重力场。

7. 发明授权

US4187979A Method and system for fractionating a quantity of blood into the components thereof 失效
$Method and system for fractionating a quantity of blood into the components thereof$
公开(公告)号：US4187979A
公开(公告)日：1980-02-12
申请号：US944640
申请日：1978-09-21
申请人： Herbert M. Cullis , Evelyn E. Dorsey , James H. De Vries
发明人： Herbert M. Cullis , Evelyn E. Dorsey , James H. De Vries
IPC分类号： A61M1/36 , B04B5/04 , B04B15/12
CPC分类号： B04B5/0442 , A61M1/3603 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/3306
摘要： The method, and system for carrying out the steps of the method, are utilized in taking whole blood from a supply of blood withdrawn from a donor or from a previously banked supply of whole blood in a container, centrifuging the blood in a centrifuge device to separate the whole blood into its components, and then collecting the components, namely red blood cells, white blood cells, platelets and plasma. The fractionation of the whole blood in the centrifuge device takes place in first, second and third separation chambers. The first chamber has a square shape and is positioned in the centrifuge device in a diamond position. Each corner of the first separation chamber has an opening. Whole blood is pumped into one side corner opening and red blood cells are withdrawn from the other side corner opening and returned to the container for recirculation through the first chamber. White blood cells, platelets and plasma are withdrawn from the upper corner opening and passed through the second chamber wherein white blood cells are separated by centrifugal force. The plasma and platelets are then withdrawn from the second chamber and passed through the third chamber wherein the platelets are separated from the plasma by centrifugal force. The plasma exiting from the third separation chamber is passed back into the bottom corner of the first chamber to cause a flow of plasma across the flow of whole blood and red blood cells to elute white blood cells and plateletstherefrom and to wash the red blood cells. By appropriate operation of electromechanically controlled clamps associated with tubing carrying the various blood components, plasma can be siphoned off into a plasma collection receptacle located outside the centrifuge device. After the red blood cells have been recirculated several times through the first separation chamber, the red blood cells then can be directed to a red blood cell collection receptacle by operation of other electromechanically controlled clamps.

8. 发明授权

US4120448A Centrifugal liquid processing apparatus with automatically positioned collection port 失效
标题翻译：离心液体处理设备具有自动定位的收集口
公开(公告)号：US4120448A
公开(公告)日：1978-10-17
申请号：US804697
申请日：1977-06-08
申请人： Herbert M. Cullis
发明人： Herbert M. Cullis
IPC分类号： B04B5/04 , B04B11/06
CPC分类号： B04B5/0442 , B04B2005/045
摘要： An intervivos blood processor includes a processing chamber wherein whole blood is separated into its red blood cell, white blood cell and plasma components in the presence of a centrifugal force field. The white blood cell component is removed from the chamber by means of a tubing segment having a free floating end within the chamber and a density corresponding to the density of the white blood cell component. Since the free end of the tubing assumes the same position in the chamber as the white blood cell component the tubing collects only this component notwithstanding variations in the flow rate of the blood through the chamber and the centifugal force field applied to the chamber.
摘要翻译：间歇血液处理器包括处理室，其中在存在离心力场的情况下，全血分离成其红细胞，白细胞和血浆成分。通过在腔室内具有自由浮动端的管段和与白细胞组分的密度相对应的密度将白细胞成分从腔室中除去。由于管道的自由端与白细胞组件在腔室中呈现相同的位置，所以管道仅收集该部件，尽管血液通过腔室的流速和施加到腔室的离心力场的变化。

9. 发明授权

US5217426A Combination disposable plastic blood receiving container and blood component centrifuge 失效
标题翻译：组合一次性塑料血液接收容器和血液成分离心机
公开(公告)号：US5217426A
公开(公告)日：1993-06-08
申请号：US744947
申请日：1991-08-14
申请人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
发明人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
IPC分类号： B04B1/00 , B04B5/04 , C07K16/06 , C07K16/30 , F04B9/02 , F04B43/10
CPC分类号： C07K16/06 , B04B1/00 , B04B5/0428 , B04B5/0442 , C07K16/30 , F04B43/10 , F04B9/02 , B04B2005/045 , B04B2005/0464
摘要： A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
摘要翻译：血液成分分离装置包括适于在离心机中围绕其轴旋转的离心机碗。碗定义了外弧形壁加上与外壁间隔开的内周壁，以限定适于接收血液成分的弧形槽。接入管适用于与槽连通。优选地，在狭槽中设置细长的，柔性的可折叠内衬。单独的进入管也可以与细长的可收缩容器的端部之间的细长的容器内部连通。此外，槽的一部分可以限定向外延伸的螺旋的形状，以在流体沿着狭槽移动时为其中的流体提供增加的重力场。

10. 发明授权

US4829002A System for metering nutrient media to cell culture containers and method 失效
标题翻译：用于计量营养培养基至细胞培养容器和方法的系统
公开(公告)号：US4829002A
公开(公告)日：1989-05-09
申请号：US862344
申请日：1986-05-12
申请人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
发明人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
IPC分类号： C12M3/00 , C12M1/00 , C12M1/26 , C12N5/00 , C12N5/10
CPC分类号： C12M23/14 , C12M33/07
摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.
摘要翻译：用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。在优选的实施方案中，无菌连接器可用于基本上无菌的条件。分支导管在与端部间隔开的位置处从流动管道延伸。分支管道与用于从所述一端通过介质流动管道接收预定体积等分的介质的装置连通。流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚

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