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1. 发明申请

US20120093942A1 PHARMACEUTICAL COMPOSITION FOR TREATING NEPHROPATHY AND HEALTHY FOOD COMPRISING HERB EXTRACTS 失效
标题翻译：用于治疗胃肠病的药物组合物和包含草药提取物的健康食品
公开(公告)号：US20120093942A1
公开(公告)日：2012-04-19
申请号：US13334583
申请日：2011-12-22
申请人： Jei-Man RYU , Moon-Jung LEEM , Yang-Kook ROH , Hwan-Bong CHANG , Seong-Jun OH , Hyun-Yong LEE , Sae-Kwang KU , Hee-Bog YANG , Jung-Woo RHEE , Yun-Jung KIM , Joo Byoung YOON
发明人： Jei-Man RYU , Moon-Jung LEEM , Yang-Kook ROH , Hwan-Bong CHANG , Seong-Jun OH , Hyun-Yong LEE , Sae-Kwang KU , Hee-Bog YANG , Jung-Woo RHEE , Yun-Jung KIM , Joo Byoung YOON
IPC分类号： A61K36/488 , A61K35/64 , A61K36/25 , A61K36/605 , A61P13/12
CPC分类号： A61K36/25 , A61K36/488 , A61K36/60 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition and health food comprising herb extracts of one or more herbs selected from the group consisting of Puerariae Radix, Bombycis corpus and Araliae Continentalis Radix. The herb medicine of this invention comprising a single or mixed composition may be useful for the prevention and treatment of renal diseases as well as improvement of renal functions.
摘要翻译：公开了一种药物组合物和保健食品，其包含一种或多种选自由葛根，Bombycis语料库和Araliae Continentalis Radix组成的组的草药提取物。包含单一或混合组合物的本发明药草可用于预防和治疗肾脏疾病以及改善肾功能。

2. 发明申请

US20100215764A1 Pharmaceutical Composition For Treating Nephropathy and Healthy Food Comprising Herb Extracts 审中-公开
标题翻译：用于治疗含有草药提取物的肾病和健康食品的药物组合物
公开(公告)号：US20100215764A1
公开(公告)日：2010-08-26
申请号：US11814716
申请日：2006-01-31
申请人： Jei-Man Ryu , Moon-Jung Leem , Yang-Kook Roh , Hwan-Bong Chang , Seong-Jun Oh , Hyun-Yong Lee , Sae-Kwang Ku , Hee-Bog Yang , Jung-Woo Rhee , Yun-Jung Kim , Joo Byoung Yoon
发明人： Jei-Man Ryu , Moon-Jung Leem , Yang-Kook Roh , Hwan-Bong Chang , Seong-Jun Oh , Hyun-Yong Lee , Sae-Kwang Ku , Hee-Bog Yang , Jung-Woo Rhee , Yun-Jung Kim , Joo Byoung Yoon
IPC分类号： A61K35/64 , A61K36/488 , A61K36/25 , A61K36/605 , A61P13/12 , A23L1/30
CPC分类号： A61K36/25 , A61K36/488 , A61K36/60 , A61K2300/00
摘要： This invention relates to a pharmaceutical composition and health food comprising herb extracts of one or more herbs selected from the group consisting of Puerariae Radix, Bombycis corpus and Araliae Continentalis Radix. The herb medicine of this invention comprising a single or mixed composition may be useful for the prevention and treatment of renal diseases as well as improvement of renal functions.
摘要翻译：本发明涉及一种药物组合物和保健食品，其包含一种或多种草药的草药提取物，所述草药提取物选自由葛根葛根，Bombycis语料库和Araliae Continentalis Radix组成的组。包含单一或混合组合物的本发明药草可用于预防和治疗肾脏疾病以及改善肾功能。

3. 发明授权

US08637097B2 Pharmaceutical composition for treating nephropathy and healthy food comprising herb extracts 失效
标题翻译：用于治疗肾病和健康食品的药物组合物，包括草药提取物
公开(公告)号：US08637097B2
公开(公告)日：2014-01-28
申请号：US13334583
申请日：2011-12-22
申请人： Jei-Man Ryu , Moon-Jung Leem , Yang-Kook Roh , Hwan-Bong Chang , Seong-Jun Oh , Hyun-Yong Lee , Sae-Kwang Ku , Hee-Bog Yang , Jung-Woo Rhee , Yun-Jung Kim , Joo Byoung Yoon
发明人： Jei-Man Ryu , Moon-Jung Leem , Yang-Kook Roh , Hwan-Bong Chang , Seong-Jun Oh , Hyun-Yong Lee , Sae-Kwang Ku , Hee-Bog Yang , Jung-Woo Rhee , Yun-Jung Kim , Joo Byoung Yoon
IPC分类号： A61K36/00 , A01N65/00
CPC分类号： A61K36/25 , A61K36/488 , A61K36/60 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition and health food comprising herb extracts of one or more herbs selected from the group consisting of Puerariae Radix, Bombycis corpus and Araliae Continentalis Radix. The herb medicine of this invention comprising a single or mixed composition may be useful for the prevention and treatment of renal diseases as well as improvement of renal functions.
摘要翻译：公开了一种药物组合物和保健食品，其包含一种或多种选自由葛根，Bombycis语料库和Araliae Continentalis Radix组成的组的草药提取物。包含单一或混合组合物的本发明药草可用于预防和治疗肾脏疾病以及改善肾功能。

4. 发明申请

US20080166297A1 Radionuclide-Chitosan Complex Having an Improved Stablilized Gelatin in Administering Them to the Body and Their Preparation Method 审中-公开
标题翻译：具有改善的稳定明胶的放射性核素 - 壳聚糖复合物在体内及其制备方法
公开(公告)号：US20080166297A1
公开(公告)日：2008-07-10
申请号：US11720572
申请日：2005-12-01
申请人： Jei-Man Ryu , Dong-Hyuk Shin , Seung-Kyoo Seong , Hee-Bog Yang , Young-Jun Song , Eun-Jung Bae , Kyung-Bae Park , Byung-Chul Shin
发明人： Jei-Man Ryu , Dong-Hyuk Shin , Seung-Kyoo Seong , Hee-Bog Yang , Young-Jun Song , Eun-Jung Bae , Kyung-Bae Park , Byung-Chul Shin
IPC分类号： A61K51/04 , C07F5/00
CPC分类号： A61K51/06 , A61K31/22 , A61K51/1213
摘要： The present invention relates to a radionuclide-chitosan complex solution and its preparation method, and more particularly to the radionuclide-chitosan complex solution having a viscosity of 300˜2,400 cps, comprising an aqueous chitosan solution or a freeze-dried chitosan labeled with a radionuclide. The radionuclide-chitosan complex solution according to the present invention has a stable gelation state at a target region when injected into the body while maintaining a labeling yield of radioisotope to chitosan above 99%. Side effects may be minimized and treatment efficiency may be increased when injected to a patient.
摘要翻译：本发明涉及放射性核素 - 壳聚糖复合溶液及其制备方法，更具体地涉及粘度为300〜2400cps的放射性核素 - 壳聚糖复合溶液，其包含壳聚糖水溶液或用放射性核素标记的冷冻干燥壳聚糖。本发明的放射性核素 - 壳聚糖复合溶液在注射到体内时在靶区域具有稳定的凝胶化状态，同时保持壳聚糖的放射性同位素的标记收率高于99％。副作用可能最小化，并且当注射到患者时可以增加治疗效率。

5. 发明授权

US07923443B2 Pharmaceutical composition for the treatment of bone fracture 失效
$Pharmaceutical composition for the treatment of bone fracture$
标题翻译：用于治疗骨折的药物组合物
公开(公告)号：US07923443B2
公开(公告)日：2011-04-12
申请号：US11631828
申请日：2005-07-05
申请人： Jei Man Ryu , Jin Soo Lee , Sae Kwang Ku , Jung Woo Lee , Hee Bog Yang
发明人： Jei Man Ryu , Jin Soo Lee , Sae Kwang Ku , Jung Woo Lee , Hee Bog Yang
IPC分类号： A01N43/00 , A61K31/33
CPC分类号： A61K31/426
摘要： Disclosed herein is a composition for the treatment bone fracture comprising N-hydroxy-4-{5-[4-( 5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxyl-benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salts thereof as a medicinally effective ingredient. The composition of the present invention can significantly reduce the volume of bony callus, and increase bony density and strength of bony callus, and decrease the contents of connective tissue and cartilage tissue in bony callus, and thus promote loss and ossification of the bony callus formed during the fracture healing process. Therefore, the composition of the present invention is useful for the treatment of bone fracture.
摘要翻译：本文公开了一种用于治疗骨折的组合物，其包含N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基 - 苄脒，4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或其药学上可接受的盐作为药物有效成分。本发明的组合物可显着减少骨愈伤组织的体积，增加骨愈伤组织的骨密度和强度，并减少骨愈伤组织中结缔组织和软骨组织的含量，从而促进形成的骨愈伤组织的损失和骨化在骨折愈合过程中。因此，本发明的组合物可用于治疗骨折。

6. 发明申请

US20080287509A1 Pharmaceutical Composition for the Treatment of Bone Fracture 失效
标题翻译：用于治疗骨折的药物组合物
公开(公告)号：US20080287509A1
公开(公告)日：2008-11-20
申请号：US11631828
申请日：2005-07-05
申请人： Jei Man Ryu , Jin Soo Lee , Sae Kwang Ku , Jung Woo Lee , Hee Bog Yang
发明人： Jei Man Ryu , Jin Soo Lee , Sae Kwang Ku , Jung Woo Lee , Hee Bog Yang
IPC分类号： A61K31/426 , C07D277/28 , A61P19/00
CPC分类号： A61K31/426
摘要： Disclosed herein is a composition for the treatment bone fracture comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxyl-benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salts thereof as a medicinally effective ingredient. The composition of the present invention can significantly reduce the volume of bony callus, and increase bony density and strength of bony callus, and decrease the contents of connective tissue and cartilage tissue in bony callus, and thus promote loss and ossification of the bony callus formed during the fracture healing process. Therefore, the composition of the present invention is useful for the treatment of bone fracture.
摘要翻译：本文公开了一种用于治疗骨折的组合物，其包含N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基 - 苄脒，4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或其药学上可接受的盐作为药物有效成分。本发明的组合物可显着减少骨愈伤组织的体积，增加骨愈伤组织的骨密度和强度，并减少骨愈伤组织中结缔组织和软骨组织的含量，从而促进形成的骨愈伤组织的损失和骨化在骨折愈合过程中。因此，本发明的组合物可用于治疗骨折。

7. 发明申请

US20060286032A1 A radiosotope-chitosan complex for treatment of prostate cancer 审中-公开
标题翻译：一种用于治疗前列腺癌的放射性脱氧壳聚糖复合物
公开(公告)号：US20060286032A1
公开(公告)日：2006-12-21
申请号：US10570295
申请日：2004-09-08
申请人： Jei-Man Ryu , Dong-Hyuk Shin , Seung-Kyoo Seong , Hee-Bog Yang , Eun-Jung Bae , Young-Jun Song , Kyung-Bae Park , Byung-Chul Shin
发明人： Jei-Man Ryu , Dong-Hyuk Shin , Seung-Kyoo Seong , Hee-Bog Yang , Eun-Jung Bae , Young-Jun Song , Kyung-Bae Park , Byung-Chul Shin
IPC分类号： A61K51/00 , C08B37/08
CPC分类号： A61K51/06 , A61K51/1282
摘要： Disclosed is a composition for treating prostate cancer. The composition for treating prostate cancer comprises as an effective ingredient a radioisotope-chitosan complex that includes a therapeutic radioisotope emitting beta radiation and chitosan. Also, the present invention discloses a kit for preparing the composition. When directly administered to a prostate cancer tissue, the radioisotope- chitosan complex is deposited in the applied target site while not leaking from the applied target site, and strongly inhibits the growth of prostate cancer cells while minimizing the side effects of conventional therapies, including urinary incontinence, urethral stricture and rectal bleeding. In addition, the radioisotope-chitosan complex may be used as an effective therapeutic agent for hormone-independent prostate cancer that is resistant to hormone therapy.
摘要翻译：公开了用于治疗前列腺癌的组合物。用于治疗前列腺癌的组合物包括放射性同位素 - 壳聚糖复合物作为有效成分，其包括发射β辐射和壳聚糖的治疗性放射性同位素。此外，本发明公开了一种用于制备组合物的试剂盒。当直接施用于前列腺癌组织时，放射性同位素 - 壳聚糖复合物沉积在施用的靶位点，而不会从施用的靶位点泄漏，并强烈地抑制前列腺癌细胞的生长，同时最小化常规治疗的副作用，包括尿尿失禁，尿道狭窄和直肠出血。此外，放射性同位素 - 壳聚糖复合物可用作对激素治疗具有抗性的激素非依赖性前列腺癌的有效治疗剂。

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