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1. 发明申请

US20110150929A1 SARS vaccine compositions and methods of making and using them 失效
标题翻译： SARS疫苗组合物及其使用方法
公开(公告)号：US20110150929A1
公开(公告)日：2011-06-23
申请号：US12655299
申请日：2009-12-28
申请人： Hassibullah Akeefe , Moiz Kitabwalla
发明人： Hassibullah Akeefe , Moiz Kitabwalla
IPC分类号： A61K39/215 , A61P11/00 , C12N7/06 , A61P37/04 , A61P31/14
CPC分类号： A61K39/12 , A61K2039/5158 , A61K2039/5252 , A61K2039/5258 , A61K2039/545 , A61K2039/55566 , C07K14/005 , C12N7/00 , C12N2730/10022 , C12N2730/10122 , C12N2730/10162 , C12N2740/15022 , C12N2740/16122 , C12N2770/20022 , C12N2770/20034 , C12N2770/20062 , C12N2770/24322
摘要： Described is a composition and method for reducing the occurrence and severity of infectious diseases, especially infectious diseases such as SARS, in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating immunogenic modified, partially delipidated viral particles with reduced infectivity. The present invention provides delipidated viral vaccine compositions, such as therapeutic vaccine compositions, comprising these modified, partially delipidated viral particles with reduced infectivity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism or, in case of a therapeutic vaccine, to treat or alleviate infection against the lipid-containing infections viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.
摘要翻译：描述了用于减少感染性疾病，特别是SARS等感染性疾病的发生和严重性的组合物和方法，其中在诸如血液的生物流体中发现含有脂质的感染性病毒生物。本发明使用可用于从含脂质的感染性病毒生物体中提取脂质的溶剂，从而产生具有降低的感染性的免疫原性修饰的，部分脱脂的病毒颗粒。本发明提供脱脂病毒疫苗组合物，例如治疗性疫苗组合物，其包含具有降低的感染性的这些经修饰的部分脱脂的病毒颗粒，任选与药学上可接受的载体或免疫刺激剂组合。将疫苗组合物施用于患者以提供针对含脂质感染性病毒生物体的保护，或在治疗性疫苗的情况下，治疗或减轻针对含脂感染病毒生物体的感染。本发明的疫苗组合物包括由一种或多种病毒株和/或一种或多种病毒获得的经修饰的病毒颗粒的组合疫苗。

2. 发明申请

US20080234621A1 Methods and Apparatus for Creating Particle Derivatives of HDL with Reduced Lipid Content 有权
公开(公告)号：US20080234621A1
公开(公告)日：2008-09-25
申请号：US12054162
申请日：2008-03-24
申请人： Marc Bellotti , H. Bryan Brewer , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
IPC分类号： A61M1/38 , A61K9/14 , B01D11/00 , A61K38/17 , A61P9/10
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

3. 发明申请

US20080214438A1 Methods and Apparatus for Creating Particle Derivatives of HDL with Reduced Lipid Content 审中-公开
公开(公告)号：US20080214438A1
公开(公告)日：2008-09-04
申请号：US12042924
申请日：2008-03-05
申请人： Marc Bellotti , H. Bryan Brewer , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
IPC分类号： A61K38/02
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

4. 发明申请

US20050004004A1 Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权
标题翻译：用于产生脂质含量降低的HDL颗粒衍生物的方法和装置
公开(公告)号：US20050004004A1
公开(公告)日：2005-01-06
申请号：US10796691
申请日：2004-03-08
申请人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
发明人： Marc Bellotti , H. Brewer , Hassibullah Akeefe , Adam Conner , Timothy Perlman
IPC分类号： A61K9/127 , A61K38/17
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译：本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。本方法可用于治疗动脉粥样硬化性血管疾病，并可与其他疗法（如他汀类药物，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制）结合使用。

5. 发明授权

US08435531B2 Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response 失效
标题翻译：治疗癌细胞以产生引发免疫原性反应的修饰的癌细胞的方法
公开(公告)号：US08435531B2
公开(公告)日：2013-05-07
申请号：US12775300
申请日：2010-05-06
申请人： Moiz Kitabwalla , Hassibullah Akeefe
发明人： Moiz Kitabwalla , Hassibullah Akeefe
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154
摘要： The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation of the cancer cells, a portion of the cancer cell antigens remain intact. These exposed antigens, or epitopes, foster and promote antibody production. The resulting modified cancer cell particle, or portions of the cancer cell, initiate a positive immunogenic response when administered to an animal or human and help to treat, prevent or delay the onset of cancer. The present invention provides autologous and heterologous vaccine compositions comprising the modified cancer cell with a pharmaceutically acceptable carrier. The present invention provides method of administering these vaccines to treat, prevent or delay the onset of cancer.
摘要翻译：本发明涉及使用可用于从癌细胞中提取脂质的溶剂系统的脱脂方法，从而产生修饰的癌细胞颗粒。在癌细胞脱皮时，一部分癌细胞抗原保持完整。这些暴露的抗原或表位促进和促进抗体产生。所产生的修饰的癌细胞颗粒或癌细胞的一部分在施用于动物或人时起始阳性免疫原性应答，有助于治疗，预防或延迟癌症发作。本发明提供了包含修饰的癌细胞与药学上可接受的载体的自体和异源疫苗组合物。本发明提供了施用这些疫苗以治疗，预防或延迟癌症发病的方法。

6. 发明申请

US20080187559A1 Method of Treating Cancer Cells to Create a Modified Cancer Cell That Provokes an Immunogenic Response 失效
标题翻译：治疗癌细胞以产生调节免疫原性反应的修饰的癌细胞的方法
公开(公告)号：US20080187559A1
公开(公告)日：2008-08-07
申请号：US12044107
申请日：2008-03-07
申请人： Moiz Kitabwalla , Hassibullah Akeefe
发明人： Moiz Kitabwalla , Hassibullah Akeefe
IPC分类号： A61K39/00 , C12N5/06 , A61P37/00 , A61K35/12
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154
摘要： The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation of the cancer cells, a portion of the cancer cell antigens remain intact. These exposed antigens, or epitopes, foster and promote antibody production. The resulting modified cancer cell particle, or portions of the cancer cell, initiate a positive immunogenic response when administered to an animal or human and help to treat, prevent or delay the onset of cancer. The present invention provides autologous and heterologous vaccine compositions comprising the modified cancer cell with a pharmaceutically acceptable carrier. The present invention provides method of administering these vaccines to treat, prevent or delay the onset of cancer.
摘要翻译：本发明涉及使用可用于从癌细胞中提取脂质的溶剂系统的脱脂方法，从而产生修饰的癌细胞颗粒。在癌细胞脱皮时，一部分癌细胞抗原保持完整。这些暴露的抗原或表位促进和促进抗体产生。所产生的修饰的癌细胞颗粒或癌细胞的一部分在施用于动物或人时起始阳性免疫原性应答，有助于治疗，预防或延迟癌症发作。本发明提供了包含修饰的癌细胞与药学上可接受的载体的自体和异源疫苗组合物。本发明提供了施用这些疫苗以治疗，预防或延迟癌症发病的方法。

7. 发明授权

US07361739B2 Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权
标题翻译：用于产生脂质含量降低的HDL颗粒衍生物的方法和装置
公开(公告)号：US07361739B2
公开(公告)日：2008-04-22
申请号：US10996570
申请日：2004-11-23
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
IPC分类号： C07K1/00
CPC分类号： G01N33/92 , A61K9/1275 , A61K38/1709 , C07K14/775 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译：本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。

8. 发明申请

US20070026006A1 Method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response 失效
标题翻译：治疗癌细胞以产生引发免疫原性反应的修饰的癌细胞的方法
公开(公告)号：US20070026006A1
公开(公告)日：2007-02-01
申请号：US11493936
申请日：2006-07-26
申请人： Moiz Kitabwalla , Hassibullah Akeefe
发明人： Moiz Kitabwalla , Hassibullah Akeefe
IPC分类号： A61K39/00 , C12N5/06
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5154
摘要： The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation of the cancer cells, a portion of the cancer cell antigens remain intact. These exposed antigens, or epitopes, foster and promote antibody production. The resulting modified cancer cell particle, or portions of the cancer cell, initiate a positive immunogenic response when administered to an animal or human and help to treat, prevent or delay the onset of cancer. The present invention provides autologous and heterologous vaccine compositions comprising the modified cancer cell with a pharmaceutically acceptable carrier. The present invention provides method of administering these vaccines to treat, prevent or delay the onset of cancer.
摘要翻译：本发明涉及使用可用于从癌细胞中提取脂质的溶剂系统的脱脂方法，从而产生修饰的癌细胞颗粒。在癌细胞脱皮时，一部分癌细胞抗原保持完整。这些暴露的抗原或表位促进和促进抗体产生。所产生的修饰的癌细胞颗粒或癌细胞的一部分在施用于动物或人时起始阳性免疫原性应答，有助于治疗，预防或延迟癌症发作。本发明提供了包含修饰的癌细胞与药学上可接受的载体的自体和异源疫苗组合物。本发明提供了施用这些疫苗以治疗，预防或延迟癌症发病的方法。

9. 发明授权

US08637460B2 Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权
标题翻译：用于产生脂质含量降低的HDL颗粒衍生物的方法和装置
公开(公告)号：US08637460B2
公开(公告)日：2014-01-28
申请号：US13601131
申请日：2012-08-31
申请人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
发明人： Marc Bellotti , H. Bryan Brewer, Jr. , Hassibullah Akeefe , Adam Paul Conner , Timothy Jon Perlman
IPC分类号： A61K38/17 , A61P3/06
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译：本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。

10. 发明申请

US20130052167A1 Methods and Apparatus for Creating Particle Derivatives of HDL with Reduced Lipid Content 有权
标题翻译：用于创建具有降低的脂质含量的HDL的颗粒衍生物的方法和装置
公开(公告)号：US20130052167A1
公开(公告)日：2013-02-28
申请号：US13601131
申请日：2012-08-31
申请人： Marc BELLOTTI , H. Bryan BREWER, JR. , Hassibullah AKEEFE , Adam Paul CONNER , Timothy Jon PERLMAN
发明人： Marc BELLOTTI , H. Bryan BREWER, JR. , Hassibullah AKEEFE , Adam Paul CONNER , Timothy Jon PERLMAN
IPC分类号： A61K38/17 , A61P9/10 , A61P3/06 , A61K35/14
CPC分类号： C07K14/775 , A61K9/1275 , A61K31/685 , A61K38/1709 , B01D11/0492 , B01D15/00 , B01D15/426 , G01N33/92 , A61K2300/00
摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
摘要翻译：本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。

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