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1. 发明授权

US09101306B2 Medical system having plug and play function 有权
标题翻译：医疗系统具有即插即用功能
公开(公告)号：US09101306B2
公开(公告)日：2015-08-11
申请号：US13240092
申请日：2011-09-22
申请人： Nicole Bernini , Harvey B. Buck, Jr. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
发明人： Nicole Bernini , Harvey B. Buck, Jr. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
IPC分类号： A61B5/00 , A61B5/145 , A61N1/372
CPC分类号： G06F19/3406 , A61B5/0015 , A61B5/0024 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/4839 , A61B5/7271 , A61B5/74 , A61B90/98 , A61B2560/0406 , A61B2560/045 , A61N1/37235 , G06F19/00 , G06F21/32 , G06F21/445 , G16H40/63 , H04L67/12 , H04W4/70 , H04W4/80
摘要： A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.
摘要翻译：公开了一种医疗系统，其可以特别用于监视和/或控制用户的至少一个身体功能。医疗系统包括控制装置和与控制装置分开体现的至少一个医疗用户元件。医疗用户元件和控制装置被设计为无线地交换数据。医疗系统被设计成能够进行自动分配步骤，其中通过自动分配步骤来实现医疗用户元件和控制装置之间的个人数据的交换。医疗系统还被设计成通过医疗用户元件和控制装置之间的分配耦合来自动启动自动分配步骤。医疗系统还被设计成能够在分配步骤之后分离用于医疗系统的医疗操作的分配耦合。

2. 发明授权

US08298828B2 System and method for determining the concentration of an analyte in a sample fluid 有权
标题翻译：用于确定样品流体中分析物浓度的系统和方法
公开(公告)号：US08298828B2
公开(公告)日：2012-10-30
申请号：US13418611
申请日：2012-03-13
申请人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
发明人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
IPC分类号： G01N27/00 , G01N27/06
CPC分类号： G01N27/3274 , G01N33/49
摘要： The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.
摘要翻译：本公开涉及使用电化学测试方法测量存在于生物流体中的分析物的量的各种方法。公开了各种实施例，包括使用AC测试信号和在大约3.0秒或更短时间内具有总测试时间的测试和/或具有临床上低的总系统误差的测试。

3. 发明授权

US07751864B2 System and method for operating an electrochemical analyte sensor 有权
标题翻译：用于操作电化学分析物传感器的系统和方法
公开(公告)号：US07751864B2
公开(公告)日：2010-07-06
申请号：US11680963
申请日：2007-03-01
申请人： Harvey B. Buck, Jr.
发明人： Harvey B. Buck, Jr.
IPC分类号： A61B5/05
CPC分类号： G01N27/3274 , A61B5/14503 , A61B5/14532 , A61B5/1486 , A61B5/1495
摘要： A method of operating an electrochemical analyte sensor having one or more electrodes may comprise applying a time-varying input signal to at least one of the one or more electrodes, monitoring a time-varying output signal produced by the sensor in response to application of the time-varying input signal, determining a complex impedance of the sensor based on the time-varying input and output signals, and determining from the complex impedance information relating to operation of the sensor.
摘要翻译：操作具有一个或多个电极的电化学分析物传感器的方法可以包括将时变输入信号施加到所述一个或多个电极中的至少一个电极，监测响应于所述传感器的应用而由传感器产生的时变输出信号时变输入信号，基于时变输入和输出信号确定传感器的复阻抗，并根据与传感器的操作有关的复阻抗信息来确定。

4. 发明授权

US06294062B1 Method and device for electrochemical immunoassay of multiple analytes 有权
标题翻译：多种分析物的电化学免疫测定方法和装置
公开(公告)号：US06294062B1
公开(公告)日：2001-09-25
申请号：US09330422
申请日：1999-05-28
申请人： Harvey B. Buck, Jr. , Zhi David Deng , Eric R. Diebold
发明人： Harvey B. Buck, Jr. , Zhi David Deng , Eric R. Diebold
IPC分类号： G02N2726
CPC分类号： C07F15/0026 , C07K5/101 , C07K7/02 , C07K7/06 , C07K9/001 , C07K14/805 , G01N27/3277 , G01N33/532 , G01N33/536 , G01N33/58 , G01N33/723 , G01N2333/805 , G01N2458/30 , Y10S436/805 , Y10S436/806 , Y10T436/105831
摘要： A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and second redox reversible species having redox potentials differing by at least 50 millivolts. At least one of the redox reversible species comprises a liquid sample diffusible conjugate of a ligand analog of an analyte in the liquid sample and a redox reversible label. A predetermined amount of at least one specific binding partner for each analyte to be measured is combined with the sample and current flow is measured at first and second anodic and cathodic potentials and correlated with current flows for known concentrations of the respective diffusible redox reversible species. Diagnostic devices and kits, including such devices and the specified specific binding partner(s) and redox reversible species are also described.
摘要翻译：描述了用于在液体样品中检测和定量生物学显着性分析物的方法和装置。该方法包括使体积的液体样品与预定量的至少50毫伏的氧化还原电位的至少第一和第二氧化还原可逆物质接触。至少一种氧化还原可逆物质包括液体样品中分析物的配体类似物和氧化还原可逆标记的液体样品可扩散共轭物。将待测量的每种待测量分析物的至少一个特定结合配偶体的预定量与样品组合，并且在第一和第二阳极和阴极电位处测量电流，并且与已知浓度的各个可扩散的氧化还原可逆物质的电流相关。还描述了诊断装置和试剂盒，包括这些装置和指定的特异性结合配偶体和氧化还原可逆物质。

5. 发明授权

US4798577A Separator device and method 失效
标题翻译：分离装置及方法
公开(公告)号：US4798577A
公开(公告)日：1989-01-17
申请号：US862301
申请日：1986-05-12
申请人： Allen J. Brenneman , Harvey B. Buck, Jr. , Jerry T. Pugh , Steven P. Robertson
发明人： Allen J. Brenneman , Harvey B. Buck, Jr. , Jerry T. Pugh , Steven P. Robertson
IPC分类号： B04B1/02 , B04B5/04 , B04B7/08 , B04B1/04
CPC分类号： B04B7/08 , B04B5/0407
摘要： Separation device and method for the fractionation and separation of finely divided solid particulate material suspended in a liquid are disclosed. The separation device comprises upper and lower portions which are joined together to form an inner cavity retaining liquid and a capillary gap which extends outwardly radially from said cavity. During rotation solid particles present in the suspending liquid pass outwardly along and/or become entrapped in the capillary gap(s).
摘要翻译：公开了用于分离和分离悬浮在液体中的细碎固体颗粒材料的分离装置和方法。分离装置包括连接在一起以形成内腔保持液体的上部和下部，以及从所述腔径向向外延伸的毛细管间隙。在旋转期间，存在于悬浮液中的固体颗粒沿着和/或被夹带在毛细管间隙中向外通过。

6. 发明申请

US20120245438A1 MEDICAL SYSTEM HAVING PLUG AND PLAY FUNCTION 有权
标题翻译：具有插头和播放功能的医疗系统
公开(公告)号：US20120245438A1
公开(公告)日：2012-09-27
申请号：US13240092
申请日：2011-09-22
申请人： Nicole Bernini , Harvey B. Buck, JR. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
发明人： Nicole Bernini , Harvey B. Buck, JR. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： G06F19/3406 , A61B5/0015 , A61B5/0024 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/4839 , A61B5/7271 , A61B5/74 , A61B90/98 , A61B2560/0406 , A61B2560/045 , A61N1/37235 , G06F19/00 , G06F21/32 , G06F21/445 , G16H40/63 , H04L67/12 , H04W4/70 , H04W4/80
摘要： A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.
摘要翻译：公开了一种医疗系统，其可以特别用于监测和/或控制用户的至少一个身体功能。医疗系统包括控制装置和与控制装置分开体现的至少一个医疗用户元件。医疗用户元件和控制装置被设计为无线地交换数据。医疗系统被设计成能够进行自动分配步骤，其中通过自动分配步骤来实现医疗用户元件和控制装置之间的个人数据的交换。医疗系统还被设计成通过医疗用户元件和控制装置之间的分配耦合来自动启动自动分配步骤。医疗系统还被设计成能够在分配步骤之后分离用于医疗系统的医疗操作的分配耦合。

7. 发明授权

US08148164B2 System and method for determining the concentration of an analyte in a sample fluid 有权
标题翻译：用于确定样品流体中分析物浓度的系统和方法
公开(公告)号：US08148164B2
公开(公告)日：2012-04-03
申请号：US12650065
申请日：2009-12-30
申请人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
发明人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
IPC分类号： G01N27/00 , G01N27/06
CPC分类号： G01N27/3274 , G01N33/49
摘要： The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.
摘要翻译：本公开涉及使用电化学测试方法测量存在于生物流体中的分析物的量的各种方法。公开了各种实施例，包括使用AC测试信号和在大约2.0秒或更短时间内具有总测试时间的测试和/或具有临床上低的总系统误差的测试。

8. 发明授权

US06352824B1 Redox reversible bipyridyl-osmium complex conjugates 有权
标题翻译：氧化还原可逆联吡啶 - 锇络合物
公开(公告)号：US06352824B1
公开(公告)日：2002-03-05
申请号：US09322791
申请日：1999-05-28
申请人： Harvey B. Buck, Jr. , Zhi David Deng
发明人： Harvey B. Buck, Jr. , Zhi David Deng
IPC分类号： G01N33536
CPC分类号： C07F15/0026 , C07K5/101 , C07K7/02 , C07K7/06 , C07K9/001 , C07K14/805 , G01N27/3277 , G01N33/532 , G01N33/536 , G01N33/58 , G01N33/723 , G01N2333/805 , G01N2458/30 , Y10S436/805 , Y10S436/806 , Y10T436/105831
摘要： Novel bipyridyl-osmium complex conjugates, their preparation, and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials and can thus be used in combination with other electroactive redox reversible species having redox potentials differing by at least 50 millivolts in electrochemical assays designed for use of multiple electroactive species in the same cell and in the same sample without interference between the two or more redox coupled conjugate systems.
摘要翻译：描述了新的联吡啶 - 锇络合物，它们的制备及其在电化学测定中的用途。可以制备氧化还原可逆锇络合物以显示独特的可逆氧化还原电位，并且因此可以与设计用于使用多种电活性物质的电化学测定中的氧化还原电位相差至少50毫伏的其他电活性氧化还原可逆物质组合使用在相同的样品中，两个或更多个氧化还原偶联共轭体系之间没有干扰。

9. 发明申请

US20130048512A1 SYSTEM AND METHOD FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A SAMPLE FLUID 有权
公开(公告)号：US20130048512A1
公开(公告)日：2013-02-28
申请号：US13659189
申请日：2012-10-24
申请人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, JR.
发明人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, JR.
IPC分类号： G01N27/416 , G01N27/26
CPC分类号： G01N27/3274 , G01N33/49
摘要： The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.

10. 发明授权

US08180423B2 Sensor with increased biocompatibility 有权
标题翻译：传感器具有增加的生物相容性
公开(公告)号：US08180423B2
公开(公告)日：2012-05-15
申请号：US11392134
申请日：2006-03-29
申请人： Andre Mang , Harvey B. Buck, Jr. , Michael D. Garrison , Walter Jernigan
发明人： Andre Mang , Harvey B. Buck, Jr. , Michael D. Garrison , Walter Jernigan
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B2562/02 , C12Q1/006
摘要： Sensors and methods for producing them are disclosed. A cavity is created and filled with a reagent that includes a conductive matrix, enzyme, catalyst, and binding agent, in a preferred embodiment. The cavity is substantially enclosed, leaving enough of an opening to allow the sample to enter. A portion of the material surrounding the cavity is preferably permeable to a substance useful for measuring reaction, but not to the reagent or the sample. Cavities that have the shape of a cone, conical frustum, pyramidal frustum, and right circular cylinder are given as examples. Other systems include a membrane that contains the sensor's active area and defines an internal volume of fluid, where the membrane or internal volume has a particular geometric relationship to the active area.
摘要翻译：公开了用于生产它们的传感器和方法。在优选实施方案中，产生空腔并填充包含导电基质，酶，催化剂和粘合剂的试剂。空腔基本封闭，留下足够的开口以允许样品进入。围绕空腔的材料的一部分优选是可用于测量反应但不是试剂或样品的物质的透过性。具有锥体，锥形截头锥体，金字塔形截头锥体和右圆柱体的形状的腔体作为示例。其他系统包括包含传感器的活动区域并限定流体的内部体积的膜，其中膜或内部体积与活性区域具有特定的几何关系。

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