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1. 发明授权

US5116757A Mevalonic acid-producing microorganism 失效
标题翻译：生产微生物微生物
公开(公告)号：US5116757A
公开(公告)日：1992-05-26
申请号：US477572
申请日：1990-02-09
申请人： Haruyuki Yamashita , Teiyu Shimada , Hiromu Sugiyama
发明人： Haruyuki Yamashita , Teiyu Shimada , Hiromu Sugiyama
IPC分类号： C12N1/16 , C12P7/42 , C12P17/04 , C12P17/06 , C12R1/645
CPC分类号： C12R1/645 , C12P17/04 , C12P7/42 , Y10S435/911
摘要： A mevalonic acid-producing microorganism which belongs to Saccharomycopsis fibuligera and is resistant to ML-236B.

2. 发明授权

US5100789A Process for the production of mevalonic acid by a strain of Saccharomycopsis fibuligera 失效
标题翻译：通过烟草菌丝菌株生产甲酸的方法
公开(公告)号：US5100789A
公开(公告)日：1992-03-31
申请号：US475178
申请日：1990-02-05
申请人： Haruyuki Yamashita , Hiromu Sugiyama
发明人： Haruyuki Yamashita , Hiromu Sugiyama
IPC分类号： C12P7/42 , C12R1/645
CPC分类号： C12P7/42 , Y10S435/911
摘要： In the production of mevalonic acid by culturing a mevalonic acid-producing microorganism in a medium, at least peptone originating from casein and corn steep liquor are added to the medium. The content of said peptone ranges from 0.01 to 10% by weight in terms of dry matters, while that of the corn steep liquor ranges from 0.01 to 10% by weight in terms of dry matters.

3. 发明授权

US5480795A Curculin B and DNA encoding same, and process for production thereof 失效
标题翻译：姜黄素B和编码其的DNA及其生产方法
公开(公告)号：US5480795A
公开(公告)日：1996-01-02
申请号：US845592
申请日：1992-03-04
申请人： Yoshie Kurihara , Soichi Arai , Keiko Abe , Haruyuki Yamashita
发明人： Yoshie Kurihara , Soichi Arai , Keiko Abe , Haruyuki Yamashita
IPC分类号： C07K14/245 , A23L27/21 , A23L27/30 , A61K38/00 , C07K14/43 , C12N15/29 , C12P21/02 , C12P19/34
CPC分类号： C07K14/43 , A23L27/21 , A23L27/31 , A61K38/00
摘要： Essentially pure curculin B is disclosed. A process for producing curculin B, includes the steps of: culturing a transformed cell or microorganism containing a recombinant DNA containing a base sequence encoding curculin B, whereby curculin B is produced by the transformed cell or microorganism, and isolating curculin B from the transformed cell or microorganism. A DNA encoding mature or premature curculin B is also disclosed. DNA including a base sequence encoding curculin B, is produced by: separating a fraction containing a curculin B mRNA from Curculigo latifolia, preparing a single-stranded DNA from the mRNA using reverse transcriptase, preparing a double-stranded DNA from the single-stranded DNA, inserting the double-stranded DNA into a vector, transforming a host with the vector to produce a cDNA library, and isolating a cDNA encoding curculin B from the library, using one or more synthesized DNA's containing a base sequence coding for a partial amino acid sequence elucidated from curculin A purified from Curculigo latifolia, as a probe.
摘要翻译：本发明公开了纯的仙茅素B. 制备仙茅素B的方法包括以下步骤：培养含有含有编码仙人素B的碱基序列的重组DNA的转化细胞或微生物，由此由转化细胞或微生物产生仙茅素B，并从转化细胞中分离仙茅素B 或微生物。还公开了编码成熟或过早的仙人素B的DNA。包括编码仙人素B的碱基序列的DNA是通过以下步骤制备的：通过使用逆转录酶分离含有仙客来角质酪蛋白B mRNA的级分，使用逆转录酶从mRNA制备单链DNA，从单链DNA制备双链DNA 将双链DNA插入载体中，用载体转化宿主以产生cDNA文库，并使用一个或多个合成的DNA从文库中分离编码仙c素B的cDNA，该DNA含有编码部分氨基酸的碱基序列作为探针，从仙客来自仙客来的仙人素A中阐明。

4. 发明授权

US4701448A Metal salt of organic phosphate and an antihyperlipemic agent containing the same 失效
标题翻译：有机磷酸盐的金属盐和含有它的抗高血脂剂
公开(公告)号：US4701448A
公开(公告)日：1987-10-20
申请号：US823762
申请日：1986-01-29
申请人： Akira Endo , Haruyuki Yamashita
发明人： Akira Endo , Haruyuki Yamashita
IPC分类号： C07F9/09 , A61K31/66 , A61P3/06 , C07F9/117 , C07F5/06
CPC分类号： C07F9/117
摘要： A metal salt of an organic phosphate, having good stability and cholesterol-lowering activity, is produced by reacting a known compound ##STR1## wherein R.sub.4 and R.sub.5 are hydrogen or methyl, with a reaction agent such as metal hydroxide.
摘要翻译：具有良好的稳定性和降低胆固醇的活性的有机磷酸盐的金属盐通过其中R 4和R 5是氢或甲基的已知化合物＆lt; IMAGE＆gt;与反应剂如金属氢氧化物反应来制备。

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