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1. 发明申请

US20060094719A1 Tetralin histamine-3 receptor antagonists 审中-公开
标题翻译：四氮素组胺3受体拮抗剂
公开(公告)号：US20060094719A1
公开(公告)日：2006-05-04
申请号：US11256339
申请日：2005-10-21
申请人： Harry Howard , Mark Elliott
发明人： Harry Howard , Mark Elliott
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D209/44 , C07D211/22 , C07D211/32 , C07D211/36 , C07D211/58 , C07D211/62 , C07D211/76 , C07D213/61 , C07D239/26 , C07D295/096 , C07D307/22 , C07D307/52 , C07D401/04
摘要： This invention is directed to compounds of the formula I as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
摘要翻译：本发明涉及本文定义的式I化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用如上所述的式I化合物，以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神障碍，睡眠中的障碍或病症的方法疾病，肥胖，头晕，癫痫，晕车，呼吸系统疾病，过敏，过敏引起的气道反应，过敏性鼻炎，鼻充血，过敏充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动性和酸性分泌胃肠道，该方法包括向需要这种治疗的哺乳动物施用化合物我如上所述。

2. 发明申请

US20050154135A1 Toughened polymer compositions 有权
标题翻译：增韧的聚合物组合物
公开(公告)号：US20050154135A1
公开(公告)日：2005-07-14
申请号：US10754045
申请日：2004-01-08
申请人： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John Wood , John Andries
发明人： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John Wood , John Andries
IPC分类号： C08F8/00 , C08F8/50
CPC分类号： C08F8/50
摘要： Toughened thermoplastic compositions comprising a thermoplastic polymer toughened by the inclusion of a thermoplastic elastomer derived from a particulate rubber dynamically vulcanized in the presence of a matrix polymer. The toughened thermoplastic composition exhibits properties including toughness, improved impact resistance, and improved hardness. The compositions are utilized wherever toughened, high performance polymers are desired. A method for forming the toughened polymer compositions is also described. Processing methods, such as rotational molding, utilizing the toughened polymer compositions are described.
摘要翻译：增韧的热塑性组合物包含热塑性聚合物，所述热塑性聚合物通过包含衍生自在基体聚合物存在下动态硫化的颗粒状橡胶的热塑性弹性体而增韧。增韧的热塑性组合物具有包括韧性，改进的耐冲击性和改善的硬度的性能。组合物被用于任何增韧的地方，需要高性能聚合物。还描述了形成增韧的聚合物组合物的方法。描述了使用增韧的聚合物组合物的加工方法，例如旋转模塑。

3. 外观设计

USD431521S Personal watercraft 失效
公开(公告)号：USD431521S
公开(公告)日：2000-10-03
申请号：US112292
申请日：1999-10-13
申请人： Harry Howard , Tara Ann Howard
设计人： Harry Howard , Tara Ann Howard

4. 发明授权

US4073556A Rigid mobile cabinet for audio-visual aids 失效
标题翻译：刚性移动柜用于视听辅助
公开(公告)号：US4073556A
公开(公告)日：1978-02-14
申请号：US725239
申请日：1976-09-21
申请人： Harry Howard Wilson, Jr.
发明人： Harry Howard Wilson, Jr.
IPC分类号： A47B55/00 , A47B57/16 , A47B43/00
CPC分类号： A47B57/16 , A47B55/00 , Y10S248/917
摘要： A mobile utility cabinet for audio-visual aids, adaptable to house and transport video tape, recording, projection and like materials and equipment, and for use as a learning center, said cabinet having a plurality of removable and adjustable interior and exterior shelves and components, all supported by means formed integral with the walls of the cabinet and having vertically adjustable means for selectively supporting said audio-visual aids, the said cabinet being rigidly constructed and having means in its frame cooperating with said adjustable means to resist impact and damage during transport and storage.
摘要翻译：一种适用于房屋和运输录像带，记录，投影和类似材料和设备的视听设备的移动实用机柜，并用作学习中心，所述机柜具有多个可拆卸和可调节的内部和外部货架和部件所有这些装置都由与机柜壁形成一体的装置支撑，并且具有用于选择性地支撑所述视听辅助装置的垂直可调节装置，所述机壳刚性地构造并且具有在其框架中与所述可调节装置配合的装置，以抵抗在运输和存储。

5. 发明授权

US3930459A Indicator instrument assemblies 失效
标题翻译：指示器组件
公开(公告)号：US3930459A
公开(公告)日：1976-01-06
申请号：US410270
申请日：1973-10-26
申请人： John Harry Howard Barrow
发明人： John Harry Howard Barrow
IPC分类号： G01P1/08 , G01P1/12
CPC分类号： G01P1/08 , G01P1/122
摘要： A combined speedometer and tachograph assembly has speedometer and tachograph indicia respectively arranged at one and the other side of a translucent plate and respectively adapted to be illuminated by separate light sources at opposite sides of said plate, the light transmission capability of the plate being such that the speedometer indicia when viewed from said one side of the plate are visible by the reflection from the indicia of artificial or natural light incident from said one side, but the tachograph indicia are only rendered clearly visible by the transmission through the plate of light incident on the tachograph indicia from an artificial light source at the other side of the plate.
摘要翻译：组合的速度计和行车记录器组件具有分别布置在半透明板的一侧和另一侧的速度计和行车记录仪标记，并且分别适于由所述板的相对侧处的单独的光源照射，所述板的透光能力使得当从所述板的所述一侧观察时，速度计标记可以通过来自所述一侧入射的人造或自然光的标记的反射而可见，但是行进记录仪标记仅通过穿过板上的光的透射而变得清晰可见，来自板材另一侧的人造光源的行车记录仪标记。

6. 发明授权

US07557162B2 Toughened polymer compositions 有权
标题翻译：增韧的聚合物组合物
公开(公告)号：US07557162B2
公开(公告)日：2009-07-07
申请号：US10754045
申请日：2004-01-08
申请人： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
发明人： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
IPC分类号： C08L23/00 , C08L23/04 , C08L25/02 , C08L9/02 , C08L33/02 , C08L33/18
CPC分类号： C08F8/50
摘要： Toughened thermoplastic compositions comprising a thermoplastic polymer toughened by the inclusion of a thermoplastic elastomer derived from a particulate rubber dynamically vulcanized in the presence of a matrix polymer. The toughened thermoplastic composition exhibits properties including toughness, improved impact resistance, and improved hardness. The compositions are utilized wherever toughened, high performance polymers are desired. A method for forming the toughened polymer compositions is also described. Processing methods, such as rotational molding, utilizing the toughened polymer compositions are described.
摘要翻译：增韧的热塑性组合物包含热塑性聚合物，所述热塑性聚合物通过包含衍生自在基体聚合物存在下动态硫化的颗粒状橡胶的热塑性弹性体而增韧。增韧的热塑性组合物具有包括韧性，改进的耐冲击性和改善的硬度的性能。组合物被用于任何增韧的地方，需要高性能聚合物。还描述了形成增韧的聚合物组合物的方法。描述了使用增韧的聚合物组合物的加工方法，例如旋转模塑。

7. 发明授权

US07041741B2 Toughened polymer compositions 有权
公开(公告)号：US07041741B2
公开(公告)日：2006-05-09
申请号：US11030243
申请日：2005-01-06
申请人： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
发明人： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
IPC分类号： C08F8/00 , C08L9/00 , C08L23/00 , C08L23/04 , C08L25/02 , C08L33/02 , C08L33/18 , C08L33/20
CPC分类号： C08F8/50
摘要： Toughened thermoplastic compositions comprising a thermoplastic polymer toughened by the inclusion of a thermoplastic elastomer derived from a particulate rubber dynamically vulcanized in the presence of a matrix polymer. The toughened thermoplastic composition exhibits properties including toughness, improved impact resistance, and improved hardness. The compositions are utilized wherever toughened, high performance polymers are desired. A method for forming the toughened polymer compositions is also described. Processing methods, such as rotational molding, utilizing the toughened polymer compositions are described.

8. 发明申请

US20050282811A1 Diazabicyclic histamine-3 receptor antagonists 审中-公开
标题翻译：二氮杂双环组胺3受体拮抗剂
公开(公告)号：US20050282811A1
公开(公告)日：2005-12-22
申请号：US11152273
申请日：2005-06-14
申请人： Harry Howard , Bishop Wlodecki
发明人： Harry Howard , Bishop Wlodecki
IPC分类号： A61K31/498 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04
摘要： This invention is directed to compounds of the formula I and II as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I or II, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I or II as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I or II as described above.
摘要翻译：本发明涉及如本文所定义的式I和II的化合物或其药学上可接受的盐; 含有式I或II化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用式I或II化合物以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意力缺陷多动障碍（ADHD）过敏反应，过敏性鼻炎，鼻充血，过敏性充血，充血，低血压，心血管疾病，胃肠道疾病，过氧化物酶，过氧化物酶胃肠道的运动不足和酸性分泌，所述方法包括向需要这种治疗的哺乳动物施用com 磅如式I或II所述。

9. 发明申请

US20050182049A1 Combination of gamma-aminobutyric acid modulators and 5-HT1B receptor antagonists 审中-公开
标题翻译： γ-氨基丁酸调节剂和5-HT1B受体拮抗剂的组合
公开(公告)号：US20050182049A1
公开(公告)日：2005-08-18
申请号：US11046974
申请日：2005-01-31
申请人： Harry Howard
发明人： Harry Howard
IPC分类号： A61K31/195 , A61K31/197 , A61K31/541 , A61K45/06
CPC分类号： A61K31/195 , A61K31/197 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition for treating a disorder or condition selected from the group consisting of hypertension, depression, generalized anxiety disorder, phobias, posttraumatic stress disorder, avoidant personality disorder, sexual dysfunction, eating disorders, obesity, chemical dependencies, cluster headache, migraine, pain, Alzheimer's disease, obsessive-compulsive disorder, panic disorder, memory disorders, Parkinson's diseases, endocrine disorders, cerebellar atazia, gastrointestinal tract disorders, negative symptoms of schizophrenia, premenstrual syndrome, Fibromyalgia Syndrome, stress incontinence, Tourette syndrome, trichotillomania, kleptomania, male impotence, cancer, chronic paroxysmal hemicrania and headache in a mammal, preferably a human, comprising (i) a γ-aminobutyric acid modulator or a pharmaceutically acceptable salt thereof, (ii) a 5-HT1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally (iii) a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及一种用于治疗选自高血压，抑郁症，广泛性焦虑症，恐惧症，创伤后应激障碍，避孕人格障碍，性功能障碍，进食障碍，肥胖，化学依赖性，集群头痛，偏头痛，疼痛，阿尔茨海默病，强迫症，惊恐障碍，记忆障碍，帕金森病，内分泌失调，小脑阿扎西亚，胃肠道疾病，精神分裂症阴性症状，经前综合征，纤维肌痛综合征，压力性尿失禁，图雷特综合征，哺乳动物，优选人类的头痛，恐怖症，男性阳ence，癌症，慢性阵发性高血压和头痛，包括（i）γ-氨基丁酸调节剂或其药学上可接受的盐，（ii）5-HT 1B 受体拮抗剂或其药学上可接受的盐，其中 5-HT 1B 1受体拮抗剂选自（A）如说明书中所述的式I化合物和（B）如说明书中所述的式II化合物，和任选地（iii）药学上可接受的载体。

10. 发明授权

US2120610A Counter display stand 失效
标题翻译：计数器显示架
公开(公告)号：US2120610A
公开(公告)日：1938-06-14
申请号：US8888336
申请日：1936-07-03
申请人： HARRY HOWARD EUGENE
发明人： HARRY HOWARD EUGENE
IPC分类号： A47F7/28
CPC分类号： A47F7/281 , Y10S206/821

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