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1. 发明授权

US08841430B2 Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权
标题翻译：在神经元确定的细胞中使用调节序列用于特异性，瞬时表达
公开(公告)号：US08841430B2
公开(公告)日：2014-09-23
申请号：US12894766
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元测定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异的早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

2. 发明授权

US08815505B2 Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权
标题翻译：在神经元确定的细胞中使用调节序列用于特异性，瞬时表达
公开(公告)号：US08815505B2
公开(公告)日：2014-08-26
申请号：US12894884
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

3. 发明授权

US07947448B2 Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权
标题翻译：在神经元确定的细胞中使用调节序列用于特异性，瞬时表达
公开(公告)号：US07947448B2
公开(公告)日：2011-05-24
申请号：US12209974
申请日：2008-09-12
申请人： Sebastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sebastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C12Q1/68 , A01K67/027 , C12N5/06
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

4. 发明申请

US20110020790A1 USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS 有权
标题翻译：神经元测定细胞中特异性，瞬时表达的调节序列的使用
公开(公告)号：US20110020790A1
公开(公告)日：2011-01-27
申请号：US12894884
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

5. 发明申请

US20090170099A1 Use of Regulatory Sequences for Specific, Transient Expression in Neuronal Determined Cells 有权
标题翻译：在神经元确定的细胞中使用调节序列用于特异性，瞬时表达
公开(公告)号：US20090170099A1
公开(公告)日：2009-07-02
申请号：US12209974
申请日：2008-09-12
申请人： Sebastien COUILLARD-DESPRES , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sebastien COUILLARD-DESPRES , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C12Q1/68 , A01K67/027 , C12N5/06
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

6. 发明申请

US20110016547A1 USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS 有权
标题翻译：神经元测定细胞中特异性，瞬时表达的调节序列的使用
公开(公告)号：US20110016547A1
公开(公告)日：2011-01-20
申请号：US12894766
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： A61K48/00 , C07H21/04 , C12N5/10 , C12N15/09 , A01K67/027 , C12N15/63 , A61K35/12 , C12Q1/68 , A61P35/00
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元测定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异的早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

7. 发明授权

US3935355A Wrapping material 失效
标题翻译：包装材料
公开(公告)号：US3935355A
公开(公告)日：1976-01-27
申请号：US317056
申请日：1972-12-20
申请人： Hans Georg Kuhn
发明人： Hans Georg Kuhn
IPC分类号： A61D9/00 , A61F5/058 , A61F13/00 , A61F13/04 , A61L15/07 , A61L27/14 , A61L27/18 , A61L27/40 , E04C2/20 , E04G23/02 , B32B3/10
CPC分类号： E04G23/02 , A61F13/00029 , A61F13/00059 , A61L15/07 , A61L27/14 , A61L27/18 , A61L27/40 , B29C70/08 , E04C2/20 , A61F2013/00119 , A61F2013/00182 , A61F2013/00251 , A61F2013/00846 , A61F2013/00859 , Y10S428/913 , Y10T24/4634 , Y10T24/505 , Y10T403/472 , Y10T428/24331 , Y10T428/24446 , Y10T428/249923
摘要： An elongated wrapper which is initially flexible and which, when wrapped around one or more bodies, is adapted to be stretched and assume a substantially rigid condition. The wrapper has an outer, elongated, tubular, elastic envelope assembly which is of a generally flat cross section and which is adapted to surround one or more bodies while being longitudinally stretched and wrapped around the bodies. This envelope assembly has an inner surface carrying one of a pair of materials which, when they combine, react to assume a hardened condition. The other of these materials is situated in the interior of the envelope assembly and is separated from the one of the pair of materials by a separating layer structure which is located in the envelope assembly between the pair of materials separating them from each other to prevent them from combining. This separating layer assembly has the property of responding to the longitudinal stretching of the envelope assembly when the latter is wrapped around one or more bodies to assume a non-separating condition placing the materials in contact with each other so that they will then combine to assume the hardened condition.
摘要翻译：最初是柔性的并且当被缠绕在一个或多个主体周围的细长包装件适于被拉伸并呈现基本刚性的状况。包装物具有外部细长的管状弹性包络组件，其具有大致平坦的横截面并且适于围绕一个或多个身体，同时被纵向拉伸并缠绕在身体周围。该包络组件具有承载一对材料之一的内表面，当它们组合时，该表面反应以呈现硬化状态。这些材料中的另一个位于信封组件的内部，并且通过分离层结构与一对材料中的一个分离，分离层结构位于一对材料之间的封套组件中，以将它们彼此分开以防止它们从组合。当分离层组件缠绕在一个或多个主体上时，该分离层组件具有响应于包络组件的纵向拉伸的性质，以呈现将材料彼此接触的非分离条件，使得它们将组合起来呈现硬化条件。

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