专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100015243A1 METHOD FOR PREPARING MATERIALS HAVING ANTITHROMBOTIC ACTIVITY FROM MUSKRAT MUSK AND MATERIALS OBTAINED FROM THE METHOD 审中-公开
标题翻译：从MUSKRAT MUSK制备具有抗菌活性的材料的方法和从该方法获得的材料
公开(公告)号：US20100015243A1
公开(公告)日：2010-01-21
申请号：US12519342
申请日：2007-12-17
申请人： Keun Ki Kim , Han Seok Kang , Yong Ju Choi , Teak Sooki Shin , Seon Ku Kim , Jae Ho Lee , Yong Gyun Kim , Sang Yoon Jeon
发明人： Keun Ki Kim , Han Seok Kang , Yong Ju Choi , Teak Sooki Shin , Seon Ku Kim , Jae Ho Lee , Yong Gyun Kim , Sang Yoon Jeon
IPC分类号： A61K35/55
CPC分类号： A61K35/12 , A61K35/48
摘要： Disclosed herein is a method of preparing an antithrombotic agent from muskrat musk and an antithrombotic agent having a high potency obtained therefrom, wherein the antithrombotic agent is prepared by treating muskrat musk with ethanol to obtain an ethanol extract; carrying out two normal phase column chromatographies while raising the combination ratio of hexane and ethyl acetate to obtain numerous fractions; carrying out thin layer chromatographies and identifying the material patterns of the fractions with UV lamps and 10% sulfuric acid to divide the materials which have a similar moving distance into groups; measuring a thrombin time of each group to isolate a group having a potent antithrombotic activity; carrying out a reverse phase column chromatography while raising the combination ratio of acetonitrile and water to obtain numerous fractions; and isolating an antithrombotic agent material having a high potency therefrom. According to the present invention which provides an antithrombotic agent having a high potency from muskrat musk, the value added of muskrat musk is raised.
摘要翻译：本文公开了一种从麝香麝香制备抗血栓形成剂的方法和由其获得的高效力的抗血栓形成剂，其中通过用乙醇处理麝香麝香得到乙醇提取物制备抗血栓形成剂; 进行两个正相柱色谱，同时提高己烷和乙酸乙酯的组合比例，得到许多级分; 进行薄层色谱，并用UV灯和10％硫酸鉴定级分的材料图案，将具有相似移动距离的材料分成组; 测量每组的凝血酶时间以分离具有有效抗血栓形成活性的组; 进行反相柱色谱，同时提高乙腈和水的组合比例，得到许多级分; 并从其中分离具有高效力的抗血栓形成剂材料。根据本发明，提供了具有麝香麝香的高效力的抗血栓形成剂，提高了麝香麝香的添加量。

IPRDB

热门服务

关于我们

友情链接

联系方式