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1. 发明授权

US5576200A Process for production of avermectin aglycones and cultures therefor 失效
标题翻译：生产除虫菌素糖苷配基及其培养物的方法
公开(公告)号：US5576200A
公开(公告)日：1996-11-19
申请号：US323479
申请日：1994-10-14
申请人： Lapyuen Lam , Hamish A. I. McArthur , Richard G. Wax
发明人： Lapyuen Lam , Hamish A. I. McArthur , Richard G. Wax
IPC分类号： C12P17/18 , C12N1/20
CPC分类号： C12R1/465 , C12P17/181
摘要： Mutants of Streptomyces avermitilis lacking ability to produce glycosylated avermectins and lacking branched-chain 2-oxo acid dehydrogenase activity, method for preparation thereof, and use thereof to produce natural and non-natural avermectin aglycones useful as parasiticides.
摘要翻译：阿维链霉菌链霉菌的突变体缺乏产生糖基化阿维菌素并缺乏支链2-氧代酸脱氢酶活性的能力，其制备方法及其用于制备可用作杀寄生虫剂的天然和非天然除虫菌素糖苷配基。

2. 发明授权

US5240850A Cultures for production of avermectin aglycones 失效
标题翻译：用于生产除虫菌素糖苷配基的培养物
公开(公告)号：US5240850A
公开(公告)日：1993-08-31
申请号：US660972
申请日：1991-02-26
申请人： Lapyuen H. Lam , Hamish A. I. McArthur , Richard G. Wax
发明人： Lapyuen H. Lam , Hamish A. I. McArthur , Richard G. Wax
IPC分类号： C12P17/18
CPC分类号： C12R1/465 , C12P17/181
摘要： Mutants of Streptomyces avermitilis lacking ability to produce glycosylated avermectins and lacking branched-chain 2-oxo acid dehydrogenase activity, method for preparation thereof, and use thereof to produce natural and non-natural avermectin aglycones useful as parasiticides.
摘要翻译：阿维链霉菌链霉菌的突变体缺乏产生糖基化阿维菌素并缺乏支链2-氧代酸脱氢酶活性的能力，其制备方法及其用于制备可用作杀寄生虫剂的天然和非天然除虫菌素糖苷配基。

3. 发明授权

US07229615B2 Method for the purification, recovery, and sporulation of cysts and oocysts 有权
标题翻译：囊肿和卵囊的净化，恢复和孢子形成的方法
公开(公告)号：US07229615B2
公开(公告)日：2007-06-12
申请号：US11248552
申请日：2005-10-12
申请人： Harold N. Conkle , Joseph E. Schultz , Scott J. Blonigen , Fred H. Weber , David R. Kilanowski , Bruce Monzyk , Timothy M. Werner , Chad M. Cucksey , Hamish A. I. McArthur , Ted L. Tewksbury
发明人： Harold N. Conkle , Joseph E. Schultz , Scott J. Blonigen , Fred H. Weber , David R. Kilanowski , Bruce Monzyk , Timothy M. Werner , Chad M. Cucksey , Hamish A. I. McArthur , Ted L. Tewksbury
IPC分类号： A61K63/00 , C12N1/00 , C12N1/10
CPC分类号： A61K39/012 , C12N1/10 , Y10S435/947
摘要： A vaccine for in ovo vaccination against avian coccidiosis produced by a method including obtaining the coccidial oocysts from a fecal suspension, homogenizing the fecal suspension, separating the oocysts from the fecal debris by either salt flotation using sodium sulfate or gas flotation using air, sporulating the oocysts using hydrogen peroxide and air sparging, bleaching the sporulated oocysts, washing the bleached oocysts, concentrating the sterile washed oocysts and combining the concentrates of various species of coccidial oocysts, and producing a vaccine. The method in whole or in part can be applied to other kinds of encysted protozoa to produce vaccines for various types of animals.
摘要翻译：一种用于通过包括从粪便悬浮液获得球虫卵囊，粪便悬浮液均质化，通过使用硫酸钠的盐浮选或使用空气气浮法从粪便碎片中分离卵囊的方法产生的针对禽类球虫病的疫苗的疫苗，使用过氧化氢和空气喷射的卵囊，漂白孢子化的卵囊，洗涤漂白的卵囊，浓缩无菌洗涤的卵囊并组合各种球虫卵囊的浓缩物，并生产疫苗。该方法全部或部分可应用于其他类型的包囊原生动物，以生产各种类型动物的疫苗。

4. 发明授权

US5776735A Process for dienone macrolides 失效
标题翻译：二烯酮大环内酯类的方法
公开(公告)号：US5776735A
公开(公告)日：1998-07-07
申请号：US744474
申请日：1996-11-06
申请人： Claudio D. Denoya , Edmund W. Hafner , Hamish A. I. McArthur
发明人： Claudio D. Denoya , Edmund W. Hafner , Hamish A. I. McArthur
IPC分类号： C12N15/00 , C07H17/08 , C12N1/20 , C12N9/08 , C12N15/01 , C12N15/53 , C12N15/74 , C12P19/62 , C12R1/29
CPC分类号： C07H17/08 , C12N15/74 , C12N9/0065 , C12P19/62 , C12R1/29
摘要： The process of this invention is directed to isolating or otherwise obtaining an olefinic macrolide producing microorganism which microorganism does not contain epoxidase enzyme activity. This invention also relates to a process for preparing said olefinic macrolide by fermenting a mutant microorganism lacking epoxidase activity, designated rosX herein, which mutant is obtained from the wild-type microorganism. This invention also relates to a rosX mutant of Micromonospora rosaria, and to any microorganism having the identifying characteristics thereof, said mutant also designated ATCC 55709. This invention also relates to a process for preparing repromicin, the compound of formula (II), ##STR1## by mutating a wild-type microorganism capable of producing rosamicin to produce a mutant microorganism lacking epoxidase activity such that repromicin is produced by said mutant microorganism.
摘要翻译：本发明的方法涉及分离或以其它方式获得微生物不含有环氧酶酶活性的烯烃大环内酯生产微生物。本发明还涉及一种通过发酵缺少环氧酶活性的突变体微生物制备所述烯烃大环内酯的方法，本文命名为rosX，该突变体获自野生型微生物。本发明还涉及Roson突变体和具有鉴定特征的任何微生物，所述突变体也称为ATCC 55709.本发明还涉及一种制备repromicin，式（II）化合物，IMAGE （II）通过突变能够产生罗素霉素的野生型微生物来产生缺少环氧酶活性的突变微生物，使得所述突变微生物产生repromicin。

5. 发明授权

US5583029A Cultures for production of avermectin aglycones 失效
标题翻译：用于生产除虫菌素糖苷配基的培养物
公开(公告)号：US5583029A
公开(公告)日：1996-12-10
申请号：US323247
申请日：1994-10-14
申请人： Lapyuen H. Lam , Hamish A. I. McArthur , Richard G. Wax
发明人： Lapyuen H. Lam , Hamish A. I. McArthur , Richard G. Wax
IPC分类号： C12P17/18 , C12N1/20 , C12N15/00
CPC分类号： C12R1/465 , C12P17/181
摘要： Mutants of Streptomyces avermitilis lacking ability to produce glycosylated avermectins and lacking branched-chain 2-oxo acid dehydrogenase activity, method for preparation thereof, and use thereof to produce natural and non-natural avermectin aglycones useful as parasiticides.
摘要翻译：阿维链霉菌链霉菌的突变体缺乏产生糖基化阿维菌素并缺乏支链2-氧代酸脱氢酶活性的能力，其制备方法及其用于制备可用作杀寄生虫剂的天然和非天然除虫菌素糖苷配基。

6. 发明授权

US06984378B1 Method for the purification, recovery, and sporulation of cysts and oocysts 有权
公开(公告)号：US06984378B1
公开(公告)日：2006-01-10
申请号：US09701760
申请日：2000-02-25
申请人： Harold N. Conkle , Joseph E. Schultz , Scott J. Blonigen , Fred H. Weber , David R. Kilanowski , Bruce Monzyk , Timothy M. Werner , Chad M. Cucksey , Hamish A. I. McArthur , Ted L. Tewksbury
发明人： Harold N. Conkle , Joseph E. Schultz , Scott J. Blonigen , Fred H. Weber , David R. Kilanowski , Bruce Monzyk , Timothy M. Werner , Chad M. Cucksey , Hamish A. I. McArthur , Ted L. Tewksbury
IPC分类号： A61K63/00 , C12N1/00 , C12N1/10
CPC分类号： A61K39/012 , C12N1/10 , Y10S435/947
摘要： A vaccine for in ovo vaccination against avian coccidiosis produced by a method including obtaining the coccidial oocysts from a fecal suspension, homogenizing the fecal suspension, separating the oocysts from the fecal debris by either salt flotation using sodium sulfate or gas flotation using air, sporulating the oocysts using hydrogen peroxide and air sparging, bleaching the sporulated oocysts, washing the bleached oocysts, concentrating the sterile washed oocysts and combining the concentrates of various species of coccidial oocysts, and producing a vaccine. The method in whole or in part can be applied to other kinds of encysted protozoa to produce vaccines for various types of animals.

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