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1. 发明授权

US08986651B2 Compounds with reduced ring size for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same 有权
标题翻译：用于诊断和治疗黑素瘤，包括转移性黑色素瘤的环尺寸减小的化合物及其相关方法
公开(公告)号：US08986651B2
公开(公告)日：2015-03-24
申请号：US13497738
申请日：2010-11-30
申请人： Yubin Miao , Haixun Guo
发明人： Yubin Miao , Haixun Guo
IPC分类号： A61K51/00 , A61M36/14 , A61K51/08 , A61K38/00
CPC分类号： C07K14/68 , A61K38/00 , A61K45/06 , A61K51/08 , A61K51/086 , A61K51/088 , C07K7/54
摘要： The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于成像癌症的新型非侵入性诊断工具/化合物，特别是黑素瘤，包括体内转移性黑素瘤。本发明化合物在癌细胞和组织中表现出增强的摄取，并且减少了肾中的肾摄取，证明了本发明化合物的有利的药代动力学。根据本发明的化合物代表使用非侵入性分子成像技术在黑色素瘤的诊断和治疗中的进展，包括转移性黑素瘤。本发明的新型探针也可用于开始黑色素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

2. 发明申请

US20120225016A1 COMPOUNDS WITH REDUCED RING SIZE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME 有权
标题翻译：具有减少环尺寸的化合物用于诊断和治疗MELANOMA，包括METASTATIC MELANOMA及其相关方法
公开(公告)号：US20120225016A1
公开(公告)日：2012-09-06
申请号：US13497738
申请日：2010-11-30
申请人： Yubin Miao , Haixun Guo
发明人： Yubin Miao , Haixun Guo
IPC分类号： A61K51/08 , A61P35/00 , A61P35/04 , C07K14/68
CPC分类号： C07K14/68 , A61K38/00 , A61K45/06 , A61K51/08 , A61K51/086 , A61K51/088 , C07K7/54
摘要： The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于成像癌症的新型非侵入性诊断工具/化合物，特别是黑素瘤，包括体内转移性黑素瘤。本发明化合物在癌细胞和组织中表现出增强的摄取，并且减少了肾中的肾摄取，证明了本发明化合物的有利的药代动力学。根据本发明的化合物代表使用非侵入性分子成像技术在黑色素瘤的诊断和治疗中的进展，包括转移性黑素瘤。本发明的新型探针也可用于开始黑色素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

3. 发明授权

US09393330B2 Compounds for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same 有权
标题翻译：用于诊断和治疗黑素瘤的化合物，包括转移性黑素瘤及与其相关的方法
公开(公告)号：US09393330B2
公开(公告)日：2016-07-19
申请号：US14067064
申请日：2013-10-30
申请人： Yubin Miao , Haixun Guo
发明人： Yubin Miao , Haixun Guo
IPC分类号： A61K49/00 , A61K51/08 , C07K14/685 , G01N33/574 , G01N33/60
CPC分类号： A61K51/088 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K45/06 , C07K14/685 , G01N33/5743 , G01N33/60
摘要： The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

4. 发明授权

US08603435B2 Compounds and methods for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same 有权
标题翻译：用于诊断和治疗黑素瘤的化合物和方法，包括转移性黑素瘤及与其相关的方法
公开(公告)号：US08603435B2
公开(公告)日：2013-12-10
申请号：US12811946
申请日：2009-01-12
申请人： Yubin Miao , Haixun Guo
发明人： Yubin Miao , Haixun Guo
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/088 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K45/06 , C07K14/685 , G01N33/5743 , G01N33/60
摘要： The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. The present invention represents a step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。本发明代表使用非侵入性分子成像技术在黑色素瘤的诊断和治疗中包括转移性黑素瘤的进展。本发明的新型探针也可用于引发黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

5. 发明申请

US20110033380A1 COMPOUNDS AND METHODS FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME 有权
标题翻译：用于诊断和治疗MELANOMA的化合物和方法，包括METASTATIC MELANOMA及其相关方法
公开(公告)号：US20110033380A1
公开(公告)日：2011-02-10
申请号：US12811946
申请日：2009-01-12
申请人： Yubin Mlao , Haixun Guo
发明人： Yubin Mlao , Haixun Guo
IPC分类号： A61K51/08 , C07K7/52
CPC分类号： A61K51/088 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K45/06 , C07K14/685 , G01N33/5743 , G01N33/60
摘要： The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

6. 发明申请

US20140147385A1 COMPOUNDS FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME 有权
标题翻译：用于诊断和治疗MELANOMA的化合物，包括METASTATIC MELANOMA及其相关方法
公开(公告)号：US20140147385A1
公开(公告)日：2014-05-29
申请号：US14067064
申请日：2013-10-30
申请人： Yubin Miao , Haixun Guo
发明人： Yubin Miao , Haixun Guo
IPC分类号： A61K51/08
CPC分类号： A61K51/088 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K45/06 , C07K14/685 , G01N33/5743 , G01N33/60
摘要： The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

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