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1. 发明授权

US09194801B2 Systems and methods for a DNA-based thermometer 有权
标题翻译：基于DNA的温度计的系统和方法
公开(公告)号：US09194801B2
公开(公告)日：2015-11-24
申请号：US13595106
申请日：2012-08-27
申请人： Kenneth L. Shepard , Ioannis Kymissis , Haig Norian
发明人： Kenneth L. Shepard , Ioannis Kymissis , Haig Norian
IPC分类号： G01N25/00 , G01N21/64 , B01J19/00 , G01K11/20
CPC分类号： G01N21/6486 , B01J19/0046 , G01K11/20 , G01K2213/00 , G01N21/6428
摘要： DNA-based temperature sensor for measuring temperature through a transition of one or more strands of DNA from a coupled configuration to a decoupled configuration at a temperature threshold, and a fluorescent dye adapted to emit fluorescence when the DNA is in the coupled configuration, includes a receptacle adapted to receive the DNA and the fluorescent dye in a solution, an imaging device adapted to acquire an image of fluorescence emitted from the solution, the image having a plurality of regions, and a processor adapted to determine a plurality of fluorescence levels corresponding to each of the plurality of regions of the image and to generate a temperature map based on the determined fluorescence levels. A method for measuring temperature and a DNA-based temperature sensing solution are also provided.
摘要翻译：基于DNA的温度传感器，用于通过一个或多个DNA链从温度阈值的耦合配置转变为解耦配置来测量温度，以及当DNA处于耦合配置时适于发射荧光的荧光染料包括：适于在溶液中接收DNA和荧光染料的容器，适于获取从溶液发射的荧光图像的成像装置，具有多个区域的图像，以及适于确定对应于多个区域的多个荧光水平的处理器每个图像的多个区域，并且基于所确定的荧光水平生成温度图。还提供了一种测量温度的方法和基于DNA的温度感测解决方案。

2. 发明申请

US20130224879A1 SYSTEMS AND METHODS FOR A DNA-BASED THERMOMETER 有权
标题翻译：一种基于DNA的温度计的系统和方法
公开(公告)号：US20130224879A1
公开(公告)日：2013-08-29
申请号：US13595106
申请日：2012-08-27
申请人： Kenneth L. Shepard , Ioannis Kymissis , Haig Norian
发明人： Kenneth L. Shepard , Ioannis Kymissis , Haig Norian
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , B01J19/0046 , G01K11/20 , G01K2213/00 , G01N21/6428
摘要： DNA-based temperature sensor for measuring temperature through a transition of one or more strands of DNA from a coupled configuration to a decoupled configuration at a temperature threshold, and a fluorescent dye adapted to emit fluorescence when the DNA is in the coupled configuration, includes a receptacle adapted to receive the DNA and the fluorescent dye in a solution, an imaging device adapted to acquire an image of fluorescence emitted from the solution, the image having a plurality of regions, and a processor adapted to determine a plurality of fluorescence levels corresponding to each of the plurality of regions of the image and to generate a temperature map based on the determined fluorescence levels. A method for measuring temperature and a DNA-based temperature sensing solution are also provided.
摘要翻译：基于DNA的温度传感器，用于通过一个或多个DNA链从温度阈值的耦合配置转变为解耦配置来测量温度，以及当DNA处于耦合配置时适于发射荧光的荧光染料包括：适于在溶液中接收DNA和荧光染料的容器，适于获取从溶液发射的荧光图像的成像装置，具有多个区域的图像，以及适于确定对应于多个区域的多个荧光水平的处理器每个图像的多个区域，并且基于所确定的荧光水平生成温度图。还提供了一种测量温度的方法和基于DNA的温度感测解决方案。

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