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1. 发明申请

US20060166934A1 Composition comprising phytosphingosine derivatives for apoptosis induction 审中-公开
标题翻译：包含用于凋亡诱导的植物鞘氨醇衍生物的组合物
公开(公告)号：US20060166934A1
公开(公告)日：2006-07-27
申请号：US10524562
申请日：2002-10-08
申请人： Tae-Yoon Kim , Hye-Jung Kim , Shin-Hee Kim , Ha-Young Hwang
发明人： Tae-Yoon Kim , Hye-Jung Kim , Shin-Hee Kim , Ha-Young Hwang
IPC分类号： A61K31/685 , A61K31/59
CPC分类号： A61K31/59 , A61K8/68 , A61K31/164 , A61K31/685 , A61Q19/08 , A61K2300/00
摘要： The present invention is related to compositions for the induction of apoptosis containing phytosphingosine derivatives as effective components. The present invention is related to compositions for the induction of apoptosis containing Vit D3 or calcipotriol as an effective component in addition to phytosphingosine derivatives. The compositions of the present invention include pharmaceutical compositions or cosmetic compositions having an activity to induce apoptosis. The present invention offers a method of prevention or treatment of various skin diseases, various tumors, various cancers, etc. that may be prevented or cured by the induction of the activity of apoptosis in living bodies, which is comprised of the steps of administration of compositions for the induction of apoptosis containing phytosphingosine derivatives as effective components and irradiation of UVB to psoriatic lesions. Therefore, the compositions of the present invention are useful for the prevention or treatment of various skin diseases, various tumors, various cancers, etc. that may be prevented or cured by the induction of the activity of apoptosis in living bodies.
摘要翻译：本发明涉及含有植物鞘氨醇衍生物作为有效成分的诱导凋亡的组合物。本发明涉及除了植物鞘氨醇衍生物外，含有维生素D3或卡泊三醇作为有效成分的诱导凋亡的组合物。本发明的组合物包括具有诱导凋亡活性的药物组合物或化妆品组合物。本发明提供了通过诱导活体细胞凋亡活性可以预防或治愈各种皮肤疾病，各种肿瘤，各种癌症等的方法，其包括以下步骤：施用用于诱导含有植物鞘氨醇衍生物的凋亡作为有效成分并将UVB照射到牛皮癣病变的组合物。因此，本发明的组合物可用于预防或治疗可通过诱导活体中细胞凋亡活性而预防或治愈的各种皮肤疾病，各种肿瘤，各种癌症等。

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