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1. 发明授权

US08314283B2 Medical wraps 有权
标题翻译：医疗包装
公开(公告)号：US08314283B2
公开(公告)日：2012-11-20
申请号：US10738847
申请日：2003-12-16
申请人： Howard A. Kingsford , Holly Isabelle , George A. Provost , William H. Shepard
发明人： Howard A. Kingsford , Holly Isabelle , George A. Provost , William H. Shepard
IPC分类号： A61F13/00 , A61F7/00
CPC分类号： A61B5/6833 , A61B5/02233 , A61F13/00063 , A61F13/00987 , A61F13/0273 , A61F13/06 , A61F13/62 , A61F15/006 , A61F2013/00187 , A61F2013/00429 , B29C2043/465 , B29L2031/729 , F42B3/087 , F42D3/02 , Y10T156/1084
摘要： A medical wrap includes a flexible, sheet-form substrate with a discrete medical function delivery region having a surface adapted to be placed against a patient's skin to provide a desired medical effect. The substrate carries a field of fibers exposed on one side thereof for engagement by fastener elements, and an array of fastener elements extending from a side of the substrate opposite the exposed fibers. The fastener elements each have a respective stem extending integrally from a film of resin disposed in a band across the substrate and encapsulating surface features of the substrate. The fastener elements are constructed to snag the exposed fibers when the substrate is wrapped about a patient in an overlapping manner, to secure the wrap about the patient with the medical function delivery region in a desired position. The wrap is useful as a hot or cold pack, medical dressing or drug delivery device.
摘要翻译：医疗包装包括具有离散医疗功能递送区域的柔性片状基底，该区域具有适于放置在患者皮肤上以提供期望的医疗效果的表面。衬底承载在其一侧上露出用于由紧固件元件接合的纤维场，以及从衬底的与暴露的纤维相对的一侧延伸的紧固件元件阵列。紧固元件各自具有从设置在带中的树脂膜整体延伸穿过基底并且封装基底的表面特征的相应的杆。紧固件元件构造成当衬底以重叠的方式缠绕在患者周围时将暴露的纤维缠绕在一起，以将患者的包裹物固定在期望位置的医疗功能递送区域。包装可用作热或冷包装，医疗敷料或药物递送装置。

2. 发明授权

US07785691B2 Flexible building construction laminates with fasteners 有权
标题翻译：具有紧固件的柔性建筑结构层压板
公开(公告)号：US07785691B2
公开(公告)日：2010-08-31
申请号：US10524881
申请日：2003-08-20
申请人： William H. Shepard , George A. Provost
发明人： William H. Shepard , George A. Provost
IPC分类号： B32B3/06 , B32B9/00
CPC分类号： B32B7/08 , A44B18/0049 , A44B18/0069 , A47G27/0468 , B29C2043/465 , B29L2031/729 , B32B5/022 , B32B5/06 , B32B7/06 , B32B7/12 , B32B29/02 , B32B2250/02 , B32B2260/021 , B32B2260/028 , B32B2260/046 , B32B2307/3065 , B32B2307/748 , B32B2307/75 , B32B2317/122 , B32B2471/00 , B32B2471/04 , E04F13/0882 , E04F15/02038 , E04F15/02138 , E04F2201/0107 , Y10T428/24008 , Y10T428/24017 , Y10T428/24025 , Y10T428/24033 , Y10T442/494 , Y10T442/659 , Y10T442/693
摘要： A material for covering a surface of a home or building is provided in the form of a flexible laminate having a fastening side comprising a sheet-form fastener component, and an opposite side formed by a sheet of paper laminated to the fastener component to increase the dimensional stability of the fastener component for covering and fastening over a wide area. The fastener component can have either hooks or loops. The laminate is particularly useful for laying flooring with low backlash between adjacent pieces.
摘要翻译：提供了一种用于覆盖家庭或建筑物的表面的材料，其形式为具有紧固侧的柔性层压体，该紧固侧包括片状紧固件部件，以及由叠置在紧固件部件上的一张纸形成的相对侧，以增加紧固件部件的尺寸稳定性用于在广泛的区域上覆盖和紧固。紧固件组件可以具有钩或环。层压板特别适用于在相邻件之间铺设低间隙的地板。

3. 发明授权

US07499879B2 Cooperative e-business complex 有权
标题翻译：合作电子商务综合体
公开(公告)号：US07499879B2
公开(公告)日：2009-03-03
申请号：US10060996
申请日：2002-01-30
申请人： Bryan E. Aupperle , Sajan K. Sankaran , Spencer H Shepard, IV , Yih-Shin Tan
发明人： Bryan E. Aupperle , Sajan K. Sankaran , Spencer H Shepard, IV , Yih-Shin Tan
IPC分类号： G06Q30/00
CPC分类号： G06Q10/10 , G06Q20/207 , G06Q30/06 , G06Q30/0619 , G06Q30/0635 , G06Q30/0643
摘要： A cooperative e-business complex. The cooperative e-business complex can include one or more electronically accessible e-business complex management services configured to handle e-business processing in the e-business complex on behalf of electronically associated virtual store operators, vendors, business partners and professional services providers. A virtual management office can be included which is configured to coordinate e-business transactions between the associated virtual store operators, the on-line shoppers, the vendors, the business partners, and the professional services providers in the e-business complex. Finally, one or more e-business complex management services requesters can be configured to remotely invoke selected ones of the electronically accessible e-business complex management services. Each e-business complex management services requester can invoke the electronically accessible e-business complex management services on behalf of one of the associated virtual store operators, vendors, business partners and professional services providers.
摘要翻译：合作电子商务综合体。合作电子商务综合体可以包括一个或多个电子可访问的电子商务复杂管理服务，其被配置为代表电子关联的虚拟商店运营商，供应商，业务伙伴和专业服务提供商处理电子商务综合体中的电子商务处理。可以包括虚拟管理办公室，其被配置为协调相关联的虚拟商店运营商，在线购物者，供应商，业务伙伴以及电子商务综合体中的专业服务提供商之间的电子商务交易。最后，一个或多个电子商务复杂的管理服务请求者可被配置为远程调用电子可访问的电子商务复杂管理服务中的所选择的电子商务。每个电子商务综合管理服务请求者可以代表相关的虚拟商店运营商，供应商，业务合作伙伴和专业服务提供商之一来调用电子可访问的电子商务综合管理服务。

4. 发明授权

US07451532B2 Forming discrete fastener element regions 有权
标题翻译：形成离散的紧固件元件区域
公开(公告)号：US07451532B2
公开(公告)日：2008-11-18
申请号：US11336321
申请日：2006-01-20
申请人： George A. Provost , William H. Shepard , William P. Clune
发明人： George A. Provost , William H. Shepard , William P. Clune
IPC分类号： A44B18/00
CPC分类号： B29C47/32 , A44B18/0049 , B29C43/222 , B29C43/46 , B29C47/0021 , B29C2043/461 , B29C2043/465 , B29L2031/729 , Y10T24/27 , Y10T24/2783
摘要： A method of making a fastener product having discrete regions of fastener element stems extending from a strip-form base includes providing a gap formed along a peripheral surface of a rotating mold roll, the mold roll having a plurality of cavities exposed about the peripheral surface. A sleeve is introduced to the gap. The sleeve is positioned about the mold roll and covers selected cavities. Molten resin is introduced to the gap such that the resin forms at least a part of the strip-form base of the product at the peripheral mold roll surface and at least partially fills a plurality of the cavities to form fastener element stems as projections extending from the strip-form base, while the resin remains blocked from said selected ones by the sleeve. The resin is solidified and stripped from the peripheral surface of the mold roll by pulling the projections from their respective cavities.
摘要翻译：一种制造紧固件产品的方法，其具有从带状基部延伸的紧固件元件杆的离散区域，包括提供沿着旋转模具辊的周边表面形成的间隙，所述模具辊具有围绕周边表面暴露的多个空腔。套筒被引入到间隙中。套筒围绕模具辊定位并且覆盖所选择的空腔。将熔融树脂引入到间隙中，使得树脂在周边模具辊表面形成产品的带状基底的至少一部分，并且至少部分地填充多个空腔，以形成紧固件元件柄，作为从带状基底，同时树脂通过套筒保持被封闭。通过从它们各自的腔中拉出凸起，使树脂固化并从模具辊的周面剥离。

5. 发明授权

US07424796B2 Filling and using reclosable bags 有权
标题翻译：灌装和使用可重新封闭的袋子
公开(公告)号：US07424796B2
公开(公告)日：2008-09-16
申请号：US11927261
申请日：2007-10-29
申请人： William H. Shepard , William P. Clune , George A. Provost
发明人： William H. Shepard , William P. Clune , George A. Provost
IPC分类号： B65B3/16
CPC分类号： B65B61/188 , B65D33/24 , B65D2101/0023 , B65D2313/02
摘要： A method of filling a bag that includes inserting an insulator between first and second side walls of a closure strip and joining an outer surface of the second side wall of the closure strip to an inner surface of a bag wall in a region of the wall behind which the insulator is positioned.
摘要翻译：一种填充袋子的方法，该方法包括在封闭带的第一和第二侧壁之间插入绝缘体，并将封闭带的第二侧壁的外表面连接到壁壁的内表面，绝缘子被定位。

6. 发明申请

US20080113152A1 Loop Materials 审中-公开
标题翻译：环材料
公开(公告)号：US20080113152A1
公开(公告)日：2008-05-15
申请号：US11559556
申请日：2006-11-14
申请人： George A. Provost , William H. Shepard
发明人： George A. Provost , William H. Shepard
IPC分类号： B32B3/06
CPC分类号： B32B5/26 , Y10T428/24017
摘要： Loop products are provided that include a carrier sheet having a plurality of holes pierced therethrough, a layer of fibers disposed on a first side of the carrier sheet, and a scrim reinforcing layer interposed between the fibers on the first side of the carrier sheet and the carrier sheet. Loops of the fibers extend from the holes on a second side of the carrier sheet, bases of the loops being anchored on the first side of the carrier sheet.
摘要翻译：提供了环形产品，其包括具有穿过其中的多个孔的载体片，布置在载体片的第一侧上的纤维层以及插入在载体片的第一侧上的纤维之间的稀松布增强层和载板。纤维的环从承载片的第二侧的孔延伸，环的基部锚定在载体片的第一侧上。

7. 发明申请

US20070237753A1 Method for selectively transducing pathologic mammalian cells using a tumor suppressor gene 审中-公开
标题翻译：使用肿瘤抑制基因选择性转导病理性哺乳动物细胞的方法
公开(公告)号：US20070237753A1
公开(公告)日：2007-10-11
申请号：US11706563
申请日：2007-02-14
申请人： H. Shepard , Nancy Kan
发明人： H. Shepard , Nancy Kan
IPC分类号： A61K48/00 , C12N15/867
CPC分类号： C07K14/4746 , A61K38/1709 , A61K48/00 , C07K14/47 , C12N2740/13043
摘要： A method for transducing a pathologic hyperproliferative mammalian cell is provided by this invention. This method requires contacting the cell with a suitable retroviral vector containing a nucleic acid encoding a gene product having a tumor suppressive function. Also provided by this invention is a method for treating a pathology in a subject caused by the absence of, or the presence of a pathologically mutated tumor suppressor gene.
摘要翻译：用于转导病理过度增殖的哺乳动物细胞的方法由本发明提供。该方法需要使细胞与含有编码具有肿瘤抑制功能的基因产物的核酸的合适的逆转录病毒载体接触。本发明还提供了一种用于治疗由于不存在或存在病理突变的肿瘤抑制基因导致的受试者病理学的方法。

8. 发明申请

US20070087406A1 Isoforms of receptor for advanced glycation end products (RAGE) and methods of identifying and using same 审中-公开
标题翻译：用于晚期糖基化终产物的受体的同种型（RAGE）及其鉴定和使用方法
公开(公告)号：US20070087406A1
公开(公告)日：2007-04-19
申请号：US11429090
申请日：2006-05-04
申请人： Pei Jin , H. Shepard
发明人： Pei Jin , H. Shepard
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/70
摘要： Isoforms of RAGE and pharmaceutical compositions containing RAGE isoforms are provided. Methods for identifying and preparing RAGE isoforms are provided. Also provided are methods of treatment with the RAGE isoforms.
摘要翻译：提供RAGE的同种型和含有RAGE同种型的药物组合物。提供了鉴定和制备RAGE同种型的方法。还提供了用RAGE同种型治疗的方法。

9. 发明授权

US07156937B2 Needling through carrier sheets to form loops 有权
标题翻译：穿过载物片形成环
公开(公告)号：US07156937B2
公开(公告)日：2007-01-02
申请号：US10728138
申请日：2003-12-03
申请人： George A. Provost , William H. Shepard
发明人： George A. Provost , William H. Shepard
IPC分类号： B32B37/00
CPC分类号： B32B5/06 , A44B18/0011 , B32B3/266 , B32B27/12 , B32B27/32 , B32B2038/008 , B32B2262/02 , B32B2307/72 , B32B2309/105 , B32B2555/02 , D04H11/00 , D04H11/08 , D04H18/02
摘要： A loop fastener product is formed by needling a batt of fibers through a carrier sheet such as a plastic film, to form loops on the other side of the carrier sheet. A binder, such as a powder resin or plastic film, is placed over the fiber side of the product and fused to the carrier sheet to bond the fibers in place. In some cases the product is needled in only discrete areas, leaving other areas free of loops. The product may be formed into outer covers for disposable diapers. Fibers of one resin are readily combined with films and backings of other resins to produce particularly thin and low weight loop materials.
摘要翻译：通过将诸如塑料膜的载体片刺入纤维网而形成环紧固件产品，以在载体片的另一侧上形成环。将粘合剂如粉末树脂或塑料膜放置在产品的纤维侧上并与载体片材熔合以将纤维粘合到位。在某些情况下，产品仅在离散区域进行针刺，其他区域无循环。产品可以形成为一次性尿布的外盖。一种树脂的纤维容易与其他树脂的薄膜和背衬组合，以产生特别薄且重量轻的环材料。

10. 发明申请

US20050079163A1 Method for selectively transducing pathologic mammalian cells using a tumor suppressor gene 审中-公开
标题翻译：使用肿瘤抑制基因选择性转导病理性哺乳动物细胞的方法
公开(公告)号：US20050079163A1
公开(公告)日：2005-04-14
申请号：US10912261
申请日：2004-08-04
申请人： H. Shepard , Nancy Kan
发明人： H. Shepard , Nancy Kan
IPC分类号： C12N15/09 , A61K38/17 , A61K48/00 , A61P35/00 , A61P35/02 , C07K14/47 , C12N5/10 , C12N15/12 , C12N15/867
CPC分类号： C07K14/4746 , A61K38/1709 , A61K48/00 , C07K14/47 , C12N2740/13043
摘要： A method for transducing a pathologic hyperproliferative mammalian cell is provided by this invention. This method requires contacting the cell with a suitable retroviral vector containing a nucleic acid encoding a gene product having a tumor suppressive function. Also provided by this invention is a method for treating a pathology in a subject caused by the absence of, or the presence of a pathologically mutated tumor suppressor gene.
摘要翻译：用于转导病理过度增殖的哺乳动物细胞的方法由本发明提供。该方法需要使细胞与含有编码具有肿瘤抑制功能的基因产物的核酸的合适的逆转录病毒载体接触。本发明还提供了一种用于治疗由于不存在或存在病理突变的肿瘤抑制基因导致的受试者病理学的方法。

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