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1. 发明申请

US20080260717A1 Methods for Reducing Seizure-Induced Neuronal Damage 审中-公开
标题翻译：降低癫痫发作神经元损伤的方法
公开(公告)号：US20080260717A1
公开(公告)日：2008-10-23
申请号：US10577382
申请日：2004-10-28
申请人： Shi Du Yan , Guy McKhann , David M. Stern
发明人： Shi Du Yan , Guy McKhann , David M. Stern
IPC分类号： A61K39/395 , A61K31/7052 , A61P25/00
CPC分类号： C07K14/70503 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K48/00 , C12N15/8509
摘要： This invention provides a method for treating a subject either during or soon after a seizure, in order to reduce the extent of neuronal damage in the subject resulting from the seizure comprising administering to the subject, either during or soon after the seizure, a therapeutically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to thereby reduce the extent of neuronal damage in the subject. This invention further provides a method for inhibiting neuronal damage which would otherwise result from a seizure in a subject predisposed to having a seizure, comprising administering to the subject a prophylactically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to inhibit neuronal damage which would otherwise result from a seizure in the event the subject were to suffer a seizure.
摘要翻译：本发明提供了一种在癫痫发作期间或之后治疗受试者的方法，以便减少由于癫痫发作引起的受试者神经元损伤的程度，包括在癫痫发作期间或之后对受试者施用治疗有效的用于晚期糖基化终产物（RAGE）的受体抑制剂的量，从而减少受试者的神经元损伤的程度。本发明进一步提供了一种抑制神经元损伤的方法，否则这些损伤将由预先发生癫痫发作的受试者的癫痫发作引起，其包括向受试者施用预防有效量的晚期糖基化终末产物受体抑制剂（RAGE），以便以抑制在受试者遭受癫痫发作的情况下由于癫痫发作而导致的神经元损伤。

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