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1. 发明申请

US20070254828A1 Pharmaceutical composition with healing activity comprising at least one soluble dextran derivative and at least one platelet-derived growth factor 审中-公开
标题翻译：具有愈合活性的药物组合物包含至少一种可溶性葡聚糖衍生物和至少一种血小板衍生生长因子
公开(公告)号：US20070254828A1
公开(公告)日：2007-11-01
申请号：US11526678
申请日：2006-09-26
申请人： Guy Dubreucq , Latifa Dahri-correia , Jose Correia
发明人： Guy Dubreucq , Latifa Dahri-correia , Jose Correia
IPC分类号： A61K38/18 , A61P1/04
CPC分类号： A61K47/36 , A61K38/1858
摘要： Pharmaceutical composition with healing activity comprising at least one soluble dextran derivative and at least one platelet-derived growth factor. The present invention relates to a pharmaceutical composition with healing activity comprising at least one soluble dextran derivative and at least one platelet-derived growth factor, and also to the use thereof for the preparation of a medicament with healing action, in particular for use in the treatment of ulcers.
摘要翻译：具有愈合活性的药物组合物包含至少一种可溶性葡聚糖衍生物和至少一种血小板衍生生长因子。本发明涉及具有愈合活性的药物组合物，其包含至少一种可溶性葡聚糖衍生物和至少一种血小板衍生生长因子，以及其用于制备具有愈合作用的药物的用途，特别是用于治疗溃疡。

2. 发明授权

US09259389B2 Pharmaceutical oral dosage form containing a synthetic oligosaccharide 有权
标题翻译：含有合成寡糖的药物口服剂型
公开(公告)号：US09259389B2
公开(公告)日：2016-02-16
申请号：US13515965
申请日：2010-12-17
申请人： Julien Meissonnier , Nathalie Sicre , Guillaume Sabate , Guy Dubreucq , Vanessa Nancy-Portebois , Maurice Petitou
发明人： Julien Meissonnier , Nathalie Sicre , Guillaume Sabate , Guy Dubreucq , Vanessa Nancy-Portebois , Maurice Petitou
IPC分类号： A61K31/70 , A61K9/107 , A61K9/48 , A61K31/702
CPC分类号： A61K9/107 , A61K9/4891 , A61K31/702
摘要： The present invention concerns a pharmaceutical formulation intended for oral administration containing a synthetic oligosaccharides containing one to 18 monosaccharide units and having a therapeutical activity or a pharmaceutically acceptable additions salt or solvate thereof wherein the formulation contains: a) the synthetic oligosaccharide (A) in an amount of up to 5% by weight of the total weight of the formulation, advantageously up to 1% by weight of the total weight of the formulation, b), a lipophilic phase (B) consisting of triglyceride of fatty acids in an amount of 50 to 80% by weight of the total weight of the formulation, advantageously of 50 to 70% by weight of the total weight of the formulation, c) at least one lipophilic surfactant (C) with HLB below 7 consisting of partial esters of polyol and fatty acids in an amount of 10 to 30% by weight of the total weight of the formulation, advantageously of 15 to 30% by weight of the total weight of the formulation, d) at least one hydrophilic surfactant (D) with HLB above 7 in an amount of up to 20% by weight of the total weight of the formulation, advantageously up to 15% by weight of the total weight of the formulation, e) optionally, at least one hydrophilic solvent (E) in an amount of up to 15% by weight of the total weight of the formulation, advantageously up to 10% by weight of the total weight of the formulation, (F) between 0 and 30% by weight of the total weight of the formulation of a chemical and/or physical stabilization agent (F), advantageously between 0 and 20% by weight of the total weight of the formulation, wherein when the formulation is in a form of a reverse emulsion or microemulsion and contains at least one hydrophilic solvent (E), the physical stabilization agent is present and is silicon dioxide.
摘要翻译：本发明涉及用于口服给药的药物制剂，其含有含有1至18个单糖单元并具有治疗活性或其药学上可接受的添加盐或溶剂合物的合成寡糖，其中所述制剂含有：a）合成寡糖（A）最多达制剂总重量的5重量％的量，有利地高达制剂总重量的1重量％，b），由脂肪酸甘油三酯组成的亲脂相（B），其量为 50至80重量％的制剂总重量，有利地为制剂总重量的50至70重量％，c）至少一种HLB低于7的亲脂性表面活性剂（C），由多元醇的偏酯和占制剂总重量的10至30重量％的脂肪酸，有利地为制剂总重量的15至30重量％，d）至少一种HLB高于7的亲水性表面活性剂（D），其量高达制剂总重量的20重量％，有利地高达制剂总重量的15重量％，e）任选地至少一个亲水性溶剂（E）的含量高达制剂总重量的15重量％，有利的是制剂总重量的10重量％，（F）0至30重量％化学和/或物理稳定剂（F）的制剂的总重量，有利地为制剂总重量的0至20重量％，其中当制剂为反相乳液或微乳液的形式并且包含至少一种亲水性溶剂（E），物理稳定剂存在并且是二氧化硅。

3. 发明申请

US20090221805A1 Complex polymere amphiphile-PDGF 审中-公开
标题翻译：复合多聚体两亲物 - PDGF
公开(公告)号：US20090221805A1
公开(公告)日：2009-09-03
申请号：US11526735
申请日：2006-09-26
申请人： Latifa Dahri-Correia , Jose Correia , Guy Dubreucq , David Duracher , Remi Soula , Olivier Soula , Gerard Soula
发明人： Latifa Dahri-Correia , Jose Correia , Guy Dubreucq , David Duracher , Remi Soula , Olivier Soula , Gerard Soula
IPC分类号： A61K38/27
CPC分类号： A61K47/36 , A61K38/1858
摘要： Physically and chemically stable, water-soluble, amphiphilic polymer-PDGF complex, characterized in that the amphiphilic polymers include a hydrophilic polymeric backbone functionalized with hydrophobic substituents and hydrophilic groups.
摘要翻译：物理和化学稳定的水溶性两亲聚合物-PDGF络合物，其特征在于两亲性聚合物包括用疏水取代基和亲水基团官能化的亲水性聚合物骨架。

4. 发明授权

US08241620B2 Complex polymere amphiphile-PDGF 有权
标题翻译：复合多聚体两亲物 - PDGF
公开(公告)号：US08241620B2
公开(公告)日：2012-08-14
申请号：US13067299
申请日：2011-05-23
申请人： Latifa Dahri-Correia , Jose Correia , Guy Dubreucq , David Duracher , Remi Soula , Olivier Soula , Gerard Soula
发明人： Latifa Dahri-Correia , Jose Correia , Guy Dubreucq , David Duracher , Remi Soula , Olivier Soula , Gerard Soula
IPC分类号： A61K31/74
CPC分类号： A61K47/36 , A61K38/1858
摘要： Physically and chemically stable, water-soluble, amphiphilic polymer-PDGF complex, characterized in that the amphiphilic polymers include a hydrophilic polymeric backbone functionalized with hydrophobic substituents and hydrophilic groups.
摘要翻译：物理和化学稳定的水溶性两亲聚合物-PDGF络合物，其特征在于两亲性聚合物包括用疏水取代基和亲水基团官能化的亲水性聚合物骨架。

5. 发明申请

US20120316132A1 PHARMACEUTICAL ORAL DOSAGE FORM CONTAINING A SYNTHETIC OLIGOSACCHARIDE 有权
标题翻译：含有合成寡糖的药物口服剂型
公开(公告)号：US20120316132A1
公开(公告)日：2012-12-13
申请号：US13515965
申请日：2010-12-17
申请人： Julien Meissonnier , Nathalie Sicre , Guillaume Sabate , Guy Dubreucq , Vanessa Nancy-Portebois , Maurice Petitou
发明人： Julien Meissonnier , Nathalie Sicre , Guillaume Sabate , Guy Dubreucq , Vanessa Nancy-Portebois , Maurice Petitou
IPC分类号： A61K31/727 , A61P7/02 , A61P9/10 , A61K31/702
CPC分类号： A61K9/107 , A61K9/4891 , A61K31/702
摘要： The present invention concerns a pharmaceutical formulation intended for oral administration containing a synthetic oligosaccharides containing one to 18 monosaccharide units and having a therapeutical activity or a pharmaceutically acceptable additions salt or solvate thereof wherein the formulation contains: a) the synthetic oligosaccharide (A) in an amount of up to 5% by weight of the total weight of the formulation, advantageously up to 1% by weight of the total weight of the formulation, b), a lipophilic phase (B) consisting of triglyceride of fatty acids in an amount of 50 to 80% by weight of the total weight of the formulation, advantageously of 50 to 70% by weight of the total weight of the formulation, c) at least one lipophilic surfactant (C) with HLB below 7 consisting of partial esters of polyol and fatty acids in an amount of 10 to 30% by weight of the total weight of the formulation, advantageously of 15 to 30% by weight of the total weight of the formulation, d) at least one hydrophilic surfactant (D) with HLB above 7 in an amount of up to 20% by weight of the total weight of the formulation, advantageously up to 15% by weight of the total weight of the formulation, e) optionally, at least one hydrophilic solvent (E) in an amount of up to 15% by weight of the total weight of the formulation, advantageously up to 10% by weight of the total weight of the formulation, (F) between 0 and 30% by weight of the total weight of the formulation of a chemical and/or physical stabilization agent (F), advantageously between 0 and 20% by weight of the total weight of the formulation, wherein when the formulation is in a form of a reverse emulsion or microemulsion and contains at least one hydrophilic solvent (E), the physical stabilization agent is present and is silicon dioxide.
摘要翻译：本发明涉及用于口服给药的药物制剂，其含有含有1至18个单糖单元并具有治疗活性或其药学上可接受的添加盐或溶剂合物的合成寡糖，其中所述制剂含有：a）合成寡糖（A）最多达制剂总重量的5重量％的量，有利地高达制剂总重量的1重量％，b），由脂肪酸甘油三酯组成的亲脂相（B），其量为 50至80重量％的制剂总重量，有利地为制剂总重量的50至70重量％，c）至少一种HLB低于7的亲脂性表面活性剂（C），由多元醇的偏酯和占制剂总重量的10至30重量％的脂肪酸，有利地为制剂总重量的15至30重量％，d）至少一种HLB高于7的亲水性表面活性剂（D），其量高达制剂总重量的20重量％，有利地高达制剂总重量的15重量％，e）任选地至少一个亲水性溶剂（E）的含量高达制剂总重量的15重量％，有利的是制剂总重量的10重量％，（F）0至30重量％化学和/或物理稳定剂（F）的制剂的总重量，有利地为制剂总重量的0至20重量％，其中当制剂为反相乳液或微乳液的形式并且包含至少一种亲水性溶剂（E），物理稳定剂存在并且是二氧化硅。

6. 发明申请

US20110301086A1 Complex polymere amphiphile-PDGF 有权
标题翻译：复合多聚体两亲物 - PDGF
公开(公告)号：US20110301086A1
公开(公告)日：2011-12-08
申请号：US13067299
申请日：2011-05-23
申请人： Latifa Dahri-Correia , Jose Correia , Guy Dubreucq , David Duracher , Remi Soula , Olivier Soula , Gerard Soula
发明人： Latifa Dahri-Correia , Jose Correia , Guy Dubreucq , David Duracher , Remi Soula , Olivier Soula , Gerard Soula
IPC分类号： A61K38/18 , A61P17/02 , C07K17/02 , C07K17/10 , C07K17/12
CPC分类号： A61K47/36 , A61K38/1858
摘要： Physically and chemically stable, water-soluble, amphiphilic polymer-PDGF complex, characterized in that the amphiphilic polymers include a hydrophilic polymeric backbone functionalized with hydrophobic substituents and hydrophilic groups.
摘要翻译：物理和化学稳定的水溶性两亲聚合物-PDGF络合物，其特征在于两亲性聚合物包括用疏水取代基和亲水基团官能化的亲水性聚合物骨架。

7. 发明申请

US20100081708A1 ANTICOAGULANT COMPOUNDS 审中-公开
标题翻译：抗生素化合物
公开(公告)号：US20100081708A1
公开(公告)日：2010-04-01
申请号：US12444198
申请日：2007-10-05
申请人： Maurice Petitou , Guy Dubreucq , Olivier Querolle , Sandrine Zameo
发明人： Maurice Petitou , Guy Dubreucq , Olivier Querolle , Sandrine Zameo
IPC分类号： A61K31/7088 , C07H21/04 , A61P7/02
CPC分类号： C07H3/06 , C07H11/00
摘要： The present invention is concerned with anticoagulants (i.e. substances that stop blood from clotting). More specifically, the present invention is concerned with orally available antithrombic oligosaccharides.
摘要翻译：本发明涉及抗凝剂（即阻止血液凝固的物质）。更具体地说，本发明涉及口服抗凝血寡糖。

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