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1. 发明申请

US20070125160A1 Short and thin silicon cantilever with tip and fabrication thereof 有权
标题翻译：具有尖端的薄且薄的硅悬臂及其制造
公开(公告)号：US20070125160A1
公开(公告)日：2007-06-07
申请号：US11599726
申请日：2006-11-15
申请人： Chengzhi Cai , Chin-Ming Yam , Guoting Qin , Steven Pei , Qingkai Yu
发明人： Chengzhi Cai , Chin-Ming Yam , Guoting Qin , Steven Pei , Qingkai Yu
IPC分类号： G12B21/08 , H01L21/302
CPC分类号： G01Q60/38 , Y10S977/863 , Y10S977/879
摘要： Thin and short cantilevers possess both a low force constant and a high resonance frequency, thus are highly desirable for atomic force microscope (AFM) imaging and force measurement. According to some embodiments, the invention provides small silicon (Si) cantilevers integrated with a Si tip, for example fabricated from SOI wafers that are used for reducing the variation of thickness of the cantilevers. In one example, the fabrication process provided SOI chips containing 40 silicon cantilevers integrating with an ultra-sharp Si tip. The resolution of images obtained with these tips was much higher than those obtained with the commercial tips, while the force constants were much less, that is, more suitable for imaging soft samples. The availability of such SOI chips greatly facilitates large scale modification of the surfaces of the silicon cantilever tips with a monolayer of oligo(ethylene glycol) derivatives that resist the non-specific interactions with proteins, rendering them most suitable for imaging and measurement of biological samples.
摘要翻译：薄且短的悬臂具有低的力常数和高的共振频率，因此对于原子力显微镜（AFM）成像和力测量是非常需要的。根据一些实施例，本发明提供了与Si尖端集成的小硅（Si）悬臂，例如由用于减小悬臂的厚度变化的SOI晶片制造的。在一个示例中，制造工艺提供了包含与超尖锐Si尖端集成的40个硅悬臂的SOI芯片。使用这些尖端获得的图像的分辨率远高于用商业尖端获得的图像的分辨率，而力常数更小，也就是更适合于成像软样品。这种SOI芯片的可用性极大地促进了用悬臂梁尖端表面的大规模修饰，其中单层的寡聚（乙二醇）衍生物抵抗与蛋白质的非特异性相互作用，使其最适合于生物样品的成像和测量。

2. 发明申请

US20130324738A1 COMPOSITIONS AND METHODS FOR MAKING AND USING MULTIFUNCTIONAL POLYMERIZED LIPOSOMES 有权
公开(公告)号：US20130324738A1
公开(公告)日：2013-12-05
申请号：US13894101
申请日：2013-05-14
申请人： Chengzhi Cai , Guoting Qin , Amit Kumar
发明人： Chengzhi Cai , Guoting Qin , Amit Kumar
IPC分类号： C08F4/04
CPC分类号： C08F4/04 , A61K9/1271 , A61K9/1277 , A61K47/6911 , A61K47/6915 , A61K49/0002 , A61K49/0021 , A61K49/0043 , A61K49/0084 , B01J31/1815 , B01J2231/44 , B01J2531/16 , C08F30/02
摘要： According to some embodiments, the present invention provides compositions and methods for making and using multifunctional polymerized liposomes finding relevant application in medical sciences, particularly in bioimaging, diagnostics, drug delivery, and drug formulation. The compositions and methods involve lipids that are both polymerizable and have a “clickable” group that provides the ability to functionalize via a click reaction with various functional moieties useful for the above-listed applications.

3. 发明申请

US20110190623A1 THERMALLY-ACTIVATABLE LIPOSOME COMPOSITIONS AND METHODS FOR IMAGING, DIAGNOSIS AND THERAPY 审中-公开
标题翻译：热激活脂肪组合物和成像，诊断和治疗方法
公开(公告)号：US20110190623A1
公开(公告)日：2011-08-04
申请号：US13057671
申请日：2009-08-05
申请人： King Chuen Li , Zheng Li , Guoting Qin
发明人： King Chuen Li , Zheng Li , Guoting Qin
IPC分类号： A61B8/00 , A61K9/127 , C12N5/00 , C12N5/071 , A61K49/00 , A61K51/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61P31/00 , A61B5/055 , A61B6/03 , A61M37/00
CPC分类号： A61K9/127 , A61K9/1273
摘要： Disclosed are thermally-activatable liposomal compositions and methods for their use in the formulation and administration of therapeutic, prophylactic, and diagnostic agents. The disclosed liposome structures are capable of carrying a variety of biologically active reagents, and permitting their controlled release in vivo by exploiting properties of their thermoregulatable lability.
摘要翻译：公开了可热活化的脂质体组合物及其用于制剂和给药治疗剂，预防剂和诊断剂的方法。所公开的脂质体结构能够携带各种生物活性试剂，并且通过利用它们的可热定性不稳定性质允许其在体内的受控释放。

4. 发明授权

US07637960B2 Short and thin silicon cantilever with tip and fabrication thereof 有权
标题翻译：具有尖端的薄且薄的硅悬臂及其制造
公开(公告)号：US07637960B2
公开(公告)日：2009-12-29
申请号：US11599726
申请日：2006-11-15
申请人： Chengzhi Cai , Chi-Ming Yam , Guoting Qin , Steven Pei , Qingkai Yu
发明人： Chengzhi Cai , Chi-Ming Yam , Guoting Qin , Steven Pei , Qingkai Yu
IPC分类号： G12B21/08
CPC分类号： G01Q60/38 , Y10S977/863 , Y10S977/879
摘要： Thin and short cantilevers possess both a low force constant and a high resonance frequency, thus are highly desirable for atomic force microscope (AFM) imaging and force measurement. According to some embodiments, the invention provides small silicon (Si) cantilevers integrated with a Si tip, for example fabricated from SOI wafers that are used for reducing the variation of thickness of the cantilevers. In one example, the fabrication process provided SOI chips containing 40 silicon cantilevers integrating with an ultra-sharp Si tip. The resolution of images obtained with these tips was much higher than those obtained with the commercial tips, while the force constants were much less, that is, more suitable for imaging soft samples. The availability of such SOI chips greatly facilitates large scale modification of the surfaces of the silicon cantilever tips with a monolayer of oligo(ethylene glycol) derivatives that resist the non-specific interactions with proteins, rendering them most suitable for imaging and measurement of biological samples.
摘要翻译：薄且短的悬臂具有低的力常数和高的共振频率，因此对于原子力显微镜（AFM）成像和力测量是非常需要的。根据一些实施例，本发明提供了与Si尖端集成的小硅（Si）悬臂，例如由用于减小悬臂的厚度变化的SOI晶片制造的。在一个示例中，制造工艺提供了包含与超尖锐Si尖端集成的40个硅悬臂的SOI芯片。使用这些尖端获得的图像的分辨率远高于用商业尖端获得的图像的分辨率，而力常数更小，也就是更适合于成像软样品。这种SOI芯片的可用性极大地促进了用悬臂梁尖端表面的大规模修饰，其中单层的寡聚（乙二醇）衍生物抵抗与蛋白质的非特异性相互作用，使其最适合于生物样品的成像和测量。

5. 发明申请

US20190133932A1 Compositions, Methods and Kits for Treating a Contact Lens 审中-公开
公开(公告)号：US20190133932A1
公开(公告)日：2019-05-09
申请号：US16096603
申请日：2017-04-28
申请人： GUOTING QIN , CHENGZHI CAI , UNIVERSITY OF HOUSTON SYSTEM
发明人： Guoting Qin , Chengzhi Cai
IPC分类号： A61K9/00 , A61K31/496 , A61L12/10
摘要： Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

6. 发明授权

US08506993B2 Compositions and methods for making and using multifunctional polymerized liposomes 有权
标题翻译：制备和使用多功能聚合脂质体的组合物和方法
公开(公告)号：US08506993B2
公开(公告)日：2013-08-13
申请号：US12191946
申请日：2008-08-14
申请人： Chengzhi Cai , Guoting Qin , Amit Kumar
发明人： Chengzhi Cai , Guoting Qin , Amit Kumar
IPC分类号： A61K9/14 , A61K9/127 , C07D249/04
CPC分类号： C08F4/04 , A61K9/1271 , A61K9/1277 , A61K47/6911 , A61K47/6915 , A61K49/0002 , A61K49/0021 , A61K49/0043 , A61K49/0084 , B01J31/1815 , B01J2231/44 , B01J2531/16 , C08F30/02
摘要： According to some embodiments, the present invention provides compositions and methods for making and using multifunctional polymerized liposomes finding relevant application in medical sciences, particularly in bioimaging, diagnostics, drug delivery, and drug formulation. The compositions and methods involve lipids that are both polymerizable and have a “clickable” group that provides the ability to functionalize via a click reaction with various functional moieties useful for the above-listed applications.
摘要翻译：根据一些实施方案，本发明提供用于制备和使用多功能聚合脂质体的组合物和方法，其在医学科学中发现相关应用，特别是在生物成像，诊断，药物递送和药物制剂中。组合物和方法包括既可聚合又具有“可点击”组的脂质，其提供通过与用于上述应用的各种功能部分的点击反应官能化的能力。

7. 发明申请

US20090162424A1 COMPOSITIONS AND METHODS FOR MAKING AND USING MULTIFUNCTIONAL POLYMERIZED LIPOSOMES 有权
标题翻译：制备和使用多功能聚合物的组合物和方法
公开(公告)号：US20090162424A1
公开(公告)日：2009-06-25
申请号：US12191946
申请日：2008-08-14
申请人： Chengzhi Cai , Guoting Qin , Amit Kumar
发明人： Chengzhi Cai , Guoting Qin , Amit Kumar
IPC分类号： A61K9/127 , C08F30/02 , B01J31/02
CPC分类号： C08F4/04 , A61K9/1271 , A61K9/1277 , A61K47/6911 , A61K47/6915 , A61K49/0002 , A61K49/0021 , A61K49/0043 , A61K49/0084 , B01J31/1815 , B01J2231/44 , B01J2531/16 , C08F30/02
摘要： According to some embodiments, the present invention provides compositions and methods for making and using multifunctional polymerized liposomes finding relevant application in medical sciences, particularly in bioimaging, diagnostics, drug delivery, and drug formulation. The compositions and methods involve lipids that are both polymerizable and have a “clickable” group that provides the ability to functionalize via a click reaction with various functional moieties useful for the above-listed applications.
摘要翻译：根据一些实施方案，本发明提供用于制备和使用多功能聚合脂质体的组合物和方法，其在医学科学中发现相关应用，特别是在生物成像，诊断，药物递送和药物制剂中。组合物和方法包括既可聚合又具有“可点击”组的脂质，其提供通过与用于上述应用的各种功能部分的点击反应官能化的能力。

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