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1. 发明授权

US5728686A Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as pharmaceuticals 失效
标题翻译：烷基黄嘌呤膦酸盐和烷基黄嘌呤膦氧化物及其作为药物的用途
公开(公告)号：US5728686A
公开(公告)日：1998-03-17
申请号：US741591
申请日：1996-10-31
申请人： Gunter Billen , Ismahan Okyayuz-Baklouti , Hiristo Anagnostopulos , Stefan Mullner
发明人： Gunter Billen , Ismahan Okyayuz-Baklouti , Hiristo Anagnostopulos , Stefan Mullner
IPC分类号： A61K31/675 , A61P3/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/02 , A61P35/00 , A61P43/00 , C07F9/6561 , C07F9/6512
CPC分类号： C07F9/65616
摘要： Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as pharmaceuticals A compound of the formula ##STR1## where R.sup.1 and R.sup.3 are identical or different and at least one of the radicals R.sup.1 and R.sup.3 is a radical of the formula XI ##STR2## in which E is a covalent bond or a (C.sub.1 -C.sub.5)-alkyl, are suitable for the production of pharmaceuticals for the treatment of muscular atrophy, cachexia, muscular dystrophy, sepsis, septic shock, endotoxic shock, systemic inflammation response syndrome, adult respiratory distress syndrome, cerebral malaria, chronic pneumonia, pulmonary sarcoidosis, reperfusion damage, scar formation, inflammation of the bowel and ulcerative colitis, as a result of infections, acquired immune deficiency syndrome, cancer, trauma and other disorders having increased protein loss, peripheral circulatory disorders, disorders having altered leucocyte adhesion, and also disorders which are accompanied by an increased or unregulated tumor necrosis factor production such as rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis and other arthritic disorders.
摘要翻译：烷基黄嘌呤膦酸盐和烷基黄嘌呤膦氧化物及其作为药物的用途下式化合物其中R 1和R 3相同或不同，R 1和R 3中的至少一个是式XI的基团。（XI）其中E是共价键或（C1-C5） - 烷基，适用于制备用于治疗肌肉萎缩，恶病质，肌营养不良症，败血症，败血性休克，内毒素性休克，全身炎症反应的药物综合征，成人呼吸窘迫综合征，脑疟疾，慢性肺炎，肺结节病，再灌注损伤，瘢痕形成，肠炎和溃疡性结肠炎，由于感染，获得性免疫缺陷综合征，癌症，创伤和其他具有增加的蛋白质的疾病损失，外周循环障碍，具有改变的白细胞粘附的病症，以及伴有增加或不调节的肿瘤坏死因子p 类风湿关节炎，类风湿性脊柱炎，骨关节炎和其他关节炎疾病。

2. 发明授权

US6159995A Substituted diaminocarboxylic acids 失效
标题翻译：取代的二氨基羧酸
公开(公告)号：US6159995A
公开(公告)日：2000-12-12
申请号：US74587
申请日：1998-05-08
申请人： Werner Thorwart , Wilfried Schwab , Manfred Schudok , Burkhard Haase , Bernhard Neises , Gunter Billen
发明人： Werner Thorwart , Wilfried Schwab , Manfred Schudok , Burkhard Haase , Bernhard Neises , Gunter Billen
IPC分类号： C07D295/18 , A61K31/195 , A61K31/215 , A61K31/27 , A61K31/275 , A61K31/33 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/48 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61P1/02 , A61P9/10 , A61P19/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C311/13 , C07C311/19 , C07C311/22 , C07C311/29 , C07C323/59 , C07D207/16 , C07D207/34 , C07D207/38 , C07D209/46 , C07D209/48 , C07D213/81 , C07D213/82 , C07D215/14 , C07D233/54 , C07D233/61 , C07D233/64 , C07D233/74 , C07D235/08 , C07D241/24 , C07D249/08 , C07D249/12 , C07D261/10 , C07D275/04 , C07D277/06 , C07D277/28 , C07D307/24 , C07D307/54 , C07D307/58 , C07D307/68 , C07D333/22 , C07D333/24 , C07D333/38 , C07D401/12 , A61K31/55 , A61K31/495 , A61K31/505 , A61K31/54 , C07D207/18 , C07D207/30 , C07D207/40 , C07D209/02 , C07D209/36 , C07D235/04 , C07D243/00 , C07D277/62 , C07D403/02 , C07D417/00 , C07D513/00
CPC分类号： C07C323/59 , C07C311/19 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2603/74
摘要： Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.
摘要翻译：式（I）化合物适用于生产用于预防和治疗病症的药物，其中涉及基质降解性金属蛋白酶活性增加。

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