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1. 发明申请

US20100173001A1 Metal Ion-Treated Biocompatible Polymers Useful for Nanoparticles 审中-公开
标题翻译：用于纳米颗粒的金属离子处理生物相容性聚合物
公开(公告)号：US20100173001A1
公开(公告)日：2010-07-08
申请号：US12664610
申请日：2008-06-16
申请人： Gretchen M. Unger
发明人： Gretchen M. Unger
IPC分类号： A61K9/16 , A61K38/00 , A61K31/7088 , C07K2/00 , C07H1/00 , A61P35/04
CPC分类号： A61K9/5169 , A61K47/62 , A61K47/6929 , A61K47/6939 , B82Y5/00
摘要： Disclosed are methods for forming particles useful for the treatment of hyperproliferative disease. The method includes providing a bioactive component and a metal ion-treated biocompatible polymer component; coating the bioactive component with a surfactant having an HLB value of less than about 6.0 units under conditions which form a coated bioactive component; associating the coated bioactive component with the a metal ion-treated biocompatible polymer under conditions which associate the coated bioactive component with the metal-ion treated biocompatible polymer to form a particle, where the particles have an average diameter of less than about 50 nanometers. Related compositions and methods to treat disease using the particles are also disclosed.
摘要翻译：公开了形成用于治疗过度增殖性疾病的颗粒的方法。该方法包括提供生物活性组分和金属离子处理的生物相容性聚合物组分; 在形成涂覆的生物活性成分的条件下用HLB值小于约6.0单位的表面活性剂涂覆生物活性组分; 将涂覆的生物活性组分与金属离子处理的生物相容性聚合物在使涂覆的生物活性组分与金属离子处理的生物相容性聚合物缔合以形成颗粒的条件下缔合，其中颗粒的平均直径小于约50纳米。还公开了使用该颗粒治疗疾病的相关组合物和方法。

2. 发明授权

US07741304B2 Casein kinase 2 antisense therapy 有权
标题翻译：酪蛋白激酶2反义治疗
公开(公告)号：US07741304B2
公开(公告)日：2010-06-22
申请号：US11763366
申请日：2007-06-14
申请人： Joel W. Slaton , Khalil Ahmed , Gretchen M. Unger , Alan Davis , Dan Sloper
发明人： Joel W. Slaton , Khalil Ahmed , Gretchen M. Unger , Alan Davis , Dan Sloper
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12Q1/68 , C12N5/00
CPC分类号： A61K48/0008 , A01K2267/0331 , C12N15/1137 , C12N2310/11 , C12Y207/11001
摘要： The invention provides for antisense oligonucleotides that hybridize to casein kinase 2 nucleic acid sequences and methods of using such antisense oligonucleotides to inhibit expression of casein kinase 2 and reduce the size of solid tumors.
摘要翻译：本发明提供与酪蛋白激酶2核酸序列杂交的反义寡核苷酸以及使用这种反义寡核苷酸抑制酪蛋白激酶2的表达并减少实体瘤大小的方法。

3. 发明申请

US20080220072A1 BIOLOGIC MODULATIONS WITH NANOPARTICLES 审中-公开
标题翻译：与纳米颗粒的生物调节
公开(公告)号：US20080220072A1
公开(公告)日：2008-09-11
申请号：US12027863
申请日：2008-02-07
申请人： Gretchen M. Unger , Roderic M.K. Dale , Theresa L. Thompson
发明人： Gretchen M. Unger , Roderic M.K. Dale , Theresa L. Thompson
IPC分类号： A61K9/14 , C07H21/04 , A61K31/70
CPC分类号： A61K9/5138 , A61K9/0019 , A61K9/5094 , A61K39/0011 , A61K47/62 , A61K47/645 , A61K47/6935 , A61K48/0008 , A61K48/0041 , A61K49/0065 , A61K49/0067 , A61K2039/55555 , A61L31/10 , A61L31/16 , B82Y5/00 , C12N15/111 , C12N15/87 , C12N2320/32
摘要： Certain aspects of the invention relate to the use of small particles in biological systems, including the delivery of biologically active agents to cells or tissues using nanoparticles of less than about 200 nm in approximate diameter. Embodiments include collection of particles having a bioactive component, a surfactant molecule, a biocompatible polymer, and a cell recognition component, wherein the cell recognition component has a binding affinity for a cell recognition target. Compositions and methods of use are also set forth, including the use of antisense directed against Protein Kinase CK2, CK2alpha, CK2 alpha′, and CK2 beta.
摘要翻译：本发明的某些方面涉及在生物系统中使用小颗粒，包括使用近似直径小于约200nm的纳米颗粒将生物活性剂递送至细胞或组织。实施方案包括收集具有生物活性成分的颗粒，表面活性剂分子，生物相容性聚合物和细胞识别组分，其中细胞识别组分对细胞识别目标具有结合亲和性。还阐述了组合物和使用方法，包括使用针对蛋白激酶CK2，CK2alpha，CK2α'和CK2β的反义。

4. 发明授权

US06632671B2 Nanoparticle encapsulation system and method 有权
标题翻译：纳米粒子封装体系及方法
公开(公告)号：US06632671B2
公开(公告)日：2003-10-14
申请号：US09796575
申请日：2001-02-28
申请人： Gretchen M. Unger
发明人： Gretchen M. Unger
IPC分类号： C12N1588
CPC分类号： B01J13/08 , A61K9/1075 , A61K9/5138 , A61K9/5161 , A61K9/5192 , B01J13/02 , Y10S977/773 , Y10S977/795 , Y10S977/897 , Y10S977/915 , Y10S977/92
摘要： The present invention generally relates to nanocapsules and methods of preparing these nanocapsules. The present invention includes a method of forming a surfactant micelle and dispersing the surfactant micelle into an aqueous composition having a hydrophilic polymer to form a stabilized dispersion of surfactant micelles. The method further includes mechanically forming droplets of the stabilized dispersion of surfactant micelles, precipitating the hydrophilic polymer to form precipitated nanocapsules, incubating the nanocapsules to reduce a diameter of the nanocapsules, and filtering or centrifuging the nanocapsules.
摘要翻译：本发明一般涉及纳米胶囊和制备这些纳米胶囊的方法。本发明包括形成表面活性剂胶束并将表面活性剂胶束分散到具有亲水性聚合物的水性组合物中以形成稳定的表面活性剂胶束分散体的方法。该方法还包括机械地形成稳定的表面活性剂胶束分散体的液滴，沉淀亲水性聚合物以形成沉淀的纳米胶囊，孵育纳米胶囊以减小纳米胶囊的直径，以及过滤或离心纳米胶囊。

5. 发明申请

US20100247662A1 Biologic Modulations with Nanoparticles 审中-公开
标题翻译：纳米颗粒的生物调节
公开(公告)号：US20100247662A1
公开(公告)日：2010-09-30
申请号：US11622359
申请日：2007-01-11
申请人： Gretchen M. Unger
发明人： Gretchen M. Unger
IPC分类号： A61K9/14 , A61K39/395 , A61K38/00 , A61K31/70 , A61K31/7088 , A61P35/04 , A61K31/351
CPC分类号： A61K9/5138 , A61K9/0019 , A61K9/5094 , A61K39/0011 , A61K47/62 , A61K47/645 , A61K47/6935 , A61K48/0008 , A61K48/0041 , A61K49/0065 , A61K49/0067 , A61K2039/55555 , A61L31/10 , A61L31/16 , B82Y5/00 , C12N15/111 , C12N15/87 , C12N2320/32
摘要： Certain aspects of the invention relate to the use of small particles in biological systems, including the delivery of biologically active agents to cells or tissues using nanoparticles of less than about 200 nm in approximate diameter. Embodiments include collection of particles having a bioactive component, a surfactant molecule, a biocompatible polymer, and a cell recognition component, wherein the cell recognition component has a binding affinity for a cell recognition target. Compositions and methods of use arc also set forth.
摘要翻译：本发明的某些方面涉及在生物系统中使用小颗粒，包括使用近似直径小于约200nm的纳米颗粒将生物活性剂递送至细胞或组织。实施方案包括收集具有生物活性成分的颗粒，表面活性剂分子，生物相容性聚合物和细胞识别组分，其中细胞识别组分对细胞识别目标具有结合亲和性。还阐述了组合和使用方法。

6. 发明申请

US20110269813A1 Gene Silencing by Single-Stranded Polynucleotides 审中-公开
标题翻译：基因沉默单链多核苷酸
公开(公告)号：US20110269813A1
公开(公告)日：2011-11-03
申请号：US12525652
申请日：2008-02-01
申请人： Gretchen M. Unger
发明人： Gretchen M. Unger
IPC分类号： A61K31/7088 , C12N15/00 , C12Q1/68
CPC分类号： A61K31/7125 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/51 , C12N2320/32 , G01N33/5308 , C12N2310/3521
摘要： The present invention relates to compositions and methods for concurrently activating antisense and double-stranded RNase (dsRNase) mechanisms for inhibiting expression of a targeted gene, by delivering a single stranded bifunctional chimeric DNA/RNA oligonucleotide optimized for siRNA activity as well as antisense activity, into the nucleus of a target cell.
摘要翻译：本发明涉及通过递送针对siRNA活性和反义活性而优化的单链双功能嵌合DNA / RNA寡核苷酸同时激活用于抑制靶基因表达的反义和双链RNA酶（dsRNase）机制的组合物和方法，进入靶细胞的细胞核。

7. 发明申请

US20090238883A1 LIVER-SPECIFIC NANOCAPSULES AND METHODS OF USING 审中-公开
标题翻译：肝脏特异性纳米粒子和使用方法
公开(公告)号：US20090238883A1
公开(公告)日：2009-09-24
申请号：US12298883
申请日：2007-04-27
申请人： Betsy T. Kren , Clifford J. Steer , Gretchen M. Unger
发明人： Betsy T. Kren , Clifford J. Steer , Gretchen M. Unger
IPC分类号： A61K9/14 , A61K38/02 , A61K48/00 , A61K38/48
CPC分类号： A61K48/005 , A61K47/61 , A61K47/62 , A61K47/6907 , A61K48/0008 , B82Y5/00
摘要： This disclosure describes liver-specific nanocapsules for specifically targeting liver cells. This disclosure also provides methods of using such liver-specific nanocapsules to deliver one or more cargo moieties to the liver cells.
摘要翻译：本公开描述了用于特异性靶向肝细胞的肝特异性纳米胶囊。本公开还提供了使用这种肝特异性纳米胶囊将一个或多个货物部分递送至肝细胞的方法。

8. 发明申请

US20080113932A1 CASEIN KINASE 2 ANTISENSE THERAPY 有权
标题翻译： CASEIN KINASE 2抗生素治疗
公开(公告)号：US20080113932A1
公开(公告)日：2008-05-15
申请号：US11763366
申请日：2007-06-14
申请人： Joel W. Slaton , Khalil Ahmed , Gretchen M. Unger , Alan Davis , Dan Sloper
发明人： Joel W. Slaton , Khalil Ahmed , Gretchen M. Unger , Alan Davis , Dan Sloper
IPC分类号： A61K48/00 , C07H21/04
CPC分类号： A61K48/0008 , A01K2267/0331 , C12N15/1137 , C12N2310/11 , C12Y207/11001
摘要： The invention provides for antisense oligonucleotides that hybridize to casein kinase 2 nucleic acid sequences and methods of using such antisense oligonucleotides to inhibit expression of casein kinase 2 and reduce the size of solid tumors.
摘要翻译：本发明提供与酪蛋白激酶2核酸序列杂交的反义寡核苷酸以及使用这种反义寡核苷酸抑制酪蛋白激酶2的表达并减少实体瘤大小的方法。

9. 发明申请

US20120058180A1 Liver-specific Nanocapsules and Methods of Using 审中-公开
标题翻译：肝特异性纳米胶囊和使用方法
公开(公告)号：US20120058180A1
公开(公告)日：2012-03-08
申请号：US13221552
申请日：2011-08-30
申请人： Betsy T. Kren , Clifford J. Steer , Gretchen M. Unger
发明人： Betsy T. Kren , Clifford J. Steer , Gretchen M. Unger
IPC分类号： A61K9/51 , A61K38/48 , A61K38/37 , A61K31/713 , A61P1/16 , A61P3/00 , A61P7/00 , A61P31/14 , A61P37/00 , A61P11/00 , A61P35/00 , A61K31/711 , A61P7/04 , B82Y5/00
CPC分类号： A61K48/005 , A61K47/61 , A61K47/62 , A61K47/6907 , A61K48/0008 , B82Y5/00
摘要： This disclosure describes liver-specific nanocapsules for specifically targeting liver cells. This disclosure also provides methods of using such liver-specific nanocapsules to deliver one or more cargo moieties to the liver cells.
摘要翻译：本公开描述了用于特异性靶向肝细胞的肝特异性纳米胶囊。本公开还提供了使用这种肝特异性纳米胶囊将一个或多个货物部分递送至肝细胞的方法。

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