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1. 发明授权

US09498439B2 Prodrug compositions, prodrug nanoparticles, and methods of use thereof 有权
标题翻译：前药组合物，前药纳米颗粒及其使用方法
公开(公告)号：US09498439B2
公开(公告)日：2016-11-22
申请号：US13641252
申请日：2011-04-15
申请人： Gregory M. Lanza , Dipanjan Pan
发明人： Gregory M. Lanza , Dipanjan Pan
IPC分类号： A61K9/14 , A61K9/127 , A61K31/336 , A61K33/24 , A61K47/48 , A61K41/00 , A61K9/00 , A61K9/08 , A61K9/10
CPC分类号： A61K9/145 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/1075 , A61K9/1271 , A61K31/336 , A61K31/337 , A61K33/24 , A61K41/0071 , A61K47/4813 , A61K47/488 , A61K47/555 , A61K47/6907 , Y10S977/773 , Y10S977/906
摘要： Nanoparticles comprising a prodrug and prodrugs linked to phospholipids, wherein the linkages facilitate release of the prodrugs from the nanoparticles to sites within a target cell or cell membrane by fusion of the particle and the cell membrane are disclosed. Also disclosed are methods for producing and using the nanoparticles and their constituents.
摘要翻译：包含前体药物和与磷脂连接的前体药物的纳米粒子，其中所述连接通过所述颗粒和细胞膜的融合促进前药从纳米颗粒释放到靶细胞或细胞膜内的位点。还公开了制备和使用纳米颗粒及其组分的方法。

2. 发明申请

US20080241061A1 METHODS OF IMAGING EMPLOYING CHELATING AGENTS 审中-公开
标题翻译：使用洗礼剂的成像方法
公开(公告)号：US20080241061A1
公开(公告)日：2008-10-02
申请号：US11944271
申请日：2007-11-21
申请人： Gregory M. LANZA , Samuel A. Wickline
发明人： Gregory M. LANZA , Samuel A. Wickline
IPC分类号： A61K51/12 , A61M36/00 , C07F13/00 , A61P35/00
CPC分类号： A61K51/088 , A61K51/1217 , A61K51/1244
摘要： Methods to image neovasculature associated with tumors using emulsions of targeted lipid/surfactant coated nanoparticles coupled to chelating agents containing radioisotopes are described.
摘要翻译：描述了使用与含有放射性同位素的螯合剂偶联的靶向脂质/表面活性剂包被的纳米颗粒的乳液来成像与肿瘤相关的新血管系统的方法。

3. 发明授权

US07344698B2 Integrin targeted imaging agents 失效
标题翻译：整合素靶向成像剂
公开(公告)号：US07344698B2
公开(公告)日：2008-03-18
申请号：US11305416
申请日：2005-12-16
申请人： Gregory M. Lanza , Samuel A. Wickline , Tom Harris
发明人： Gregory M. Lanza , Samuel A. Wickline , Tom Harris
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/223 , A61K47/6907 , A61K49/0002 , A61K49/1833 , B82Y5/00
摘要： Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for αvβ3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
摘要翻译：优选由高沸点液体全氟化学物质形成的纳米颗粒，所述涂覆有脂质/表面活性剂涂层的颗粒由活化内皮细胞的区域特异性地形成，所述纳米颗粒通过将所述纳米颗粒与特异于α 除了抗体以外，还有3个整联蛋白。纳米颗粒可以进一步包括生物活性剂，放射性核素或其它成像剂。

4. 发明申请

US20070232909A1 Ultrasonic Characterization of Internal Body Conditions Using Information Theoretic Signal Receivers 审中-公开
标题翻译：使用信息理论信号接收机的内部身体条件的超声波表征
公开(公告)号：US20070232909A1
公开(公告)日：2007-10-04
申请号：US11692706
申请日：2007-03-28
申请人： Michael S. Hughes , Samuel A. Wickline , Gregory M. Lanza
发明人： Michael S. Hughes , Samuel A. Wickline , Gregory M. Lanza
IPC分类号： A61B8/00
CPC分类号： A61K49/225 , A61B8/481 , A61K49/1809 , B82Y5/00
摘要： Disclosed herein is a technique for performing medical imaging on a region of interest (ROI) wherein information theoretic signal receivers are used to enhance the detection and monitoring of pathologies such as angiogenesis and muscular dystrophy. Examples of information theoretic signal receivers that can be used in the practice of the invention include Shannon entropy signal receivers, continuous limit Shannon entropy signal receivers, Renyi entropy signal receivers, specific heat analog signal receivers, and thermodynamic energy analog signal receivers. The contrast enhancement provided by contrast agents, either targeted contrast agents or bubble-based contrast agents, is enhanced through the use of such information theoretic signal receivers. Further still, the contrast agents can be heated to further enhance visualization with information theoretic signal receivers.
摘要翻译：本文公开了一种用于在感兴趣区域（ROI）上进行医学成像的技术，其中使用信息理论信号接收器来增强诸如血管生成和肌营养不良症等病理学的检测和监测。可用于本发明实践的信息理论信号接收机的例子包括香农熵信号接收机，连续极限香农熵信号接收机，仁义熵信号接收机，比热模拟信号接收机和热力学能量模拟信号接收机。通过使用这种信息理论信号接收器，可以增强由造影剂，即目标对比剂或基于气泡的造影剂提供的对比度增强。此外，还可以加热造影剂以进一步增强信息理论信号接收器的可视化。

5. 发明授权

US07235227B2 Paramagnetic particles that provide improved relaxivity 失效
标题翻译：提供改善的松弛度的顺磁性颗粒
公开(公告)号：US07235227B2
公开(公告)日：2007-06-26
申请号：US10400379
申请日：2003-03-26
申请人： Gregory M. Lanza , Samuel A. Wickline
发明人： Gregory M. Lanza , Samuel A. Wickline
IPC分类号： A61B5/055
CPC分类号： B82Y5/00 , A61K49/1881
摘要： An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent. A tether offsetting the chelate from the surface of the particle may optionally contain cleavage sites permitting more facile excretion of the chelated paramagnetic ion.
摘要翻译：用于磁共振成像的改进的造影剂包括颗粒，其中每个颗粒与多个含有顺磁离子的螯合剂偶联。在改进剂中，离子的位置偏离颗粒的表面，从而提高造影剂赋予的松弛度。螯合物从颗粒表面偏移的系链可以任选地含有允许螯合顺磁离子更容易排泄的切割位点。

6. 发明授权

US06821506B2 Site specific binding system, imaging compositions and methods 失效
标题翻译：场地特异性结合系统，成像组合物和方法
公开(公告)号：US06821506B2
公开(公告)日：2004-11-23
申请号：US10036317
申请日：2001-12-28
申请人： Gregory M. Lanza , Samuel A. Wickline
发明人： Gregory M. Lanza , Samuel A. Wickline
IPC分类号： A61B5055
CPC分类号： A61K51/1217 , A61K49/18 , A61K49/1812 , G01N33/586
摘要： A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
摘要翻译：在体内或体外，脂质包封的颗粒与表面上的分子表位的基于配体的结合的方法包括顺序施用（a）用生物素活化剂活化的位点特异性配体; （b）抗生物素蛋白活化剂; 和（c）用生物素活化剂活化的脂质包封的颗粒，由此配体通过抗生物素蛋白 - 生物素相互作用与颗粒缀合，并且所得到的缀合物结合到这种表面上的分子表位。该共轭物通过X射线，超声，磁共振或正电子发射断层扫描成像是有效的。还公开了用于天然或合成表面的超声成像和增强其声反射率的组合物。

7. 发明授权

US5780010A Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system 失效
标题翻译：使用抗生物素蛋白 - 生物素缀合乳剂作为位点特异性结合系统的MRI方法
公开(公告)号：US5780010A
公开(公告)日：1998-07-14
申请号：US647277
申请日：1996-05-23
申请人： Gregory M. Lanza , Samuel A. Wickline
发明人： Gregory M. Lanza , Samuel A. Wickline
IPC分类号： G01R33/28 , A61B5/055 , A61B8/06 , A61K9/107 , A61K9/127 , A61K49/00 , A61K49/04 , A61K49/18 , A61K51/00 , A61K51/12 , G01N33/58
CPC分类号： A61K49/18 , A61K49/1812 , G01N33/586 , Y10S514/937
摘要： A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
摘要翻译：在体内或体外，脂质包封的颗粒与表面上的分子表位配体基结合的方法包括依次施用（a）用生物素活化剂活化的位点特异性配体; （b）抗生物素蛋白活化剂; 和（c）用生物素活化剂活化的脂质包封的颗粒，由此配体通过抗生物素蛋白 - 生物素相互作用与颗粒缀合，并且所得到的缀合物结合到这种表面上的分子表位。该共轭物通过X射线，超声，磁共振或正电子发射断层扫描成像是有效的。还公开了用于天然或合成表面的超声成像和增强其声反射率的组合物。

8. 发明授权

US5612057A Acoustically reflective liposomes and methods to make and use same 失效
标题翻译：声反射脂质体和使用方法相同
公开(公告)号：US5612057A
公开(公告)日：1997-03-18
申请号：US541185
申请日：1995-10-11
申请人： Gregory M. Lanza , M. Hayat Onyuksel , Melvin E. Klegerman , Michael J. Vonesh , David L. McPherson
发明人： Gregory M. Lanza , M. Hayat Onyuksel , Melvin E. Klegerman , Michael J. Vonesh , David L. McPherson
IPC分类号： A61K49/22 , A61K9/127
CPC分类号： A61K49/227 , Y10S436/829 , Y10T428/2984
摘要： This invention relates to tissue specific acoustically reflective oligolamellar liposomes containing internally separated bilayers and methods to make and to use the same, alone as a perfusion ultrasonic contrast agent or conjugated to a ligand for tissue-specific ultrasonic image enhancement.
摘要翻译：本发明涉及包含内部分离的双层的组织特异性反射性低聚糖脂质体，以及制备和使用它们的方法，单独作为灌注超声造影剂或与用于组织特异性超声波图像增强的配体结合。

9. 发明申请

US20130122100A1 PRODRUG COMPOSITIONS, PRODRUG NANOPARTICLES, AND METHODS OF USE THEREOF 有权
标题翻译： PRODRUG组合物，PRODRUG纳米材料及其使用方法
公开(公告)号：US20130122100A1
公开(公告)日：2013-05-16
申请号：US13641252
申请日：2011-04-15
申请人： Gregory M. Lanza , Dipanjan Pan
发明人： Gregory M. Lanza , Dipanjan Pan
IPC分类号： A61K9/14
CPC分类号： A61K9/145 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/1075 , A61K9/1271 , A61K31/336 , A61K31/337 , A61K33/24 , A61K41/0071 , A61K47/4813 , A61K47/488 , A61K47/555 , A61K47/6907 , Y10S977/773 , Y10S977/906
摘要： Nanoparticles comprising a prodrug and prodrugs linked to phospholipids, wherein the linkages facilitate release of the prodrugs from the nanoparticles to sites within a target cell or cell membrane by fusion of the particle and the cell membrane are disclosed. Also disclosed are methods for producing and using the nanoparticles and their constituents.
摘要翻译：包含前体药物和与磷脂连接的前体药物的纳米粒子，其中所述连接通过所述颗粒和细胞膜的融合促进前药从纳米颗粒释放到靶细胞或细胞膜内的位点。还公开了制备和使用纳米颗粒及其组分的方法。

10. 发明授权

US07566442B2 Integrin targeted imaging agents 失效
标题翻译：整合素靶向成像剂
公开(公告)号：US07566442B2
公开(公告)日：2009-07-28
申请号：US11971818
申请日：2008-01-09
申请人： Gregory M. Lanza , Samuel A. Wickline , Tom Harris
发明人： Gregory M. Lanza , Samuel A. Wickline , Tom Harris
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/223 , A61K47/6907 , A61K49/0002 , A61K49/1833 , B82Y5/00
摘要： Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for αvβ3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
摘要翻译：优选由高沸点液体全氟化学物质形成的纳米颗粒，所述涂覆有脂质/表面活性剂涂层的颗粒通过将所述纳米颗粒与除抗体以外的α-角蛋白3整联蛋白特异性的配体结合而对活化内皮细胞的区域特异性。纳米颗粒可以进一步包括生物活性剂，放射性核素或其它成像剂。

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