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    • 2. 发明申请
    • Transcutaneous immunization without heterologous adjuvant
    • 没有异源佐剂的经皮免疫
    • US20060002949A1
    • 2006-01-05
    • US11141690
    • 2005-06-01
    • Gregory GlennCarl Alving
    • Gregory GlennCarl Alving
    • A61K39/00
    • A61K39/08A61K39/008A61K39/015A61K39/0258A61K39/05A61K39/099A61K39/102A61K39/104A61K39/107A61K39/116A61K39/12A61K2039/5252A61K2039/53A61K2039/54A61K2039/545A61K2039/55505A61K2039/55522A61K2039/55533A61K2039/55544A61K2039/55555A61K2039/55561A61K2039/70C12N2740/16234C12N2760/16134C12N2760/16234C12N2760/20134Y02A50/474
    • Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response without the use of a heterologous adjuvant. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigens. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced. Immune responses that provide prophylactic and/or therapeutic treatments are preferred. Antigenic activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a dry or liquid formulation to the skin, patches and other medical devices may be used to deliver antigen for immunization.
    • 经皮免疫可通过角质层将免疫系统的抗原递送到皮肤真皮层,而不会物理或化学渗透到真皮层。 该递送系统在不使用异源佐剂的情况下诱导抗原特异性免疫应答。 虽然不需要完整皮肤的穿孔,但皮肤的表面渗透或微穿透可以作为增强剂; 类似地,水合可以增强免疫应答。 该系统可以在外皮施用含有一种或多种抗原的制剂后诱导抗原特异性免疫效应物。 制剂可以引发诸如抗原摄取,加工和表达的过程; 朗格汉斯细胞活化,从皮肤迁移到其他免疫器官,并分化成成熟树突状细胞; 使抗原与淋巴细胞接触细胞表面的同源抗原受体及其刺激; 及其组合。 可诱导全身和/或区域免疫。 提供预防和/或治疗治疗的免疫应答是优选的。 制剂中的抗原活性可以在相同的分子中发现,两个或更多个不同的分子彼此解离,或者通过共价或非共价键形成的复合物中的多个分子。 对于蛋白质的抗原,它们可以作为经皮基因免疫的多核苷酸提供在制剂中。 除了干燥或液体制剂对皮肤的简单应用之外,还可以使用贴片和其它医疗装置来递送用于免疫的抗原。
    • 4. 发明申请
    • Solar cell structure with integrated discrete by-pass diode
    • 具有集成离散旁路二极管的太阳能电池结构
    • US20050072457A1
    • 2005-04-07
    • US10677191
    • 2003-10-02
    • Gregory Glenn
    • Gregory Glenn
    • H01L31/02H01L31/00
    • H01L31/052H01L27/1421H01L31/0504Y02E10/50
    • A solar cell structure has a solar cell unit structure including a heat sink, and a solar cell having a front side, a back side, and a solar-cell projected area coverage on the heat sink. The solar cell has an active semiconductor structure that produces a voltage between the front side and the back side when the front side is illuminated. An intermediate structure is disposed between and joined to the back side of the solar cell and to the heat sink. The intermediate structure has an intermediate-structure projected area coverage on the heat sink and includes a by-pass diode having a diode projected area coverage on the heat sink. The diode projected area coverage on the heat sink may be substantially the same as the intermediate-structure projected coverage on the heat sink. Alternatively, the diode projected area coverage on the heat sink maybe less than the solar-cell projected area coverage on the heat sink, and the intermediate structure further includes a substrate coplanar with the by-pass diode.
    • 太阳能电池结构具有包括散热器的太阳能电池单元结构和在散热片上具有正面,背面和太阳能电池投影面积的太阳能电池。 太阳能电池具有有源半导体结构,当正面被照亮时,该半导体结构在正面和背面之间产生电压。 中间结构设置在太阳能电池的背面并连接到散热片。 中间结构在散热器上具有中间结构的投影面积,并且包括在散热器上具有二极管投影面积的旁路二极管。 散热片上的二极管投影面积可能与散热片上的中间结构投影覆盖基本相同。 或者,散热器上的二极管投影面积可以小于散热器上的太阳能电池投影面积,并且中间结构还包括与旁路二极管共面的衬底。
    • 5. 发明授权
    • Ski pole
    • 滑雪杖
    • US06460891B1
    • 2002-10-08
    • US09412769
    • 1999-10-04
    • Gregory Glenn Jones
    • Gregory Glenn Jones
    • A63C1122
    • A63C11/222A45B2009/025A63C11/221Y10S16/12
    • A shock absorbing ski pole with an articulating hand grip that flexes to allow for angular motion between handle and shaft during normal use. The handle contains a spring mechanism that keeps the shaft angled away from the skier when no load is applied. When the skier plants their pole, his forward motion compresses the spring and the shaft flexes into a vertical position, in-line with the grip. The grip also contains a quick release mechanism that allows the ski glove to be quickly and directly attached and unattached to the grip. In addition, the basket of the ski pole is adjustable to allow for different ski conditions. The basket consists of two disks with petals that may be rotated relative to each other. By rotating the disks coincident to each other to reduce wind resistance. However, for soft snow conditions the disks may be rotated such that the petals are offset from each other creating a greater amount of contact with the snow.
    • 具有铰接手柄的减震滑雪杖在正常使用期间弯曲以允许手柄和轴之间的角度运动。 手柄包含弹簧机构,当没有施加负载时,该机构可使轴远离滑雪者。 当滑雪者放置他们的杆时,他的向前运动压缩弹簧,并且轴弯曲成垂直位置,与握把一致。 手柄还包含一个快速释放机构,可以使滑雪手套快速而直接地附着在手柄上。 此外,滑雪杆的篮子是可调节的,以适应不同的滑雪条件。 篮子由具有可相对于彼此旋转的花瓣的两个盘组成。 通过使彼此重合的盘旋转以降低风阻。 然而,对于软雪条件,盘可以旋转,使得花瓣彼此偏移,产生更大量的与雪的接触。
    • 8. 发明授权
    • Combined vehicle sun visor extender and CD holder
    • 组合车辆遮阳板延长器和CD支架
    • US07344177B1
    • 2008-03-18
    • US11595460
    • 2006-11-09
    • Gregory Glenn
    • Gregory Glenn
    • B60J1/04
    • B60J3/0208
    • A sun visor extender and CD holder includes a frame and a pair of longitudinal sides. A plurality of notches is formed along a top surface of the sides. Oppositely disposed ends are formed with the sides and oriented orthogonal thereto. Open top and bottom faces define a central region between the sides and the ends. Straps traverse across a width of the frame and are anchored thereto and span subjacent to the top and bottom faces. A storage rack is attached to the frame and has shoulders bulging outwardly from a bottom surface thereof. The rack is oppositely faced from the straps and extends along an entire surface area of the top surface of the frame. A sun-blocking plate has a body interfitted between the sides and the ends and is supported by the straps.
    • 遮阳板延伸器和CD支架包括框架和一对纵向侧面。 沿着侧面的顶表面形成多个凹口。 相对设置的端部形成有侧面并且与其正交定向。 敞开的顶面和底面限定了侧面和端部之间的中心区域。 带横过框架的宽度并锚定在其上并跨越顶面和底面的下方。 存储架附接到框架并且具有从其底表面向外凸出的肩部。 机架相对地从带子面对并且沿框架顶表面的整个表面区域延伸。 防晒板具有在侧面和端部之间相互配合并由带支撑的身体。