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1. 发明授权

US08278622B2 Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem 有权
标题翻译：用多个过滤装置串联精确地区分气相离子的方法和装置
公开(公告)号：US08278622B2
公开(公告)日：2012-10-02
申请号：US12946435
申请日：2010-11-15
申请人： Juan Fernandez de la Mora , Alejandro Casado , Gonzalo Fernandez de la Mora
发明人： Juan Fernandez de la Mora , Alejandro Casado , Gonzalo Fernandez de la Mora
IPC分类号： G01N15/00
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译：基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法，，全部排列在一起。两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。当MS的入口区域发生碎裂时，该过程不一定需要串联MS。即使使用相对便宜又轻的单一四极杆MS系统，单个离子监测模式（SIM）对于大量目标物种可以进行快速准确的鉴别，其中各种过滤器串联放置可以打开预先配置的适合通过的窄窗口的列表中的每个离子。

2. 发明授权

US07855360B2 Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem 有权
标题翻译：用多个过滤装置串联精确地区分气相离子的方法和装置
公开(公告)号：US07855360B2
公开(公告)日：2010-12-21
申请号：US12070937
申请日：2008-02-23
申请人： Juan Fernandez de la Mora , Alejandro Casado , Gonzalo Fernandez de la Mora
发明人： Juan Fernandez de la Mora , Alejandro Casado , Gonzalo Fernandez de la Mora
IPC分类号： G01N15/00
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译：基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法，，全部排列在一起。两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。当MS的入口区域发生碎裂时，该过程不一定需要串联MS。对于大量目标物种，单离子监测模式（SIM）可以进行快速准确的鉴别，即使是相对便宜又轻的单一四极杆MS系统，其中串联的各种过滤器将打开适合通过的预配置窄窗口的列表中的每个离子。

3. 发明申请

US20080236249A1 Method for identification of persons based on the analysis of volatile substances 审中-公开
标题翻译：基于挥发性物质分析的人员识别方法
公开(公告)号：US20080236249A1
公开(公告)日：2008-10-02
申请号：US12008186
申请日：2008-01-09
申请人： Gonzalo Fernandez de la Mora
发明人： Gonzalo Fernandez de la Mora
IPC分类号： G01N33/88
CPC分类号： A61B5/117 , G06K9/00543 , G06K9/00885
摘要： The breath, body fluids or skin secretions of persons contain numerous volatile substances at concentrations permitting their chemical analysis directly from surrounding ambient gas. Based on the different odor patterns revealed by such analyses for different individuals, a non-contact method is taught that permits the identification of persons and is relatively immune to evasion.
摘要翻译：人的呼吸，体液或皮肤分泌物含有许多挥发性物质，其浓度允许其直接从周围环境气体进行化学分析。基于对不同个体的这种分析揭示的不同气味图案，教导了一种非接触方法，允许识别人，并且相对免于逃避。

4. 发明授权

US09297785B2 Method for detecting atmospheric vapors at parts per quadrillion (PPQ) concentrations 有权
标题翻译：用于检测每千瓦（PPQ）浓度的大气蒸气的方法
公开(公告)号：US09297785B2
公开(公告)日：2016-03-29
申请号：US13532146
申请日：2012-06-25
申请人： Mario Amo , Daoiz Zamora , Alejandro Casado , Gonzalo Fernandez de la Mora , Guillermo Vidal-de-Miguel , Juan Fernandez de la Mora
发明人： Mario Amo , Daoiz Zamora , Alejandro Casado , Gonzalo Fernandez de la Mora , Guillermo Vidal-de-Miguel , Juan Fernandez de la Mora
IPC分类号： G01N1/20 , G01N27/62 , H01J49/16 , G01N33/00
CPC分类号： G01N27/622 , G01N33/0057 , H01J49/165
摘要： Improvements are provided in the detection of atmospheric vapors by ionizing them near ambient pressure, and analyzing them as ions. Lowest detection limits of parts per quadrillion (ppq) concentrations are enabled by a combination of improvements, including the use of a filter to remove occasional intense signal from explosive particles. Several sources of chemical background are identified and solutions for their reduction or elimination are presented. Gains in response time may be achieved by operating at elevated temperature. When the ionizer is an electrospray source, the use of high boiling point solvents is indicated. An increased selectivity is achieved by operating a differential mobility analyzer (DMA) in series with a mass spectrometer. However, ppq sensitivities require various improvements in the DMA system including a special coupling to the ionizer, controlling the temperature in the DMA pump circuit, avoidance of induction on the DMA electrodes from heating devices, etc.
摘要翻译：通过在大气压附近电离大气蒸气并分析它们作为离子，提供了改进。通过改进的组合实现了每千瓦（ppq）浓度的最低检测限，包括使用过滤器去除爆炸性颗粒的偶然强烈信号。确定了化学背景的几个来源，并提出了其减少或消除的解决方案。响应时间的增益可以通过在高温下运行来实现。当电离器是电喷雾源时，指示使用高沸点溶剂。通过与质谱仪串联操作差示迁移率分析仪（DMA）来实现增加的选择性。然而，ppq灵敏度需要DMA系统的各种改进，包括与离子发生器的特殊耦合，控制DMA泵电路中的温度，避免加热装置上DMA电极的感应等。

5. 发明申请

US20110057096A1 METHOD AND APPARATUS TO ACCURATELY DISCRIMINATE GAS PHASE IONS WITH SEVERAL FILTERING DEVICES IN TANDEM 有权
标题翻译：在TANDEM中精确地分离气相相关离子的方法和装置，具有多个过滤装置
公开(公告)号：US20110057096A1
公开(公告)日：2011-03-10
申请号：US12946435
申请日：2010-11-15
申请人： JUAN FERNANDEZ DE LA MORA , ALEJANDRO CASADO , GONZALO FERNANDEZ DE LA MORA
发明人： JUAN FERNANDEZ DE LA MORA , ALEJANDRO CASADO , GONZALO FERNANDEZ DE LA MORA
IPC分类号： H01J49/00
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译：基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法，，全部排列在一起。两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。当MS的入口区域发生碎裂时，该过程不一定需要串联MS。即使使用相对便宜又轻的单一四极杆MS系统，单个离子监测模式（SIM）对于大量目标物种可以进行快速准确的鉴别，其中各种过滤器串联放置可以打开预先配置的适合通过的窄窗口的列表中的每个离子。

6. 发明申请

US20120325024A1 Method for Detecting Atmospheric Vapors at Parts per Quadrillion (PPQ) Concentrations 有权
标题翻译：用于检测每四分之一部分（PPQ）浓度的大气蒸气的方法
公开(公告)号：US20120325024A1
公开(公告)日：2012-12-27
申请号：US13532146
申请日：2012-06-25
申请人： Guillermo Vidal-de-Miguel , Daoiz Zamora , Mario Amo , Alejandro Casado , Gonzalo Fernandez de la Mora , Juan Fernandez de la Mora
发明人： Guillermo Vidal-de-Miguel , Daoiz Zamora , Mario Amo , Alejandro Casado , Gonzalo Fernandez de la Mora , Juan Fernandez de la Mora
IPC分类号： G01N1/22
CPC分类号： G01N27/622 , G01N33/0057 , H01J49/165
摘要： Improvements are provided in the detection of atmospheric vapors by ionizing them near ambient pressure, and analyzing them as ions. Lowest detection limits of parts per quadrillion (ppq) concentrations are enabled by a combination of improvements, including the use of a filter to remove occasional intense signal from explosive particles. Several sources of chemical background are identified and solutions for their reduction or elimination are presented. Gains in response time may be achieved by operating at elevated temperature. When the ionizer is an electrospray source, the use of high boiling point solvents is indicated. An increased selectivity is achieved by operating a differential mobility analyzer (DMA) in series with a mass spectrometer. However, ppq sensitivities require various improvements in the DMA system including a special coupling to the ionizer, controlling the temperature in the DMA pump circuit, avoidance of induction on the DMA electrodes from heating devices, etc.
摘要翻译：通过在大气压附近电离大气蒸气并分析它们作为离子，提供了改进。通过改进的组合实现了每千瓦（ppq）浓度的最低检测限，包括使用过滤器去除爆炸性颗粒的偶然强烈信号。确定了化学背景的几个来源，并提出了其减少或消除的解决方案。响应时间的增益可以通过在高温下运行来实现。当电离器是电喷雾源时，指示使用高沸点溶剂。通过与质谱仪串联操作差示迁移率分析仪（DMA）来实现增加的选择性。然而，ppq灵敏度需要DMA系统的各种改进，包括与离子发生器的特殊耦合，控制DMA泵电路中的温度，避免加热装置上DMA电极的感应等。

7. 发明申请

US20080203290A1 Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem 有权
标题翻译：用多个过滤装置串联精确地区分气相离子的方法和装置
公开(公告)号：US20080203290A1
公开(公告)日：2008-08-28
申请号：US12070937
申请日：2008-02-23
申请人： Juan Fernandez de la Mora , Alejandro Casado , Gonzalo Fernandez de la Mora
发明人： Juan Fernandez de la Mora , Alejandro Casado , Gonzalo Fernandez de la Mora
IPC分类号： B01D59/44
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译：基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法，，全部排列在一起。两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。当MS的入口区域发生碎裂时，该过程不一定需要串联MS。对于大量目标物种，单离子监测模式（SIM）可以进行快速准确的鉴别，即使是相对便宜又轻的单一四极杆MS系统，其中串联的各种过滤器将打开适合通过的预配置窄窗口的列表中的每个离子。

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