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1. 发明授权

US09226897B2 Self-assembling nanoparticles for the release of bisphosphonates in the treatment of human cancers 有权
标题翻译：用于在治疗人类癌症中释放二膦酸盐的自组装纳米颗粒
公开(公告)号：US09226897B2
公开(公告)日：2016-01-05
申请号：US13876581
申请日：2011-09-30
申请人： Giuseppe De Rosa , Michele Caraglia , Pierfrancesco Tassone , Maria Immacolata La Rotonda , Alberto Abbruzzese Saccardi , Giuseppina Salzano , Monica Marra , Carlo Leonetti
发明人： Giuseppe De Rosa , Michele Caraglia , Pierfrancesco Tassone , Maria Immacolata La Rotonda , Alberto Abbruzzese Saccardi , Giuseppina Salzano , Monica Marra , Carlo Leonetti
IPC分类号： A61K9/127 , A61K38/17 , A61K47/48
CPC分类号： A61K9/1271 , A61K38/1709 , A61K47/62 , A61K47/6911 , A61K47/6923
摘要： The present invention describe nanocomplexes also called auto-assembling nanoparticles comprising biphosphonates, lipid nanovectors and inorganic nanovectors.In particular the invention describes zoledronic acid complexed with calcium phosphate base nanoparticles; said particles in their turn mixed with lipidic particles e.g. liposomes.Said nanocomplexes are useful, and showed to be efficient in vivo, as pharmaceutical formulations of biphosphonates for the treatment or prevention of tumor growth and/or metastasis. Tumors can be solids and/or haematological such as prostate, lung, head/neck, colon, liver, breast, pancreas, kidneys, bladder, male and female urogenital tract, bones, multiple myeloma, primitive and secondary tumors of the central nervous system and lymphomas.
摘要翻译：本发明描述了纳米复合物，也称为包含二膦酸盐，脂质纳米医药和无机纳米药物的自组装纳米颗粒。特别地，本发明描述了与磷酸钙基础纳米颗粒络合的唑来膦酸; 所述颗粒又与脂质颗粒混合，例如脂质体。作为用于治疗或预防肿瘤生长和/或转移的二膦酸盐的药物制剂，所述纳米复合物是有用的并且显示在体内是有效的。肿瘤可以是固体和/或血液学，例如前列腺，肺，头/颈，结肠，肝，乳腺，胰腺，肾脏，膀胱，男性和女性泌尿生殖道，骨骼，多发性骨髓瘤，中枢神经系统原始和继发性肿瘤和淋巴瘤。

2. 发明申请

US20120134267A1 CHROMATIC SCHEDULER FOR NETWORK TRAFFIC WITH DISPARATE SERVICE REQUIREMENTS 有权
标题翻译：用于具有不同服务要求的网络交通的色彩调度器
公开(公告)号：US20120134267A1
公开(公告)日：2012-05-31
申请号：US13363764
申请日：2012-02-01
申请人： Dimas Noriega , Arthur Brisebois , Giuseppe De Rosa
发明人： Dimas Noriega , Arthur Brisebois , Giuseppe De Rosa
IPC分类号： H04W28/10
CPC分类号： H04W72/1236 , H04W72/0486 , H04W84/045
摘要： System(s) and method(s) are provided for managing network capacity in a wireless network that serves various traffic flows with disparate quality of service requirements. Management can be based on multi-stage scheduling in frequency-time domain. A first scheduling stage can generate an allocation of radio resources that minimizes inter-cell interference amongst a plurality of base stations. Based on the first-stage allocation of radio resources, a second scheduling stage can compute flow capacity for a set of radio resources specific to a base station, and acquire guaranteed-bit-rate (GBR) and non-guaranteed GBR traffic flows. GBR traffic flows can be matched to computed flow capacity to generate an allocation of frequency-time resources. In second scheduling stage, GBR traffic flows can be scheduled based at least in part on allocated resources and priority queuing. Based on allocation(s) in first and second scheduling stages, a third scheduling stage can schedule non-GBR traffic flows based at least in part on fair scheduling.
摘要翻译：提供了系统和方法，用于管理服务于具有不同服务质量要求的各种业务流的无线网络中的网络容量。管理可以基于频域多阶段调度。第一调度阶段可以生成使多个基站之间的小区间干扰最小化的无线电资源的分配。基于无线电资源的第一阶段分配，第二调度阶段可以计算特定于基站的一组无线资源的流量，并获得保证比特率（GBR）和非保证GBR业务流。 GBR流量可以与计算的流量匹配，以产生频率 - 时间资源的分配。在第二调度阶段，可以至少部分地基于分配的资源和优先级排队来调度GBR业务流。基于第一和第二调度阶段的分配，第三调度阶段可以至少部分地基于公平调度来调度非GBR业务流。

3. 发明申请

US20100151857A1 FEMTO-BASED HOME MACRO SECTOR AND ASSOCIATED SCANNING OPERATION 有权
标题翻译：基于FEMTO的家庭部门和相关扫描操作
公开(公告)号：US20100151857A1
公开(公告)日：2010-06-17
申请号：US12337139
申请日：2008-12-17
申请人： Arthur Richard Brisebois , Giuseppe De Rosa
发明人： Arthur Richard Brisebois , Giuseppe De Rosa
IPC分类号： H04W4/00
CPC分类号： H04W24/10 , H04W48/08 , H04W84/045 , H04W88/18
摘要： System(s) and method(s) are provided to determine a home macro sector linked to a femto access point and adjust inter-carrier scanning in a mobile device that operates in the home macro sector. A femto access point (AP) can determine a home macro sector through cell or sector identifier that is extracted via scan(s) of macro wireless environment of the femto AP. Femto AP can rank extracted sector identifier(s) and establish home macro sector (HMS) identifier(s), and also can generate scanning requirements for idle-mode scan(s) by mobile device(s) that operates in a HMS. Scanning requirement(s) can force periodic inter-carrier measurements of a HMS wireless environment, and establish HMS-specific radio link quality threshold(s). Wireless network can receive at least one of HMS identifier(s) and scanning requirement(s) and deliver same to mobile device(s) authorized to exploit wireless coverage through femto AP associated with the HMS ID(s) and the scanning requirement(s).
摘要翻译：提供系统和方法以确定链接到毫微微接入点的归属宏扇区并且调整在归属宏扇区中操作的移动设备中的载波间扫描。毫微微接入点（AP）可以通过通过毫微微AP的宏无线环境的扫描提取的小区或扇区标识符来确定归属宏扇区。毫微微AP可以对提取的扇区标识符进行排序并建立归属宏扇区（HMS）标识符，并且还可以通过在HMS中操作的移动设备产生对空闲模式扫描的扫描要求。扫描要求可以强制HMS无线环境的周期性载波间测量，并建立HMS特定的无线链路质量阈值。无线网络可以接收HMS标识符和扫描需求中的至少一个，并将其传送给被授权利用与HMS ID相关联的毫微微AP和扫描要求（s）的无线覆盖的移动设备）。

4. 发明申请

US20100144363A1 LOAD-BASED ADAPTIVE INACTIVITY TIMERS 审中-公开
标题翻译：基于负载的自适应无功定时器
公开(公告)号：US20100144363A1
公开(公告)日：2010-06-10
申请号：US12569662
申请日：2009-09-29
申请人： Giuseppe De Rosa , Arthur Richard Brisebois
发明人： Giuseppe De Rosa , Arthur Richard Brisebois
IPC分类号： H04W72/00
CPC分类号： H04W72/0486 , H04W52/0206 , Y02D70/1224 , Y02D70/1242 , Y02D70/1244 , Y02D70/1246 , Y02D70/1262 , Y02D70/1264 , Y02D70/142 , Y02D70/146 , Y02D70/164
摘要： System(s) and method(s) are provided to for optimizing cellular network resource utilization under variable load conditions. To optimize resource(s) reallocation, inactivity timers that regulate network resource utilization between activity periods are dynamically adjusted based at least in part on current cell load condition(s). Lookup table(s) or computation based on load-timer mapping(s) can enable, at least in part, configuration of an inactivity timer setting. Inactivity timer values and magnitude of adjustments effected as a function of changes in cell load condition(s) can provide an optimal balance of at least one of network resource utilization; battery life of a served device; or signaling load associated with operation of the device. Inactivity timer setting(s) can be based at least in part on load condition estimates, which mitigate signaling associated with current load condition(s) assessment. Inactivity timers can be autonomously determined.
摘要翻译：提供系统和方法以在可变负载条件下优化蜂窝网络资源利用。为了优化资源重新分配，至少部分地基于当前小区负载条件来动态地调整在活动周期之间调节网络资源利用的不活动定时器。基于负载定时器映射的查找表或计算可以至少部分地实现非活动定时器设置的配置。不活动定时器值和作为小区负载状况变化的函数的调整幅度可以提供网络资源利用中的至少一个的最佳平衡; 服务设备的电池寿命; 或与设备的操作相关联的信令负载。不活动定时器设置可以至少部分地基于负载条件估计，其减轻与当前负载条件评估相关联的信令。不活动计时器可以自主确定。

5. 发明授权

US08521169B2 FEMTO jamming of macro pilot 有权
标题翻译： FEMTO干扰宏观飞行员
公开(公告)号：US08521169B2
公开(公告)日：2013-08-27
申请号：US13601334
申请日：2012-08-31
申请人： Arthur Brisebois , Giuseppe De Rosa
发明人： Arthur Brisebois , Giuseppe De Rosa
IPC分类号： H04W36/00
CPC分类号： H04W52/244 , H04K3/42 , H04K3/43 , H04K3/45 , H04K2203/16 , H04K2203/18 , H04W36/04 , H04W48/16 , H04W52/44 , H04W84/045
摘要： A system and methodology that facilitates triggering device scanning and efficient femtocell detection in areas dominated by macro cells is provided. In particular, the system can includes a jamming component that generates a small and measured amount of interference to user equipment or user equipments (UEs) camping on nearby macro carriers. Moreover, the power utilized to introduce the interference can be enough to cause macro signal quality around the femtocell access point (AP) to fall below a scan trigger level. The UE(s) can detect the macro signal quality decline below the scan trigger level and scan other frequency bands, including the femtocell, on which to camp. Additionally, the system can perform femto pilot gating, such that the jamming component can scan the radio environment surrounding the femto AP during an off state, to determine information that facilitates jamming of a macro pilot.
摘要翻译：提供了一种有助于在由宏小区主导的区域中触发设备扫描和有效的毫微微小区检测的系统和方法。特别地，系统可以包括干扰组件，其产生对驻留在附近的宏载波上的用户设备或用户设备（UE）产生小的和测量的干扰量。此外，用于引入干扰的功率可以足以使得毫微微小区接入点（AP）周围的宏信号质量下降到扫描触发电平以下。 UE可以检测到低于扫描触发电平的宏信号质量下降并扫描包括毫微微小区在内的其他频带。此外，系统可以执行毫微微导频选通，使得干扰组件可以在关闭状态期间扫描毫微微AP周围的无线电环境，以确定有助于宏导频干扰的信息。

6. 发明授权

US08270431B2 Femto-based home macro sector and associated scanning operation 有权
标题翻译：以美国为基地的家庭宏观部门和相关扫描行动
公开(公告)号：US08270431B2
公开(公告)日：2012-09-18
申请号：US12337139
申请日：2008-12-17
申请人： Arthur Richard Brisebois , Giuseppe De Rosa
发明人： Arthur Richard Brisebois , Giuseppe De Rosa
IPC分类号： H04J3/00
CPC分类号： H04W24/10 , H04W48/08 , H04W84/045 , H04W88/18
摘要： System(s) and method(s) are provided to determine a home macro sector linked to a femto access point and adjust inter-carrier scanning in a mobile device that operates in the home macro sector. A femto access point (AP) can determine a home macro sector through cell or sector identifier that is extracted via scan(s) of macro wireless environment of the femto AP. Femto AP can rank extracted sector identifier(s) and establish home macro sector (HMS) identifier(s), and also can generate scanning requirements for idle-mode scan(s) by mobile device(s) that operates in a HMS. Scanning requirement(s) can force periodic inter-carrier measurements of a HMS wireless environment, and establish HMS-specific radio link quality threshold(s). Wireless network can receive at least one of HMS identifier(s) and scanning requirement(s) and deliver same to mobile device(s) authorized to exploit wireless coverage through femto AP associated with the HMS ID(s) and the scanning requirement(s).
摘要翻译：提供系统和方法以确定链接到毫微微接入点的归属宏扇区并且调整在归属宏扇区中操作的移动设备中的载波间扫描。毫微微接入点（AP）可以通过经由毫微微AP的宏无线环境的扫描提取的小区或扇区标识符来确定归属宏扇区。毫微微AP可以对提取的扇区标识符进行排序并建立归属宏扇区（HMS）标识符，并且还可以通过在HMS中操作的移动设备产生对空闲模式扫描的扫描要求。扫描要求可以强制HMS无线环境的周期性载波间测量，并建立HMS特定的无线链路质量阈值。无线网络可以接收HMS标识符和扫描需求中的至少一个，并将其传送给被授权利用与HMS ID相关联的毫微微AP和扫描要求（s）的无线覆盖的移动设备）。

7. 发明申请

US20110149879A1 CHROMATIC SCHEDULER FOR NETWORK TRAFFIC WITH DISPARATE SERVICE REQUIREMENTS 失效
标题翻译：用于具有不同服务要求的网络交通的色彩调度器
公开(公告)号：US20110149879A1
公开(公告)日：2011-06-23
申请号：US12646809
申请日：2009-12-23
申请人： Dimas Noriega , Arthur Brisebois , Giuseppe De Rosa
发明人： Dimas Noriega , Arthur Brisebois , Giuseppe De Rosa
IPC分类号： H04W72/04
CPC分类号： H04W72/1236 , H04W72/0486 , H04W84/045
摘要： System(s) and method(s) are provided for managing network capacity in a wireless network that serves various traffic flows with disparate quality of service requirements. Management is based on multi-stage scheduling in frequency-time domain. A first scheduling stage generates an allocation of radio resources that minimizes inter-cell interference amongst a plurality of base stations. Based on the first-stage allocation of radio resources, a second scheduling stage computes flow capacity for a set of radio resources specific to a base station, and acquires guaranteed-bit-rate (GBR) and non-guaranteed GBR traffic flows. GBR traffic flows are matched to computed flow capacity to generate an allocation of frequency-time resources. In second scheduling stage, GBR traffic flows are scheduled based at least in part on allocated resources and priority queuing. Based on allocation(s) in first and second scheduling stages, a third scheduling stage schedules non-GBR traffic flows based at least in part on fair scheduling.
摘要翻译：提供了系统和方法，用于管理服务于具有不同服务质量要求的各种业务流的无线网络中的网络容量。管理是基于频域多阶段调度。第一调度阶段生成使多个基站之间的小区间干扰最小化的无线电资源的分配。基于无线电资源的第一阶段分配，第二调度阶段计算特定于基站的一组无线电资源的流量，并获得保证比特率（GBR）和非保证GBR业务流。 GBR业务流量与计算的流量匹配，以产生频率 - 时间资源的分配。在第二调度阶段，至少部分地基于分配的资源和优先级排队来调度GBR业务流。基于第一和第二调度阶段的分配，第三调度阶段至少部分地基于公平调度来调度非GBR业务流。

8. 发明申请

US20100151858A1 SCANNING OF WIRELESS ENVIRONMENT IN A FEMTO-BASED HOME MACRO SECTOR 有权
标题翻译：在基于FEMTO的家庭宏观部门扫描无线环境
公开(公告)号：US20100151858A1
公开(公告)日：2010-06-17
申请号：US12337247
申请日：2008-12-17
申请人： Arthur Richard Brisebois , Giuseppe De Rosa
发明人： Arthur Richard Brisebois , Giuseppe De Rosa
IPC分类号： H04W8/00
CPC分类号： H04W48/16 , H04W8/22 , H04W16/32 , H04W24/10 , H04W36/08 , H04W48/02 , H04W48/08 , H04W48/20 , H04W84/045 , H04W88/18
摘要： System(s) and method(s) are provided to trigger inter-carrier scanning in a mobile device based at least in part on location thereof. Femto access point (AP) that can serve the mobile device can determine location through cell or sector identifier that is extracted via scan(s) of macro wireless environment of the femto AP. Femto AP can rank extracted sector identifier(s) and establish home macro sector (HMS) identifier(s), and also can generate scanning requirements for idle-mode scan(s) by a mobile device that operates in a HMS and is authorized to access wireless coverage through the femto AP. Scanning requirement(s) can force periodic inter-carrier measurements of a HMS wireless environment, and establish HMS-specific radio link quality threshold(s). Wireless network can receive at least one of HMS identifier(s) and scanning requirement(s) and deliver same to mobile device(s) authorized to exploit wireless coverage through femto AP associated with the HMS ID(s) and the scanning requirement(s).
摘要翻译：提供系统和方法以至少部分地基于其位置来触发移动设备中的载波间扫描。可以服务于移动设备的毫微微接入点（AP）可以通过经由毫微微AP的宏无线环境的扫描提取的小区或扇区标识符来确定位置。 Femto AP可以对提取的扇区标识符进行排序并建立归属宏扇区（HMS）标识符，并且还可以由在HMS中操作的移动设备生成针对空闲模式扫描的扫描要求，并被授权通过毫微微AP接入无线覆盖。扫描要求可以强制HMS无线环境的周期性载波间测量，并建立HMS特定的无线链路质量阈值。无线网络可以接收HMS标识符和扫描需求中的至少一个，并将其传送给被授权利用与HMS ID相关联的毫微微AP和扫描要求（s）的无线覆盖的移动设备）。

9. 发明申请

US20140086979A1 Self-Assembling Nanoparticles for the Release of Bisphosphonates in the Treatment of Human Cancers 有权
标题翻译：用于释放二膦酸盐在人类癌症治疗中的自组装纳米颗粒
公开(公告)号：US20140086979A1
公开(公告)日：2014-03-27
申请号：US13876581
申请日：2011-09-30
申请人： Michele Caraglia , Giuseppe De Rosa
发明人： Giuseppe De Rosa , Michele Caraglia , Pierfrancesco Tassone , Maria Immacolata La Rotonda , Alberto Abbruzzese Saccardi , Giuseppina Salzano , Monica Marra , Carlo Leonetti
IPC分类号： A61K9/127 , A61K38/17
CPC分类号： A61K9/1271 , A61K38/1709 , A61K47/62 , A61K47/6911 , A61K47/6923
摘要： The present invention describe nanocomplexes also called auto-assembling nanoparticles comprising biphosphonates, lipid nanovectors and inorganic nanovectors.In particular the invention describes zoledronic acid complexed with calcium phosphate base nanoparticles; said particles in their turn mixed with lipidic particles e.g. liposomes.Said nanocomplexes are useful, and showed to be efficient in vivo, as pharmaceutical formulations of biphosphonates for the treatment or prevention of tumor growth and/or metastasis. Tumors can be solids and/or haematological such as prostate, lung, head/neck, colon, liver, breast, pancreas, kidneys, bladder, male and female urogenital tract, bones, multiple myeloma, primitive and secondary tumours of the central nervous system and lymphomas.
摘要翻译：本发明描述了纳米复合物，也称为包含二膦酸盐，脂质纳米医药和无机纳米药物的自组装纳米颗粒。特别地，本发明描述了与磷酸钙基础纳米颗粒络合的唑来膦酸; 所述颗粒又与脂质颗粒混合，例如脂质体。作为用于治疗或预防肿瘤生长和/或转移的二膦酸盐的药物制剂，所述纳米复合物是有用的并且显示在体内是有效的。肿瘤可以是固体和/或血液学，例如前列腺，肺，头/颈，结肠，肝，乳腺，胰腺，肾脏，膀胱，男性和女性泌尿生殖道，骨骼，多发性骨髓瘤，中枢神经系统原始和继发性肿瘤和淋巴瘤。

10. 发明授权

US08487516B2 Scanning of wireless environment in a femto-based home macro sector 有权
标题翻译：在基于毫微微的家庭宏部门中扫描无线环境
公开(公告)号：US08487516B2
公开(公告)日：2013-07-16
申请号：US12337247
申请日：2008-12-17
申请人： Arthur Richard Brisebois , Giuseppe De Rosa
发明人： Arthur Richard Brisebois , Giuseppe De Rosa
IPC分类号： H04B7/00
CPC分类号： H04W48/16 , H04W8/22 , H04W16/32 , H04W24/10 , H04W36/08 , H04W48/02 , H04W48/08 , H04W48/20 , H04W84/045 , H04W88/18
摘要： System(s) and method(s) are provided to trigger inter-carrier scanning in a mobile device based at least in part on location thereof. Femto access point (AP) that can serve the mobile device can determine location through cell or sector identifier that is extracted via scan(s) of macro wireless environment of the femto AP. Femto AP can rank extracted sector identifier(s) and establish home macro sector (HMS) identifier(s), and also can generate scanning requirements for idle-mode scan(s) by a mobile device that operates in a HMS and is authorized to access wireless coverage through the femto AP. Scanning requirement(s) can force periodic inter-carrier measurements of a HMS wireless environment, and establish HMS-specific radio link quality threshold(s). Wireless network can receive at least one of HMS identifier(s) and scanning requirement(s) and deliver same to mobile device(s) authorized to exploit wireless coverage through femto AP associated with the HMS ID(s) and the scanning requirement(s).
摘要翻译：提供系统和方法以至少部分地基于其位置来触发移动设备中的载波间扫描。可以服务于移动设备的毫微微接入点（AP）可以通过经由毫微微AP的宏无线环境的扫描提取的小区或扇区标识符来确定位置。 Femto AP可以对提取的扇区标识符进行排序并建立归属宏扇区（HMS）标识符，并且还可以由在HMS中操作的移动设备产生对空闲模式扫描的扫描要求，并被授权通过毫微微AP接入无线覆盖。扫描要求可以强制HMS无线环境的周期性载波间测量，并建立HMS特定的无线链路质量阈值。无线网络可以接收HMS标识符和扫描需求中的至少一个，并将其传送给被授权利用与HMS ID相关联的毫微微AP和扫描要求（s）的无线覆盖的移动设备）。

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