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1. 发明申请

US20080274539A1 Bioreactor for Studying the Effects of Imposed Stimuli on Cellular Activity 有权
标题翻译：用于研究刺激刺激对细胞活性的影响的生物反应器
公开(公告)号：US20080274539A1
公开(公告)日：2008-11-06
申请号：US11629917
申请日：2005-06-16
申请人： Arti Ahluwalia , Federico Vozzi , Giovanni Vozzi , Nicola Forgione , Antonio Previti , Valerio Rossi , Cristiano Scarpa
发明人： Arti Ahluwalia , Federico Vozzi , Giovanni Vozzi , Nicola Forgione , Antonio Previti , Valerio Rossi , Cristiano Scarpa
IPC分类号： C12M1/00
CPC分类号： C12M41/00 , B01L3/5027 , C12M23/22 , C12M29/10 , C12M29/26 , C12M35/04 , C12M35/08 , C12M41/46
摘要： A bioreactor device for studying the effects of physical, chemical, mechanical and electromagnetic stimuli on the cellular activity. In particular, the device uses a sensorized premixing chamber (1), a culture chamber (2) for observing the development of the cells by a microscope (40). Output signals are transmitted to a control unit for amplifying and filtering the signals (50), which transmits the treated signals to a computer (52). To another control unit (51) actuating electrovalves (20), (21) and (22) are connected that adjust the introduction of gas in the premixing chamber. The culture medium is drawn from the premixing chamber (1) through a duct (4) and its flow is adjusted by a peristaltic pump (30). The culture medium crosses then the culture chamber (2) and continues its path in a duct (3), returning again in the premixing chamber (1). At the outlet of the culture chamber (2) the duct has a sample point (23) for picking up an amount of culture medium to analyse. Immediately before, along the duct, a temperature sensor is provided (24) that transmits a signal to the control unit (50) by an electrical cable (9).
摘要翻译：用于研究物理，化学，机械和电磁刺激对细胞活性的影响的生物反应器装置。特别地，该装置使用传感的预混合室（1），用于通过显微镜（40）观察细胞的发育的培养室（2）。输出信号被发送到控制单元，用于对将经处理的信号发送到计算机（52）的信号（50）进行放大和滤波。连接到驱动电阀（20），（21）和（22）的另一个控制单元（51），其调节在预混合室中引入气体。培养基从预混合室（1）通过管道（4）抽出，其流动由蠕动泵（30）调节。培养基与培养室（2）交叉，并在管道（3）中继续其路径，再次在预混合室（1）中返回。在培养室（2）的出口处，管道具有用于拾取一定量的培养基进行分析的样品点（23）。在紧接着之前，沿着导管提供温度传感器（24），其通过电缆（9）将信号传输到控制单元（50）。

2. 发明授权

US09243220B2 Bioreactor chamber 有权
标题翻译：生物反应器室
公开(公告)号：US09243220B2
公开(公告)日：2016-01-26
申请号：US13057083
申请日：2009-07-31
申请人： Arti Ahluwalia , Daniele Mazzei , Bruna Vinci , Giovanni Vozzi
发明人： Arti Ahluwalia , Daniele Mazzei , Bruna Vinci , Giovanni Vozzi
IPC分类号： C12M1/00 , C12M3/00 , B01J19/00 , C12M1/12 , C12M1/04
CPC分类号： C12M29/04 , B01J19/0073 , B01J2219/00011 , C12M23/24 , C12M23/26 , C12M23/34 , C12M23/44 , C12M23/46 , C12M25/02 , C12M29/10
摘要： Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion.
摘要翻译：本发明的实施例提供了一种用于生物反应器的腔室，所述腔室具有流体入口孔口和流体出口孔口，该腔室设置在腔室的相应不同位置处，相对于腔室的正常竖直取向，腔室设置有限定室的上边界的上壁部分。上壁部分具有内表面，该内表面具有相对于第二部分垂直移位的第一部分。上壁部分的内表面被布置成促使捕获的气泡通过出口孔排出，上壁部分的第一和第二部分各自包括倾斜部分。

3. 发明申请

US20110129911A1 Bioreactor Chamber 有权
标题翻译：生物反应器室
公开(公告)号：US20110129911A1
公开(公告)日：2011-06-02
申请号：US13057083
申请日：2009-07-31
申请人： Arti Ahluwalia , Daniele Mazzei , Bruna Vinci , Giovanni Vozzi
发明人： Arti Ahluwalia , Daniele Mazzei , Bruna Vinci , Giovanni Vozzi
IPC分类号： C12M1/00
CPC分类号： C12M29/04 , B01J19/0073 , B01J2219/00011 , C12M23/24 , C12M23/26 , C12M23/34 , C12M23/44 , C12M23/46 , C12M25/02 , C12M29/10
摘要： Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion.
摘要翻译：本发明的实施例提供了一种用于生物反应器的腔室，所述腔室具有流体入口孔口和流体出口孔口，该腔室设置在腔室的相应不同位置处，相对于腔室的正常竖直取向，腔室设置有限定室的上边界的上壁部分。上壁部分具有内表面，该内表面具有相对于第二部分垂直移位的第一部分。上壁部分的内表面被布置成促使捕获的气泡通过出口孔排出，上壁部分的第一和第二部分各自包括倾斜部分。

4. 发明授权

US08715436B2 Microfabricated biopolymer scaffolds and method of making same 有权
标题翻译：微生物聚合物支架及其制备方法
公开(公告)号：US08715436B2
公开(公告)日：2014-05-06
申请号：US10750293
申请日：2003-12-31
申请人： Sangeeta N. Bhatia , Giovanni Vozzi
发明人： Sangeeta N. Bhatia , Giovanni Vozzi
IPC分类号： A61F2/00 , B29C65/00 , B32B3/10
CPC分类号： A61F2/00 , B29C67/202 , Y10T428/24273 , Y10T428/24322 , Y10T428/26 , Y10T428/269
摘要： The invention is a series of soft lithographic methods for the microfabrication of biopolymer scaffolds for use in tissue engineering and the development of artificial organs. The methods present a wide range of possibilities to construct two- and three-dimensional scaffolds with desired characteristics according to the final application. The methods utilize an elastomer mold which the biopolymer scaffold is cast. The methods allow for the rapid and inexpensive production of biopolymer scaffolds with limited specialized equipment and user expertise.
摘要翻译：本发明是用于组织工程和人造器官发育的生物聚合物支架的微细加工的一系列软平版印刷方法。根据最终应用，该方法具有广泛的可能性来构建具有所需特征的二维和三维支架。该方法利用生物聚合物支架铸造的弹性体模具。该方法允许以有限的专门设备和用户专业知识快速而廉价地生产生物聚合物支架。

5. 发明申请

US20130230907A1 HIGH-THROUGHPUT SENSORIZED BIOREACTOR FOR APPLYING HYDRODYNAMIC PRESSURE AND SHEAR STRESS STIMULI ON CELL CULTURES 审中-公开
标题翻译：用于在细胞培养上应用水动力压力和剪切应力刺激的高通量感应生物反应器
公开(公告)号：US20130230907A1
公开(公告)日：2013-09-05
申请号：US13637944
申请日：2010-04-21
申请人： Arti Ahluwalia , Carmelo De Maria , Daniele Mazzei , Giovanni Vozzi
发明人： Arti Ahluwalia , Carmelo De Maria , Daniele Mazzei , Giovanni Vozzi
IPC分类号： C12M1/42
CPC分类号： C12M35/04 , C12M41/12 , C12M41/26
摘要： A bioreactor (1) for subjecting a cell culture (3) to a hydrodynamic pressure stimulus is described. This hydrodynamic pressure is generated inside at least one culture chamber (2) by means of variation of the mean distance, with a controlled speed, of a surface relative to the surface on which the culture (3) is positioned and between which the culture medium (5) is free to flow.
摘要翻译：描述了用于使细胞培养物（3）进行流体动力学压力刺激的生物反应器（1）。通过以相对于培养物（3）所在表面的表面的受控速度的平均距离的变化在培养室（2）内产生该流体动力学压力，并且培养基（5）可自由流动。

6. 发明授权

US07790444B2 Bioreactor for studying the effects of imposed stimuli on cellular activity 有权
标题翻译：用于研究强化刺激对细胞活性的影响的生物反应器
公开(公告)号：US07790444B2
公开(公告)日：2010-09-07
申请号：US11629917
申请日：2005-06-16
申请人： Arti Ahluwalia , Federico Vozzi , Giovanni Vozzi , Nicola Forgione , Antonino Previti , Valerio Rossi , Cristiano Scarpa
发明人： Arti Ahluwalia , Federico Vozzi , Giovanni Vozzi , Nicola Forgione , Antonino Previti , Valerio Rossi , Cristiano Scarpa
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M41/00 , B01L3/5027 , C12M23/22 , C12M29/10 , C12M29/26 , C12M35/04 , C12M35/08 , C12M41/46
摘要： A bioreactor device for studying the effects of physical, chemical, mechanical and electromagnetic stimuli on the cellular activity. In particular, the device uses a sensorized premixing chamber (1), a culture chamber (2) for observing the development of the cells by a microscope (40). Output signals are transmitted to a control unit for amplifying and filtering the signals (50), which transmits the treated signals to a computer (52). To another control unit (51) actuating electrovalves (20), (21) and (22) are connected that adjust the introduction of gas in the premixing chamber. The culture medium is drawn from the premixing chamber (1) through a duct (4) and its flow is adjusted by a peristaltic pump (30). The culture medium crosses then the culture chamber (2) and continues its path in a duct (3), returning again in the premixing chamber (1). At the outlet of the culture chamber (2) the duct has a sample point (23) for picking up an amount of culture medium to analyze. Immediately before, along the duct, a temperature sensor is provided (24) that transmits a signal to the control unit (50) by an electrical cable (9).
摘要翻译：用于研究物理，化学，机械和电磁刺激对细胞活性的影响的生物反应器装置。特别地，该装置使用传感的预混合室（1），用于通过显微镜（40）观察细胞的发育的培养室（2）。输出信号被发送到控制单元，用于对将经处理的信号发送到计算机（52）的信号（50）进行放大和滤波。连接到驱动电阀（20），（21）和（22）的另一个控制单元（51），其调节在预混合室中引入气体。培养基从预混合室（1）通过管道（4）抽出，其流动由蠕动泵（30）调节。培养基与培养室（2）交叉，并在管道（3）中继续其路径，再次在预混合室（1）中返回。在培养室（2）的出口处，管道具有用于拾取一定量的培养基进行分析的样品点（23）。在紧接着之前，沿着导管提供温度传感器（24），其通过电缆（9）将信号发送到控制单元（50）。

7. 发明申请

US20050008675A1 Microfabricated biopolymer scaffolds and method of making same 有权
标题翻译：微生物聚合物支架及其制备方法
公开(公告)号：US20050008675A1
公开(公告)日：2005-01-13
申请号：US10750293
申请日：2003-12-31
申请人： Sangeeta Bhatia , Giovanni Vozzi
发明人： Sangeeta Bhatia , Giovanni Vozzi
IPC分类号： B29C67/20 , A61F2/00 , B29C41/34
CPC分类号： A61F2/00 , B29C67/202 , Y10T428/24273 , Y10T428/24322 , Y10T428/26 , Y10T428/269
摘要： The invention is a series of soft lithographic methods for the microfabrication of biopoilymer scaffolds for use in tissue engineering and the development of artificial organs. The methods present a wide range of possibilities to construct two- and three-dimensional scaffolds with desired characteristics according to the final application. The methods utilize an elastomer mold which the biopolymer scaffold is cast. The methods allow for the rapid and inexpensive production of biopolymer scaffolds with limited specialized equipment and user expertise.
摘要翻译：本发明是用于组织工程和人造器官发育的生物体支架的微细加工的一系列软平版印刷方法。根据最终应用，该方法具有广泛的可能性来构建具有所需特征的二维和三维支架。该方法利用生物聚合物支架铸造的弹性体模具。该方法允许以有限的专门设备和用户专业知识快速而廉价地生产生物聚合物支架。

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