专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07309701B2 Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them 有权
标题翻译：哒嗪酮衍生物作为药物和含有它们的药物组合物
公开(公告)号：US07309701B2
公开(公告)日：2007-12-18
申请号：US10715358
申请日：2003-11-19
申请人： Swen Hölder , Thorsten Naumann , Karl Schönafinger , David William Will , Hans Matter , Günther Müller , Dominique Le Suisse , Bernard Baudoin , Thomas Rooney , Franck Halley , Gilles Tiraboschi
发明人： Swen Hölder , Thorsten Naumann , Karl Schönafinger , David William Will , Hans Matter , Günther Müller , Dominique Le Suisse , Bernard Baudoin , Thomas Rooney , Franck Halley , Gilles Tiraboschi
IPC分类号： C07D413/12 , C07D403/12 , C07D237/04 , A61K31/501 , A61K31/50
CPC分类号： C07D401/04 , C07D237/14 , C07D237/24 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14 , C07D513/04
摘要： The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl, aryl-(C1-C10-alkyl)-, heteroaryl, heteroaryl-(C1-C10-alkyl)-, heterocyclyl, heterocyclyl-(C1-C10-alkyl)-, C3-C10-cycloalkyl, polycycloalkyl, C2-C10-alkenyl or C2-C10-alkinyl and Ar is unsubstituted or at least monosubstituted aryl or heteroaryl.
摘要翻译：本发明涉及通式（I）的新的哒嗪酮衍生物，其中A为A 1或A 2; R是未取代的或至少单取代的C 1 -C 10 - 烷基，芳基，芳基 - （C 1 -C 10 - 烷基） - ，杂芳基，杂芳基 - （C 1 -C 10 - 烷基） - ，杂环基，杂环基 - （C 1 -C 12 - C 1 -C 10 - 烷基） - ，C 3 -C 10 - 环烷基，多环烷基，C 2 - C 10 - 链烯基或C 2 -C 10 - 炔基，Ar是未取代的或至少单取代的芳基或杂芳基。

2. 发明申请

US20050203170A1 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof 审中-公开
标题翻译： 1,3-二芳基丙-2-烯-1-酮，含有它们的组合物及其用途
公开(公告)号：US20050203170A1
公开(公告)日：2005-09-15
申请号：US11108855
申请日：2005-04-19
申请人： Patrick Mailliet , Cecile Combeau , Marie-Christine Bissery , Marie-Pierre Cherrier , Thomas Caulfield , Gilles Tiraboschi
发明人： Patrick Mailliet , Cecile Combeau , Marie-Christine Bissery , Marie-Pierre Cherrier , Thomas Caulfield , Gilles Tiraboschi
IPC分类号： C07C225/22 , C07C237/04 , C07C279/36 , C07D207/16 , C07D209/08 , C07D405/06 , A61K31/401 , A61K31/135 , A61K31/198
CPC分类号： C07D405/06 , C07C225/22 , C07C237/04 , C07C279/36 , C07D207/16 , C07D209/08
摘要： 1,3-Diarylprop-2-en-1-ones and derivatives, compositions containing them, manufacturing process and use. Substituted 1,3-diarylprop-2-en-1-ones with therapeutic activity may be used in oncology.
摘要翻译： 1,3-二芳基丙-2-烯-1-酮及其衍生物，含有它们的组合物，制造方法和用途。具有治疗活性的取代的1,3-二芳基丙-2-烯-1-酮可用于肿瘤学。

3. 发明申请

US20050020593A1 Aryl-heteroaromatic compounds, compositions comprising them and use 审中-公开
标题翻译：芳基杂芳族化合物，包含它们的组合物和用途
公开(公告)号：US20050020593A1
公开(公告)日：2005-01-27
申请号：US10898517
申请日：2004-07-23
申请人： Patrick Mailliet , Alain Le-Brun , Fabienne Thompson , Gilles Tiraboschi
发明人： Patrick Mailliet , Alain Le-Brun , Fabienne Thompson , Gilles Tiraboschi
IPC分类号： A61K31/496 , A61K31/52 , A61K31/53 , A61P35/00 , A61P43/00 , C07D209/42 , C07D231/56 , C07D333/68 , C07D471/04
CPC分类号： C07D209/42 , C07D231/56 , C07D333/68 , C07D471/04
摘要： A series of aryl-heteroaromatic compounds, compositions comprising them and use thereof are disclosed and claimed. The present invention relates in particular to novel aryl-heteroaromatic compounds exhibiting anticancer activity, and in particular inhibitory activity with regard to tubulin polymerization.
摘要翻译：一系列芳基杂芳族化合物，包含它们的组合物及其用途被公开并要求保护。本发明特别涉及具有抗癌活性的新型芳基 - 杂芳族化合物，特别是关于微管蛋白聚合的抑制活性。

4. 发明申请

US20110178134A1 Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof 审中-公开
标题翻译：新的苯基取代的咪唑啉，其制备方法，包含所述化合物的药物及其用途
公开(公告)号：US20110178134A1
公开(公告)日：2011-07-21
申请号：US12852038
申请日：2010-08-06
申请人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
发明人： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
IPC分类号： A61K31/4439 , C07D233/02 , C07D401/06 , A61K31/4166 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/18
CPC分类号： C07D233/72 , C07D401/06
摘要： The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
摘要翻译：本发明涉及其中基团具有所述含义的式（I）化合物及其生理上相容的盐。所述化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。

5. 发明授权

US07629374B2 Use of aminoindazole derivatives for the inhibition of tau phosphorylation 失效
标题翻译：氨基吲唑衍生物用于抑制tau磷酸化
公开(公告)号：US07629374B2
公开(公告)日：2009-12-08
申请号：US12143070
申请日：2008-06-20
申请人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney , Gilles Tiraboschi
发明人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney , Gilles Tiraboschi
IPC分类号： A61K31/415
CPC分类号： C07D231/56 , A61K31/416 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D403/12 , C07D405/12
摘要： The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, OR8, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl, to treat a disease selected from the group consisting of: neurodegenerative diseases, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovaries syndrome, syndrome X, immunodeficiency and cancer.
摘要翻译：本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或与（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1基团稠合的杂芳基） R 5，R 6和R 7彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，OR 8，COOH，C（O）OR 8，-OC（O）R 8，NR 8 R 9，NHC ）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O）R8，SO2R8，NHSO2R8，SO2NR8R9，-O-SO2R8，-SO2-O-R8，三氟甲基，三氟甲氧基，（1-6C）烷基，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环烷基，选自以下的疾病：神经变性疾病，中风，颅脑和脊髓创伤和周围神经病变，肥胖症，代谢疾病，II型糖尿病，原发性高血压，动脉粥样硬化性心血管疾病，多囊卵巢综合征，综合征X，免疫缺陷和癌症。

6. 发明申请

US20080261997A1 USE OF AMINOINDAZOLE DERIVATIVES FOR THE INHIBITION OF TAU PHOSPHORYLATION 失效
标题翻译：氨基吖啶衍生物用于抑制TAO磷酸化的用途
公开(公告)号：US20080261997A1
公开(公告)日：2008-10-23
申请号：US12143070
申请日：2008-06-20
申请人： Dominique LESUISSE , Gilles DUTRUC-ROSSET , Franck HALLEY , Didier BABIN , Thomas ROONEY , Gilles TIRABOSCHI
发明人： Dominique LESUISSE , Gilles DUTRUC-ROSSET , Franck HALLEY , Didier BABIN , Thomas ROONEY , Gilles TIRABOSCHI
IPC分类号： A61K31/496 , A61K31/454 , A61K31/415 , A61P25/00
CPC分类号： C07D231/56 , A61K31/416 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D403/12 , C07D405/12
摘要： The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, OR8, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl, to treat a disease selected from the group consisting of: neurodegenerative diseases, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovaries syndrome, syndrome X, immunodeficiency and cancer.
摘要翻译：本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或与（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（ - NH）NR1基; R 5，R 6和R 7彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，OR 8，COOH，C（ O）OR 8，-OC（O）R 8，NR 8 R 9，NHC（O）R 8，C（O）NR 8 R 9，NHC（S）R 8，C（S）NR 8 R 9，SR 8，S（O）R 8，SO 2 R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环烷基，以治疗选自以下的疾病：神经变性疾病，中风，颅脑和脊髓创伤和周围神经病变，肥胖症，代谢疾病，II型糖尿病，原发性高血压，动脉粥样硬化心血管疾病，多囊卵巢综合征，综合征X，免疫缺陷和癌症。

7. 发明授权

US07407981B2 Aminoindazole derivatives as medicaments and pharmaceutical compositions including them 失效
标题翻译：氨基吲唑衍生物作为药物和药物组合物，包括它们
公开(公告)号：US07407981B2
公开(公告)日：2008-08-05
申请号：US11683452
申请日：2007-03-08
申请人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney , Gilles Tiraboschi
发明人： Dominique Lesuisse , Gilles Dutruc-Rosset , Franck Halley , Didier Babin , Thomas Rooney , Gilles Tiraboschi
IPC分类号： A61K31/415 , C07D231/00
CPC分类号： C07D231/56 , A61K31/416 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D403/12 , C07D405/12
摘要： The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, OR8, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl, to treat a disease selected from the group consisting of: neurodegenerative diseases, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovaries syndrome, syndrome X, immunodeficiency and cancer.
摘要翻译：本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或与（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（ - NH）NR1基; R 5，R 6和R 7彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，OR 8，COOH，C（ O）OR 8，-OC（O）R 8，NR 8 R 9，NHC（O）R 8，C（O）NR 8 R 9，NHC（S）R 8，C（S）NR 8 R 9，SR 8，S（O）R 8，SO 2 R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2，（1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基，炔基，金刚烷基或多环烷基，以治疗选自以下的疾病：神经变性疾病，中风，颅脑和脊髓创伤和周围神经病变，肥胖症，代谢疾病，II型糖尿病，原发性高血压，动脉粥样硬化心血管疾病，多囊卵巢综合征，综合征X，免疫缺陷和癌症。

8. 发明授权

US06887904B2 Substituted arylcycloalkanes, compositions containing them and use thereof 失效
标题翻译：取代的芳基环烷烃，含有它们的组合物及其用途
公开(公告)号：US06887904B2
公开(公告)日：2005-05-03
申请号：US10309250
申请日：2002-12-04
申请人： Patrick Mailliet , Marc Capet , Gilles Tiraboschi , Thomas Caulfield
发明人： Patrick Mailliet , Marc Capet , Gilles Tiraboschi , Thomas Caulfield
IPC分类号： C07C49/84 , A61K31/122 , A61K31/136 , A61K31/277 , A61K31/403 , A61K31/47 , A61K31/473 , A61P35/00 , C07C49/825 , C07C225/22
CPC分类号： C07C49/84 , C07C225/22 , C07C2601/02 , C07C2601/04 , C07C2601/14
摘要： Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.
摘要翻译：取代的芳基环烷烃，含有它们的组合物及其用途。本发明特别涉及具有治疗活性的取代的芳基环烷烃，其可以用于肿瘤学。

9. 发明申请

US20050014765A1 Aryl-heteroaromatic products, compositions comprising them and use 审中-公开
标题翻译：芳基杂芳族产物，包含它们的组合物和用途
公开(公告)号：US20050014765A1
公开(公告)日：2005-01-20
申请号：US10859740
申请日：2004-06-03
申请人： Patrick Mailliet , Alain Le Brun , Fabienne Thompson , Gilles Tiraboschi
发明人： Patrick Mailliet , Alain Le Brun , Fabienne Thompson , Gilles Tiraboschi
IPC分类号： C07D207/34 , C07D233/90 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/06 , C07D401/12 , C07D417/06 , A61K31/496 , A61K31/4439 , C07D413/02
CPC分类号： C07D263/34 , C07D207/34 , C07D233/90 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/06 , C07D401/12 , C07D417/06
摘要： Aryl-heteroaromatic products, compositions comprising them and use. The present invention relates to novel chemical compounds, particularly to novel aryl-heteroaromatic products, to compositions comprising them, and to their use as medicaments, in particular in oncology.
摘要翻译：芳基杂芳族产物，包含它们的组合物和用途。本发明涉及新颖的化合物，特别是新颖的芳基杂芳族产物，包含它们的组合物，以及它们作为药物，特别是在肿瘤学中的用途。

10. 发明授权

US07462613B2 Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them 失效
标题翻译：哒嗪酮衍生物作为药物和含有它们的药物组合物
公开(公告)号：US07462613B2
公开(公告)日：2008-12-09
申请号：US10715556
申请日：2003-11-19
申请人： Swen Hölder , Thorsten Naumann , Karl Schönafinger , David William Will , Hans Matter , Günther Müller , Dominique Le Suisse , Bernard Baudoin , Thomas Rooney , Franck Halley , Gilles Tiraboschi , Cécile Combeau , Ingrid Sassoon , Anke Steinmetz
发明人： Swen Hölder , Thorsten Naumann , Karl Schönafinger , David William Will , Hans Matter , Günther Müller , Dominique Le Suisse , Bernard Baudoin , Thomas Rooney , Franck Halley , Gilles Tiraboschi , Cécile Combeau , Ingrid Sassoon , Anke Steinmetz
IPC分类号： C07D403/02 , A61K31/501
CPC分类号： C07D401/04 , C07D237/14
摘要： The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; R is unsubstituted or at least monosubstituted C1-C10-alkyl, aryl, aryl-(C1-C10-alkyl)-, heteroaryl, heteroaryl-(C1-C10-alkyl)-, heterocyclyl, heterocyclyl-(C1-C10-alkyl)-, C3-C10-cycloalkyl, polycycloalkyl, C2-C10-alkenyl or C2-C10-alkinyl and Ar is unsubstituted or at least monosubstituted aryl or heteroaryl.
摘要翻译：本发明涉及通式（I）的新的哒嗪酮衍生物，其中A为A 1或A 2; R是未取代的或至少单取代的C 1 -C 10 - 烷基，芳基，芳基 - （C 1 -C 10 - 烷基） - ，杂芳基，杂芳基 - （C 1 -C 10 - 烷基） - ，杂环基，杂环基 - （C 1 -C 10 - 烷基） C 3 -C 10 - 环烷基，多环烷基，C 2 -C 10 - 烯基或C 2 -C 10 - 炔基，Ar是未取代的或至少单取代的芳基或杂芳基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式